This episode was originally recorded for The Kevin Rose Show . Given some of the unique discussions we had, I had no choice but to ask the great Kevin Rose if he would let me re-post it over here on the FoundMyFitness podcast feed. A request which he graciously obliged. In this episode, you'll discover: 00:00:00 - Introduction 00:08:00 - Increasing omega-3 levels in the brain with phospholipid DHA 00:27:23 - Metformin's effects on longevity and possible harms 00:48:23 - Fasting and NAD+ suppleme...
Jan 06, 2020•1 hr 37 min
Rhonda gives a summary of the science of resveratrol including its effects in animals and humans, mechanisms, and the bottom line on resveratrol supplementation and safety. In this episode, you'll discover: (00:00) Introduction (03:39) Resveratrol improves cardiovascular biomarkers in clinical trials (06:49) Anti-inflammatory effects of resveratrol (08:11) Improved cognition and memory in clinical studies (11:23) Resveratrol improved healthspan, but not lifespan, in animals (12:28) Induction of ...
Dec 30, 2019•29 min
In this episode, Rhonda describes NAD+ (perhaps one of the most important molecules in the human body), why it is so important for aging, and why it declines with age. In this episode, you'll discover: (00:00) Introduction (03:07) Overview of NAD+, a source of cellular energy (09:18) NAD+ fuels PARP and sirtuin enzymes, promoting longevity (12:37) How can I raise NAD+ levels? (17:03) Can NAD+ boosters (NMN & NR) promote cancer growth? (19:15) Making sense of the research so far (27:03) Why n...
Nov 13, 2019•36 min
David A. Sinclair David A. Sinclair, PhD, is a professor in the Department of Genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging. He is the co-founder of the journal Aging , where he serves as co-chief editor. Dr. Sinclair's work focuses on understanding the mechanisms that drive human aging and identifying ways to slow or reverse aging's effects. In particular, he has examined the role of sirtuins in disease and aging, with spec...
Nov 06, 2019•1 hr 22 min
This podcast is the audio from a presentation Dr. Rhonda Patrick gave on how the sauna may be an exercise mimetic for heat health and healthspan. Sauna use has emerged as a means to increase lifespan and improve overall health, based on compelling data from observational, interventional, and mechanistic studies. Listen in to find out more. In this episode, you'll discover: (00:00) Introduction (03:01) Clinical research shows that sauna improves cardiovascular health (09:19) Finnish sauna vs Waon...
Sep 16, 2019•47 min
In this short episode, Dr. Patrick discusses some of the compelling science including observational studies, randomized controlled trials, and human mechanistic studies that suggests exercise is a powerful tool for preventing or managing the symptoms of depression and mental illness. Moreover, she talks about the specific types of exercise and exercise parameters that evidence suggests might be the most helpful for depression. This podcast started its life as a video, so make sure to check out t...
Aug 03, 2019•18 min
Elissa Epel Elissa Epel, PhD, is a Professor in the Department of Psychiatry at the University of California, San Francisco where she serves as the director of the Aging, Metabolism, and Emotions Center. Her research centers on the mechanisms of healthy aging and the associations between stress, telomere length, addiction, eating, and metabolic health. In this episode, we dive deep into the world of telomeres, the length of which is one of the useful biomarkers scientists have for getting a sens...
Jun 10, 2019•1 hr 13 min
Matthew Walker Matthew Walker, Ph.D., is a professor of neuroscience and psychology at the University of California, Berkeley, and serves as the Director of the Center for Human Sleep Science. Walker's research examines the impact of sleep on human health and disease. One area of interest focuses on identifying "vulnerability windows" during a person's life that make them more susceptible to amyloid-beta deposition from loss of slow wave sleep and, subsequently, Alzheimer's disease later in life...
Feb 28, 2019•2 hr 48 min
This episode features a Q&A session with Dr. Rhonda Patrick. The questions were sourced from social media followers of both FoundMyFitness and also Zero Fasting Tracker , a convenient mobile app used widely in the fasting community for logging. In this 45-minute podcast, Dr. Patrick answers some of the most popular questions related to fasting, including: (00:00) Introduction (03:46) What effects do coffee, supplements, and amino acids have on fasting? (12:29) Should you consume electrolytes...
Jan 09, 2019•50 min
Dale E. Bredesen Dale E. Bredesen, M.D., is a professor of neurology at the Easton Laboratories for Neurodegenerative Disease Research at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr. Bredesen's laboratory focuses on identifying and understanding basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective treatments for Alzheimer's disease and other neurodegenerative conditions. He has collaborated ...
Oct 01, 2018•1 hr 15 min
Dr. Valter Longo Dr. Longo is the current director of the longevity institute at the University of Southern California and also director of the Oncology and Longevity Program at the Institute of Molecular Oncology Foundation in Milan, Italy. Dr. Longo's research focuses understanding the biological mechanisms that regulate the aging process, the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases. In this episo...
Jul 09, 2018•1 hr 18 min
Charles Raison Charles Raison, M.D. is a professor at the School of Human Ecology at the University of Wisconsin-Madison and Founding Director of the Center for Compassion Studies in the College of Social and Behavioral Sciences at the University of Arizona. Dr. Raison's research focuses on inflammation and the development of depression in response to illness and stress. He also examines the physical and behavioral effects of compassion training on the brain, inflammatory processes, and behavior...
Mar 19, 2018•1 hr 59 min
Eric M. Verdin Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF. Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer's, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to man...
Dec 13, 2017•1 hr 3 min
Dr. Satchin Panda Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. We talk about dealing with shift work, black coffee when fasting, and some of the distinctions between Satchin's approach to time-restricted eating which is influenced by his deep background in circadian biology and more conventional protocols like 16:8 that many people are familiar with. In addition to these important and very practical how-to tid...
Oct 30, 2017•2 hr 3 min
Dr. Guido Kroemer Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy. He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death. In this episode...
Jul 31, 2017•1 hr 10 min
Jari Laukkanen This podcast features Jari Laukkanen, M.D., Ph.D., a cardiologist and scientist at the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. In this episode, you'll discover: (00:00) Introduction (01:50) Sauna use improves cardiovascular health and reduces risk of death (06:42) How sauna use lowe...
Jun 15, 2017•27 min
Dr. Judith Campisi is a professor of biogerentology at the Buck Institute for Research on Aging and a co-editor in chief of the Aging Journal. As an expert on cellular senescence, the discussion involves a lot of talk about aging and cancer, where senescence plays a very important fundamental role. What are some of the strategies we might use in the future to prevent senescent cells? What causes them in the first place? In this episode, you'll discover: (00:00) Introduction (05:12) Fundamental m...
Apr 28, 2017•1 hr 8 min
Dr. Gordon Lithgow of the Buck Institute for Research on Aging tells us about worms! This unassuming scientific model has a lot of important advantages for science: they can be frozen and subsequently thawed and retain viability, they are extremely well understood down to the precise number of cells in their body and the wiring of their nervous system, known as the connectome. Additionally, they have a short lifespan and are cheap to work with. Why would that be advantageous, you may ask? This i...
Apr 04, 2017•47 min
If you're anything like me, having the facts straight can sometimes help you to push through the tough part of building new habits or breaking old bad ones. This podcast talks about the realities of what the science says surrounding the consumption of refined sugar. Some of the facts may surprise you! In this episode, you'll discover: (00:00) Introduction (01:16) Excess sugar consumption is common and dangerous (05:16) Sugar accelerates the aging process itself (09:14) Refined sugar harms the br...
Mar 16, 2017•16 min
Today we try to answer or at least explore a big question in the world of health: does saturated fat cause heart disease? This is not an unreasonable concern given the fact that there have been several associative studies that have found a link between saturated fat and heart disease, which is, no doubt, a fat that we find abundantly in the typical American diet since it is richly found in staples like fatty beef, pork, butter, cheese, and other dairy products. And if you're in the United States...
Feb 10, 2017•25 min
Does meat consumption cause cancer? Or, put another way… does avoiding meat help prevent cancer? If you aren't already savvy to the topic, this may sound more absurd than it should. Here's why: there have been many, many, many correlative studies that have found that higher meat consumption is associated with a significantly higher risk of cancer and cancer mortality. In this episode, you'll discover: (00:00) Introduction (01:18) How cancer starts (04:49) Growth factors make cancer thrive (08:54...
Jan 28, 2017•15 min
The World Health Organization estimates that more than 350 million individuals of all ages have depression and approximately one-third of all patients with depression fail to respond to conventional antidepressant therapies like SSRI's. The good news is that today, good science is starting to illuminate the underlying biological mechanisms of depression. This new understanding may soon help the clinical world develop new and more effective treatments. In this episode, you'll discover: (00:00) Th...
Jan 25, 2017•16 min
Dr. Roland R. Griffiths Dr. Roland R. Griffiths is a clinical pharmacologist at Johns Hopkins and has been researching mood-altering compounds for over 40 years. As an unusually prolific scientist, having published over 360-times, he's also responsible for having started the psilocybin research program at Johns Hopkins nearly 2 decades ago. In this podcast, you'll discover: (00:00) Introduction (04:05) Psilocybin produces meaningful mind-altering effects (12:52) Psilocybin can treat depression a...
Jan 19, 2017•1 hr 18 min
Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University. In this episode, you'll discover: (00:00) Introduction (03:44) What is sulforaphane? (10:25) The NRF2 pathway, a master regulator of antioxidants (14:22) Cruciferous vegetables are rich sources of sulforaphane (20:39) Does cooking broccoli destroy sulforaphane? (26:00) Sulforaphane supplements vary widely in quality (36:41) Antibiotics wipe out...
Jan 06, 2017•2 hr 32 min
This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway. The most potent naturally-occurring inducer of this pathway, a plant compound known as sulforaphane, may be one of the most potent health-enhancing compounds at our disposal and yet... no one is keeping it out of your hands! No $1,000 per pill markup is keeping it out of your hands -- it's available to anyone willing to take the little bit of time it takes each w...
Dec 12, 2016•52 min
Dr. Valter Longo This episode of the FoundMyFitness podcast features Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California. Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases. In this podcast, Valter and I discuss... (00:00) Introduction (03:...
Sep 30, 2016•1 hr 22 min
Dr. Ruth Patterson Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. In this episode, we chat about: (00:00) Introduction (03:33) Lifestyle modifications that reduce breast cancer risk (11:18) Modern life disrupts our circadian rhythm, causing us to eat at odd times (14:31) Women who practiced time-restr...
Jul 08, 2016•47 min
Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. In this video we discuss... (00:00) Introduction (06:42) Why humans developed an internal clock (i.e., the circadian rhythm) (15:28) Light is necessary to regulate our circadian clock (25:02) Morning bright light exposure lowers cortisol levels and lifts mood, but the indoors are dim (30:25) Using light exposure to reset jet-lag and help shift workers stay healthy (...
Jun 30, 2016•1 hr 39 min
Ray Cronise Ray Cronise is a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. The interesting thing about this interview, isn't strictly raised professional background, however, but instead his propensity towards aggressive self-experimentation. In this episode, Ray and I discuss... (00:00) Introduction (03:40) Ray's 23-day (and counting) water fast (05:13) Using fasting and cold stress to lose weight (...
May 03, 2016•2 hr 4 min
Dr. Dominic D'Agostino This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all-around expert on ketosis. In this podcast we discuss: (00:00) Introduction (03:46) Ketosis has abundant therapeutic potential (10:20) What to eat to maintain nutritional ketosis (19:58) Does a high-fat diet harm the gut? (29:14) Adaptations to a ketogenic diet expand mitochondrial capacity (38:45) How the brain uses ketones (46:36) Ketones improve Alzheim...
Mar 23, 2016•1 hr 54 min
