In this episode, Dr Gideon Hirschfield meets with patient advocate Jess Schnur to discuss challenges related to the diagnosis and management of primary biliary cholangitis (PBC) to provide actionable strategies for healthcare professionals to incorporate into patient care, including: Disease concerns and frequently asked questions from a patient perspective Managing symptoms Treatment options and supportive care Importance of awareness and education Presenters: Gideon Hirschfield, MA, MB BChir, ...
Jun 26, 2025•14 min•Ep. 446
In this podcast, Sonal Kumar, MD, MPH, meets with patient advocate Maria Morais to discuss actionable steps that healthcare providers can incorporate into the care of people with primary biliary cholangitis (PBC). Listen as they discuss: The chronic nature of PBC Going beyond biochemical markers to assess and address symptoms such as fatigue and pruritus The importance of referral to patient support groups Presenters : Sonal Kumar, MD, MPH Assistant Professor of Medicine Director, General Gastro...
Jun 26, 2025•27 min•Ep. 445
In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau, use an illustrative patient case to explore the roles of ALP and other biochemical markers in PBC management, and explain what to expect from treatment. Topics covered include: How baseline ALP can affect ALP normalization after second-line treatment with elafibranor and seladelpar Potential outcomes if ALP normalization cannot be achieved The importance of managing fatigue, pruritus, and sleep disturbances independently of the...
Jun 26, 2025•21 min•Ep. 444
In this podcast, expert faculty, Dr Stuart Gordon and Dr Nancy Reau discuss an illustrative patient case to demonstrate how they individualize primary biliary cholangitis (PBC) therapy for patients with cirrhosis. Topics covered include: AASLD guideline recommendations for second-line therapy for PBC Considerations when using newer agents for second-line treatment of PBC in patients with cirrhosis: elafibranor and seladelpar Presenters: Stuart C. Gordon, MD Professor of Medicine Wayne State Uni...
Jun 26, 2025•16 min•Ep. 443
In this podcast, Brett M. Elicker, MD, and David E. Griffith, MD, ATSF, FACCP, FRSM, discuss the pathophysiology of non–cystic fibrosis bronchiectasis (NCFBE), the patient burden, and best practices with diagnosing NCFBE, including: The vicious vortex of NCFBE (ie, airway dysfunction, inflammation, infection) Cough as the most significant symptom and burden Imaging bronchiectasis with classic and inflammatory findings Differentiating the causes of NCFBE to inform patient care Presenters Brett M....
Jun 18, 2025•24 min•Ep. 442
In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss how they assess the symptoms of primary biliary cholangitis (PBC) and explore how new therapeutic agents may help alleviate symptom burden. Topics include: Strategies and tools for assessing pruritus Nonpharmacologic and pharmacologic management of pruritus Second-line agents and their impact on pruritus Investigational treatments for pruritus Presenters : Alan Bonder, MD, AGAF Associate Professor of Medicine ...
Jun 18, 2025•19 min•Ep. 441
How do you decide when to move from first-line to second-line treatment for primary biliary cholangitis (PBC)? In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss this question and more, including: How and when to measure treatment response Evidence-based goals of therapy Considerations for second-line treatment New agents for second-line treatment: PPAR agonists Presenters : Alan Bonder, MD, AGAF Associate Professor of Medicine Medical Director of Liver Transp...
Jun 18, 2025•19 min•Ep. 440
Respiratory Syncytial Virus (RSV) significantly impacts adults, especially those over age 60 and those with chronic conditions. In this podcast, nurse practitioners Drs. Carrico and Stevenson discuss the underestimated burden of RSV. The podcast also explores practical strategies for increasing vaccine uptake that you can apply to your practice starting today so that you can protect your patients against RSV. Listen as they discuss: The Burden of Adult RSV RSV Vaccines for Adults: Data and Recom...
Jun 11, 2025•1 hr 7 min•Ep. 439
Listen in as Carolyn Bridges, MD, FACP, and Laura P. Hurley, MD, MPH, discuss barriers to respiratory syncytial virus (RSV) vaccination for adults, including insurance coverage and vaccine hesitancy, and explore effective, practical strategies for overcoming these barriers. Topics covered include: Helping patients understand why they need an RSV vaccine Ways to discuss real-world vaccine efficacy Approaches to build vaccine confidence and discuss vaccine safety Methods to overcome financial barr...
Jun 02, 2025•26 min•Ep. 438
Listen in as Carolyn Bridges, MD, FACP, reviews the estimated burden of respiratory syncytial virus (RSV) disease in older adults and discusses the latest updates on RSV vaccination recommendations and safety data. Topics covered include: Rates of RSV hospitalizations and emergency department visits RSV vaccine development FDA-approved RSV vaccines Vaccine safety data: rates of atrial fibrillation and Guillain-Barré syndrome ACIP RSV vaccine recommendations Risk factors for severe RSV disease RS...
Jun 02, 2025•12 min•Ep. 437
In this episode, Jewel Mullen, MD, MPH, MPA, and Dallas Nelson, MD, CMD, FACP discuss overcoming barriers to RSV vaccine uptake in post-acute and long-term care facilities, including: How to incorporate the latest RSV vaccination recommendations into clinical practice Practical strategies for navigating insurance Effective and empathetic methods of addressing vaccine hesitancy. Presenters: Jewel Mullen, MD, MPH, MPA Associate Dean for Health Equity Associate Professor of Population Health and In...
Apr 10, 2025•20 min•Ep. 436
In this episode, Chloe Orkin, MBChB, FRCP, MD, and Jean-Michel Molina, MD, PhD, discuss highlights from CCO’s independent conference coverage of CROI 2025, including: Advances in HIV treatment based on results from CARES Potential HIV therapies in the pipeline, such as doravirine/islatravir Effects of broadly neutralizing antibodies on HIV treatment and cure Key clinical data on HIV and STI prevention obtained from PILLAR, HPTN 083, PURPOSE 1, and STOMP Presenters: Chloe Orkin, MBChB, FRCP, MD P...
Apr 04, 2025•39 min•Ep. 435
Listen in as Cristina Mussini, MD; Martin Witzenrath, MD, FERS; and Michele Bartoletti, MD, PhD, discuss treatment strategies for people who are immunocompromised with COVID-19 in the hospital setting, including: Antiviral therapy with remdesivir Dexamethasone for patients with hematologic malignancies Considerations regarding other immunomodulators such as JAK inhibitors or IL-6 inhibitors A detailed patient case to illustrate key takeaways Presenter s: Michele Bartoletti, MD, PhD Associate Pr...
Mar 13, 2025•25 min•Ep. 431
In this episode, Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss treatment strategies for people who have severe COVID-19, including: Antiviral therapy with remdesivir Dexamethasone and other systemic corticosteroids Immunomodulators, such as JAK inhibitors or IL-6 inhibitors Overviews of clinical trial data demonstrating how and when to use these therapies Presenters: Stephen Cantrill, MD, FACEP Associate Director and Medical Director (Retired) ...
Mar 10, 2025•21 min•Ep. 434
In this episode, Patricia D. Jones, MD, MSCR; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and patient advocate, Jennifer Wild, MS, RN, OCN, discuss practical strategies to overcome barriers to hepatitis B virus (HBV) care, including: Overcoming health insurance navigation Improving access to HBV care in immigrant communities Dispelling HBV myths and stigma Solutions to language barriers Community-based interventions Presenters: Patricia D. Jones, MD, MSCR Associate Professor of Clinical Medicine Di...
Mar 10, 2025•20 min•Ep. 433
In this episode, Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss: Workup of COVID-19 in the emergency department Methods of COVID-19 risk stratification Treatment recommendations for people with severe COVID-19, including how to effectively use antiviral therapy, dexamethasone, and other immunomodulators [CC1] in this population A detailed patient case to illustrate key takeaways Presenters: Stephen Cantrill, MD, FACEP Associate Director and Medica...
Mar 10, 2025•15 min•Ep. 432
In this episode, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss the management of mild to moderate COVID-19 in patients who are immunocompromised, including: Initial workup, which may include laboratory tests and/or imaging Latest data on the use of remdesivir or nirmatrelvir plus ritonavir for mild to moderate COVID-19, including considerations for drug–drug interactions Presenters: Martin Witzenrath, MD, FERS Medical Director Charite Centrum 12 Internal Medicine & De...
Feb 06, 2025•13 min•Ep. 430
In this episode, Patricia D. Jones, MD, MSCR; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and patient advocate, Jennifer Wild, MS, RN, OCN, discuss best practices in hepatitis B virus (HBV) care, including: 2023 CDC HBV screening recommendations Summary of guideline recommendations for hepatitis delta virus (HDV) screening Use of HDV reflex testing to avoid loss to follow-up 2024 WHO HBV treatment recommendations, including recommendations for pregnant persons Presenters: Patricia D. Jones, MD, MSC...
Feb 05, 2025•34 min•Ep. 429
In this episode, Cristina Mussini, MD, Martin Witzenrath, MD, FERS, and Michele Bartoletti, MD, PhD, discuss: Current SARS-CoV-2 trends in the EU Risk factors for severe COVID-19 outcomes, including the spectrum of risk based on immune system status Factors that may affect vaccine efficacy in chronic lymphocytic leukemia and other lymphoid malignancies Considerations for determining people at high risk for COVID-19 progression Presenters: Cristina Mussini, MD Full Professor of Infectious Disease...
Feb 05, 2025•17 min•Ep. 428
In this episode, Tzu-Hao (Howard) Lee, MD; Tatyana Kushner, MD, MSCE; and patient advocate Andrew Reynolds discuss hepatitis C virus (HCV) care in men who have sex with men and pregnant people, including: HCV disease burden in the United States Screening recommendations Strategies to overcome barriers to HCV screening Treatment recommendations, including simplified treatment guidance and considerations for pregnant people Strategies to improve treatment uptake Presenters: Tzu-Hao (Howard) Lee, M...
Jan 08, 2025•1 hr 5 min•Ep. 427
In this episode, Sonal Kumar, MD, MPH, discusses key findings from primary biliary cholangitis (PBC) studies presented at AASLD 2024, including: ELATIVE, a phase III trial of elafibranor for PBC RESPONSE, a phase III trial of seladelpar for PBC ASSURE, another phase III trial of seladelpar for PBC Presenter: Sonal Kumar, MD, MPH Director, Clinical Gastroenterology and Hepatology Assistant Professor of Medicine Weill Cornell Medical College New York, New York Link to full program: https://bit.ly/...
Jan 07, 2025•20 min•Ep. 426
Listen in as Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss current trends in and risk factors for progression to severe COVID-19, including for those for whom COVID-19 is not their primary concern when presenting to the emergency department (ED). Key topics of discussion include: How to complete a comprehensive patient workup in the ED Considerations regarding pulse oximetry Risk stratification—what places patients at higher risk of severe disease...
Jan 02, 2025•16 min•Ep. 423
In this episode, Stacey B. Trooskin, MD, PhD, MPH, Mark S. Sulkowski, MD, FIDSA, FAASLD, and Ronni Marks discuss hepatitis C virus (HCV) screening and treatment, focusing on people who use drugs, and highlight the following topics: Screening recommendations Strategies to improve HCV screening HCV testing Treatment goals Strategies to improve HCV treatment uptake Presenters: Stacey B. Trooskin, MD, PhD, MPH Executive Medical Officer Mazzoni Center Faculty, University of Pennsylvania Perelman Scho...
Dec 23, 2024•1 hr 8 min•Ep. 425
Listen in as Stephen Cantrill, MD, FACEP; Rajesh T. Gandhi, MD; and Payal K. Patel, MD, MPH, FIDSA, discuss best practices in treating patients hospitalized with mild to moderate COVID-19, including: Current guidelines from the Infectious Diseases Society of America and National Institutes of Health How to optimize therapy selection based on patient risk factors, including key data supporting best practices A detailed patient case to illustrate key takeaways Presenters: Stephen Cantrill, MD, FAC...
Dec 19, 2024•16 min•Ep. 424
Clinical gaps in the treatment of pruritus in primary biliary cholangitis (PBC) remain. In this episode, taken from a recent symposium, Marlyn J. Mayo, MD; Stuart C. Gordon, MD; and Pam Rivard, RN, a person living with PBC, discuss emerging therapies currently in clinical trials for the management of this disease that can dramatically affect patients’ quality of life. Listen as they discuss: Gaps in current management Patient perspectives: why we should not dismiss itching as an underlying psych...
Dec 18, 2024•24 min•Ep. 422
Although there is currently no FDA-approved treatment for pruritus in primary biliary cholangitis (PBC), symptoms can be mitigated with nonpharmacologic or pharmacologic agents. In this episode, Marlyn J. Mayo, MD; Stuart C. Gordon, MD; and Pam Rivard, RN, a person living with PBC, discuss the clinical management of pruritus in PBC, including: Pruritus assessment tools Optimal use of tools, including frequency of assessment Current management of pruritus Nonpharmacologic interventions Pharmacolo...
Dec 18, 2024•21 min•Ep. 421
In this episode, Marlyn J. Mayo, MD; Stuart C. Gordon, MD; and Pam Rivard, RN, a person living with primary biliary cholangitis (PBC), discuss the burden of pruritus in PBC and the impact it has on quality of life, including both physical and mental health, from a patient’s perspective. Presenters: Marlyn J. Mayo, MD Professor of Internal Medicine Division of Digestive & Liver Diseases UT Southwestern Medical Center Dallas, Texas Stuart C. Gordon, MD Professor of Medicine Wayne State Univers...
Dec 18, 2024•12 min•Ep. 420
In this episode, Jean-Michel Molina, MD, PhD, and Joseph J. Eron, Jr., MD, discuss results from key clinical trials on HIV prevention and treatment as well as sexually transmitted infection (STI) prevention presented at IDWeek and Glasgow 2024, including: PURPOSE 1 and 2 comparing lenacapavir injection vs oral TDF/FTC TRIO Health Cohort and OPERA examining long-acting cabotegravir as PrEP DOLCE comparing DTG/3TC as first-line therapy in treatment-naive patients with HIV PRIDOX evaluating the use...
Dec 17, 2024•49 min•Ep. 419
In this episode, Christopher L. Bowlus, MD, discusses recent advances in the management of primary biliary cholangitis (PBC), including: Treatment goals Use of PPAR agonists for the treatment of PBC Clinical trial results for elafibranor (ELATIVE), seladelpar (RESPONSE), and bezafibrate (BEZURSO) Presenter: Christopher L. Bowlus, MD Lena Valente Professor and Chief Division of Gastroenterology and Hepatology University of California Davis School of Medicine Sacramento, California Link to full pr...
Dec 13, 2024•9 min•Ep. 418
In this episode, a transfemme nonbinary individual living with HIV shares her experience navigating the healthcare system, alongside her infectious disease physician, Michelle D. Collins-Ogle, MD, FAAP, FPIDS, AAHIVS. Hear them discuss key considerations when caring for gender-diverse individuals, including: Understanding how people are more than just a diagnosis Prioritizing individuals’ needs and providing whole-person care using shared decision-making Strategies to make an environment more af...
Nov 13, 2024•32 min•Ep. 417
