In this episode, Nancy Reau, MD, and Lydia Tang, MBChB, discuss how to increase linkage to care rates for persons with hepatitis D virus, including: Updates on currently low rates of linkage to care Barriers preventing patients with HBV/HDV coinfection from engaging in care Interventions to increase retention in care for patients with HDV Faculty: Nancy Reau, MD Professor of Medicine Chief , Section of Hepatology Associate Director , Solid Organ Transplantation Richard B. Capps Chair of Hepatolo...
Feb 23, 2023•26 min•Ep. 258
In this episode, Jill Blumenthal, MD, MAS, and William R. Short, MD, MPH, AAHIVS, address key considerations when evaluating ART safety and tolerability in pregnant people, those trying to conceive, and transgender individuals, such as: Approaching patients trying to conceive on nonpreferred ART regimens (eg, 2-drug regimens like LA CAB and RPV) Optimizing the use of the Antiretroviral Pregnancy Registry Addressing unique barriers to ARV adherence in transgender individuals with HIV (eg, drug fo...
Feb 23, 2023•23 min•Ep. 258
In this episode, Coleman I. Smith, MD, and Lydia Tang, MBChB, discuss how to screen for hepatitis delta virus (HDV), including: Algorithm for evaluation of HDV Diagnosis of different stages of HDV infection Strategies to increase HDV testing rates Faculty: Coleman I. Smith, MD Professor of Medicine Hepatologist Georgetown Transplant Institute Georgetown University Washington, DC Lydia Tang, MBChB Assistant Professor Department of Infectious Diseases University of Maryland School of Medicine Inst...
Feb 23, 2023•15 min•Ep. 257
In this episode, Canadian HIV experts share their thoughts on some of the most important new insights from HIV treatment and prevention research over the past year. Specifically, the faculty discuss treatment strategies for patients with a history of NRTI resistance based on findings from the 2SD and NADIA trials; the latest data informing the use of 2-drug oral and injectable treatment regimens; prevention approaches for HIV and other sexually transmitted infections based on findings from the D...
Feb 17, 2023•20 min•Ep. 254
In this episode, 2 Australian HIV experts share their thoughts on some of the most important HIV insights gained during the past year in the context of HIV care in Australia. Specifically, the faculty discuss the continued dominance of second-generation INSTI-based regimens as mainstay HIV therapy in Australia, including in both 2-drug and 3-drug oral regimens; the emergence of 2-drug long-acting injectable therapy as a switch strategy; key aspects of successfully expanded oral PrEP programs in ...
Feb 17, 2023•22 min•Ep. 255
In this episode, 2 HIV experts from Latin America share their thoughts on the current status of HIV prevention strategies in the region, including recent successes and ongoing challenges. Specifically, the faculty discuss: Barriers that limit PrEP availability in many regions of Latin America despite the high need among vulnerable and at-risk groups Successful expansion of PrEP access in Brazil Key findings from the prospective ImPrEP study evaluating implementation of same-day oral PrEP among m...
Feb 17, 2023•22 min•Ep. 256
In this episode, 2 European HIV experts share their thoughts on some of the most important new antiretroviral therapy insights from HIV research over the past year. Specifically, the faculty discuss findings from real-world and long-term studies of 2-drug oral regimens, the latest on 2-drug long-acting injectable therapy, how 2-drug options fit into rapid start strategies, and other new and emerging innovations in HIV treatment, including the availability of lenacapavir for multidrug-resistant H...
Feb 17, 2023•22 min•Ep. 253
In this episode, Alba Azola, MD, and Monica Verduzco-Gutierrez, MD, discuss diagnosis and management of long COVID, including: Definitions of post COVID conditions Diagnosis, including symptoms and clinical presentation Epidemiology Risk factors Possible treatment options Clinical guidance statements Presenters: Alba Azola, MD Assistant Professor Department of Physical Medicine and Rehabilitation Johns Hopkins Co-Director Johns Hopkins Post Acute COVID Team Clinic Baltimore, Maryland Monica Verd...
Jan 31, 2023•44 min•Ep. 246
In this episode, Kenric Ware, PharmD, AAHIVP, discusses the role of college campuses in HIV pre-exposure prophylaxis (PrEP) uptake for adolescents, including the following. PrEP awareness and education Venues for ongoing PrEP conversations, including in-person dormitory discussions, virtual webinars, and social media conversations Campus health clinics that are safe and trusting and minimize stigma Individualized approaches, including: Engaging local students in discussions of regional barriers ...
Jan 31, 2023•6 min•Ep. 252
In this episode, Eric Florence, MD, PhD, discusses how clinics can prepare for the implementation of long-acting injectable antiretroviral therapy, including: Clinical infrastructure Ensuring adequate space and injection equipment Maintaining drug supply and temperature requirements Staffing Ensuring there are staff able to focus on the implementation of LA ART, including well-trained nurses to administer the injections Implementing a system for scheduling follow-up injections and providing pati...
Jan 18, 2023•5 min•Ep. 250
In this episode, Marta Boffito, MD, PhD, FRCP, and Jens D. Lundgren, MD, DMSc, address key considerations when evaluating antiretroviral therapy safety and tolerability in aging patients and those with possible cardiometabolic toxicities, including: Monitoring for cardiometabolic syndromes (eg, lipid panels, coronary artery calcification scores) Approaching antiretroviral-related weight gain in clinical practice Interpreting results from RESPOND on cardiovascular risk with integrase strand trans...
Jan 17, 2023•23 min•Ep. 251
In this episode, Jens D. Lundgren, MD, DMSc, and Barbara Rath, MD, PhD, HDR, discuss emerging insights on outpatient management of acute COVID-19 and long COVID in Europe, including: Current COVID-19 variant and subvariant landscape COVID-19 treatments, including antivirals and monoclonal antibodies ESCMID COVID-19 treatment guidelines Long COVID causes and pathophysiology Prevention and management of long COVID Presenters: Jens D. Lundgren, MD, DMSc Professor Rigshospital, University of Copenha...
Jan 13, 2023•40 min•Ep. 249
In this episode, Laurence Slama, MD, PhD, describes some of the ways that her clinic is attempting to make IM injections of long-acting antiretroviral therapy more sustainable long term. She explains the logistics of how she has allowed for patients to receive their long-acting cabotegravir and rilpivirine doses through community nurses after receiving the first 3 doses in a clinical setting. She also discusses some of the benefits and challenges of this kind of flexible system for patients and ...
Jan 05, 2023•9 min•Ep. 248
In this episode, Jason E. Farley, PhD, MPH, ANP-BC, FAAN, FAANP, AACRN, discusses optimizing HIV pre-exposure prophylaxis (PrEP) selection and persistence for men who have sex with men (MSM), including: Disparities in PrEP uptake for MSM What healthcare professionals can do to address disparities in PrEP uptake Providing PrEP within a program that includes sexual health and primary care services, in addition to prescribing PrEP PrEP medication options for MSM Helping patients access PrEP medicat...
Jan 05, 2023•19 min•Ep. 247
In this episode, Jill Blumenthal, MD, MAS, discusses HIV pre-exposure prophylaxis (PrEP) considerations for transgender and nonbinary individuals, including: Providing gender-affirming care Integrating PrEP and gender care Taking a sexual history and addressing sexual health PrEP efficacy and options for transgender individuals, including FTC/TDF, FTC/TAF, and long-acting CAB The importance of reassuring transgender individuals that data suggest there are no drug–drug interactions between gender...
Jan 05, 2023•18 min•Ep. 245
Fernando Carnavali, MD; Rasika Karnik, MS, MD; and Renslow Sherer, MD, discuss long COVID, including: Long COVID prevention strategies, including COVID-19 vaccination Long COVID treatment approaches Strategies for management of patients with long COVID Presenters: Fernando Carnavali, MD Associate Professor of Medicine Division Chief General Internal Medicine Department of Medicine Site Director COVID Center of Excellence Satellite-Ansonia Mount Sinai Health New York, New York Rasika Karnik, MS, ...
Jan 04, 2023•5 min•Ep. 244
Fernando Carnavali, MD; Rasika Karnik, MS, MD; Renslow Sherer, MD; and Joseph Torrisi, PharmD, BCIDP, discuss COVID-19 treatments and the possibility for antiviral resistance, including: Treatment resistance mechanisms COVID-19 testing COVID-19 treatments, including antivirals and monoclonal antibodies Presenters: Fernando Carnavali, MD Associate Professor of Medicine Division Chief General Internal Medicine Department of Medicine Site Director COVID Center of Excellence Satellite-Ansonia Mount ...
Jan 04, 2023•7 min•Ep. 243
Fernando Carnavali, MD; Rasika Karnik, MS, MD; Renslow Sherer, MD; and Joseph Torrisi, PharmD, BCIDP, discuss COVID-19 rebound, including: Prevalence of COVID-19 rebound COVID-19 rebound and antiviral use Management of COVID-19 rebound Presenters: Fernando Carnavali, MD Associate Professor of Medicine Division Chief General Internal Medicine Department of Medicine Site Director COVID Center of Excellence Satellite-Ansonia Mount Sinai Health New York, New York Rasika Karnik, MS, MD Assistant Prof...
Dec 30, 2022•5 min•Ep. 242
In this episode, Princy N. Kumar, MD, FIDSA, MACP, discusses key considerations for selecting ART in treatment-naive persons with HIV. Her discussion includes a review of the following studies on ART and weight gain: ADVANCE: men vs women receiving DTG + FTC/TAF, DTG + FTC/TDF, and EFV + FTC/TDF Comparison of ART regimens (eg, INSTI-, NNRTI- and PI-based regimens) in a pooled analysis of 8 phase III randomized controlled trials GEMINI-1 and GEMINI-2: DTG + 3TC vs DTG + FTC/TDF Presenter: Princy ...
Dec 30, 2022•10 min•Ep. 241
In this episode, Princy N. Kumar, MD, FIDSA, MACP, discusses key considerations for selecting ART in treatment-naive persons with HIV. Her discussion includes: DHHS Treatment Guideline recommendations Choosing among first-line recommended integrase inhibitors Recommended regimens for rapid ART start Select key studies in treatment-naïve adults: AMBER study of virologic response with DRV/COBI/FTC/TAF vs DRV/COBI + TFC/TDF DRIVE-AHEAD and DRIVE-FORWARD efficacy study results, including resistance ...
Dec 29, 2022•23 min•Ep. 239
Fernando Carnavali, MD; Rasika Karnik, MS, MD; Renslow Sherer, MD; and Joseph Torrisi, PharmD, BCIDP, discuss how to ethically prioritize patients for COVID-19 treatment when treatment supplies may be limited, including insights on: Risk stratification Medication acquisition Drug interactions Presenters: Fernando Carnavali, MD Associate Professor of Medicine Division Chief General Internal Medicine Department of Medicine Site Director COVID Center of Excellence Satellite-Ansonia Mount Sinai Heal...
Dec 29, 2022•8 min•Ep. 240
In this episode, Tamera Coyne-Beasley, MD, MPH, discusses strategies to address barriers to improve meningococcal vaccination rates by addressing social determinants of health and minimizing vaccine inequities, such as: Working closely with members of the community, including community-based organizations and adolescent and young adult influencers Involving all youth when designing vaccination outreach and messaging programs Creating and evaluating the use of technology Using graphics, voices, a...
Dec 29, 2022•11 min•Ep. 238
Fernando Carnavali, MD; Renslow Sherer, MD; and Joseph Torrisi, PharmD, BCIDP, discuss how new COVID-19 vaccines may affect risk stratification, including: Omicron-specific vaccine Role of vaccination in risk stratification Presenters: Fernando Carnavali, MD Associate Professor of Medicine Division Chief General Internal Medicine Department of Medicine Site Director COVID Center of Excellence Satellite-Ansonia Mount Sinai Health System New York, New York Renslow Sherer, MD Director International...
Dec 27, 2022•5 min•Ep. 237
In this episode, an international expert panel shares their thoughts on what will be needed from future long-acting HIV treatment and prevention strategies to address populations who are not eligible for currently available long-acting options. The faculty members also discuss important considerations for leveraging long-acting HIV approaches to address care inequities across different populations. Other episodes in this 4-part series cover additional aspects of long-acting antiretrovirals for H...
Dec 22, 2022•18 min•Ep. 235
In this episode, Carolyn Chu, MD, MSc, FAAFP, AAHIVS, discusses improving HIV pre-exposure prophylaxis accessibility and availability for PWID, including by: Integrating PrEP with services that PWID are already aware of and/or connected to (eg, harm reduction/syringe services and substance use disorder treatment programs, peer-based training/education initiatives, healthcare for the homeless programs, and emergency departments) Staffing PrEP programs with people who are trusted by PWID and deliv...
Dec 20, 2022•5 min•Ep. 236
In this episode, Monica Gandhi, MD, MPH, and Chloe Orkin, MBChB, FRCP, MD, discuss considerations for monkeypox, now called mpox, in people with HIV, including: The history of monkeypox (mpox) The current monkeypox (mpox) outbreak What we knew about monkeypox (mpox) in PWH prior to the current outbreak Data in PWH from an international case series of monkeypox (mpox) CDC data regarding monkeypox (mpox) in PWH Monkeypox (mpox) treatment recommendations Drug–drug interaction considerations between...
Dec 19, 2022•55 min•Ep. 233
In this episode, Annette Haberl, MD, and William R. Short, MD, MPH, AAHIVS, discuss when to consider an ART switch during pregnancy, including: Current DHHS, EACS, WHO, BHIVA, and German/Austrian guidelines for the use of ARVs in pregnancy What data and recommendations for the use of ARVs during pregnancy are currently missing from the guidelines Available data on newer ARVs in the ARV pregnancy registry Pharmacokinetic data for newer ARVs including BIC/FTC/TAF and LA CAB + RPV in pregnancy Reco...
Dec 19, 2022•56 min•Ep. 234
In this episode, Stephane De Wit, MD, PhD, discusses the benefits of long-acting antiretroviral therapy (ART) for migrant populations in Europe—and specifically in Belgium. He also addresses some of the challenges of accessing and following up with those populations. Dr De Wit describes some of the ways that the Belgian healthcare system is set up to improve access to ART. He then explains some of the disease parameters for considering expanding the use of long-acting ART to patients who are not...
Dec 19, 2022•12 min•Ep. 232
In this episode, Nancy Reau, MD, and Coleman I. Smith, MD, discuss the burden of undiagnosed hepatitis delta virus (HDV) infection and who should be tested, including: Epidemiology of HDV infection Clinical course of HDV infection Populations at high risk of HDV infection Guidelines for HDV testing Faculty: Nancy Reau, MD Professor of Medicine Chief, Section of Hepatology Associate Director, Solid Organ Transplantation Richard B. Capps Chair of Hepatology Rush University Medical Center Chicago, ...
Dec 15, 2022•13 min•Ep. 231
When it comes to managing adults with HBV, should age factor into your treatment decision—or is it important to treat everyone, regardless of age? Listen as Dr George Lau discusses these questions and more for strategizing the monitoring and treatment of older adults with HBV. Presenter: George Lau, MBBS (HKU), MD (HKU), FRCP (Edin, Lond), FAASLD (USA) Chairman Humanity and Health Medical Group Hong Kong, China Chair, Professor, and Co-Director Liver Diseases & Transplant Centre The Fifth Me...
Dec 15, 2022•13 min•Ep. 230
