Linnea Baudhuin, Ph.D., and Kate Kotzer, M.S., CGC, describe how Mayo Clinic Laboratories' postmortem genetic tests can provide answers after a sudden unexplained cardiac death. Test results are important for managing family members' risk for cardiovascular disease. Show notes (00:32) Would each of you share a little bit about yourselves and your backgrounds? (01:13) Could you provide us with an overview of these new tests? (02:31) Can you expand on why these postmortem cardiac tests are so impo...
Dec 28, 2023•13 min•Ep. 270
Devin Oglesbee, Ph.D., explains how Mayo Clinic Laboratories' cholestasis gene panel identifies mutations that cause low flow of bile from the liver. Test results help guide treatment decisions that can prevent liver damage. Show notes (00:32) Could you please provide us a little information about your background? (01:46) Could you please give the audience a brief overview of this assay? (03:45) Which patients should have this testing and when should it be performed? (06:39) How are the results ...
Dec 26, 2023•10 min•Ep. 269
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to reflect on key moments from 2023 and to discuss what may lie ahead in 2024. Their discussion includes: A look back at impactful events from 2023 in laboratory medicine and diagnostics. What’s top of mind today heading into the holidays. Speculating about indust...
Dec 21, 2023•13 min•Ep. 268
Antibody against the GABA-A receptor is a biomarker of autoimmune encephalopathy that occurs across the lifespan, and disproportionately affects children. In this test-specific episode of the "Answers From the Lab" podcast, Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' GABA-A receptor antibody assay aids diagnosis of this serious but treatable condition. Show notes (00:32) Could you provide a little information on your role here at Mayo Clinic? (01:11) Can you give an ...
Dec 19, 2023•18 min•Ep. 267
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss the U.S. Food and Drug Administration’s (FDA) recent approval of two gene therapies for sickle cell disease. Their discussion includes: The cause and characteristics of sickle cell disease. How the new cell-based gene therapies, Casgevy and Lyfgenia, wo...
Dec 14, 2023•16 min•Ep. 266
Maria Willrich, Ph.D., and Melissa Snyder, Ph.D., describe Mayo Clinic Laboratories' panel for proactive therapeutic drug monitoring of patients with inflammatory bowel disease. The panel expands options for clinicians assessing patients' response to the drugs infliximab and adalimumab. (00:32) Could you provide a little bit of background information about yourselves? (02:18) Would you give the audience a brief overview of the assay? (04:18) Which patients should have this testing and when shoul...
Dec 12, 2023•16 min•Ep. 265
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss the U.S. Food and Drug Administration’s (FDA) proposed rule on laboratory-developed tests (LDTs) and the comments Mayo Clinic submitted to the FDA. Their discussion includes: How Mayo Clinic responded in its comments to the FDA on the proposed rule on L...
Dec 07, 2023•13 min•Ep. 264
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss current respiratory virus activity and the importance of staying up-to-date on preventive vaccines. Their discussion includes: The current outlook on COVID-19 cases and the importance of remaining vigilant with prevention efforts. The respiratory syncyt...
Nov 30, 2023•11 min•Ep. 263
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the one-year delay to clinical laboratory payment cuts recently passed by Congress and the importance of responding to the FDA’s proposed rule on laboratory-developed tests. Specific discussion points include: How Congress passed the short-term spendi...
Nov 23, 2023•16 min•Ep. 262
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss key takeaways from Dr. Morice’s recent visit in Washington, D.C. Their discussion includes: How device manufacturers are evolving and collaborating within the changing landscape. The importance of submitting comments in response to the FDA’s proposed ...
Nov 16, 2023•14 min•Ep. 261
Lisa Rimsza, M.D., explains how Mayo Clinic Laboratories' unique PM3CX test can accurately define subtypes of large B-cell lymphoma. Precise diagnosis is critical to choosing appropriate chemotherapy for these cancers. Speaker 2: (00:32) Could you provide a brief background about yourself? Speaker 2: (01:12) Would you give us an overview of the PM3CX test? Speaker 2: (03:02) Which patients should have this testing? Speaker 2: (05:14) Is this test qualitative and RNA? Speaker 2: (06:35) After det...
Nov 14, 2023•11 min•Ep. 260
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss strategies for responsible innovation and how new standards for artificial intelligence (AI) safety will impact laboratory medicine and diagnostics. Their discussion includes: Highlights of the Executive Order issued by President Biden on Oct. 30 that...
Nov 09, 2023•11 min•Ep. 259
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the recent news of a possible cure for sickle cell disease, as well as gene editing therapies and their impact on the laboratory. Their discussion includes: Characteristics of sickle cell disease and current testing and treatment options. Advantages, ...
Nov 02, 2023•15 min•Ep. 258
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to discuss the role and expansion of at-home testing. Their discussion includes: How home test kits for COVID-19 led to the expansion of at-home tests and telehealth options across the health industry. Understanding from a laboratory perspective the best use of fu...
Oct 26, 2023•14 min•Ep. 257
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss how artificial intelligence (AI) has become a disruptive technology in the field of laboratory medicine, and how it can add value to patient care. Their discussion includes: How the conversation around AI and laboratory medicine began, and how it has ...
Oct 19, 2023•13 min•Ep. 256
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss current focus areas found across the diagnostics industry and what transformative technologies are being explored around the world. Their discussion includes: What international laboratories and diagnostics companies are working on during this post-pa...
Oct 12, 2023•12 min•Ep. 255
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the U.S. Food and Drug Administration’s (FDA) recently proposed rule that if finalized, would phase out its current enforcement discretion used for laboratory developed tests (LDTs), and regulate all laboratory tests as medical devices regardless of w...
Oct 05, 2023•12 min•Ep. 254
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Matthew Binnicker, Ph.D., director of the Clinical Virology Laboratory at Mayo Clinic, to discuss the seasonal outlook of respiratory viruses, including influenza, COVID-19, and respiratory syncytial virus (RSV). Specific topics of discussion include: What respiratory viruses are currently circulating, and what we might expect in the coming ...
Sep 28, 2023•15 min•Ep. 253
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the uptick of COVID-19 cases and the strains of the virus that are currently circulating. Their discussion includes: COVID-19 variants and how their mutations affect transmission. Lessons learned throughout the last few years with COVID-19 and immunit...
Sep 21, 2023•11 min•Ep. 252
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Nancy Wengenack, Ph.D., director of the Mycology and Mycobacteriology Laboratories at Mayo Clinic, to talk about leprosy and why it’s been in the news recently. Leprosy, also known as Hansen’s disease, is a rare infectious disease caused by the bacteria Mycobacterium leprae. Specific topics of discussion include: How leprosy is transmitted, ...
Sep 14, 2023•14 min•Ep. 251
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic. They talk about murine typhus, also known as flea-borne typhus, and the recent increase in cases in Los Angeles County and Texas. Specific topics of discussion include: How flea-borne typhus is transmitted to humans and common symptoms. How the disea...
Aug 31, 2023•12 min•Ep. 250
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Paul Jannetto, Ph.D., director of the Clinical and Forensic Toxicology Lab, Clinical Mass Spectrometry Lab, and Metals Lab at Mayo Clinic. Dr. Pritt and Dr. Jannetto discuss the current state of the opioid crisis in the United States, its impact on public health, and the important role of laboratory testing in addiction medicine and pain man...
Aug 24, 2023•22 min•Ep. 249
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss pathogens commonly found in the summertime that can cause disease and illness, and how to protect against them. Their discussion includes: Mosquito-borne and tick-borne diseases, their symptoms, and how to prevent bites. The U.S. Environmental Protect...
Aug 17, 2023•11 min•Ep. 248
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss the role that a strong public health lab and diagnostic testing capabilities play in preventing widespread infectious disease outbreaks. Their discussion includes: The reemergence of infectious diseases that were prevalent years ago in the United Stat...
Aug 10, 2023•12 min•Ep. 247
Patients with elevated LDL or "bad" cholesterol face even greater risk if their levels of small dense LDL cholesterol are also high. Vlad Vasile, M.D., Ph.D., and Leslie Donato, Ph.D., explain how Mayo Clinic Laboratories' sdLDL-c assay measures concentrations of the small dense LDL subtype, to better guide clinical care. (00:32) Could you both tell us a little about yourselves and your backgrounds? (01:24) Could you tell us a little bit about small dense LDL cholesterol and why it is an importa...
Aug 08, 2023•8 min•Ep. 246
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories. They discuss Dr. Pritt’s recent trip to Uganda where she taught a global health course as part of a Mayo Clinic-sponsored initiative to help expand knowledge around the world in global health and tropical medicine. Their discussion includes: Dr. Pritt’s experience...
Aug 03, 2023•12 min•Ep. 245
Identifying a precise genetic cause of hearing loss impacts clinical management. Nicole Boczek, Ph.D., and Melanie Meyer, M.S., CGC, explain how Mayo Clinic Laboratories' updated panel yields comprehensive results for optimal patient care. (00:31) Can you tell us a little about yourselves and your backgrounds? (01:52) Could you provide a brief overview of this assay? (02:29) Can the diagnosis lead to improved patient care? (03:51) When should this test be used? (05:25) How do the results for AHL...
Aug 01, 2023•13 min•Ep. 244
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by Vanda Lennon, M.D., Ph.D. , founder of the Neuroimmunology Laboratory and now director of the Neuroimmunology Research Laboratory at Mayo Clinic. Dr. Pritt and Dr. Lennon discuss the research and testing innovations that have led to critical advancements in the field of autoimmune neurology over the last few decades. Specific topics of discu...
Jul 27, 2023•23 min•Ep. 243
Wei Shen, Ph.D., explains how Mayo Clinic Laboratories' new breast cancer panel provides rapid results to guide critical treatment decisions. (00:32) Could you provide our listeners with a little bit about yourself and your background? (01:28) Could you give us a brief overview of the new rapid hereditary breast cancer panel? (03:42) Can you describe a little bit of the rationale behind the design and how it differs from similar tests? (05:03) Can you tell us a little bit more about which patien...
Jul 25, 2023•11 min•Ep. 242
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, and Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic, talk about dengue and chikungunya arboviral infections. Specific topics of discussion include: Why cases of dengue and chikungunya viral infections have rapidly increased in South America. What happens when a human is infected with dengue virus or chikungunya...
Jul 20, 2023•15 min•Ep. 241
