October JPGN Journal Club, led by Dr Jake Mann ! As always, keep in mind ESPGHAN’s other educational offerings : https://www.espghan.org/knowledge-center – in particular on X.25 a Monothematic Conference on Paediatric Gastric Disease ; on XI.11 the Winter School on Basic Science and Translational Research ; and on XI.15 a Masterclass on Transition from Paediatric to Adult Healthcare in Patients with GI or Liver Disease. For today’s discussion Jake has chosen a review of a small series of patient...
Sep 30, 2024•23 min
Interviewed today in the ESPGHAN podcast series is Dr Orit Waisbourd-Zinman, of Israel, who as a fellow in hepatology at the Children’s Hospital of Philadelphia was offered the chance to take part in studies of how “biliatresone”, a compound isolated from Australian plants ( Dysphania sp.), might disrupt formation of extrahepatic biliary structures, as was postulated when sheep during drought ate unusual fodder, including Dysphania , and bore lambs that had biliary atresia. Extrahepatic cholangi...
Sep 19, 2024•22 min
Dr Johanna (“Henkje”) Escher speaks with me for ESPGHAN’s podcast series today. She works in learning how best to pass along the care of paediatric patients when, rather arbitrarily, they are declared to be adults. All very well, no adolescent wants to be a child forever, but . . . well, paediatric disorders, that is, those that manifest themselves in early life, cover a far wider spectrum than do those that are unmasked only in adulthood, and to have been ill (and designated thus) for sixteen, ...
Sep 09, 2024•18 min
JPGN Journal Club, led by Dr Jake Mann, is here again for August. As always, keep in mind ESPGHAN’s other educational offerings : https://www.espghan.org/knowledge-center – in particular on IX.12, AHP Summer School ; IX.21, the Young Investigator Forum ; IX.25, the 5th Liver Transplant School ; and X.25, a Monothematic Conference on Paediatric Gastric Disease. For today’s discussion Jake has chosen a case-review series of inflammatory bowel disease manifest after non-haematologic transplantation...
Aug 31, 2024•28 min
Interviewed today in the ESPGHAN podcast series is Dr Julie Lanigan of University College London, working at several hospitals in London and lecturing in Plymouth, a dietitian whose interest is in complementary feeding (once called “weaning”, or the introduction of foods other than milk to an infant’s diet). Not just foods, but feeding , taking part in the activities that define the family – gaining a seat at the breakfast, lunch, and dinner table – goes into complementary feeding : Starting wit...
Aug 20, 2024•21 min
Bergamascheria ancora! Yes, the Bergamo team have made available for a podcast yet another member, Dr Lorenzo Norsa, a professor of paediatrics there. Dr Norsa has been a fellow in paediatric gastroenterology in Israel and in France. In Paris he became well-versed in treatment of short bowel syndrome, working with the prominent Necker team . . . perhaps their publications form a suite Bergamasque. (Apologies, M Debussy.) He speaks today on the use of teduglutide, an agent that mimicks the effect...
Aug 09, 2024•20 min
It’s JPGN Journal Club, led by Dr Jake Mann, in your electronic- device speakers, with the July podcast offering. Don’t forget to check out what ESPGHAN has available from July onward, here at https://www.espghan.org/knowledge-center -- in particular on IX.12, AHP Summer School, IX.21, the Young Investigator Forum, and on IX.25, the 5th Liver Transplant School. Jake Mann has chosen for today’s discussion from J Pediatr Gastroenterol Nutr, by Granot et al., a case review of instances of autoimmun...
Jul 31, 2024•24 min
The ESPGHAN podcast guest today is Dr Paolo Marra – the interviewer, as our producer, Selma Ertl already has told you, is same old same old me – to round out the team, a hat-tip to Manuel Schuster, engineer. Let’s get starty with the party! So, Dr Marra – an interventional radiologist, and like everyone across from whom I sit in these sessions, amazingly young to have accomplished so much. He is an expert in how to deal with a not infrequent complication of premature birth – thrombosis of the ex...
Jul 19, 2024•24 min
Interviewed today in the ESPGHAN podcast series is Hon. Prof. Dr. med. Alexandra Papadopoulou from Greece, Chair of the ESPGHAN Working Group and Special Interest Group on Eosinophilic Gastrointestinal Disorders for the last six years, Head of the Division of Gastroenterology, Hepatology and Nutrition of the First Department of Pediatrics of the National and Kapodistrian University of Athens and Head of the Department of Gastroenterology at the Athens Children's Hospital "Agia Sofia”. Among her ...
Jul 09, 2024•21 min
JPGN Journal Club reporting for duty, sah! And mem! Here’s the spoken word about the written word . . . in a glorious June, with Heaven and Earth well and true in tune, as the poem goes. Don’t forget to check out what ESPGHAN has on offer from July onward, available at https://www.espghan.org/knowledge-center ! Dr Jake Mann has chosen for today’s discussion two heavy-hitting publications. The first, from J Pediatr Gastroenterol Nutr , by Cohen et al. , addresses the value of intestinal-rehabilit...
Jun 30, 2024•21 min
ESPGHAN presents today an encounter with Prof Amit Assa, who like so many of those who have agreed to take part in these podcasts has filled all the posts of the medical-school and medical-administrative cursus honorum , steadily leaping upward from institution to institution. As of now he is at the Institute of Paediatric Gastroenterology, Shaare Zedek Medical Centre, in Jerusalem, Israel (affiliated with Hebrew University) ; his interests are concentrated on inflammatory bowel disease. Today h...
Jun 19, 2024•24 min
Today’s ESPGHAN podcast offers the opportunity to become acquainted with the effects of a revision in nomenclature. Decades ago, stout – in both senses – Mormon matrons were vastly offended to learn that the form of steatohepatitis from which they suffered was histopathologically superimposeable upon that owing to ingestion of ethanol to excess ; the Word of Wisdom, a revelation vouchsafed in 1833 to Prophet Joseph Smith, expressly forbids ethanol to members of the Church of Jesus Christ of Latt...
Jun 09, 2024•23 min
JPGN Journal Club reports from the Milan venue of ESPGHAN’s 2024 annual meeting, seizing the opportunity to learn from those rarely in Europe – as today with Prof Binita Kamath, in transit between Toronto and Philadelphia professionally, who along with Dr Jake Mann will tag-team her way down the field shooting for goal with two articles of interest (Winter et al. ’s Biomarkers predicting the effect of anti‐TNF treatment in paediatric and adult inflammatory bowel disease, from J Pediatr Gastroent...
May 31, 2024•19 min
O-makase is the word of the day, the phrase that in Japan tells your chef that your meal is both literally and metaphorically in her hands – “Choose for me,” it means. Most fine dining has an equivalent; the French say menu de dégustation , here in Milan / Mailand / Milano it’s called menù degustazione. That is: Non prevede scelte da parte del cliente! You, the diner, have no say. Either eat what’s set on the plate in front of you or stand up and leave the restaurant. O-makase, baby ! We hope yo...
May 18, 2024•28 min
Dr Alex Knisely today speaks with Prof Yvan Vandenplas of Brussels, where he was chief of paediatrics for many years. He’s a hollow-viscus gastroenterologist rather than a “liver man”, and he has made many contributions in his chosen field, particularly in feeding disorders of infancy and in cows’-milk allergy, a topic on which he has selected three articles for us, all published in 2023 : From JPGN, “An ESPGHAN position paper on the diagnosis, management and prevention of cow's milk allergy”, w...
May 14, 2024•21 min
Here again is JPGN Journal Club. It’s Spring, people! Asparagus! Strawberries! White wine! All of these can be enjoyed as an ESPGHAN podcast listener, so let’s get at it : Raise your sauce béarnaise -laden forks, your Sancerre glasses, and your play-volume settings. Dr Jake Mann has chosen for today from Hepatology, by Stonebraker et al., Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis. Genomes of substantial numbers of CFTR ...
Apr 30, 2024•24 min
Dr. Alex Knisely today is talking to Dr. Georg-Friedrich Vogel – call him “Georg” – of the Medizinische Universität Innsbruck, in Austria, where he serves on the paediatric-hepatology wards and conducts research in the department of cell biology. In Vienna this May, at the ESPGHAN annual meeting, he presented observations on the utility of an ileal bile-acid transport inhibitor, odevixibat (those last four letters, i – b – a – t, are acronymic), in a collective of children suffering from choles...
Apr 14, 2024•20 min•Season 2Ep. 8
JPGN Journal Club is again here for you! No, no point in all that applause, although we’re grateful: Remember, we can’t hear it. As always, we’re glad to be back and we hope that you’re glad to have us back. Dr Jake Mann has chosen for today from Aliment Pharmacol Ther , by Ricciuto et al. , Oral vancomycin is associated with improved inflammatory bowel disease clinical outcomes in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD) : A matched analysis from the Paedia...
Mar 31, 2024•24 min
Dr Alex Knisely today is speaking with Prof Isabelle Scheers of Louvain, Belgium, on pancreatitis in children. She has proposed three articles for discussion – from a coalition that she led, drawing on collaborators in Canada, the United States, and almost the full bank of Eurovision Song Contest participant nations, a summary and review, Autoimmune Pancreatitis in Children : Characteristic Features, Diagnosis, and Management ; a personal “position paper”, Inherited Pancreatic Exocrine Insuffici...
Mar 15, 2024•22 min
JPGN Journal Club is in your ears again! We’re glad to be back and we hope that you’re glad to have us back. Dr Jake Mann has chosen for today from Gut , by Guo et al. , early-life diet and risk of inflammatory bowel disease: A pooled study in two Scandinavian birth cohorts. This is the sort of thing that – thanks to the record-keeping in which the Northlands specialise – can’t be duplicated elsewhere but that indicates for us all how we can effectively address an aspect of disease. Fish, veggie...
Mar 01, 2024•20 min
Dr. Alex Knisely is talking today to Dr. Rut Anne Thomassen, of Oslo, who is a senior dietitian – one of only a few in the councils of ESPGHAN – and whose recent remit from ESPGHAN was to pull together a position paper that sets out for us all what is known in paediatric patients about a form of elimination-and- reïntroduction diet called FODMAP, an acronym that lists the classes of foodstuffs to be withdrawn. Some say that it works in some patients with irritable bowel syndrome . . . but conse...
Feb 15, 2024•22 min•Season 2Ep. 7
Dr Alex Knisely today in JPGN Journal Club is in a dogfight against Dr Jake Mann – it’s Jake’s first solo flight as Journal Club pilot, will he be shot down? Jake first offers us, out of Berlin, with co-authors from European and Israeli centres, and published in J Pediatr Gastroenterol Nutr : Kalveram et al., Noninvasive scores are poorly predictive of histological fibrosis in pediatric fatty liver disease. Then he steers away from the sunlit uplands of JPGN and into the dark and stormy clouds o...
Feb 01, 2024•22 min
Dr. Alex Knisely is talking today to Dr. Kaija-Leena Kolho, of Helsinki — they’ve orbited around each other for years, co-authoring this and that, but never met . . . in person or electronically, not until today, when they become good friends whilst discussing this podcast’s theme: Calprotectin. What is it? What does it do, in the body and in the diagnostic work-up? How can it be mis-used or mis-interpreted? And what superpowers does calprotectin confer upon the paediatric gastroenterologist who...
Jan 15, 2024•26 min•Season 2Ep. 5
Dr Alex Knisely today is speaking with Dr Sami Wali, of Riyadh, Saudi Arabia, senior attending gastroenterologist and chief of transplant hepatology at Prince Sultan Military Medical City. Dr Wali rose through the Saudi educational and medical-education systems, training at several Riyadh hospitals, with specialisation in paediatrics and in paediatric gastroenterology and hepatology that culminated in a year in Ontario at McMaster University and Hospital for Sick Children, Toronto – he is one of...
Jan 01, 2024•24 min•Season 2Ep. 9
Today we are speaking with Prof Thomas Attard, of the University of Missouri and Children’s Mercy Hospital of Kansas City, Missouri, where he directs gastrointestinal endoscopy services and leads the hereditary gastrointestinal polyposis multidisciplinary clinic. He is from Malta, where he studied medicine, although by far most of his career has been in the United States. At the 2023 ESPGHAN annual meeting in Vienna this May he presented his and his institution’s experience with video-capsule en...
Dec 15, 2023•26 min
Today we are not only speaking with Kassel’s best, Dr Andreas Jenke, but also with Dr Jake Mann, pride of Birmingham and the Channel Islands – that’s right, double trouble. We say thank you and goodbye to Andreas, thank you and hello to Jake, who is stepping into Andreas’ shoes as primary Journal Club discussant. Andreas leads off with Predicting Insulin Resistance in a Pediatric Population With Obesity, a JPGN article from Portugal, by Daniela Arauj́ o and colleagues, using non-invasive paramet...
Dec 01, 2023•24 min
Dr Jake Mann, of the Children’s Hospital of Birmingham and the University of Birmingham is our guest today – Dr Mann’s second contribution to these podcasts. At the annual meeting of ESPGHAN in Vienna this May Dr Mann presented information on the potential relevance of genetic variants “of unknown significance”, the sort of thing that often is uncovered in exomic or genomic studies of children with hepatobiliary disease; one can’t pin the hepatobiliary disease on those variants, not exactly, but...
Nov 15, 2023•18 min
Dr Alex Knisely today in JPGN Journal Club is bantering happily with Dr Andreas Jenke, who for discussion has chosen two articles and a pair of Letters to the Editor, thrust and parry, attack and defence. He believes that correspondence of this sort often affords insight into what is at issue in the matter addressed – and he may well be right. Along with those, we have a contribution from Dr S Bonilla of Boston Children’s Hospital – Helicobacter pylori Antimicrobial Resistance Using Next-Generat...
Nov 01, 2023•22 min
Todays guests are Prof Marc Benninga and Dr Klaartje de Bruijn, both of Amsterdam’s Academisch Medisch Centrum. Prof Benninga is visiting these podcasts for a second time ; Dr de Bruijn is facing her baptism of fire. Their topic? Shudder and thrill – faecal transplantation. In 2020 their group published a protocol for faecal transplantation in adolescents with refractory irritable-bowel syndrome (PMID : 32864480), midway through the study described. In nuce : Healthy- donor stool or recipient’s ...
Oct 14, 2023•22 min
Dr Alex Knisely today in JPGN Journal Club is – as usual ! -- speaking with Dr Andreas Jenke, who for discussion has chosen the three articles Budd-Chiari Syndrome – A Single-Centre Experience from the United Kingdom, contributed by the Birmingham paediatric team ; Body Composition and Physical Activity in Pediatric Intestinal Failure, from London’s Great Ormond Street ; and Thiopurines Maintenance Therapy in Children with Ulcerative Colitis, the work of several medical centres in Israel. Budd-C...
Sep 30, 2023•21 min
