Authentic Biochemistry

Dr Daniel J. Guerra•podcasters.spotify.com

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Episodes

Dialectical Synthesis Lecture III. The Necroptotic event in cell fate through the lens of categorical synthesis of the a priori. Dr Daniel J. Guerra. authentic Biochemistry Podcast 28.6.24

References Guerra, DJ. 2024. unpublished writings. Seminars in Cell & Developmental Biology2020. 99:86-95

Jun 28, 2024•44 min

Immune Cell Biochemistry. B cells. The XIST-RNP complex with histone epigenetic alteration of Xi -linked genomic loci mediates SLE and RA in women. DJGPhD. 25.6.24. Authentic Biochemistry Podcast

References J Biomed Sci 2017. 24, 63. Cell Death & Disease 2014. volume 5, page e1416 Haematologica. 2022 Mar 1; 107(3):721–732 Nucleic Acids Res. 2022 Jan 7; 50(D1): D413–D420 Oncogene 2017. volume 36, pages 5593–5608 Cell. 2021 Apr 1; 184(7):1790–1803.e17. Van Zant and Collins. 1973. "Tuesday's Gone" Lynyrd Skynyrd. https://youtu.be/LJrFxnvcWhc?si=EoL42Pw72Qe_atsz Lennon-McCartney. 1967. "I am the Walrus" Beatles. [Magical Mystery Tour, lp.] https://youtu.be/Ws5klxbI87I?si=QGe84-nMLK4dqgFy...

Jun 25, 2024•1 hr 1 min

Dialectical Synthesis Lecture II. 23.6.24 The Apothecary of the Alternative a priori: of Programmed cell death ontology. Dr Daniel J. Guerra Authentic Biochemistry Podcast

References Cell.2020 Mar 19; 180(6): 1115–1129.e13. Guerra, D.J. 2024. Intellectual materials. Goffin and King. 1962. "Up on the Roof" [Drfifters] https://youtu.be/puM1k-S86nE?si=LXzWj3SqiqHnr3JB Whitfield and Strong. 1969. "War" [Edwin Starr] https://youtu.be/dQHUAJTZqF0?si=bfB-xARpa6aVDwQg Kay and Godon 1963. "Thats Life" [Frank Sinatra] https://youtu.be/TnlPtaPxXfc?si=SmFfhohympSPVKd0 Van Heusen and Cahn 1960. "Aint that a Kick in the Head" 1960 [Dean Martin] https://youtu.be/K7jgZTDLeIs?si=b...

Jun 24, 2024•56 min

Authentic Biochemistry: Dialectical Syntheses Toward an Improved Evaluation of Biochemical Research. Dr Daniel J. Guerra.20.6.24.

References Guerra, Daniel J. 2024. Essays and Notes. Blood. 2017 Jun 15;129(24):3237-3244. Bach, JS. 1731. Partita 6 in E Minor https://youtu.be/TCrZyi0Sots?si=8bjua1HY5M_YWuin Simon, P. 1968. "Old Friends" https://youtu.be/c3NYWzHLEZw?si=vheTMVMR7f-2Ebgj

Jun 21, 2024•54 min

Immune Cell Biochemistry II. B-lymphocyte partially silenced X-chromosome -specific amplification of idiotypic (nc) L-RNA translation products and autoimmunity in women. DJGPhD.19.6.24

References Nucleic Acids Res. 2022 Jan 7; 50(D1): D413–D420 Cancers (Basel). 2019 May; 11(5): 678 Oncogene 2017. volume 36: 5593–5608 NAR Cancer. 2024 Jun; 6(2): zcae023. Cell. 2021 Apr 1; 184(7):1790–1803.e17 Nature Immunology 2018. volume 19: 871–884 Pisendel, JG. 1735. Violin Concerto in D major, https://youtu.be/eRVueayvMIk?si=Nitfg70Kwdmo7Xt7 Hayward, J. 1969. "Never Comes the Day" et al. from [Threshold of a Dream] lp. https://youtu.be/W8BNMfyoxgs?si=n9QH7_j_T7ZC7pnx...

Jun 19, 2024•55 min

Immune Cell Biochemistry. B cells C.12. Epigenetic Regulation. Dr Daniel. J. Guerra.17.6.24.Authentic Biochemistry Podcast

References Cell. 2021 Apr 1; 184(7):1790–1803.e17. NAR Cancer. 2024 Jun; 6(2):zcae023. Peretti, Creatore, and Weiss. 1961. "Cant Help Falling in Love". Elvis Presley. https://youtu.be/O-aavAlSYgc?si=yEHWfI2Ny-zvQLnK Lennon-McCartney. 1965. "Wait" Rubber Soul lp. https://youtu.be/qJngWval8Bc?si=CRTQilYzdVZxAtSe Mozart. WA .1788. Divertimento in E Major. K.563. https://youtu.be/E8c83bpOVXo?si=EBffyTWZz0xHZqYs...

Jun 17, 2024•44 min

Immune Cell Biochemistry. Bcell Electron transport control via calcium mobilization after BCR activation. DJGPhD. 14.6.24. Authentic biochemistry Podcast

References Guerra, Daniel J. 2024. Electron transport chain lectures Nature Immunology 2018. volume 19: 871–884 Leach, D. (Allman Brothers Band) 1971. Live at Fillmore East https://youtu.be/w9ZubobGMLs?si=30X6auZQPzrhcB4O

Jun 14, 2024•49 min

Immune Cell Biochemistry.c.10 Primer on Mitochondrial Bioenergetics I. DJGPhD.13.6.24

References Guerra, Daniel J. 2024. Bioenergetics lectures Hunter, R. 1975. "Cruel White Water" https://youtu.be/T-oBD3F74Nk?si=_b3ksQfgbaUEqHA8 Beethoven, LV. 1808. Symphony No. 6 in F, Op. 68 https://youtu.be/xWDIwsfgQnE?si=-vFCnYfdtpivpLnt

Jun 14, 2024•54 min

Immune Cell biochemistry. BCR activation results in mitochondrial alteration in ETC and OXPHOS. DJGPhD. 12June24 Authentic Biochemistry.

References Biophys Res Commun. 2024 Mar 12:700:149598. Eur J Pharmacol.2002 May 17;443(1-3):189-96 Nature Immunology2018 volume 19, 871–884 Mozart, WA 1785. C Major String Quartet 19. K 465 (The Dissonance" https://youtu.be/f3oK4XVMARs?si=xjTTKrC0OL-V1xkX

Jun 12, 2024•55 min

Immune Cell Biochemistry II. B cells. Two-component B cell activation requires Tfh and/or TLR9 signaling to mediate glucose metabolism for bioenergetic demands. DJGPhD. 10June24

References Nature Immunology 2018. volume 19, pages:871–884 Jon Anderson , Chris Squire , and Bill Bruford 1971. "Heart of the Sunrise". Yes. https://youtu.be/0vNcgL9Fi4w?si=DkXqwHwIEuQcTiMt

Jun 11, 2024•52 min

Immune Cell Biochemistry B lymphocyte c.7

References MAbs. 2022; 14(1): 2107971 Commun Biol. 2022; 5: 1292

Jun 03, 2024•42 min

Immune Cell Biochemistry II.B lymphocyte VDJ recombination is controlled by multiple methyltransferase mechanisms. Dr Daniel J. Guerra. 01June2024.Authentic Biochemistry.

References Guerra, DJ. 2024. ImmunoBiochemistry lectures. Commun Biol. 2022; 5: 1292. ACS Chem. Biol. 2017, 12, 4, 958–968 Telemann, GP., 1750. Sonata in D major, TWV 44:1 https://youtu.be/xx8ooc-s7OQ?si=1vAKmdcLroNISa-P Vivaldi, A., 1708. - Gloria (RV 589) https://youtu.be/2eWjQOdYzMQ?si=hYSOqRuXkYUA8ATl

Jun 02, 2024•43 min

Immune Cell Biochemistry II. B cells The Methyltransferase regulation of RAG 2. Dr Daniel J. Guerra. 29May24. Authentic Biochemistry Podcast

References Guerra, DJ. ImmunoBiochemistry lectures 2024. ACS Chem. Biol. 2017, 12, 4, 958–968 Genome Biol. 2005; 6(8): 227 Manfredini, FO. 1718. 12 Concerti Grossi | Op. 3 https://youtu.be/4t-E3wlMkDQ?si=GX0GCLUm48J4V8OY

May 30, 2024•46 min

Immune Cell Biochemistry II. B Cell Event Ontology. 28May24. Authentic Biochemistry Podcast. Dr Daniel J. Guerra

References ACS Chem. Biol. 2017, 12, 4, 958–968 Nat Rev Immunol. 2016 Apr; 16(4): 234–246 Guerra, DJ. 2024. Immuno-Biochemistry Lectures Vivaldi, A. 1705. Trio Sonata in D minor, RV 63 https://youtu.be/kPpaeW3DObU?si=nfJmUWlmiK8BZXxD Albinoni , T. 1708. Adagio in G Minor https://youtu.be/z6WOfH2kV00?si=Mf7_6JwuLETu7YEC Scarlotti, D. 1720. Fandango in D Minor https://youtu.be/QQbW75y3P9g?si=MODaHGMa-MSP5Nld...

May 29, 2024•53 min

Immune Cell Biochemistry II. Authentic Biochemistry Podcast. B cell Biochemistry c4. Dr Daniel J. Guerra 27.5.24.

References Guerra, DJ. 2024. Immunology Lectures (archives). Pisendel, JG. 1720. : Concerto in E-flat major or Violin, Strings & B.c Jun P I.3 https://youtu.be/SZI2IgOOSPU?si=8xNIyvzxPnkV2zlK Biber, HI. 1676. Passacaglia. G- minor, C.105 https://youtu.be/sgcR183f8gA?si=vYnlxQJDq8LgG_B4

May 27, 2024•41 min

Authentic Biochemistry Podcast. B-Cell Membrane Biochemistry.c.3. Dr. Daniel J. Guerra. 26.5.24

References Cancer Science June 2014. 105(9) Acc Chem Res. 2021 May 4;54(9):2110-2120. Nat Immunol. 2022 Jan; 23(1): 99–108. . Bach, JS. 1704.Toccata and Fugue in D minor BWV 565 https://youtu.be/erXG9vnN-GI?si=o6YlpjXM2dRLpyZQ Leach, D. 1965"Catch the Wind" https://youtu.be/J8hjEYTpwE8?si=XeWU1HSy6CGBlEeT...

May 26, 2024•44 min

Authentic Biochemistry Podcast. B Cell Membrane Biochemistry.c.2.Dr. Daniel J. Guerra. 25.5.24

References Cellular & Molecular Immunology. 2018. volume 15, pages 676–684. Stem Cells Int. 2020: 1047896. Published online Jul 8 Cancer Science. 2014. June.105(9)

May 26, 2024•30 min

Immune Cell Biochemistry II. B Cell Membranes. Introductory Lecture. Dr Daniel J. Guerra. 22May24 Authentic Biochemistry.

References Nat Commun. 2022; 13: 5371 Schubert, F. 1822.Symphony No. 8 in B Minor "Unfinished," D. 759 https://youtu.be/3tisvEpblig?si=WLsVj4R6gedi7-_a

May 23, 2024•1 hr

Authentic Biochemistry Podcast Philosophical Interlude. The Epistemological concurrence of biochemical research with dialectical event ontology. Dr Dan Guerra 20.5.24.

References Guerra, DJ. 2019-2024. Previous public lectures and podcasts. Bach, JS. 1721 Brandenburg Concerto No. 2 in F major, BWV 1047 https://youtu.be/3HSRIDtwsfM?si=AA-KdJF2Hyq8RlrE

May 20, 2024•46 min

T cell Membrane Biochemistry. FINE c.25. 18 May 2024.Authentic Biochemistry Podcast.Dr Daniel J. Guerra

References Nature 2024.volume 629, pages 417–425 Front. Immunol., 26 April 2019 Sec. NK and Innate Lymphoid Cell Biology. Nature Communications 2020.volume 11. Article 2437 Scientific Reports 2018. volume 8.Article 8700 Int J Mol Sci. 2020 Sep; 21(18): 6497 Hunter-Garcia& Lesh,P. 1969. "Cumberland Blues" On [Workingman's Dead lp.] https://youtu.be/xosZDm01ffc?si=fydGeAchCEAK_5vZ Haydn, FJ. 1784. Symphony No 101 D major "Die Uhr“ https://youtu.be/jK9EPZ3qdgU?si=d25AWgnswI3OKU_5...

May 18, 2024•30 min

T Cell Membrane Biochemistry Fine C24. Endometrial Cancer NK cells:a biochemical pseudoparadox revealing event ontology dialectics. Dr Daniel J. Guerra. 17.5.24

References Nature Communications 2020. volume 11, Article:2437 Scientific Reports. 2018. volume 8, Article 8700 Front. Immunol., 26 April 2019 Sec. NK and Innate Lymphoid Cell Biology

May 17, 2024•30 min

Authentic Biochemistry Podcast. T cell Membrane Lipid Biochemistry c.23 Fine I. 15.5.24. Dr. Daniel J. Guerra

References Biol Sex Diff. 2021.12:64 Nature 2024. volume 629, pages 417–425 Int. J. Mol. Sci. 2019, 20(3), 646 Front. Immunol.2109. 09 October Sec. Cancer Immunity and Immunotherapy. Volume 10 Schubert, F. 1814-15. Symphonie 2. in B♭ major, D. 125 https://youtu.be/-26Gt4rGaQA?si=_C7MXMG-0piT_4eV Donovan.1968 "Lalena" https://youtu.be/1kA3nZwGHHA?si=f9GFhezzQcOcHapc Dylan, R.1965. "Mr Tambourine Man" https://youtu.be/1kA3nZwGHHA?si=f9GFhezzQcOcHapc...

May 15, 2024•58 min

Immune Cell Biochemistry. T cell Membranes Coda VII. C.22 Dr Daniel J. Guerra. Authentic Biochemistry 13.5.24

Cancers (Basel). 2023 Nov; 15(21): 5177 GUERRA, DANIEL J.(2022) CYTOEPIGENETICS: DIALECTICAL REVIEW OF A SUBCELLULAR ENDO-MEMBRANOUS COORDINATION OF GENE EXPRESSION AND CELLULAR FATE. Journal of Disease and Global Health, 15 (3). pp. 22-47. ISSN 2454-1842 McCartney-Lennon. 1968 "Martha My Dear." https://youtu.be/RXawa90YU2s?si=_CgaG0yOdbpcflYr

May 14, 2024•47 min

Immune Cell Biochemistry. T cell Membranes. Coda VI. c.21 Methylation Specific Treg differentiation I. 11May24. DJGPhD Authentic Biochemistry Podcast

References Acta Pharmacol Sin. 2019 Aug;40(8): 1076–1084 Nucleus. 2022; 13(1): 236–276. Cancers (Basel). 2023 Nov; 15(21): 5177 Dylan, R. 1965 "Like a Rolling Stone" https://youtu.be/IwOfCgkyEj0?si=1vnIW2vqfsg-9MGp Dvorak, A. 1893. Symphony 9 in E minor. Op.95.B178. "From the New World" https://youtu.be/jOofzffyDSA?si=LiM8g7l487jmD22J

May 11, 2024•37 min

Immune Cell Biochemistry.Tcell Membranes. Coda V. C.20

References Cancers (Basel). 2023 Nov; 15(21): 5177 Front Oncol. 2021; 11: 750789

May 09, 2024•30 min

Immune Cell Biochemistry I. T cell Membrane Biochemistry. CODA-IV. C.19. Authentic Biochemistry Podcast. Dr. Daniel J. Guerra . 07May24

References Cancers (Basel). 2023 Nov; 15(21): 5177. Cancer Discov. 2022 Mar 1; 12(3): 856–871 Gastroenterology. 2023 Feb;164(2): 256–271.e10. Jagger-Richards 1966. "Ruby Tuesday" [Between the Buttons, lp.) Rolling Stones. https://youtu.be/mAyj9q2quYc?si=fv07ARFvr0P2hEAs Schubert, F. 1816. Symphony No. 5 in B♭ major, D. 485. https://youtu.be/OHkot1TmvZU?si=bW0qNDjiAcqJzzvd

May 08, 2024•30 min

Immune Cell Biochemistry I. T Cell Membranes CoDA3/C.18 Authentic Biochemistry Dr. Daniel J. Guerra 06MAY24

References Gastroenterology. 2023 Feb; 164(2): 256–271.e10. Ada R. Habershon, and Charles H. Gabriel. 1907. "Will the Circle Be Unbroken" Performed by the Carter Family incl. Johnny Cash. https://youtu.be/JLFbUbmH7To?si=rLPSkV-mHYq3Aodf Mozart, WA. 1783. Mass in C Minor K. 427. https://youtu.be/KsiP4-mCnQ0?si=XoNwMiTO1JK5jPOK...

May 07, 2024•30 min

Immune Cell Biochemistry I. T Cell Membranes c.17 Authentic Biochemistry Dr. Daniel J. Guerra 05MAY24

References The Journal of Biological Chemistry2018 293, 19001-19011 Cell Death & Disease volume 10, Article number: 315 Experimental & Molecular Medicine 2019. volume 51, Article number: 80. Trends in Immunology. 2017. REVIEW| VOL. 38,Issue 4, P287-297, April 01. Gastroenterology. 2023 Feb; 164(2): 256–271.e10 Squire/ Anderson. 1971. "The South Side of the Sky. on [ Yes -Fragile; lp] https://youtu.be/hBAauFYod80?si=bTGJiM-dCEsHjRnJ Mozart, WA. 1772. Symphony No. 25 in G minor, K. 183 htt...

May 05, 2024•30 min

Immune Cell Biochemistry I. T cell Membrane Biochemistry.CODA 1.Authentic biochemistry Podcast.Dr. Daniel J. Guerra

References Gastroenterology. 2023 Feb;164(2): 256–271.e10. The Journal of Biological Chemistry 2018 293, 19001-19011 Leitch, D. 1965 "Catch the Wind" https://youtu.be/J8hjEYTpwE8?si=VfSaLDcP5JxzzP-p Hendrix, J. 1967. "The Wind Cries Mary" https://youtu.be/ARO2vbGFLJM?si=_IIEFN0BOEy6DfqW Bach, JS. 1717. Partita in D Minor, BWV 1004 https://youtu.be/qtyTaE7LvVs?si=q7Xe7rnzDBbEx-xc

May 04, 2024•30 min

Immune Cell Biochemistry I. T Lymphocyte Membrane.C.15. Authentic Biochemistry Podcast.Dr Daniel J. Guerra.01May2024.

References Trends in Immunology. 2017. REVIEW| VOLUME 38, ISSUE 4, P287-297. FASEB J. 2020 May;34(5):6185-6197. Couperin, F. 1714. Troisième Leçon De Ténèbres À 2 Voix https://youtu.be/UbREakKFTow?si=JqmA1GQQpTOItUSg Lennon-McCartney. 1970. "Let it Be" https://youtu.be/QDYfEBY9NM4?si=nH4LJs4gprJVvcR1

May 02, 2024•30 min

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