Eric M. Verdin Eric M. Verdin, M.D. is the fifth president and chief executive officer of the Buck Institute for Research on Aging and is a professor of Medicine at UCSF. Dr. Verdin's laboratory focuses on the role of epigenetic regulators in the aging process, the role of metabolism and diet in aging and on the chronic diseases of aging, including Alzheimer’s, proteins that play a central role in linking caloric restriction to increased healthspan, and more recently a topic near and dear to man...
Dec 13, 2017•1 hr 3 min
Dr. Satchin Panda Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. We talk about dealing with shift work, black coffee when fasting, and some of the distinctions between Satchin's approach to time-restricted eating which is influenced by his deep background in circadian biology and more conventional protocols like 16:8 that many people are familiar with. In addition to these important and very practical how-to tid...
Oct 30, 2017•2 hr 3 min
Dr. Guido Kroemer Dr. Guido Kroemer is a professor at the University of Paris Descartes and an expert in immunology, cancer biology, aging, and autophagy. He is one of the most highly cited authors in the field of cell biology and was the most highly cited cell biologist for the period between 2007 and 2013. Especially notable among his contributions: he was the first to discover that the permeabilization of mitochondrial membranes is a concrete step towards apoptotic cell death. In this episode...
Jul 31, 2017•1 hr 10 min
Jari Laukkanen This podcast features Jari Laukkanen, M.D., Ph.D., a cardiologist and scientist at the Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio. Dr. Laukkanen has been conducting long-term trials looking at the health effects of sauna use in a population of over 2,000 middle-aged men in Finland. In this episode, you’ll discover: (00:00) Introduction (01:50) Sauna use improves cardiovascular health and reduces risk of death (06:42) How sauna use lowe...
Jun 15, 2017•27 min
Dr. Judith Campisi is a professor of biogerentology at the Buck Institute for Research on Aging and a co-editor in chief of the Aging Journal. As an expert on cellular senescence, the discussion involves a lot of talk about aging and cancer, where senescence plays a very important fundamental role. What are some of the strategies we might use in the future to prevent senescent cells? What causes them in the first place? In this episode, you’ll discover: (00:00) Introduction (05:12) F undamental ...
Apr 28, 2017•1 hr 8 min
Dr. Gordon Lithgow of the Buck Institute for Research on Aging tells us about worms! This unassuming scientific model has a lot of important advantages for science: they can be frozen and subsequently thawed and retain viability, they are extremely well understood down to the precise number of cells in their body and the wiring of their nervous system, known as the connectome. Additionally, they have a short lifespan and are cheap to work with. Why would that be advantageous, you may ask? This i...
Apr 04, 2017•47 min
If you're anything like me, having the facts straight can sometimes help you to push through the tough part of building new habits or breaking old bad ones. This podcast talks about the realities of what the science says surrounding the consumption of refined sugar. Some of the facts may surprise you! In this episode, you'll discover: (00:00) Introduction (01:16) Excess sugar consumption is common and dangerous (05:16) Sugar accelerates the aging process itself (09:14) Refined sugar harms the br...
Mar 16, 2017•16 min
Today we try to answer or at least explore a big question in the world of health: does saturated fat cause heart disease? This is not an unreasonable concern given the fact that there have been several associative studies that have found a link between saturated fat and heart disease, which is, no doubt, a fat that we find abundantly in the typical American diet since it is richly found in staples like fatty beef, pork, butter, cheese, and other dairy products. And if you're in the United States...
Feb 10, 2017•25 min
Does meat consumption cause cancer? Or, put another way… does avoiding meat help prevent cancer? If you aren't already savvy to the topic, this may sound more absurd than it should. Here's why: there have been many, many, many correlative studies that have found that higher meat consumption is associated with a significantly higher risk of cancer and cancer mortality. In this episode, you'll discover: (00:00) Introduction (01:18) How cancer starts (04:49) Growth factors make cancer thrive (08:54...
Jan 28, 2017•15 min
The World Health Organization estimates that more than 350 million individuals of all ages have depression and approximately one-third of all patients with depression fail to respond to conventional antidepressant therapies like SSRI’s. The good news is that today, good science is starting to illuminate the underlying biological mechanisms of depression. This new understanding may soon help the clinical world develop new and more effective treatments. In this episode, you'll discover: (00:00) Th...
Jan 25, 2017•16 min
Dr. Roland R. Griffiths Dr. Roland R. Griffiths is a clinical pharmacologist at Johns Hopkins and has been researching mood-altering compounds for over 40 years. As an unusually prolific scientist, having published over 360-times, he's also responsible for having started the psilocybin research program at Johns Hopkins nearly 2 decades ago. In this podcast, you'll discover: (00:00) Introduction (04:05) Psilocybin produces meaningful mind-altering effects (12:52) Psilocybin can treat depression a...
Jan 19, 2017•1 hr 18 min
Dr. Jed Fahey is a multi-decade veteran of isothiocyanate research and is the director of the Cullman Chemoprotection Center at Johns Hopkins University. In this episode, you'll discover: (00:00) Introduction (03:44) What is sulforaphane? (10:25) The NRF2 pathway, a master regulator of antioxidants (14:22) Cruciferous vegetables are rich sources of sulforaphane (20:39) Does cooking broccoli destroy sulforaphane? (26:00) Sulforaphane supplements vary widely in quality (36:41) Antibiotics wipe out...
Jan 06, 2017•3 hr 32 min
This podcast is about one of the most important biological pathways you could possibly take the time to learn about: the NRF2 pathway. The most potent naturally-occurring inducer of this pathway, a plant compound known as sulforaphane, may be one of the most potent health-enhancing compounds at our disposal and yet... no one is keeping it out of your hands! No $1,000 per pill markup is keeping it out of your hands -- it’s available to anyone willing to take the little bit of time it takes each w...
Dec 12, 2016•52 min
Dr. Valter Longo This episode of the FoundMyFitness podcast features Dr. Valter Longo, a professor of gerontology and biological sciences and director of the longevity institute at the University of Southern California. Dr. Longo has made huge contributions to the field of aging, including the role of fasting and diet in longevity and healthspan in humans as well as metabolic fasting therapies for the treatment of human diseases. In this podcast, Valter and I discuss... (00:00) Introduction (03:...
Sep 30, 2016•1 hr 22 min
Dr. Ruth Patterson Dr. Ruth Patterson, a professor in the UC San Diego Department of Family Medicine and Public Health as well as Associate Director of Population Sciences and leader of the Cancer Prevention program at Moores Cancer Center at UC San Diego Health. In this episode, we chat about: (00:00) Introduction (03:33) Lifestyle modifications that reduce breast cancer risk (11:18) Modern life disrupts our circadian rhythm, causing us to eat at odd times (14:31) Women who practiced time-restr...
Jul 08, 2016•47 min
Dr. Satchidananda (Satchin) Panda is a professor in the Regulatory Biology Laboratory at the Salk Institute for Biological Studies. In this video we discuss... (00:00) Introduction (06:42) Why humans developed an internal clock (i.e., the circadian rhythm) (15:28) Light is necessary to regulate our circadian clock (25:02) Morning bright light exposure lowers cortisol levels and lifts mood, but the indoors are dim (30:25) Using light exposure to reset jet-lag and help shift workers stay healthy (...
Jun 30, 2016•2 hr 39 min
Ray Cronise Ray Cronise is a former NASA material scientist and cofounder of zero gravity, a company that offers weightless parabolic flights to consumers and researchers. The interesting thing about this interview, isn't strictly raised professional background, however, but instead his propensity towards aggressive self-experimentation. In this episode, Ray and I discuss... (00:00) Introduction (03:40) Ray's 23-day (and counting) water fast (05:13) Using fasting and cold stress to lose weight (...
May 03, 2016•2 hr 4 min
Dr. Dominic D'Agostino This podcast is with Dr. Dominic D'Agostino, an assistant professor at the University of South Florida in Tampa and all-around expert on ketosis. In this podcast we discuss: (00:00) Introduction (03:46) Ketosis has abundant therapeutic potential (10:20) What to eat to maintain nutritional ketosis (19:58) Does a high-fat diet harm the gut? (29:14) Adaptations to a ketogenic diet expand mitochondrial capacity (38:45) How the brain uses ketones (46:36) Ketones improve Alzheim...
Mar 23, 2016•2 hr 54 min
Dr. Peter Attia Peter is the founder of Attia Medical, a medical practice with offices in San Diego and New York City, focusing on the applied science of longevity and optimal performance. In addition to being a medical doctor, Dr. Attia has done research on the role of regulatory T cells in cancer regression and other immune-based therapies for cancer. Regulatory T cells have also been, in the past, referred to as suppressor T cells because of their role in actually attenuating or reducing the ...
Mar 13, 2016•1 hr 9 min
Dr. Rhonda Patrick explains how cold shock is a type of hormesis, which is a description of a type of stress that, in the right doses, is enough to shock the body and kick off adaptive processes and response mechanisms that are hardwired into our genes, and, once on, are able to create a resilience that actually exceeds what was needed to counter the initial stimuli. In this episode, you'll discover: (00:00) Introduction (03:09) Cold exposure is good stress for the brain (15:42) Cryotherapy redu...
Feb 12, 2016•1 hr 2 min
Rich Roll This podcast features Rich Roll. Rich is an author, a podcaster ("Rich Roll Podcast" on iTunes) , as well as founder and first person to complete the EPIC5 Challenge. The EPIC5 challenge involves completing 5 Full Iron Distance triathlons on 5 Hawaiian islands in under a week. Rich has also been a repeated top finisher in the Ultraman World Championships in Hawaii, which is a three-day, 515km (320 mile) annual endurance race held on the Big Island of Hawaii. You can read about Rich's j...
Jan 23, 2016•2 hr 40 min
In this episode, Dr. Rhonda Patrick chats with Dr. Darya and Kevin Rose. Dr. Darya Rose, PhD is a neuroscientist, author of “Foodist: Using Real Food and Real Science to Lose Weight Without Dieting,” and creator of Summer Tomato, which was featured in TIME magazine’s list of the web’s 50 best websites in 2011. Kevin you may know from TV, the investing world, or any of a wide variety of things he’s well known for (founding digg.com, just for starters). More recently, Kevin hosts a podcast where h...
Dec 25, 2015•54 min
Dr. Pierre Capel Dr. Pierre Capel is a professor emeritus in experimental immunology at the Utrecht University in the Netherlands where he researched a wide range of topics from genetic modification to cancer immunotherapy. Pierre also works with Wim Hof, otherwise known as the iceman (guest on the last podcast ) who is especially well-known for some of his amazing physical feats, like staying in a tub with direct contact to ice for over an hour and fifty three minutes. Pierre explains some of t...
Nov 06, 2015•1 hr 16 min
Wim Hof Wim Hof, also known as "the Iceman", holds the world record for the longest ice bath (1 hour and 53 minutes and 12 seconds), just to name one of his many impressive feats. Dr. Patrick and Wim talk a bit about Wim's back story that culminated in him trying out cold water immersion, the relatively recent 2014 scientific publication of the "Wim Hof Method" which includes cold exposure during training, exposure to bacterial endotoxin, Wim's breathing techniques, and meditation. In this episo...
Oct 22, 2015•50 min
Dr. Rhonda Patrick delivers the keynote lecture at the Orthomolecular Medicine Congress in Bussum, Netherlands (MBOG Congres 2015). In this talk, you'll learn about: (00:00) Introduction (04:52) Micronutrient inadequacies and triage theory (10:42) Role of DNA damage in cancer and aging (21:10) Vitamin D, serotonin, and the development of autism (41:39) Omega-3s also regulate serotonin If you’re interested in learning more, you can read the full show notes here . Join over 300,000 people and get ...
Oct 15, 2015•58 min
In this podcast, I discuss some of the mechanisms by which chronic stress (and rumination) affect health and aging and how meditation can reduce rumination and buffer stress. In this episode, you'll discover: (00:00) Introduction (02:41) Eustress such as exercise vs distress such as fear (06:15) Effects of stress on the brain (07:30) Effects of stress on the gut and microbiome (10:21) Stress accelerates biological aging (15:04) Meditation reduces rumination and promotes empathy (19:53) Effects o...
Sep 25, 2015•41 min
In this episode Rhonda talks about: (00:00) Introduction (03:00) Heat stress makes the body more resilient to the stresses of aging (14:45) Possible mechanisms why sauna use reduces heart disease risk (16:45) Sauna enhances athletic endurance and muscle growth (28:16) Sauna use stimulates neurogenesis and improves cognitive function and mood (37:34) Sauna use detoxifies BPA, PCBs, phthalates, and other metals (51:10) Practical applications sauna use and other heat stressors like hot yoga If you’...
Sep 11, 2015•1 hr 5 min
Dr. Justin Sonnenburg Dr. Justin Sonnenburg is an associate professor of microbiology and immunology at Stanford and Dr. Erica Sonnenburg is a senior research scientist in the Sonnenburg lab where they research many aspects the interaction between diet with the 100 trillion or so bacteria in the gut (specifically the colon) and how this impacts the health of the host (which in this case is a laboratory research mouse). In this episode, we discuss... (00:00) Introduction (02:50) What is the gut m...
Sep 03, 2015•47 min
Dr. Ronald Krauss Dr. Ronald Krauss, M.D. is the director of atherosclerosis research at Children’s Hospital Oakland Research Institute, Adjunct Professor at UCSF and UC Berkeley. Dr. Krauss is really one of the pioneering scientists that changed the way we all think about cholesterol and saturated fat. He developed an assay that allows the quantification of low density lipoprotein particle size and concentration (known to the wider world as LDL cholesterol) based on a technique which determines...
Aug 27, 2015•1 hr 24 min
CHORI Bar Team Meet some of the CHORI bar team: Dr. Bruce Ames, Dr. Joyce McCann, and Dr. Mark Shigenaga. On this podcast we talk about the different types of HDL and LDL cholesterol and what they do in the body. We discuss a low-calorie, micronutrient- and fiber-dense nutrition bar (referred to as the CHORI bar) that Bruce and I briefly touched on in a previous conversation, how each of the components of the bar from the vitamins and minerals to the fiber and polyphenols are all really importan...
Aug 20, 2015•1 hr 1 min
