Our todays guest is Prof. Anil Dhawan of King’s College Hospital in London, leader of the paediatric liver service there, about Prof. Dhawan’s lifelong especial interest within paediatric hepatology: Acute liver failure. In May, 2023, at the annual meeting of ESPGHAN, he sketched – from his personal vantage point – the horrorshow with which this clinical diagnosis confronted caregivers thirty-plus years ago; what steps have been taken to improve the prognosis of children with acute liver failure...
Sep 14, 2023•21 min•Season 2Ep. 8
Dr Alex Knisely today in JPGN Journal Club is – as usual ! -- speaking with Dr Andreas Jenke, who for discussion has chosen two full-size articles, call them “mains”, and a pair of linked items from among the “starters”, that is, a letter to the editors of the journal and a response from ESPGHAN. The two “mains” are Efficacy and Safety of Teduglutide in Infants and Children With Short Bowel Syndrome Dependent on Parenteral Support, from a coalition of Japanese, British, and Finnish centres suppo...
Aug 31, 2023•24 min
Today we are talking to Prof. (and Dr.) Richard Thompson, of London’s King’s College Hospital, who there for twenty-five years has broadened and heightened his leading role in studies of the genetics, physiology, and treatment of forms of intrahepatic cholestasis, disorders that come to clinical attention principally in childhood. Richard and Alex for fifteen years were on the same team at King’s, sometimes shoulder to shoulder, sometimes pushmi-pullyu, but always having fun. Their chat today, a...
Aug 14, 2023•29 min•Season 2Ep. 7
Dr Alex Knisely today is speaking with Dr Andreas Jenke – it’s Journal Club again. Dr Jenke has chosen from the August, 2023, number of JPGN three articles for discussion – from Brisbane (Queensland), Australia, and, in India, Lucknow, Jodhpur, and Rishikesh (a thousand-kilometre span across the centre and north of the subcontinent ! ), Oral Tacrolimus in Steroid-Refractory and - Dependent Pediatric Ulcerative Colitis - a Systematic Review and Meta-Analysis ; from a group in San Diego, Californi...
Jul 31, 2023•23 min
Today we are talking to Prof. Dr. Tobias Cantz, of Hanover / Hannover, Germany, on a topic that offers the chance to re-work many approaches to both acquired and inborn disease not just of the liver but also of the biliary tree. Prof. Cantz is a regenerative hepatologist, conducting research into how hepatocellular or cholangiocellular organoids – or, more complexly, organoids that include all the components of the differentiated and polarised and vascularised hepatic lobule – can be used to exa...
Jul 14, 2023•23 min•Season 2Ep. 6
Dr Alex Knisely today is speaking with Dr Andreas Jenke – it’s Journal Club again. Skipping over the June, 2023, number of JPGN, Dr Jenke has chosen from the July number not two but three articles for discussion – from a Scandinavian consortium, Risk Factors of Cancer in Pediatric-Onset Inflammatory Bowel Disease in Denmark and Finland ; from a group in California, Prevalence of Elevated ALT in Adolescents in the US 2011-2018; and from a group in Birmingham, England, Liver Disease inGLIS3 Mutati...
Jun 30, 2023•26 min•Season 2Ep. 5
Today we are talking to Dr. Andreas Jenke — Journal Club again! Two articles of particular interest and significance from the May, 2023, number of JPGN are discussed. From Eva Karbaum and colleagues in Hamburg (Protocol Biopsies in Pediatric Liver Transplantation Recipients Improve Graft Histology and Personalize Immunosuppression) we learn that using protocol-biopsy findings to fine-tune liver transplant recipients’ drug regimens, either increasing them or decreasing them, on follow-up biopsy i...
Jun 14, 2023•19 min•Season 2Ep. 4
Todays guest is Prof. Dr. Christos Tsivinikos of the Al Jalila Children’s Specialty Hospital, Dubai (United Arab Emirates), by way of Liverpool, UK, where he worked long-term. Over the past several years he and his colleagues have built up in Dubai not just a comprehensive paediatric gastroenterology and hepatology service but also an aerodigestive-diseases service, with collaboration from a variety of specialists in coördinated treatment of the complex problems that both underlie and arise fro...
Jun 07, 2023•22 min•Season 2Ep. 3
Dr. Alex Knisely is talking to, or with, or even maybe mostly listening to Prof. Dr. Michael Trauner, of Vienna – Professor Trauner has a lot to say on today’s topic, on which he recently provided the keynote address at the May, 2023, annual meeting of ESPGHAN. The topic is bile acids: They’re paracrine and endocrine hormones, not just lipid solubilisers ; modified versions offer promise in modulating and treating many paediatric and adult hepatobiliary and gastrointestinal processes and disorde...
May 31, 2023•22 min•Season 2Ep. 2
We are talking to Dr. Elena Cernat, of Leeds out of Romania, and the topic is oven-fresh : What was the 2023 annual meeting of ESPGHAN like? Elena last year gave us her opinions on interesting and very likely significant presentations at the previous annual meeting, and the Education Committee earlier this month again sent her out onto the convention floor to reconnoitre for more of the same. She came back lugging a sackful of those opinions, and she’ll share them with you in what you’re about t...
May 24, 2023•21 min•Season 2Ep. 1
Dr. Alex Knisely is talking today to Dr. Ana Močić-Pavić, of Zagreb, whose great love is hollow-viscus work – inflammatory bowel disease, its demographics and its manifestations, particularly in Croatia, where she has been prominent among the teams that validated in Croatian children the utility of Impact-III scoring, that set up the first IBD registry in Croatia, and – this was a first not just for Croatia, but world-wide – that documented altered eating patterns and nutritional status in ch...
May 14, 2023•24 min•Season 1Ep. 27
Dr Alex Knisely is talking to Dr. Andreas Jenke — Journal Club again ! Two articles of particular interest and significance from the April, 2023, edition of JPGN are discussed. One examines how pre-term infants fare nutritionally during several years' follow-up and identifies a surprise risk factor for poor outcome : Prolonged ventilation (10 days or more). The other, which on behalf of the Histopathologists' Guild to which I belong as well as personally I find very welcome, validates the concep...
Apr 30, 2023•20 min•Season 1Ep. 29
Dr. Alex Knisely is talking today to Dr. Mike Thomson of Sheffield (England), a gastroenterologist whose true love is endoscopy – interventional endoscopy. Mike has contributed substantially to systematising approaches to upper endoscopy in the setting of acute haemorrhage in children : As always, the indications differ between children and adults. Not only that, too few persons, whether paediatric or adult gastroenterologists, are trained well enough to manage such haemorrhage efficiently, whic...
Apr 14, 2023•21 min•Season 1Ep. 26
We are talking to Dr. Andreas Jenke — Journal Club again! Two articles of particular interest and significance from the March, 2023, number of JPGN are discussed. One examines plasma constituents in children with untreated eosinophilic oesophagitis, mapping a wide range of small molecules. The “metabolomic profile” obtained is abnormal, but will any abnormalities resolve with successful treatment? Still waiting for that shoe to drop, and a long way to go before biomarkers are identified for clin...
Apr 01, 2023•19 min•Season 1Ep. 25
It’s the February JPGN Journal Club podcast, with Dr Andreas Jenke as docent and Dr Alex Knisely as interviewer. The two articles selected for discussion deal with, first, functional gastrointestinal disease as encountered in routine paediatric visits among infant and toddler populations in three regions of Italy – the conclusions will surprise you – and, second, with what patients, parents, and caregivers can expect in the first year after a bout of pancreatitis, as observed in a single academi...
Mar 14, 2023•20 min•Season 1Ep. 24
We are talking to Dr. Hania Szajewska of Warsaw, who as a newly fledged paediatric hepatogastroenterologist one day in Houston at a joint ESPGHAN / NASPGHAN meeting a few years back volunteered to collaborate in an international research investigation of -biotics (pro-, pre-, sym-, and post- are the flavours that she defines for us) and from then on has made the evidence-based study of these aids to establishing, maintaining, and restoring enteral health her high-flying career. Heady times, when...
Feb 28, 2023•26 min•Season 1Ep. 22
We are talking to Prof. Valerie McLin of Geneva, Switzerland, where at the Hôpitaux universitaires de Genève she heads the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, about the clinically Protean — and thus as fascinating as they are challenging — disorders called portosystemic vascular shunts. Intrahepatic or extrahepatic, they all should be closed. But how are they to be recognized, assessed, and best closed? What resources are available to assist caregivers without spec...
Feb 15, 2023•31 min•Season 1Ep. 21
Dr. Alex Knisely is talking to Prof. Andreas Jenke — based in Kassel, Germany; but that’s less important today than is his position on the ESPGHAN Education Committee. Enough touchy-feely in these podcasts it’s Journal Club today, where two articles of particular interest and significance from the January, 2023, number of JPGN are discussed. Neither article, however, lays down the law: THIS IS WHAT TO DO. One, an immense retrospective study of oral immunotherapy and the chance that it might pred...
Feb 01, 2023•22 min•Season 21Ep. 1
Dr. Alex Knisely is talking to Dr. Olzhas Abdrakhmanov of the Scientific Centre of Pediatrics and Children’s Surgery, Almaty, Kazakhstan, until recently the nation’s capital (and still her premier city), about the hurdles and satisfactions of working as a paediatrician passionate about hepatogastroenterology who lacks the benefits of formal training in that discipline. His motto as he progressed through his twenties — he’s not yet into his fourth decade — has necessarily been “Learn from your pa...
Jan 14, 2023•36 min•Season 1Ep. 20
We are talking to Dr. Andreia Nita of Bucharest, Romania, and Great Ormond Street Hospital for Children, London, about her personal route into paediatric gastroenterology and about the opportunities that ESPGHAN, and particularly “Young ESPGHAN”, in which she is active — cut-off upper age forty, but for the right woman or man they’ll stretch a point — make available not only to trainees but also to the senior members of ESPGHAN who gain from mentoring those on the rise. Pairings between hopeful ...
Dec 31, 2022•32 min•Season 1Ep. 19
Dr. Alex Knisely is talking to Dr. Patrick Bontems of Hôpital Universitaire des Enfants Reine Fabiiola in Brussels / Brüssel / Bruxelles, Belgium, about Helicobacter pylori infection — how does one recognise it, diagnose it, treat it, and demonstrate success in treating it? What does one do with asymptomatic close family or social contacts? What about screening the asymptomatic in high-incidence populations? So much work on H. pylori has been published, and that work is so fragmentary, that most...
Dec 14, 2022•35 min•Season 1Ep. 18
Dr. Alex Knisely is talking to Dr. Miguel Sáenz de Pipaón of Hospital Universitario La Paz and the Universidad Autónoma de Madrid, a Madrileño with Basque-country heritage, about the challenges of ensuring growth in prematurely born infants —what constitutes proper nutrition, how to supply that nutrition, how to determine with follow-up studies over both the short and the long term if the nutrition supplied indeed was proper and the growth achieved was adequate — with both dietary and pharmacolo...
Nov 30, 2022•34 min•Season 1Ep. 17
Dr. Jutta Köglmeier of Great Ormond Street Hospital for Sick Children, in London, talks to us about blended diets for tube feedings and how they can contribute to patient care. Do they permit adequate nutrition? Do they let parents and other caregivers bond more closely, as members of a family, with the children who are thus fed? Nutrition for the spirit as well as for the body is the principal topic — but she also gives us a look-in at what it’s like to be a girl from the Black Forest of German...
Nov 15, 2022•33 min•Season 1Ep. 16
We are talking to Dr. Ulrich Baumann of Hannover, Germany, about Prof Baumann's experiences both as a junior researcher in Birmingham, UK, investigating the population of cells from which liver regeneration occurs and as a senior clinical caregiver in Hannover using a newly developed inhibitor of enteric bile-salt uptake to treat — with success — a number of the complications that follow liver transplantation in severe ATP8B1 disease (progressive familial intrahepatic cholestasis type 1)....
Oct 31, 2022•35 min•Season 1Ep. 15
Dr. Alex Knisely is talking to Dr. Jake Mann of the UK, who has one foot in Birmingham and the other in Cambridge, about how computational biology and paediatric hepatology intersect in Dr Mann's work, which addresses animal-model assay validation, genetic susceptibilities to fatty liver disease, and population-wide assessment of incidence of various disorders. For prospective holiday-makers, Jake also supplies objective information on which is the best Channel Island.
Oct 14, 2022•32 min•Season 1Ep. 14
We are talking to Dr. Marco Gasparetto of Padua, Italy, and of Cambridge and East London, UK, about the prospects for genetically individualised treatment of paediatric inflammatory bowel disease. Brace yourselves for computational biology in pre-clinical validation studies. Also on the agenda, this question: for a devoted musician, did the move from Padua to Britain mean trading down? Featuring: Dr. Marco Gasparetto ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Record...
Sep 30, 2022•35 min•Season 1Ep. 13
Dr. Alex Knisely is talking to Dr. Lorenzo D ´Antiga of Bergamo about under-appreciated biliary disease after liver transplantation, the role of molecular studies in neonatal liver disease, and the long-ago shared times at King’s College Hospital before either man went grey : Liver disease and mis-spent youth . Featuring: Dr. Lorenzo D´Antiga ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
Sep 14, 2022•37 min•Season 1Ep. 12
Dr. Alex Knisely is talking to Dr. Susan Hill of London about small-bowel disease that requires long-term parenteral alimentation. Short-bowel problems and the need for teamwork among care-givers are the themes principally addressed. Featuring: Dr. Susan Hill ESPGHAN Podcast Host: Dr. Alex Knisely Production Management: Selma Ertl Recording: Manuel Schuster
Aug 31, 2022•34 min•Season 1Ep. 11
Dr. Alex Knisely is talking to Dr. Andrew Barclay of Glasgow about gastrointestinal dystonia, a disorder or class of disorders now coming into focus for those who attend neurodevastated children. How is gastrointestinal dystonia to be recognised? Does administration of cannabinoids help?
Aug 14, 2022•30 min•Season 1Ep. 10
We are talking to Dr. Marc Benninga of Amsterdam about the complex challenges that children with abnormal stooling, in particular faecal retention and “overflow” leakage, present to physicians, other care-givers, and families.
Jul 31, 2022•41 min•Season 1Ep. 9
