In this Lecture I define and then implement a dialectical approach to biomedical scientific research methods that involves event ontologies relative to a non-paradoxical understanding of cancer pathobiochemistry. Published 19 June 2020 by Dr Daniel Guerra
Dr. Dan Guerra apprehends several research publications going back to 2012 and proceeding through 2019 in a synthesis of oppostional logic and the published scientific evidence to explain the mediation of metabolic zonation, transcriptional control, and bioenergetcs using PEDF to mitigate cancer progression.
A brief concluding lecture on the linkage of obesity with Type 2 diabetes plus a clinical case study discussion and review question of a mis-diagnosis via anchoring.
Dr Guerra lays out the prodromal manifestations of metabolic syndrome and insulin resitance that can lead to Type 2 diabetes in the obese sedentary aging population.
Dr Guerra lays down the basics of bioenergetics and the roles of carbohydrate and lipid metabolism in the obese state leading to type 2 diabetes and the pathophysiological sequalae in chronic disease. 25 May 2020b.
Dr Guerra reminds his audience that obesity is the global health pandemic of a generation and that it leads to multiple high mortality diseases associated with a corruption in lipid metabolism, both innate and acquired immunity and associated cancer and cardiovascular disorders. Because obesity sets as a precondition and continued distress to human health and well-being, the predisposition to a constellation of diseases both infectious and non-infectious is obtained. Recorded and produced on 25 ...
Dr Guerra provides the basic detail necessary to prepare one for our future examination of the current peer-reviewed literature involving hormonal control over health , infection and inflammation via the immune system.
Dr Guerra discusses hormonal ontology via receptor -binding mechanisms plus the cascade of the hypothalamic-pituitary axis.
Dr Guerra gives a fast paced knowledge-laden series of lectures on the medical physiological and biochemical features of human hormonal signaling. Lecture I Introduction and Classification. Published on line 04 May 2020
Dr Guerra opens up the refereed published scientific literature to provide verified evidence associated with the arcuate nucleus of the hypothalamic arc leading to hormonal control over nutrition and the immune system. Published 28 April 2020
Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus aureus. Dr Daniel J Guerra published on 27 April 2020.
facebook.com/danguerra00 DJ Guerra (My YouTube channel!) Please subscribe to all of y sites and make a friend request on FB Thank you so much for listening! Authentic Biochemistry Rules!
Dr Guerra delivers his third informed discussion of Membrane lipid raft biology and the role of Sphingolipids in mediating an immune response that results in massive tissue damage and poor disease outcome. Published 11 April 2020
In this audio lecture presentation, Dr Guerra gives an aggregated explanation for the association of subcellular biochemical metabolism of sphingolipids via the target of Cationic Amphipathic Drugs such as SSRI's in altering cell fate from programmed cell death to tissue preserving autophagy. Published 11 April 2020.
Dr Guerra uses the Dialectical Method via the Logical Square of Opposition combined with an analysis of the current biomedical evidence associated with the COVID 19 corona virus to obtain validated conclusions. 23 March 2020.
In this third segment on the grounding of Natural Science and the world View it advances, Dr Dan Guerra introduces the endojective perspective for space-time and the foundation of knowledge toward the representation of phenomena as pattern recognition from a possibilistic metaphysical landscape via freely chosen inductive reasoning in an ultimately uncertain universe. Published 20 March 2020.
In this second philosophical segment, Dr. Guerra introduces space-time as a physical manifestation of the synthetic a priori of Phenomenological Metaphysics as he draws inferences from pre-Socratic concepts of vortices and co-mingles these ideas with Clerk Maxwell's explanation of the electromagnetic theory and quantifiable resolution for the velocity of light. Published on the IDES of March 2020.
In this first segment of a three part series, Dr Guerra sets out to ground his scientific principles with an a priori epistemological reasoning that leads to the transcendental method for instantiating metaphysics to perform biochemical, genetic and physiological research. Recorded 11 March 2020.
Dr Guerra explains how there is a cumulative balance between S1P and Ceramide will influence apoptosis and change the regulation of autophagy by the complex interplay between mTOR, beclin, and Bcl-2 where S1P-dependent autophagy is thought to be a homeostatic, pro-survival response involved in the clearance of intra-cellular debris.Describing these systems within the context of inflammation and pathobiochemistry will be obtained.
Today's podcast establishes the significance of sphingolipids in maintaining normal biochemical and physiological homeostasis by detailing membrane organization of pathways and linkage to cell fate and the potential for pathobiology in human disease. Published 03 March 2020 by Daniel J. Guerra, PhD
Dr. Dan Guerra discusses a new publication reviewing the process of resident pulmonary macrophages and innate lymphoid cells in disease with attention to pathogen activation and hyperinflammation as potentiated by co-morbidities leading to poor clinical outcome. 01 March 2020
Dr Dan Guerra recombines Coronavirus with Ceramide linked Neurological Disease and the Pro-Inflammatory Response. 28 February 2020.
In this Authentic Biochemistry Podcast, Dr. Dan Guerra explains the roles of acid sphingomyelinases and associated ceramide production on the NLRP3 inflammasome activation as linked to coronavirus pathogen molecular patterns and the production of proinflammatory cytokines 19 February 2020.
Dr. Guerra discusses a published NEJM paper from late January (2020) that details the initial epidemiology of the novel Coronavirus from China and gives an insight on how sphingolipid metabolism may be a potential pharmacotherapeutic target. Podcast Published 03 February 2020.
Dr Guerra of Authentic Biochemistry starts his lecture series on the current disease-causing Coronavirus from China. This first segment gives detail on the basics of molecular arrangement, replication, intracellular trafficking through the ER-Golgi and ultimate virion transmission with some medical-historical references to the more common animal Nidovirales/Coronavirales and the previous human outbreaks of related SARS and MERS CoV. Please visit https://www.facebook.com/danguerra00 and contribut...
Professor Guerra arrives at the functionality of autophagy and bioenergetic coupling via chemokine and cytokine signalling through antigen presenting cell population mediated germ center secondary lymphoid organ resident B cell somatic hypermutation via T follicular-helper cell activation thus evincing the autoimmune paradigmatic disease system lupus erythematosus. 28 January 2020.
Authentic Biochemistry's Dr Dan Guerra gathers published biomedical literature to offer mechanisms and means for sphingolipids and amino acids to make a pathobiochemical donation to immunoepigenomic neurodegenerative disease. 21 January 2020.
19 January 2020. This is a podcast delivering Part 3 in my new arc describing the significance of biochemical and epigenetic reprogramming of T lymphocytes in human autoimmune disease. Parts 1&2 of this series are found as video lectures at https://www.youtube.com/playlist?list=UUcEoA2N9WSlNvDk1BtuznfQ . Dr Daniel J. Guerra of VerEvMed and Authentic Biochemistry.
Dr Guerra investigates T and B cell mediated autoimmune induction in this critical podcast lecture before the full analysis of these destructive human diseases are authentically examined in the peer-reviewed biomedical literature.
As it turns out, autoimmune bacterial epitope mimicry can play a crucial role in autoimmune primary biliary cholangitis and may correlate to major human disorders such as lupus . Prof. Guerra examines a series of papers from the primary literature to focus attenuation on T cell sub-population differentiating dynamics production.related to Plasma cell IgG
