Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

Membrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.

References Dr Guerra's membrane lipid lectures Neuron 2015. Volume 85, Issue 4.Pages 695–702

Oct 04, 2022•30 min

Membrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic Biochemistry

Referewnce Guerra basics lecture

Oct 01, 2022•30 min

Membrane Biochemistry 58. Cardiolipin biosynthesis involves a PC-linoleic acid requiring maturase and a unique phosphatidylglycerol phosphate phosphatase. DJGPhD.25.9.22.Authentic Biochemistry

References Dr Guerra membrane lectures Cell Metab. 2020 Dec 1;32(6):981-995.e7 PNAS 2011.108 (29) 11860-11865 J. Dev. Biol. 2020, 8(2), 10. Chem & Phys of Lipids.2000. June. 106:1-29

Sep 26, 2022•30 min

Membrane Biochemistry 57. c-Fos osteoclastogenesis and control over acetyl ceramide mediated apoptosis.Dr Daniel J.Guerra.22.9.22 Authentic Biochemistry

References Dr Guerra Tumor lectures Nature Reviews Endocrinology 2020.volume 16, pages224–233 J Neurochem. 2006 Nov;99(4):1237-50. doi: 10.1111/j.1471-4159

Sep 22, 2022•28 min

Membrane Biochemistry 56. Membrane Associated Cholesterol hydroxylation leads to bile acid conjugate- promoting human breast cancer stem cell proliferation. DJGPhD.19.9.22 Authentic Biochemistry.

References Dr Guerra's membrane sterol lecture notes Cells. 2019 Apr; 8(4): 293.

Sep 20, 2022•30 min

Membrane Biochemistry 55. A phosphoglycerolipid primer. Dr Daniel J. Guerra. Authentic Biochemistry Podcast. 16 Sept. 2022.

References Dr Guerra's Lecture notes

Sep 17, 2022•30 min

Membrane Biochemistry 54. De-phospho TYR cFos doubles the VMax of specific glycolipid and phospholipid biosynthetic enzymes via ER stabilization.Dr Daniel J. Guerra. Authentic Biochemistry.14.9.22

References Dr Guerra's lipid and membranes lectures Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014.Volume 1841, Issue 9, Pages 1241-1246 Onco Targets Ther . 2017;10:5491-5524

Sep 14, 2022•30 min

Membrane Biochemistry 53. cFos correlates with light-induced retinal membrane retailoring without de novo transcription. Dr Dan Guerra. 13.9.22.Authentic Biochemistry Podcast

References Dr Guerra's lecture notes Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014. Volume 1841, Issue 9, Pages 1241-1246

Sep 13, 2022•30 min

Membrane Biochemistry 52. Epigenetic modifications in pathophysiology and the synthesis of nascent membrane lipid in cell cycle progression. DJGPhD.12Sept22. AUthentic Biochemistry

References Dr Guerra's membrane lecture notes Biochimica et BiophysicaActa (BBA) - Molecular and Cell Biology of Lipids.2014. Volume 1841, Issue 9, September Pages 1241-1246 BioEssays, Volume: 40, Issue: 5, First published: 30 March 2018, DOI: (10.1002/bies.201800007) International Journal of Molecular Sciences. 2015. 16(1):1928-48

Sep 12, 2022•30 min

Membrane Biochemistry 51. The BRD4 epigenetic reader control over cardiac mitochondrial function via bioenergetic gene expression may be corrupted in oncogenic pharmacotherapy driven BETi. DJGPhD.

References Circulation. 2020 Dec 15;142(24):2356-2370. Journal of Biological Chemistry 2016. 291, 23756-23768. Nature Reviews Drug Discovery 2014, Vol. 13 Issue 9, p673-691

Sep 08, 2022•30 min

Membrane Biochemistry L (50). SCFA's work via membrane free fatty acid receptors through transcription factor Nrf2 to reduce ROS with an epigenetic mark-up.DJGPhD.7Sept22.Authentic Biochemistry.

References Nature Reviews Drug Discovery. 2014, Vol. 13 Issue 9, p673-691 Redox Biology 2021.Volume 47, November. 102165

Sep 07, 2022•30 min

Membrane Biochemistry 49. linking membrane reception and endocrine steroid lipid signaling to disease and longevity.DJGPhD.06Sept22

References Redox Biology 2021 Volume 47, November. 102165 Front. Immunol., 26 August 2020

Sep 07, 2022•29 min

Membrane Biochemistry 48.Coxsackievirus B enterovirus causes myocarditis in young men due to lack of estrogen-receptor-mediated control of mitochondrial fission/fusion & inflammation. DJGPhD.3Sept22

References J Virol. 2017 Dec 15; 91(24): e01347-17 Br J Pharmacol. 2014 Apr; 171(8): 1890–1906 European Review for Medical and Pharmacological Sciences 2021; 25: 3762-3771 •Mol Med Rep. 2014 Dec; 10(6): 2811–2818.

Sep 04, 2022•30 min

Membrane Biochemistry 47. AMPK is regulated by steroid hormone activating kinases and calcium. DJGPhD. 02September2022, Authentic Biochemistry Podcast

References Nature Cell Biology, 02 Sep 2011, 13(9):1016-1023 Cell Biochem Biophys. 2015 Jul;72(3):701-7 Int J Mol Sci. 2018 Sep; 19(9): 2753. Sci Signal. 2017 Jan 31; 10(464): eaaf7478.

Sep 02, 2022•30 min

Membrane Biochemistry 46. Lung and endometrial cancer vs neurodegersative disease in steroid-sex-hormone NK cell biochemistry.DJGPhD.31.8.22. Authentic Biochemistry.

references Am J Physiol Regul Integr Comp Physiol2018. 314: R909–R915. Obesity (Silver Spring). 2008 Jun; 16(6): 1284–1288 Front. Immunol., 26 April 2019 Sec. NK and Innate Lymphoid Cell Biology Journal of Biological Chemistry 2018. 293: 2422-2437

Aug 31, 2022•30 min

Membrane Biochemistry XXXXV. Female NK Cytotoxicity due to Membrane Surface Receptors may Obtain Reduced Pathogen Infection Rates and Cancer in Women v. Men.DJGPhD.30.8.22 Authentic Biochemistry.

References Mechanisms of Ageing and Development 2016. 156: 25-33 The Journal of Biological Chemistry 2018. 293: 2422-2437

Aug 31, 2022•30 min

Membrane Biochemistry 44. Synthesis of Lectures Video. Part One. Attached in show notes. Dr. Daniel J. Guerra. 29.8.22 Authentic biochemistry Podcast.

https://youtu.be/GIdDBdEywzk

Aug 29, 2022•35 sec

Membrane Biochemistry 43. Action potentials and the mechanisms of electrochemical communication in biological systems. DJGPhD.26.8.22. Authentic Biochemistry

References Dr Guerra's neuroscience lectures

Aug 26, 2022•26 min

Membrane Biochemistry XXXXII. Basic Electrobiochemistry of Biological Membranes. Dr Daniel J. Guerra. 24.8.22b Authentic Biochemistry Podcast Audio Lectures.

References Dr Guerra's membrane biochemistry/electrophyiology lectures

Aug 24, 2022•30 min

membrane Biochemistry XXXXI. A priori Synthesis of Sex-linked Biochemical Dimorphism and Canonical Membrane Event Ontology. Dr. Daniel J. Guerra. 24.8.22.Authentic Biochemistry Podcast.

References Dr Guerra's lecture marginalia

Aug 24, 2022•30 min

Membrane Biochemistry XXXX. Immunological Response to Molecular Sex-linked Pattern Dimorphism Includes the Presentation of Differential Autoinflammatory Diseases. DJGPhD 22.8.22b.Authentic Biochem.

References Dr Guerra's Immunology Lecture notes Redox Biol. 2020 Apr; 31: 101482. Mechanisms of Ageing and Development.2006. Volume 127, Issue 9: 705-718

Aug 22, 2022•30 min

Membrane Biochemistry XXXIX. Maternal Inheritance of Mitochondrial DNA and the Heterozygous XY Chromosomal Contributions to Sexually Dimorphic Biochemical Processes.DJGPhD.22.8.22. Authentic Biochem.

References Mechanisms of Ageing and Development.2006. Volume 127, Issue 9, Pages 705-718 J Bioenerg Biomembr. 2015 April ; 47(1-2): 173–188

Aug 22, 2022•30 min

Membrane Biochemistry XXXVIII. Sexual Biochemical Dimorphism Epigenetic Involvement in Early Infant CRF/HPA Axis and Subsequent Adult Neuropsychiatric Disease. DJGPhD.19.8.22. Authentic Biochemistry.

References Biol Psychiatry. 2019 Sep 15; 86(6): 421–432.

Aug 19, 2022•30 min

Membrane Biochemistry XXXVII. CRF Receptor Studies in Pre-Clinical Research as Bootstrapped to Human MDD, GAD, PTSD and Addiction.DJGPhD.19.8.22. Authentic Biochemistry

References Journal of Neuroscience Research. 2020. Aug.Vol. 98, Issue 8 1097-4547. Dr. Guerra Neuroscience lecture notes

Aug 19, 2022•30 min

Membrane Biochemistry XXXVI. Sexual Differential CRF Signaling Accorded to Downstream Processing and Associated Neuropsychiatric and Phyiological Disorders.DJGPhD.17.8.22 Authentic Biochemistry.

References Trends Pharmacol Sci. 2013 Aug; 34(8): 437–444. Dr Guerra's Neuroscience lecture notes

Aug 17, 2022•30 min

Membrane Biochemistry XXXV. Lipocortin-1 induces cortisol thus suppressing phospholipase A2, blocking eicosanoid and leukocyte inflammatory events. DJGPhD.16.8.22. Authentic Biochemistry

References Dr Guerra's notes Curr Neuropharmacol. 2013 Mar; 11(2): 141–159 Advances in Neurobiology, 01 Jan 2014, 11:13-30

Aug 16, 2022•30 min

Membrane Biochemistry XXXIV. Assymetric Glucocorticoid Pharmacotherapy in Rheumatoid Autoimmune Disease with T2Diabetes and the Fear Axis.DJGPhD.Authentic Biochemistry 15.8.22

References Genes Immun. 2020 May; 21(3): 150–168 BMC Rheumatology 2020. volume 4, Article number: 4 Nature Immunology.2002. August. volume 3 no 8 Cell Tissue Res. 2019 Jan; 375(1): 143–172.

Aug 16, 2022•30 min

Membrane Biochemistry XXXIII> Are Oxytocin and Corticotropin Releasing Factor Antiinflammatory, Analgesic and Anxiolytic? Dr Daniel J. Guerra. 14.8.22. Authentic Biochemistry

References Cell Tissue Res. 2019 Jan; 375(1): 143–172. Int. J. Mol. Sci. 2021, 22(21), 11465

Aug 15, 2022•30 min

Membrane Biochemistry XXXII. The Subcortico-limbic network in Fear Conditioning as seen through the Dialectical Event Ontology lens. DJGPhD.10.AUG.22. Authentic Biochemistry

References Dr Guerra's notes Curr Neuropharmacol. 2013 Mar; 11(2): 141–159

Aug 11, 2022•30 min

Membrane Biochemistry XXXI. Corticotropin Releasing Factor and "Fear" Neurobiochemical Correlates in the CNS. Dr Daniel J. Guerra. 9Aug2022. Authentic Biochemistry Podcast

References Dr Guerra's neuroscience lectures Neurosci BiobehavRev. 2019 Aug; 103: 50–59

Aug 09, 2022•30 min

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