During the 2023 American Association of the Study of Liver Diseases (AASLD) conference, exciting and important results from many primary biliary cholangitis (PBC) clinical trials were reported, including 3 late-breaking studies on the PPAR-delta agonist seladelpar, the dual PPAR agonist elafibranor, and the combination of the FXR agonist obeticholic acid and a fibrate. In this episode, Marlyn J. Mayo, MD, discusses topline results from several of these studies and more, including: A phase III st...
Dec 06, 2023•9 min•Ep. 356
In this episode, Martin Rios discusses how pre-exposure prophylaxis (PrEP) persistence depends on healthcare professional knowledge, including: Their own experiences with the various PrEP providers they have seen The relief that has come with seeing PrEP providers who are supportive and knowledgeable about the different PrEP options The challenges that have come with seeing PrEP providers who are unwilling to prescribe PrEP altogether or who will prescribe PrEP when asked but are not knowledgeab...
Dec 04, 2023•4 min•Ep. 353
In this episode, Meredith Clement, MD, and Whitney C. Irie, MSW, PhD, discuss key considerations for pre-exposure prophylaxis (PrEP) uptake in cisgender women, including: How to incorporate conversations on PrEP during a short clinic visit Helpful resources about PrEP to share with patients Leveraging clinic staff to improve PrEP uptake and persistence Available data on on-demand PrEP Approach to discussing PrEP contraindications and adverse events with patients Considerations for PrEP in pregna...
Dec 04, 2023•36 min•Ep. 354
In this episode, Helen Y. Chu, MD, MPH, shares updates on RSV seasonality, including: Surveillance limitations due to the testing availability in adults Current 2023/2024 season trends, including predictions for other respiratory viruses (eg, influenza, SARS-CoV-2) Considerations for RSV administration RSV vaccine coadministration with influenza and COVID-19 vaccines Faculty: Helen Y. Chu, MD, MPH Associate Professor of Medicine Division of Allergy & Infectious Diseases University of Washing...
Nov 30, 2023•8 min•Ep. 341
In this episode, Rick Zimmerman, MD, MPH, FAAFP, discusses RSV vaccines in older adults, including: Breakthroughs in RSV vaccine development RSV vaccine snapshot in older adults FDA-approved RSV vaccines for older adults CDC evidence to recommendations framework for vaccines RSV burden in older populations Benefits and harms of RSV vaccination RSV vaccine efficacy and safety in older adults CDC Advisory Committee Immunization Practices recommendations for RSV vaccines in older adults Populations...
Nov 30, 2023•16 min•Ep. 350
In this episode, Angela Branche, MD; Pamela Rockwell, DO, FAAFP; and Richard Zimmerman, MD, MPH, FAAFP, discuss the clinical presentation of RSV in older adults and available diagnostic tests for RSV, including: Comparison of RSV clinical symptoms to influenza and COVID-19, including differentiating symptoms at infection onset RSV disease progression RSV diagnostic approaches How RSV diagnosis of adults may differ from diagnosis of children Clinical considerations for RSV testing How to improve ...
Nov 30, 2023•9 min•Ep. 351
In this episode, Samantha V. Hill, MD, MPH, and Eunice E. Radcliff, MD, discuss key considerations for PrEP uptake in adolescents, including: Advice on talking with parents about the importance of adolescents having alone time with their healthcare professionals Maintaining confidentiality when someone is on their parents’ insurance Strategies to increase awareness, uptake, engagement, and persistence on PrEP among adolescents Having discussions about HIV prevention and PrEP along with the HPV v...
Nov 30, 2023•16 min•Ep. 347
In this episode, Jean-Michel Molina, MD, PhD, discusses the data and recommendations for considering on-demand PrEP as a strategy to support PrEP persistence and engagement for men who have sex with men, including: Nondaily PrEP options recommended for cisgender men Data from the ANRS IPERGAY study evaluating on-demand FTC/TDF vs placebo in men who have sex with men Real-world data on the effectiveness of on-demand PrEP Considerations for on-demand FTC/TDF in people with renal dysfunction Data o...
Nov 30, 2023•15 min•Ep. 352
Should quantitative HBsAg testing be used routinely in clinical practice for patients living with chronic hepatitis B? In this episode, Tatyana Kushner, MD, MSCE, discusses the role of quantitative hepatitis B surface antigen testing in people living with chronic hepatitis B, including: Determination of inactive carrier status Prediction of liver fibrosis/cirrhosis Prediction of hepatocellular carcinoma development Monitoring response to treatment, including future HBV treatments in the developm...
Nov 29, 2023•19 min•Ep. 343
Are we treating HBV early enough? Is it time to move the goalposts regarding the timing of treatment initiation? What are the potential benefits of earlier treatment? To answer these questions, Ira M. Jacobson, MD, leads a panel discussion with Tatyana Kushner, MD, MSCE, and Paul Y. Kwo, MD, exploring which patients with HBV we should be treating, including a focus on: Guideline-based treatment recommendations and their limitations Data describing the relationship between viral suppression and H...
Nov 29, 2023•21 min•Ep. 345
In this episode, Angela Branche, MD; Pamela Rockwell, DO, FAAFP; and Rick Zimmerman, MD, MPH, FAAFP, discuss the burden of RSV in older adults, including: RSV burden throughout life RSV seasonality in the United States Comparative burden and incidence of RSV and influenza in adults aged 65 years or older Cardiopulmonary hospitalizations of long-term care facility residents with influenza and/or RSV Risk factors for severe RSV (eg, hospitalization, mortality) in older adults RSV incidence by pres...
Nov 29, 2023•12 min•Ep. 344
In this episode, Beatriz Grinsztejn, MD, PhD, discusses the data and recommendations for addressing social determinants as a strategy to support PrEP persistence and engagement for transgender women, including: HIV prevalence among transgender women Data on the PrEP cascade from the PrEParadas study of daily FTC/TDF among transgender women Data from the ImPrEP Study on early loss to follow-up, adherence, long-term engagement, and HIV incidence among transgender women Barriers to PrEP uptake and ...
Nov 28, 2023•15 min•Ep. 342
In this accredited podcast episode, Dr Christina Madison and Dr Mary Bridgeman provide practical strategies for implementing RSV vaccination into practice, including: Educating older adults on RSV vaccines Providing effective, evidence-based recommendations Shared decision-making Identifying and addressing vaccine hesitancy Proactive strategies in vaccinating for RSV Predicting and overcoming barriers to RSV vaccination Presenters: Mary Barna Bridgeman, PharmD, BCPS, BCGP, FASCP, FCCP, FNAP Clin...
Nov 27, 2023•20 min•Ep. 338
In this accredited podcast episode, Dr Christina Madison and Dr Mary Bridgeman discuss the latest practical strategies for preventing RSV infection in older adults, including: Role of basic public health precautions Available and emerging vaccines Mechanisms of action, therapeutic targets, and pharmacology Efficacy and safety data FDA approval status and ACIP recommendations Presenters: Mary Barna Bridgeman, PharmD, BCPS, BCGP, FASCP, FCCP, FNAP Clinical Professor Ernest Mario School of Pharmacy...
Nov 21, 2023•17 min•Ep. 339
In this accredited podcast episode, Dr Mary Bridgeman discusses the most important things for pharmacists across all settings to know about RSV infections in patients 60 years of age or older, including: Incidence and prevalence of RSV in older adults, including hospitalization, mortality, epidemiology Seasonality Clinical manifestations Risk factors for severe outcomes Vulnerable groups and comorbidities Presenter: Mary Barna Bridgeman, PharmD, BCPS, BCGP, FASCP, FCCP, FNAP Clinical Professor E...
Nov 21, 2023•13 min•Ep. 337
In this episode, Aniruddha (Anu) Hazra, MD, and Ofole Mgbako, MD, discuss key considerations for PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including: Data on drug–drug interactions between PrEP options and gender-affirming hormone therapy Contributing factors to inequities in PrEP uptake for Black and Latino individuals Data on FTC/TAF PrEP for transgender individuals How to decide whether to do an oral lead-in before starting injectable cab...
Nov 21, 2023•42 min•Ep. 340
In this episode,Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections caused by NDM-producing Enterobacterales, including: Ambler classification of β-lactamases Mechanisms of resistance 2023 IDSA guidance recommendations The latest clinical data by antimicrobial regimen: Ceftazidime/avibactam and aztreonam Cefiderocol Investigational aztreonam/avibactam Clinical case of NDM-producing E. coli with p...
Nov 16, 2023•17 min•Ep. 336
In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving Pseudomonas aeruginosa with difficult-to-treat resistance, including: Mechanisms of β-lactam resistance Effect of resistance mechanism on susceptibility to antipseudomonal agent 2023 IDSA guidance recommendations Activity against newer antipseudomonal β-lactams in the United States The latest clinical data by antimicro...
Nov 16, 2023•17 min•Ep. 335
In this episode, Emily Heil, PharmD, MS, BCIDP, AAHIVP; Laila Woc-Colburn, MD; and Trevor Van Schooneveld, MD, FSHEA, FACP, discuss their approach to managing infections involving carbapenem-resistant Acinetobacter baumannii (CRAB), including: Mechanisms for β-lactam resistance Additional resistance mechanisms and virulence factors 2023 IDSA guidance recommendations for moderate to severe CRAB infections The latest clinical data by antimicrobial therapy/regimen: Sulbactam Meropenem and colistin ...
Nov 15, 2023•29 min•Ep. 334
In this second of 3 episodes, global HIV experts and advocates discuss how HIV care can better meet the diverse needs of people living with HIV as new treatment strategies emerge and continue to evolve, including: How the emergence of long-acting injectable HIV treatment has been a game-changer for many people living with HIV Emerging strategies that are expanding the application of long-acting ART to address unmet treatment needs Potential for future innovations in ART that are hoped will furth...
Nov 15, 2023•29 min•Ep. 333
In this episode, global PrEP experts and advocates discuss how current PrEP regimens represent a revolutionary step forward in enabling many individuals to avoid HIV acquisition, including: How PrEP has empowered people to take control of their sexual lives, revolutionized people’s sexual experiences, and, for some, improved their experiences with healthcare in general The extraordinary progress that has been made in New South Wales and specifically in inner Sydney toward HIV transmission elimin...
Nov 13, 2023•26 min•Ep. 318
In this episode, global PrEP experts and advocates discuss barriers that have prevented the full potential of today’s PrEP regimens from being delivered, how those barriers might be overcome, and how the next generation of PrEP modalities may address unmet needs, including: How access and implementation of PrEP have limited its benefit and led to disparities in uptake among racial and ethnic groups in the United States and among key populations globally The challenges of adherence to PrEP for he...
Nov 13, 2023•46 min•Ep. 321
In this episode, Lillian Abbo, MD, MBA, FIDSA, discusses appropriate antimicrobial selection for managing uncomplicated UTIs, including: Balancing discrepancies in available guidelines Individualizing antimicrobial selection based on patient characteristics and local resistance patterns Incorporating tools, like antibiograms, into daily practice Being a good steward of currently available antimicrobial agents Planning ahead for emerging therapies for uncomplicated UTIs Presenter : Lillian Abbo, ...
Nov 13, 2023•25 min•Ep. 332
In this episode, Richard Colgan, MD, discusses the burden of uncomplicated UTIs (uUTIs) and best practices in their management, including: Accurate diagnosis and classification Risk factors for uUTIs and treatment failure Burdens of uUTIs on patients Innovations in care, including self-diagnosis and virtual management The importance of avoiding screening and management of asymptomatic bacteriuria in most patients We will also hear from a patient who details the impact of uUTI on her quality of l...
Nov 13, 2023•18 min•Ep. 330
In this episode, Lilly C. Lee, MD, SM, FACEP, FAAEM, discusses the best practices in management of uUTI in the emergency department, including: Patient triage Diagnostic stewardship Interdisciplinary care Strategies to overcome treatment barriers Presenter : Lilly C. Lee, MD, SM, FACEP, FAAEM Chief of Emergency Medicine Jackson Memorial Hospital Florida Poison Information Center Roxcy Bolton Rape Treatment Center Affiliated Assistant Professor of Surgery DeWitt Daughtry Family Department of Surg...
Nov 13, 2023•14 min•Ep. 331
In this episode, Atul Humar, MD, FRCP(C); Hannah Imlay, MD, MS; and Raymund Razonable, MD, discuss cytomegalovirus (CMV) management strategies in solid organ transplantation recipients, including: Evaluation of current data on CMV prevention in liver transplant recipients Practical considerations for switching an institution’s antiviral therapy of choice for primary prophylaxis Barrier of resistance to antiviral therapies Factors to consider when deciding CMV treatment duration Use of lymphocyte...
Nov 06, 2023•11 min•Ep. 328
In this episode, Hannah Imlay, MD, MS, discusses cytomegalovirus (CMV) prevention strategies in solid organ transplantation (SOT) recipients including: Strategies for preventing CMV in SOT International guideline recommendations for CMV prevention strategies by organ type Antivirals used for CMV prevention Comparison of preemptive therapy vs prophylaxis for CMV prevention in liver transplant recipients Comparison of letermovir vs valganciclovir for CMV prophylaxis in kidney transplant recipients...
Nov 06, 2023•18 min•Ep. 327
In this episode, Raymund Razonable, MD, discusses cytomegalovirus (CMV) management strategies beyond primary prophylaxis in solid organ transplantation recipients including: CMV treatment goals CMV treatment and monitoring recommendations Role of secondary prophylaxis Use of CMV cell–mediated immunity (CMI) monitoring for CMV relapse risk Use of CMV CMI for secondary prophylaxis Proposed use of CMV CMI monitoring for secondary prophylaxis Incidence and outcomes with antiviral resistance Risk fac...
Nov 06, 2023•18 min•Ep. 329
Arthur Kim, MD, and Renslow Sherer, MD, discuss how new data on COVID-19 vaccines and treatments may affect practice, including: Real-world data on COVID-19 outcomes COVID-19 prevention: current and emerging concepts COVID-19 therapeutics: new clinical trial and real-world data Presenters: Arthur Kim, MD Associate Professor of Medicine Harvard Medical School Division of Infectious Diseases Massachusetts General Hospital Boston, Massachusetts Renslow Sherer, MD Director International HIV Training...
Nov 06, 2023•48 min•Ep. 326
In this first of 3 episodes, global HIV experts and advocates discuss how innovative models of care are minimizing barriers to HIV care engagement to improve uptake by key underserved populations, including: How peer support programs empower people to combat stigma, become more educated about treatment, and be engaged participants in their HIV care Strategies for addressing potential unmet mental healthcare needs among people living with HIV Approaches to reengage people with HIV who transit thr...
Nov 01, 2023•47 min•Ep. 322
