T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains
The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating the molecular mechanisms employed.
Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.
Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019
Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019
Dr Guerra of Authentic Biochemistry provides his third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019.
Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis
Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019
In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a proinflammatory cytokine transcription thus inhibiting obese adipose inflammation. 08 September 2019.
Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid. 04 Sept 2019.
Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations.
This is volume VI of the Tregs lecture narrative in which Dr. Guerra provides an introduction to a Diaeventontological process for navigating the labyrinth of T cell biochemistry. Published 17 August 2019. Authentic Biochemistry Podcast.
Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3. This is an important contribution to the T lymphocyte literature as it points t...
Prof. Guerra provides a narrative focusing on evolutionary perspectives and the resultant lymphocyte differentiating foundations for the adaptive immune response as a means to apprehend the event-ontological diverse transcriptional mediation ultimately landing on the Treg FOXp3 promoter . Part IV
In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response
Dr Dan Guerra presents "T regulatory Cells in Human Biology and Disease. An update on transcriptional control". Vol.I. This first segment introduces the elaborate nature of innate and acquired lymphoid cells and the transcription factors that drive lineage differentiation.
This is a brief introduction to what will be a multi-segmented sequence of podcasts on the complexity of T cell mediated immunity and its native regulation via Treg activation.
In this podcast, Authentic Biochemistry's own Dr. Dan Guerra ties the actuated Moebius strip of anti-apoptosis rendered neuronal differentiation amidst a tempest of ceramide synthetic possibility.
Dr Guerra of Authentic Biochemistry navigates through the protease inhibitor literature and starts a journey into hepatitis C virus (HCV)-mediated HCC induction and some of the pharmacotherapies impacting this axis.
Dr. Guerra focuses on emerging signaling and immunoepigenetic variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry.
Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeutic anisotropy.
Dr.Guerra of Authentic Biochemistry provides a primer on polypeptide proteases and their mode of action as well as their control via processing and inhibition in clinical medicine
Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease potentiation leading to subcellular protein aggregation, enhanced inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient conditions in HCC.
In this segment I provide more discussion of the published evidence linking glycolytic pathway enzymes to HCC progression. The expression of certain interfering RNA's that differentially regulate gene expression and promoter habilitation can lead to cyclin dependent kinase mediated chromatin remodeling enhancing cell -specific expression of enzyme isoforms that promote rather than defeat disease progression.
Dr. Guerra of Authentic Biochemistry continues with the 4th in a series of HCC lectures from the primary research literature by explaining the interacting roles of pyruvate kinase M2 and phosphofructokinase 2 promote aerobic glycolysis-enhancing cancer progression.
Authentic Biochemistry's host, Dr Dan Guerra, continues his in depth cellular and molecular discussion of hepatocellular carcinoma (HCC) by introducing the non-universal yet a priori role for the glycolytic enzyme pyruvate kinase isoform M2 in paradigmatic tumor associated aerobic glycolysis.
Dr Guerra takes a deeper dive into the hormonal and subcellular dysfunctional arrays linking obesity to Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma
This is Part One of what will be a 3-5 part sequence of podcast lectures giving Authentic Biochemical discussion concerning the links between obesity , sedentary lifestyle, alcohol consumption and inflammatory diseases of the liver that may lead to the high mortality cancer, Hepatocellular Carcinoma.
Because HDAC4 closely resembles the structural component of the superfamily of histone deacetylases, in might be assumed it functions to catalyze the removal of LYS bound acetate. But since HDAC4 does not contain the catalytically necessary TYR-OH but rather an HIS-imidizole it has no deacetylase enzymatic activity. However HDAC4 does interact with other proteins and the net result is protective of skeletal muscle atrophy and motor neuron degeneration in a murine mutant human SOD1 model of Amyot...
Dr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B
