In this special episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the final rule issued by the U.S. Food and Drug Administration (FDA) on April 29, 2024, to make explicit its plan to regulate laboratory-developed tests (LDT) as medical devices under the Federal Food, Drug, and Cosmetic Act. Their discussion includes: High...
May 02, 2024•18 min
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Robin Patel, M.D., director of the Infectious Diseases Research Laboratory and co-director of the Bacteriology Laboratory at Mayo Clinic. They discuss antimicrobial resistance and why it’s a major global health concern. Specific topics of discussion include: Background information on antimicrobial resistance and why it is a growing threat to global health...
May 02, 2024•8 min•Ep. 299
David S. Viswanatha, M.D., explains how Mayo Clinic Laboratories' new assay provides rapid, definitive diagnosis of VEXAS, a recently identified syndrome affecting older men. Early diagnosis is key to managing the condition, which severely impacts multiple organs and blood. (00:31) Could you please provide a little bit about yourself and your background? (01:30) Would you please share a brief overview of the UBA1Q assay? (02:13) Would you provide an overview of VEXAS syndrome? (05:30) When is th...
Apr 30, 2024•15 min•Ep. 298
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss testing innovations for Alzheimer’s disease and cognitive impairments, and how laboratorians can responsibly help shape the future of healthcare. Their discussion includes: The latest news about the U.S. Food and Drug Administration’s (FDA) proposed rule around reg...
Apr 25, 2024•11 min•Ep. 297
Maryam Shahi, M.D., explains how Mayo Clinic Laboratories' unique biomarker test (TEST ID: AFOLR ) determines which patients would likely benefit from a new treatment for recurrent epithelial ovarian cancer. Disease recurrence is common, and about one-third of patients respond to the new medication. (00:32) Could you provide us with a little bit of information about yourself and your background? (01:18) Can you start with a brief overview of the assay? (02:13) Which patients should have this tes...
Apr 23, 2024•6 min•Ep. 296
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss current events including Medical Laboratory Professionals Week, recent healthcare conferences, advocacy efforts, measles, and bird flu. Their discussion includes: Key takeaways from the Becker’s Healthcare Annual Meeting and the College of American Pathologists’ (C...
Apr 18, 2024•11 min•Ep. 295
Maria Alice Willrich, Ph.D., explains how Mayo Clinic Laboratories' new assay provides therapeutic drug monitoring of risankizumab, or RISA. Test results help guide care for patients with plaque psoriasis, psoriatic arthritis, and Crohn's disease. (00:32) Do you mind giving the audience more information about yourself and your background? (01:53) Could you please give a brief overview of this assay? (03:35) Which patients should have this testing and when should it be performed? (04:57) How are ...
Apr 16, 2024•9 min•Ep. 294
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic, to discuss tick-borne diseases and the latest testing options. Specific topics of discussion include: The types of tick-borne diseases found throughout the United States. Algorithmic approaches and testing methods used to diagnose tick-borne diseases. Helpful reso...
Apr 11, 2024•18 min•Ep. 293
Alicia Algeciras-Schimnich, Ph.D., discusses how Mayo Clinic Laboratories’ new noninvasive blood test for Alzheimer’s disease identifies the p-tau217 biomarker, which is associated with the accumulation of amyloid beta in the brain. Positive test results can facilitate access to disease-modifying therapies. (00:32): Dr. Algeciras, could you just provide a little bit of background on your role at Mayo Clinic? (01:45): So before we get into the test itself, can you just explain a little bit about ...
Apr 09, 2024•18 min•Ep. 292
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss current events including dengue outbreaks, new colon cancer screening technology, and insurance coverage of innovative lab tests. Their discussion includes: The surge of dengue cases in Latin America, and best practices for tick and mosquito bite prevention. Advanc...
Apr 04, 2024•11 min•Ep. 291
Bobbi Pritt, M.D., explains how Mayo Clinic Laboratories' new assay identifies less-common tick-borne bacteria in whole blood. The assay is recommended when tick-borne bacterial infection is suspected but standard testing is unrevealing. (00:33) Do you mind giving us a brief introduction of yourself and what you do at Mayo? (01:45) Can you tell us a little about the test and how it came to be? (03:00) Could you explain the types of patients this test would be best suited for and how a provider m...
Apr 02, 2024•8 min•Ep. 290
The Centers for Disease Control and Prevention (CDC) issued a recent health advisory in response to the increasing number of measles outbreaks in the United States. In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Matthew Binnicker, Ph.D., professor of laboratory medicine and pathology and clinical virologist at Mayo Clinic, to discuss why measles is in the news again and how we can prevent measles outb...
Mar 28, 2024•16 min•Ep. 289
Linda Hasadsri, M.D., Ph.D., and Huong T. Cabral, M.S., C.G.C., explain how Mayo Clinic Laboratories' targeted test panel facilitates accurate diagnosis of hereditary pancreatitis, which heightens the risk for pancreatic cancer. Test results can guide cancer monitoring for patients and their families. (00:33) Dr. Hasadsri, can you tell the audience a little bit about yourself and your background? (01:32) And Ms. Cabral? (02:03) Can you please give the audience a brief overview of this assay? (03...
Mar 26, 2024•10 min•Ep. 288
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss important industry updates and legislative insights gathered from Dr. Morice’s recent trip to Washington, D.C. Their discussion includes: The status of current laboratory-related legislative efforts, including the Protecting Access to Medicare Act (PAMA), the Savin...
Mar 21, 2024•13 min•Ep. 287
Wei Shen, Ph.D., and Rhianna Urban, M.S., CGC, explain how Mayo Clinic Laboratories' gene panel establishes a diagnosis of Lynch syndrome, which heightens the risk for several cancers. Test results can guide cancer surveillance for patients and their families. (00:32) Would each of you share a little bit about yourselves and your background? Dr. Shen? (01:25) Rihanna, could we have you give a little background about yourself as well? (01:48) Could you provide us with an overview of Lynch syndrom...
Mar 19, 2024•19 min•Ep. 286
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic, to follow up on the syphilis epidemic and discuss updated testing recommendations. Specific topics of discussion include: Background information on syphilis and the epidemic occurring in the United States. The report recently published by the Centers for Disease C...
Mar 14, 2024•19 min•Ep. 285
Paul Jannetto, Ph.D., explains how Mayo Clinic Laboratories' nicotine testing benefits patients in substance-use cessation programs and other settings. The serum and urine tests quantify nicotine and various metabolites. (00:32) Can you tell us a little bit about yourself and your background? (01:42) Can you please provide an overview of substance use disorders, specifically nicotine dependence, and Mayo Clinic's nicotine testing options? (04:33) Which patients should have this testing and when ...
Mar 12, 2024•10 min•Ep. 284
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the Food and Drug Administration’s (FDA) progress on making a final rule around regulating laboratory-developed tests (LDTs). Their discussion includes: How the FDA’s proposed rule on regulating LDTs has advanced to the White House Office of Management and Budget (...
Mar 07, 2024•11 min•Ep. 283
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to honor Black History Month. They reflect on important advancements in healthcare and laboratory medicine that were led by Black healthcare professionals and scholars. They also discuss health inequities that impact communities throughout the United States. Their discussion in...
Feb 29, 2024•9 min•Ep. 282
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Stefan Grebe, M.D., Ph.D., co-director of the Clinical Mass Spectrometry and Test Development Laboratory in the Department of Laboratory Medicine and Pathology, and Irina Bancos, M.D., consultant in the Division of Endocrinology, Diabetes, and Metabolism with a joint appointment in biochemistry and immunology. They discuss the diagnosis and management of ...
Feb 22, 2024•13 min•Ep. 281
Ann Moyer, M.D., Ph.D., explains how Mayo Clinic Laboratories' test panel provides comprehensive evaluation of patients with suspected monogenic early onset inflammatory bowel disease, or IBD. Accurate diagnosis is key to guiding therapy for patients, who might be as young as age 2. (00:32) Could you please tell us a little bit about your background? (01:17) Could you please do a brief overview of our EOIBD test? (03:24) Which patients should have this testing and when should it be performed? (0...
Feb 20, 2024•13 min•Ep. 280
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss current activity of infectious diseases. Their discussion includes: Vector-borne diseases that are causing public health concerns, and the multi-agency public health strategy recently released by the U.S. Department of Health and Human Services to address the growing...
Feb 15, 2024•11 min•Ep. 279
Anne Tebo, Ph.D., explains how Mayo Clinic Laboratories' new serum tests help overcome the challenges of diagnosing primary biliary cholangitis, or PBC. Test results can guide clinical care for patients with this life-threatening autoimmune liver disease. (00:32) Could you please provide a little information about your background? (02:09) Please give a brief overview of the new test panels. (05:35) Which patients should have this testing and when should it be performed? (09:49) What alternative ...
Feb 13, 2024•17 min•Ep. 278
David Murray, M.D., Ph.D., explains how Mayo Clinic Laboratories' MASS-FIX Quantitation assay provides next-generation screening for M-proteins, which are associated with multiple myeloma and other diseases. The assay better quantitates the blood proteins, for improved patient care and simpler test ordering. (00:32) Could you provide us with a little bit about yourself and your background? (02:56) Would you elaborate on the role of you and the Mayo Clinic team in advancing insights with the use ...
Feb 06, 2024•18 min•Ep. 277
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss what companies in the healthcare and diagnostics industries are focusing on in 2024. Their discussion includes: Insights from the J.P. Morgan Healthcare Conference, and where investments are happening in the diagnostics industry. Observations from visiting Southeast ...
Feb 01, 2024•11 min•Ep. 276
Joshua Bornhorst, Ph.D., explains how Mayo Clinic Laboratories' unique blood test identifies pregnant women at risk of developing preeclampsia with severe features. Test results can guide clinical management, to safeguard maternal and neonatal health. Speaker 3: (00:32) Can you share a little about yourself and your background? Speaker 3: (01:00) Can you provide us with an overview of this new preeclampsia assay? Speaker 3: (02:33) Can you share what will be reported with this assay? Speaker 3: ...
Jan 30, 2024•5 min•Ep. 275
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic, to talk about the sexually-transmitted disease syphilis. Specific topics of discussion include: The history, cause, and symptoms of syphilis. A rare recent outbreak of ocular syphilis cases. The dramatic rise in syphilis and congenital syphilis cases in the United...
Jan 18, 2024•13 min•Ep. 274
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to welcome the new year and discuss the increase of respiratory viruses. Their discussion includes: The increasing number of COVID-19 and influenza cases across the United States. The endemic state of COVID-19 and tools for prevention. The continued need to protect public healt...
Jan 11, 2024•12 min•Ep. 273
Jeff Meeusen, Ph.D., explains how Mayo Clinic Laboratories' new MI-Heart Ceramides assay helps guide the management of patients with mildly to moderately high cholesterol. The test measures levels of lipids beyond cholesterol that boost cardiovascular risk. Show notes (00:31) Could you provide us a little bit about your background? (01:20) Could you give us a brief overview of this assay? (02:45) What patients should have this test and when should it be performed? (04:25) Could you talk a little...
Jan 04, 2024•9 min•Ep. 272
Robin Patel, M.D., explains how a new Mayo Clinic Laboratories' assay can identify central nervous system pathogens that standard tests fail to detect. Rapid, precise diagnosis is essential to preventing long-term effects from these infections. Show notes Speaker 3: (00:32) Please give us a brief introduction of yourself and your role at Mayo Clinic. Speaker 3: (01:44) Could you please expand a bit on this newly developed sequencing assay — which is a shotgun metagenomic test on CSF — and explai...
Jan 02, 2024•7 min•Ep. 271
