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Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com
Science
Natural Sciences
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Episodes

Immune Cell Biochemistry I. T Lymphocyte Membrane Biochemistry c.11. Dr. Daniel J. Guerra. Authentic Biochemistry. 24.4.24

References Circulation. 2023.Oct 17;148(16):1231-1249. Int J Mol Sci . 2019. Oct 11;20(20):5028. Front Immunol. 2019; 10: 1706 Mastin, T. 1967 "How do you Feel" [Jefferson Airplane]. Surrealistic Pillow.lp. https://youtu.be/iWUa-rKT-oY?si=1M9496MbDUBGuj0A Hunter, Garcia, Kreutzman. 1975. "Franklin's Tower" [ Grateful Dead. Blues for Alah].lp. https://youtu.be/55TOIJxKc74?si=2wiiTKbWjw5LQvxF Haydn, FJ. 1790. String Quartet in D Major, Op. 64 No. 5 https://youtu.be/vNN_Kbuf7_U?si=KSfUc226hIIAmcy-...

Apr 25, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.9. The involved CH2O sequence event ontology. DJGPhD.22.4.24

References J Am Soc Mass Spectrom. 2023 Nov 1;34(11):2481-2490 J Oleo Sci. 2011; 60(10): 537–544. Trends Immunol. 2018 Jul; 39(7): 523–535. Blood. 2014 Dec 4; 124(24): 3656–3665. George, L. and B. Payne. 1970. "Truck Stop Girl". Byrds. [Untitled] lp. https://youtu.be/fdI83TNKdX4?si=JWPrSMCHEX5G1zi9 Georgia Dobbins, William Garrett, Freddie Gorman, Brian Holland, Robert Bateman. 1961. "Mr. Postman". The Beatles. [With the Beatles ] lp. https://youtu.be/v2Kk5IG2b8E?si=xcG0eUV54Bpo_T9H Bach JS. ca....

Apr 23, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.8. 20April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra.

References Dev Cell. 2016 Jul 25; 38(2): 161–169. J Biol Chem. 2010 Jul 16; 285(29): 22328–22337 Landes Bioscience ; 2000-2013.Madame Curie Bioscience Database [Internet]. https://www.ncbi.nlm.nih.gov/books/NBK6207/ Nat Med. 2003 Aug;9(8):1020-5 National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 107970, Fingolimod. Retrieved April 20, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Fingolimod . Chopin, F. 1830. Piano Concerto No. 1 in E minor, Op. 11 https...

Apr 21, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry. c.7. .18April 2024.Authentic Biochemistry Podcast. Dr. Daniel J. Guerra

References Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666 J Exp Med. 2021 Nov 1; 218(11): e20210417 J Biol Chem. 2010 Jul 16; 285(29): 22328–22337. Brahms. J. 1879. Violin Concerto D. Major. OP 77. https://youtu.be/9L6a-JJCCzw?si=r7IAjxBC8ZBfDOaR McCartney/Lennon.1967. "She's Leaving Home" on [Beatles] SPLHCB lp. https://youtu.be/VaBPY78D88g?si=n2R4CQF6tm8TuM9h

Apr 19, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.6. 17April 2024.Authentic Biochemistry Podcast.Dr. Daniel J. Guerra.

References Cold Spring Harb Perspect Med. 2020 Jun; 10(6): a034819 Proc Natl Acad Sci U S A. 2015 Jul 14; 112(28): 8661–8666 Blood. 2010 Jul 22; 116(3): 485–494. Haydn, FJ. 1793. Symphony No 101 D major "Die Uhr“. https://youtu.be/jK9EPZ3qdgU?si=GiCVxNOchDW0fKsb Croce, J. 1970. "Time in a Bottle". https://youtu.be/9h1davKgBYM?si=YhyPwAtno04oYBks...

Apr 17, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.4. 15April 2024. Chemokine gradients and the membrane lipid raft. Authentic Biochemistry Podcast Dr. Daniel J. Guerra

References FEBS J. 2018 Aug; 285(16): 2944–2971. Nature Reviews Immunology 2023. volume 23 , pages 236–250. Angiogenesis. 2021; 24(4): 719–753. Front. Immunol. 2022 Sec. Microbial Immunology Volume 12 Camp, H. 1964. "Pride of Man". performed by Quicksilver Messenger Service. https://youtu.be/fG6A6G9uzsQ?si=tKMdQMVbpTn2x85D...

Apr 16, 2024•30 min

Immune Cell Biochemistry I. T lymphocyte Membrane Biochemistry c.3. 14 April 2024 .Authentic Biochemistry Podcast.Dr. Daniel J. Guerra

References Nat Rev Gastroenterol Hepatol. 2022 Jun;19(6):351-366 Drugs. 2016 Jul;76(11):1067-79. Front Immunol. 2021; 12: 613591 J Appl Microbiol. 2009. Jun;106(6):1908-18 Exp Cell Res. 2015 May 1; 333(2): 195–200. Mediators Inflamm. 2017; 2017: 4806541. Parsons, G. McQuinn,R. 1971. Pale Blue [ Byrds] Byrdmaniax lp. https://youtu.be/Mh3J7GqrdzY?si=Kp0XfrwPtSi4vY6q Baker, G. 1967. "Blue Condition" [Cream]. Disraeli Gears lp. https://youtu.be/bjQjEyJwPpg?si=70Nye1AGPWsgG0hs Strauss, J.(II). 1866 "...

Apr 15, 2024•30 min

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.2 Lipid mespmorph and radius assymetry direct Tcell membrane sterol and protein interdigitation that is altered by pressure via PV=nRT.

References and simple equations PV = nRT where P is pressure (in atm), V is volume (in liters), n is number of moles and T is temperature (in K); R is a constant and is equal to 0.08206 L atm/moleK. Molecular Shape including thickness(radius) of membrane curvature is v/al where v=volume,a=area per headgroup, and l=thickness of the hydrocarbon monolayer Guerra, D. Membrane Biochemistry notes

Apr 13, 2024•30 min

Immune Cell Biochemistry I.T lymphocyte Membrane Biochemistry c.1. DJGPhD.11April24.Authentic Biochemistry Podcast

References Front Immunol . 2021 Mar 10:12:613591. Guerra, D. 2020's. Membrane Biochemistry Lectures Crosby, D., Kantner, P., and Stills, S. 1968. "Wooden Ships" [Jefferson Airplane ] from Volunteers lp. https://youtu.be/ROBaoiJK0wc?si=ABsxa4m4AjjAwoms Mendelsshon, F. 1830. "The Hebrides Overture"-Fingal's Cave.OP26. https://youtu.be/MdQyN7MYSN8?si=w9G1d0_5DFJn-tzx

Apr 12, 2024•30 min

Biochemical Mosaic III. c.14. From physical chemistry to the mechanisms of sphingomyelinase mediated inflammation: abrief dialectical accounting of research involving abiotic vs biological phenomena.

References Guerra, D. 2024. Previous Lectures: Authentic Biochemistry. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Waters, R.1973. "Eclipse" from [Dark Side of the Moon]; Pink Floyd lp. https://youtu.be/k0xGxnZFNYs?si=VrfYPQuXef41Drfm Holst, G. 1918. "The Planets" https://youtu.be/HP5xhyPn58U?si=IdN_iqJNvt_tjQKP

Apr 08, 2024•30 min

Biochemical Mosaic III.c.13. A priori intralocution of inflammasome genomic loci with stress phenomena immunoepigenetically resolves defensive inflammation. DJGPhD.6April24. Authentic Biochemistry.

References Guerra, D. 2024 Previous Mosaic III lectures and content. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Hayward, J. 1969. "Never Comes the Day" from Moody Blues lp. Threshold of a Dream. https://youtu.be/8u1zH11yqFQ?si=xtXp1SWm8rF1RdFS Mozart, WA.1785. String Quartet No. 19 in C Major , K. 465 https://youtu.be/f3oK4XVMARs?si=FMypvP8O_WCII7vR Page, J.1972. "The Rain Song" Led Zeppelin Houses of the Holy lp. https://youtu.be/g8VduT7aR2c?si=zB2oS2kCV2t4WtEb...

Apr 07, 2024•30 min

Biochemical Mosaic III. c12. A prolegomena to any future biochemical Instanence. Dr Daniel J. Guerra. 4April2024. Authentic Biochemistry Podcast

Refernces Guerra, DJ. Inclusive non-extemporaneous reasoning on biochemical event ontologies. Jefferson, Blind Lemon 1927, Hunter-Garcia 1969 Jefferson's "I know You Rider" and "China Cat Sunflower" . Grateful Dead. Europe 72' LP. https://youtu.be/xCgZxrf8nrU?si=k7WGmY-fo_AjEip- Schmelzer, JH 1664. Violin Sonatas, "Romanesca". https://youtu.be/fB8G39y1uCA?si=hzGCK2Qq6TtIubAh

Apr 05, 2024•30 min

Biochemical Mosaic III. Inflamasomes c.11 A Dialectical Event Ontological conciliantus contrarion perspective.DJGPhD.3April24.Authentic Biochemistry Podcast.

REferences Guerra, DJ. 2024. Biochemical Mosaic III lectures. https://podcasts.apple.com/us/podcast/authentic-biochemistry/id1454408625 Dvorak, A. 1879. Romance in F minor, Op. 11, (B. 39). https://youtu.be/XZTeavJ9frA?si=18LFzAQ9FKfrQ_16 Dylan, R. 1975. "Tangled up in Blue" performed by Gerry Garcia Band (live;1977) https://youtu.be/8Aw7FW1Frjs?si=jURQC3jBWFPirSh8 Betts, R. 1972. "Blue Sky" Allman Brothers (Eat a Peach.lp.) https://youtu.be/wwyXQn9g40I?si=15Cv6iJxR82VAb_3...

Apr 04, 2024•29 min

Biochemical Mosaic III.c.9 Clinical associations of inflammasome mediated pathophysiology linked to epigenetic methylation patterning and DNA repair. DJGPhD.1April24.

References Redox Biol. 2020 Apr; 31: 101482 Nat Rev Microbiol. 2009 Feb; 7(2): 99–109. J Neuroinflammation. 2019; 16: 236. Front Pharmacol. 2021; 12: 643254. Biber, H. 1676. "Passagalia" por solo violin https://youtu.be/sgcR183f8gA?si=ovfSbdg6WsfuIiTw McBroom, A. 1976. "The Rose" Conway Twitty https://youtu.be/cO59ITNCxzk?si=ueMmXtzMNH4YeQ_w Hunter-Weir. 1970. "Sugar Magnolia" American Beauty L.P. https://youtu.be/ei5EmN2HmVI?si=6ZrBBPmu3cMyMOAO...

Apr 02, 2024•30 min

Biochemical Mosaic III.c.7 Convergence of Inflammasome molecular patterning obtains PRR-like sequalae that are hypo-modified epigenetically in multple Human pathophysiologies

References Int J Mol Sci. 2021 Jul; 22(14): 7580. Trends Biochem Sci. 2023 Apr;48(4):331-344 Immunology. 2020;159:142–155 Curr. Opin. Immunol. 2020;62:39–44. Nat. Rev. Mol. Cell Biol. 2019;20:569–570. Lennon-McCartney. 1963. "This Boy" https://youtu.be/lW5D7HpYhBU?si=mHyiFng3rd3pukob Lennon-McCartney.1966. "And your Bird Can Sing" https://youtu.be/sOUlbredoUM?si=nPB64c8GS4joYx9G Lennon-McCartney 1969. "Let it Be" https://youtu.be/QDYfEBY9NM4?si=H6t6bwrv3vUNWoDj Vivaldi, A. 1715 "Gloria" https://...

Mar 28, 2024•30 min

Biochemical Mosaic III. c.6. S auereus induced inflammasome activating pyroptosis circumvents immune clearance and ARDS pulmonary chronic activation share similar hyperinflammatory presentation.DJGPhD

References Front Immunol. 2019; 10: 1309 Immunity. 2018 Sep 18; 49(3):413–426.e5. Front Immunol. 2020; 11: 621733 Infect Immun . 2013 Dec; 81(12): 4478–4489. Immunity. 2023 Nov 14;56(11):2523-2541.e8. Harrison, G. 1969. "Here Comes the Sun" Abbey Road Lp. Beatles https://youtu.be/GKdl-GCsNJ0?si=xUqwi3Q7Ne694ruD Mozart, WA. 1775. Violin Concerto No.3 in G major, K. 216 https://youtu.be/j7Z6gouAVCc?si=xVwtNKAWDEDdtKMV Parsons, G. 1965 "Brass Buttons" Poco: Crazy Eyes Lp. https://youtu.be/CpFytplzL...

Mar 27, 2024•30 min

Biochemical Mosaic III. c.5. Gal3 and NRLP3 inflammasome coordinate inflammation via IL-1Beta convertase activation that is associated with NAFLD and NASH and inhibition of ABCA1 cholesterol efflux.

References Infect Immun . 2013 Dec; 81(12): 4478–4489 Cell Cycle. 2022; 21(11): 1121–1139. The Journal of Nutritional Biochem.2023.Volume 112, 109217 Lightfoot, G. 1964. "Early Morning Rain" https://youtu.be/ZFJ5Bj_put0?si=m1Ue7rFfk_ggSLR3 Simon ,P. 1968. "Old Friends" SImon and Garfunkle Bookends LP. https://youtu.be/7A76lTte8qE?si=rfk3Q6wTA6Nsiok7 Mozart, WA. 1782 Serenade in C. Minor K.388. https://youtu.be/R6iSGBNdqSw?si=S2eGPmcySUhw4uvU...

Mar 25, 2024•29 min

Biochemical MosaicIII. C.4. My oppositional dialectic and episteme- metaphysical discourse on method+ Gal3 as proinflammatory lectin may not uniformly correlate with pathobiochemical events. DJGPhD.

References Guerra, DJ. 2024. Uncollected writings. The Journal of Nutritional Biochemistry 2023. Volume 112, February. 109217 Walker, Cindy.1950 Blue Canadian Rockies. Cover "the Byrds"(1969). https://youtu.be/nzOHtU8Sb3c?si=5GAj7VPzIr7o0OO_t Heinichen J. D. 1711 (?)Concerto in A minor for violin https://youtu.be/V-E25Q-wjwc?si=bbWdZTNEUPGitY-S

Mar 23, 2024•30 min

Biochemical Mosaic III. C.2 A Non-canonical autophagic inhibition of NLRP3 inflammasome mediated inflammation in UVB-treated human keratinocytes.DJGPhD. 20.3.24.

References Front Immunol. 2019 Jun 7;10:1309. JBC 2024 . March.Article in Press DOI:https://doi.org/10.1016/j.jbc.2024.107173 FASEB J. 2016 Dec;30(12):4202-4213. Nat Rev Gastroenterol Hepatol . 2020 Feb;17(2):93-110 Bach , JS. 1731. Piano Partita No. 2 In C Minor, BWV 826 https://youtu.be/f-OdOuNZciQ?si=AmFtC5CX3x2ndzdV Slade,Mann, and Rogers. 1975 "Time is Right" Manfred Mann https://youtu.be/jzJIej8h5q4?si=3-aCFe0tqur4lfX1...

Mar 21, 2024•30 min

Biochemical Mosaic III. C.1. Inflammasomes. DJGPhD.19.3.24 Authentic Biochemistry Podcast

References I mmunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8 JBC 2024. March. Article in Press https://doi.org/10.1016/j.jbc.2024.107173 Schmelzer. J. H.1664 Sonatae unarum fidium. https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1967 "Tuesday Afternoon" Moody Blues https://youtu.be/fB8G39y1uCA?si=ZMG2Zv9eKF3go0qR Hayward, J. 1970 "Question" Moody Blues https://youtu.be/NP9iOqdxS8c?si=rfI3lzy0HhcffkWT...

Mar 20, 2024•30 min
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