In this episode, Shannon Kasperbauer, MD, discusses guideline-based treatment recommendations for people with M. abscessus , including a discussion of: Macrolide resistance Predictors for disease progression 2020 NTM guideline recommended treatment options Emerging therapies We will also hear from a patient who describes how she remained adherent during long courses of treatment for M. abscessus . Finally, we hear Dr Kasperbauer discuss a patient case with her colleagues, Charles L. Daley, MD, a...
Oct 31, 2023•21 min•Ep. 325
In this episode, Charles L. Daley, MD, discusses guideline-based treatment recommendations for nontuberculous mycobacterial (NTM) lung disease, including treatment regimens for: Mycobacterium avium complex M. kansasii M. xenopi We will also hear from a patient who describes the use of airway clearance devices and a patient who describes his typical NTM treatment course. Finally, we hear Dr. Daley discuss a patient case with his colleagues, Shannon Kasperbauer, MD, and Pamela J. McShane, MD. Pres...
Oct 31, 2023•27 min•Ep. 323
In this episode, Pamela J. McShane, MD, describes the 3 pillars for nontuberculous mycobacterial (NTM) lung disease diagnosis: Clinical symptoms Radiographic evidence Microbiologic data We will also hear from a patient who details his diagnostic journey and will hear Dr. McShane discuss an illustrative clinical case. Presenter: Pamela J. McShane, MD Professor of Medicine Division of Pulmonary and Critical Care Medicine The University of Texas Health Science Center at Tyler Tyler, Texas Link to p...
Oct 31, 2023•16 min•Ep. 324
In this episode, David Alain Wohl, MD, discusses key considerations to PrEP barriers in cisgender women, including: Prevalence of PrEP use in the US Barriers to PrEP uptake PrEP efficacy based on adherence Interventions to support PrEP adherence Recommended PrEP regimens, including considerations for use in pregnancy and breastfeeding Presenter: David Alain Wohl, MD Professor of Medicine School of Medicine Site Leader, Global Infectious Diseases Clinical Trials Unit University of North Carolina ...
Oct 23, 2023•8 min•Ep. 319
In this podcast, experts Sarah M. Wood, MD, MS, and Errol L. Fields, MD, PhD, MPH, discuss some of the challenges and concerns clinicians face when prescribing PrEP to adolescents. The faculty addresses the potential for adverse effects from PrEP, including the potential for renal impairment, decreased bone density, and whether PrEP can interfere with hormone therapy for gender-affirming care. They review the data behind these concerns and emphasize that the vast majority of adverse effects caus...
Oct 23, 2023•36 min•Ep. 320
In this episode, we hear from 2 people living with HIV: Melanie Reese from the United States and Marc Thompson from the United Kingdom. Both Melanie and Marc have done important work in the HIV field as patient advocates. Today, they will be discussing their experiences in accessing and navigating their own HIV care, with a focus on some of the barriers that can complicate and even block a person's journey across the HIV care continuum. In reviewing these challenges, Marc and Melanie share their...
Oct 18, 2023•32 min•Ep. 308
In this podcast, expert Rasika Karnik, MD, MS, discusses how to manage the health risks posed by COVID-19 infection and long COVID in individuals with metabolic syndrome or obesity. Dr Karnik discusses the interplay between COVID-19 outcomes, obesity/metabolic syndrome, and social determinants of health and delves into detail on how to address and mitigate these social determinants of health in a high-risk population. Presenters: Rasika Karnik, MD, MS Assistant Professor Division of Primary Care...
Oct 06, 2023•14 min•Ep. 317
In this podcast, experts Donna Ryan, MD, and Renslow Sherer, MD, discuss how to manage the health risks posed by COVID-19 infection and long COVID in individuals with metabolic syndrome or obesity. First, Dr Ryan presents an overview of the relationship between COVID-19 and weight, including the mechanisms of how obesity may drive COVID-19 disease and how COVID-19 may in turn worsen obesity, through both immunologic and social or societal drivers.Dr Ryan also discusses the relationship between o...
Oct 02, 2023•27 min•Ep. 316
In this episode, Oni Blackstock, MD, MHS, and Whitney Irie, MSW, PhD, discuss key considerations for PrEP uptake in cisgender women, including: Ways to perform a nonintimidating sexual history How to incorporate conversations on PrEP during a short clinic visit Discussing adverse events associated with PrEP options with patients Considerations for PrEP in women wanting to conceive How patients can navigate obtaining PrEP in areas with limited healthcare resources Guideline recommendation updates...
Sep 27, 2023•32 min•Ep. 315
In this episode, Roger Bedimo, MD, MS, FACP, discusses key considerations to PrEP barriers in adolescents, including: New HIV diagnoses in the United States Adherence barriers Healthcare professional barriers Consent laws for minors to receive sexually transmitted infection diagnosis and treatment services Interventions to support PrEP adherence Presenter: Roger Bedimo, MD, MS, FACP Professor of Medicine Division of Infectious Diseases University of Texas UT Southwestern Medical Center Section C...
Sep 21, 2023•7 min•Ep. 314
In this episode, Brooke Bates, PharmD, BCPS, AAHIVP, and Neha Sheth Pandit, PharmD, AAHIVP, BCPS, discuss the most clinically relevant studies on HIV adverse events presented at IAS 2023, including: REPRIEVE study of pitavastatin for cardiovascular prevention in people living with HIV at low to moderate cardiovascular risk Data on weight change with switch from integrase inhibitor–based ART to doravirine/islatravir in the P017 and P018 studies DEFINE study evaluating weight change after a switch...
Sep 15, 2023•15 min•Ep. 312
In this episode, Tony Brown, MPH, discusses the importance of effective patient‒provider communication in supporting PrEP persistence including: His own experience with PrEP and reasons for fluctuations in adherence over the years The importance of open, honest, and judgement-free conversations about sexual health Engaging patients in conversations about PrEP effectiveness, adverse effects, and changing life circumstances Working together to find the most effective PrEP option for each individua...
Sep 14, 2023•5 min•Ep. 311
In this episode, Nikos Dedes, Jeff Taylor, and Bernadette Sharp—people living with HIV—discuss how switching to long-acting ART has affected their quality of life. They are joined by 2 healthcare professionals—Iskandar Azwa,MBChB, MRCP, and Beng Eu, MBBS—who provide insights on how they assess and document health-related quality of life for their patients. The discussion focuses on personal experiences with how LA ART has improved health-related quality of life, including: Avoidance of drug–drug...
Sep 12, 2023•13 min•Ep. 309
In this episode, Jill Blumenthal, MD, MAS, and Kenric B. Ware, PharmD, MBA, AAHIVP, answer questions about HIV PrEP including: Considerations for selecting between oral and injectable PrEP in college students Strategies to promote PrEP persistence in adolescents Best approaches to address readiness to start PrEP in adolescents (eg, creating nonjudgmental environments, addressing misconceptions) Considerations for local consent laws Available data on PrEP young adolescents (eg, age and weight lim...
Sep 12, 2023•25 min•Ep. 310
In this episode, Iskandar Azwa, MBChB, MRCP; Nikos Dedes; Beng Eu, MBBS; Bernadette Sharp; and Jeff Taylor discuss challenges and opportunities with long-acting ART implementation, including: Personal experiences with receiving LA ART Views on long-acting ART in the development pipeline Perspectives on self-administration of LA ART Presenters: Iskandar Azwa, MBChB, MRCP Associate Professor Infectious Diseases Faculty of Medicine University of Malaya Kuala Lumpur, Malaysia Nikos Dedes Positive Vo...
Sep 11, 2023•13 min•Ep. 307
In this episode, Raphael J. Landovitz, MD, MSc, and Hyman Scott, MD, MPH, discuss key considerations for PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including: Misconceptions about PrEP eligibility Strategies to improve lab monitoring on PrEP Leveraging patient navigators and clinic staff to expand PrEP access Data on PrEP efficacy in key populations (eg, transgender men, people who inject drugs) Considerations for prescribing on-demand and sa...
Sep 08, 2023•36 min•Ep. 306
In this episode, Angela Branche, MD, discusses the Advisory Committee on Immunization Practices recommendations for RSV vaccines in older adults, including: Use of shared clinical decision-making How to approach the conversation about the RSV vaccine with patients Key populations who may benefit the most, such as those at risk for severe RSV disease (eg, increasing age and persons who are frail or have cardiopulmonary comorbidities) Faculty: Angela Branche, MD Associate Professor of Medicine Div...
Sep 08, 2023•12 min•Ep. 305
In this episode, Renslow Sherer, MD, discusses managing virologic failure in a person living with HIV who is heavily treatment experienced, including: Guideline recommendations for selecting a new ART regimen Options for patients with multidrug-resistant HIV from existing drug classes and novel mechanisms of action with no cross-resistance Data from TMB-301 and TMB-311 for ibalizumab, BRIGHTE for fostemsavir, and CAPELLA for lenacapavir on the use of these agents for people living with HIV who a...
Aug 22, 2023•20 min•Ep. 304
In this episode, Oni Blackstock, MD, MHS, and Brittany Williams, PhD,discuss key considerations to pre-exposure prophylaxis (PrEP) uptake in cisgender women, including: The misconception by patients and healthcare professionals (HCP) that cisgender women are at low risk for HIV Reframing HIV prevention from “risks” to “reasons” such as promoting self-care and taking control of one’s own sexual health CDC PrEP guidance recommendations Increasing PrEP awareness by sharing PrEP experiences with oth...
Aug 08, 2023•17 min•Ep. 303
In this episode, Kyle Molina, PharmD, BCIDP, discusses key considerations for successful implementation of long-acting lipoglycopeptides into clinical practice. Listen as he gives perspectives on: Reasons to consider use of long-acting lipoglycopeptides (eg, poor adherence to oral antibiotics, PICC-related costs and complications) Data supporting and challenging cost effectiveness of long-acting lipoglycopeptides Identifying the target patient population Selecting the right location to provide l...
Aug 08, 2023•19 min•Ep. 302
In this episode, Joseph Ahn, MD, MS, MBA; Christina Delacruz Leyson, MD; and Alice Chan, a person who experienced pregnancy as a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in people of childbearing potential and their infants, including: HBV screening and vaccination in pregnancy Management of pregnant people who are HBsAg positive Infant care Breastfeeding Presenters: Joseph Ahn, MD, MS, MBA Professor of Medicine, Section Chief Division of Gast...
Aug 03, 2023•34 min•Ep. 301
In this episode, Daniel R. Kuritzkes, MD, and Cristina Mussini, MD, discuss managing ART failure, including: The definitions of virologic blips, low-level viremia, and virologic failure on ART The infrequency of failure with resistance on first-line INSTI-based ART and the instances where this has occurred with BIC- and DTG-based ART in clinical trials and in the real world The potential reasons for ART failure, including patient/adherence-related factors, HIV-related factors, and regimen-relate...
Aug 03, 2023•49 min•Ep. 300
In this episode, Renslow Sherer, MD, discusses managing a first ART failure in the setting of COVID-19, including: Guideline recommendations for resistance testing Guideline recommendations for selecting a new ART regimen Data on retained efficacy of NRTIs in second-line regimens in the EARNEST and NADIA studies Consideration of drug‒drug interactions between ART and COVID-19 treatment Presenter: Renslow Sherer, MD Director International HIV Training Center Professor of Medicine Section of Infec...
Jul 26, 2023•18 min•Ep. 299
In this episode, Kenyon R. Farrow and Raphael J. Landovitz, MD, MSc, discuss key considerations to PrEP uptake in transgender individuals and racial and ethnic minority men who have sex with men, including: Rates of HIV diagnoses in Black and Brown communities Issues stalling success in HIV prevention (eg, stigma, healthcare coverage, and administration and operational barriers) Considerations for healthcare professionals when discussing PrEP with patients Importance of representation (eg, racia...
Jul 19, 2023•21 min•Ep. 298
In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, and Meredith Clement, MD, discuss PrEP initiation, including: The importance of taking a sexual history and getting to know your patient Recommendations for who should be considered for PrEP Practicalities of PrEP initiation including laboratory assessments, interview and physical exam, evaluating concomitant medications, counseling, and prescribing Summary of PrEP eligibility by regimen Review of the clinical trial and rea...
Jul 13, 2023•51 min•Ep. 297
In this episode, Stefan Zeuzem, MD, discusses new data on viral hepatitis presented at EASL 2023, including: Hepatitis B virus Durability of response with bepirovirsen HBsAg loss with siRNA VIR-2218 combined with either VIR-3434 (novel monoclonal antibody) or pegIFN-alfa Hepatitis delta virus 96-week follow-up of immediate vs delayed bulevirtide Off-treatment response for lonafarnib + ritonavir ± pegIFN-alfa Safety and efficacy outcomes with siRNA JNJ-3989 + nucleos(t)ide analogue Hepatitis C vi...
Jul 11, 2023•47 min•Ep. 295
In this episode, Kyle Molina, PharmD, BCIDP, provides an overview of treatment of skin and soft tissue infections (SSTIs) and challenges in practice. Listen as he gives perspectives on: Guideline recommendations for treatment of purulent and nonpurulent SSTIs Logistical challenges with IV and oral antibiotics Pros and cons of various locations of care Data supporting the safety and efficacy of long-acting lipoglycopeptides for treatment of SSTIs Use of long-acting lipoglycopeptides in special po...
Jul 11, 2023•28 min•Ep. 296
In this episode, Latesha Elopre, MD, MSPH, and Jason Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, answer questions about HIV PrEP including: How long someone can receive PrEP and the monitoring that is needed over time Recommendations for monitoring bone health while receiving oral PrEP Treatment as prevention and PrEP efficacy data and options for people who inject drugs The role of circumcision in HIV prevention The use of PrEP in pregnancy Concern for ART resistance if someone seroconverts w...
Jul 03, 2023•26 min•Ep. 294
In this episode, Milena Murray, PharmD, MSc, BCIDP, AAHIVP, FCCP, and Kevin Astle, PharmD, BCPS, BCACP, AAHIVP, CDCES, discuss key considerations to barriers to PrEP uptake, including: Limited data on “on-demand” PrEP in cisgender women Strategies on improving communication with non‒English-speaking populations Role of pharmacists with injectable PrEP CDC PrEP guideline recommendations on routine HIV-1 RNA testing Engaging with pregnant persons who might want access to PrEP in the pharmacy setti...
Jun 27, 2023•10 min•Ep. 293
In this episode, Robert S. Brown, Jr., MD, MPH; Nancy Reau, MD; and Eric, a person living with chronic hepatitis B, discuss solutions for overcoming barriers to HBV care in older adults, including: Awareness of HBV and CHB in older adults Updated HBV screening and vaccination recommendations Monitoring of renal and bone disease Adjustment of monitoring and treatment as a person with HBV ages Presenters: Robert S. Brown, Jr., MD, MPH Vincent Astor Distinguished Professor of Medicine Chief, Divisi...
Jun 23, 2023•40 min•Ep. 292
