In this episode, Tarik Asselah, MD, PhD, and Ira Jacobson, MD, provide expert insight on HDV screening, diagnosis, and management, including: Approach to screening Barriers to screening (eg, test availability) Disease progression and complications Differentiating between coinfection and superinfection Approach to treatment (eg, whom to treat and when, treatment options, considerations for combination therapy) Management of patients with decompensated cirrhosis Surrogate markers to measure treatm...
Jun 22, 2023•40 min•Ep. 291
In this episode, Helen Y. Chu, MD, MPH, shares updates on RSV vaccines, including: An overview of vaccine candidates under investigation Recently FDA-approved RSV vaccines for older adults Considerations for the next respiratory viral season Coadministration of RSV vaccines with other respiratory viral vaccines (eg, influenza, SARS-CoV-2) Target populations for RSV vaccination RSV prevention in infants with the maternal vaccine and monoclonal Faculty: Helen Y. Chu, MD, MPH Associate Professor of...
Jun 19, 2023•13 min•Ep. 289
In this episode, Nancy Reau, MD, and Heiner Wedemeyer, MD, provide expert insight on HDV management, including: Use of noninvasive imaging or biopsy for staging liver disease Screening for hepatocellular carcinoma HBV treatment Role of comedications (eg, erythropoietin, eltrombopag) Approach to complex cases, such as patients with: Significant fibrosis and low HDV RNA levels Hepatitis delta antibody positivity, but HDV RNA negativity HIV coinfection Decompensated or recently decompensated cirrho...
Jun 19, 2023•42 min•Ep. 288
In this episode, Maunank Shah, MD, PhD, discusses using HIV-ASSIST to optimize treatment for both HIV and hyperlipidemia. Listen as he covers: Hyperlipidemia and cardiovascular disease risk among people living with HIV Recommendations for lipid screening for people living with HIV Using HIV-ASSIST to support ART treatment decisions for people living with HIV with comorbidities How HIV-ASSIST prioritizes certain ART agents in the setting of hyperlipidemia, including: Deciding between bictegravir,...
Jun 09, 2023•12 min•Ep. 287
In this episode, Martin Krsak, MD, MSc, FASAM, provides background and context on skin and soft tissue infections. Listen as he gives perspectives on: Epidemiology and clinical outcomes Economic impact Bacterial etiology Importance of appropriate antimicrobial prescribing Clinical presentation Severity classification and distinction between purulent and nonpurulent infections Role of incision and debridement vs antimicrobial management Complications to be ruled out prior to treatment Faculty: Ma...
Jun 08, 2023•18 min•Ep. 286
In this episode, Marta Boffito, MD, PhD, FRCP, and Michelle Cespedes, MD, MS, discuss initial ART options, including: Recommended first-line ART options for most PWH according to DHHS, IAS-USA, EACS, BHIVA, and WHO guidelines Data for weight gain after ART initiation with different ARV classes and drugs Weight gain disparities by race and gender after ART initiation Data from the RESPOND study including risk factors for weight gain and CV event risk with INSTI vs non-INSTI–based ART The impact o...
Jun 06, 2023•47 min•Ep. 285
In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for PWH coinfected with HBV and HCV. Listen as she covers: How HIV-ASSIST supports ART selection in primary care Updates to viral hepatitis recommendations including: CDC HBV screening and testing recommendations AASLD simplified HCV treatment approach for PWH HIV-ASSIST for managing HIV/HBV coinfections, including ensuring that NRTIs that are effective for both HIV and HBV ...
May 30, 2023•6 min•Ep. 284
In this episode, Amanda Binkley, PharmD, BCIDP, AAHIVP, and Nimish Patel, PharmD, PhD, AAHIVP, discuss clinically relevant data on long-acting ART from CROI 2023, including: LA CAB + RPV in San Francisco’s Ward 86 Safety Net Clinic Serving Publicly Insured PWH SOLAR: Randomized Switch to LA CAB + RPV From BIC/FTC/TAF Amanda Binkley, PharmD, BCIDP, AAHIVP Clinical Pharmacy Specialist Infectious Disease Department of Pharmacy Penn Presbyterian Medical Center Philadelphia, Pennsylvania Nimish Patel...
May 22, 2023•10 min•Ep. 282
In this episode, Christine Katlama, MD, and Babafemi Taiwo, MBBS, discuss optimizing ART for people with HIV who are treatment experienced or failing a current ART regimen, including: Recycling agents from the NRTI, NNRTI, INSTI, and PI classes in salvage ART regimens Maintaining NRTIs in second-line and salvage ART regimens, including the use of 3TC, TFV, and ABC ART regimen simplification When to perform genotypic resistance testing, including for PWH who have been off ART When to perform DNA ...
May 16, 2023•42 min•Ep. 283
In this episode, Sonya Krishnan, MD, MHS, discusses using HIV-ASSIST to aid in the selection of an ART regimen for a virologically suppressed PWH who is planning a pregnancy. Listen as she covers: How to input patient specific factors into the HIV-ASSIST tool Discussion of available education sheets to review the data and recommendations for her current ART regimen in pregnancy An explanation of why some regimens are ranked lower because of adherence factors such as increased pill burden or dosi...
May 11, 2023•8 min•Ep. 281
In this episode, Ian Frank, MD, discusses long-acting HIV treatment with cabotegravir plus rilpivirine for people with HIV, including: Efficacy data with every-8-week dosing Real-world use in people with viremia Initiation and continuation strategies Virologic failure data Safety information Presenter: Ian Frank, MD Associate Chief Division of Infectious Diseases Professor of Medicine University of Pennsylvania Philadelphia, Pennsylvania To download the slides: https://bit.ly/3HX1GGn To view the...
May 10, 2023•27 min•Ep. 280
In this episode, Patrick W. G. Mallon, MB, BCh, PhD, FRACP, FRCPI, discusses new data on COVID-19 presented at ECCMID 2023, including: Treatment in special populations REDPINE: remdesivir in people with renal impairment hospitalized for COVID-19 pneumonia Remdesivir and readmission for COVID-19 in immunocompromised patients Molnupiravir vs nirmatrelvir plus ritonavir for COVID-19 with hematologic malignancy Management of patients with severe disease RECOVERY: higher-dose vs standard-dose cortico...
May 05, 2023•37 min•Ep. 279
In this episode, Renslow Sherer, MD, and Trinh P. Vu, PharmD, BCIDP, discuss strategies for managing ambulatory patients with acute or previous COVID-19 infection, including: Current COVID-19 landscape Rapid antigen tests and PCR tests Risk stratification of patients who have a positive SARS-CoV-2 test Antiviral treatment (nirmatrelvir + ritonavir, remdesivir, and molnupiravir) Long COVID Presenters: Renslow Sherer, MD Director, International HIV Training Center Professor of Medicine Section of ...
May 03, 2023•1 hr 15 min•Ep. 276
In this episode, David van Duin, MD, PhD, FIDSA, FAST, discusses new data on complicated clinical infections presented at ECCMID 2023, including: Gram-negative resistance Pharmacokinetic and clinical outcomes in patients receiving meropenem/vaborbactam for KPC-producing carbapenem-resistant Enterobacterales infections Comparative study of cefiderocol- vs colistin-containing regimens for CRAB VAP with concomitant bacteremia Real-world use of imipenem/cilastatin/relebactam for the treatment of inf...
May 03, 2023•30 min•Ep. 278
In this episode, Tracey Piparo, PA-C, and Renslow Sherer, MD, discuss cases of nonhospitalized patients with COVID-19, including: Young, healthy patient with no risk factors Young, healthy patient with risk factors Older patient with immunocompromise Older patient with renal dysfunction Patient experiencing hypoxia Presenters: Tracey Piparo, PA-C Department of Palliative Medicine RJWBarnabas New Brunswick, New Jersey Renslow Sherer, MD Director, International HIV Training Center Professor of Med...
May 02, 2023•57 min•Ep. 277
In this episode, Tatyana Kushner, MD, MSCE, and Stefan Zeuzem, MD, address key considerations when screening, diagnosing, and treating patients with HDV, such as: Barriers to HDV screening, including limitations to AASLD guideline recommendations Use of double reflex testing to improve HDV diagnosis Considerations for repeat HDV testing in patients who are HBsAg positive who previously tested negative for HDV Updated CDC recommendations for HBV screening for all adults using a triple panel test ...
Apr 26, 2023•40 min•Ep. 275
In this episode, Joseph Lim, MD; Mindie H. Nguyen, MD, MAS, AGAF, FAASLD; and Jennifer Wild, MS, BSN, RN, OCN, discuss strategies for overcoming barriers to HBV care in Asian American people, including: HBV-related stigma Language barriers Health insurance navigation Presenters: Joseph Lim, MD Professor of Medicine Director, Clinical Hepatology Vice-Chief, Section of Digestive Diseases Yale University School of Medicine New Haven, Connecticut Mindie H. Nguyen, MD, MAS, AGAF, FAASLD Professor of ...
Apr 25, 2023•52 min•Ep. 271
In this episode, Essa Mohamed, PhD; Daouda Ndiaye; and Ponni Perumalswami, MD, MS, discuss strategies for overcoming barriers to HBV care in African immigrant people, including: HBV awareness and misconceptions HBV-related stigma Language barriers Health insurance navigation Presenters: Essa Mohamed, PhD Clinical Researcher Division of Gastroenterology and Hepatology Mayo Clinic Rochester, Minnesota Daouda Ndiaye Patient Navigator Ponni Perumalswami, MD, MS Associate Professor of Internal Medici...
Apr 25, 2023•59 min•Ep. 274
In this episode, Daniel R. Kuritzkes, MD, discusses considerations for patients experiencing weight gain on antiretroviral therapy, including: • Commonly implicated antiretroviral therapy regimens and patient populations • Guideline recommendations for management of weight gain Presenter: Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious Diseases Brigham and Women’s Hospital Boston, Massachusetts To download the slides: bit.ly/3...
Apr 24, 2023•6 min•Ep. 272
In this episode, Isolde Butler, MD, and Brenda E. Crabtree Ramírez, MD, discuss rapid ART initiation for people newly diagnosed with HIV, including: The HIV care continuum in the United States and Latin America Barriers to HIV diagnosis, including stigma, discriminatory laws and policies, social determinants of health, and lack of access to healthcare Factors that predict delayed care linkage and inconsistent HIV care and treatment Improved clinical outcomes that have been shown with rapid ART i...
Apr 21, 2023•49 min•Ep. 273
In this episode, Daniel R. Kuritzkes, MD, discusses considerations for rapid initiation of antiretroviral therapy in patients who are newly diagnosed with HIV, including: Recommended regimens Management of patients previously receiving PrEP Timing of laboratory testing Presenter: Daniel R. Kuritzkes, MD Harriet Ryan Albee Professor of Medicine Harvard Medical School Chief, Division of Infectious Diseases Brigham and Women’s Hospital Boston, Massachusetts To download the slides: https://bit.ly/3o...
Apr 13, 2023•4 min•Ep. 269
In this episode, 2 HIV experts from the Asia-Pacific region share their thoughts on some of the most important new insights from HIV treatment and prevention research over the past year. Specifically, the faculty discuss the role of newer innovations in HIV, including 2-drug oral antiretroviral therapy (ART) regimens, 2-drug long-acting injectable ART, and long-acting HIV pre-exposure prophylaxis in HIV care in the Asia-Pacific region, as well as the implications of weight gain with ART and impo...
Mar 27, 2023•22 min•Ep. 268
In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the clinical presentation of respiratory syncytial virus (RSV) in adults and the importance of early detection, including: Clinical symptoms and presentation Complications, including exacerbations of cardiopulmonary diseases Use of medical resources compared with other respiratory viruses Diagnostic approaches and challenges Treatment and management of RSV disease Clinical impact of RSV awareness Faculty: Angela Branche, MD ...
Mar 22, 2023•12 min•Ep. 267
In this episode, Angela Branche, MD, and Helen Y. Chu, MD, MPH, discuss the impact of respiratory syncytial virus (RSV) and describe those at risk for severe RSV disease, including: RSV prevalence and seasonality RSV burden throughout life, including burden in older adults Comorbidities that increase the risk of RSV complications RSV transmission in the hospital and care home setting Implications of risk factors for severe RSV on prevention and treatment Faculty: Angela Branche, MD Associate Pro...
Mar 22, 2023•11 min•Ep. 266
In this episode, José R. Arribas, MD, and Melissa Badowski, PharmD, MPH, FIDSA, FCCP, BCIDP, BCPS, AAHIVP, discuss optimizing antiretroviral therapy (ART) for people with HIV who are treatment experienced or failing a current ART regimen, including: The use of proviral DNA genotyping for switching therapy Maintaining nucleos(t)ide reverse-transcriptase inhibitors after a first failure The role of zidovudine in salvage regimens The use of twice-daily darunavir with protease inhibitor resistance a...
Mar 21, 2023•38 min•Ep. 265
In this episode, Darrell H. S. Tan, MD, FRCPC, PhD, and Kenric Ware, PharmD, AAHIVP, discuss considerations for HIV pre-exposure prophylaxis (PrEP) persistence, including: The PrEP continuum of care in the United States, including inequities in PrEP uptake and persistence by race CDC PrEP guidance regarding PrEP indications PrEP eligibility by regimen Summary of renal, bone, and weight outcomes with different PrEP options Data on HIV acquisition following PrEP discontinuation Drug concentrations...
Mar 16, 2023•54 min•Ep. 264
In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, and Samantha Strong, PharmD, BCACP, AAHIVP, CDCES, answer questions including: Strategies to improve disparities in pre-exposure prophylaxis (PrEP) access in difficult-to-reach populations Key remaining questions related to PrEP options for cisgender women and people who inject drugs Concerns about resistance at seroconversion in patients with suboptimal PrEP compliance Implementation of molecular screening for patients receiving PrEP Expecta...
Mar 15, 2023•32 min•Ep. 263
In this episode, Maria Buti, MD, and Richard H. Davis, PA-C, address key considerations when screening, diagnosing, and treating patients with hepatitis delta virus (HDV), such as: Barriers to screening HDV screening based on patient risk factors Universal screening for all patients with positive hepatitis B surface antigen (HBsAg) Reflex testing Availability of commercial testing Monitoring suggestions in HBsAg positive and HDV antibody positive patients with negative HDV RNA Limitations to eva...
Mar 08, 2023•23 min•Ep. 262
In this episode, Latesha Elopre, MD, MSPH, discusses key considerations to barriers to PrEP uptake, including: Addressing disparities among racial and ethnic minority populations Understanding the concept of intersectionality Tackling multiple levels of intersectionality Individual (eg, self-stigma, mental health) Network (eg, access to PrEP services) Community (eg, racism, stigma, poverty) Social and structural (eg, laws/policies) Epidemic (eg, population level of viremia) Presenter: Latesha El...
Mar 06, 2023•6 min•Ep. 261
In this episode, Darcey Wooten, MD, discusses the long-acting HIV treatment agent lenacapavir for treatment-experienced people with HIV, including: Efficacy data Initiation strategies Virologic failure data Safety information Presenter: Darcy Wooten, MD Associate Professor of Medicine Division of Infectious Diseases and Global Public Health Department of Medicine University of California, San Diego San Diego, California To download the slides: http://bit.ly/3Jb1ofX To view the full online progra...
Mar 03, 2023•6 min•Ep. 259
