3-Minute 3Rs July 2018

You're listening to the July edition of 3 Minute 3Rs, brought to you this month by the North American 3Rs Collaborative (www.na3rsc.org), Lab Animal (www.nature.com/laban) and the NC3Rs (www.nc3rs.org.uk). This month, we'll be talking about refining mouse anesthesia, replacing mice with zebrafish for studying human hematopoetic stem cells, and validating genome-edited mouse lines.The papers behind the pod:* Effects of Ketamine Compared with Urethane Anesthesia on Vestibular Sensory Evoked Potentials and Systemic Physiology in Mice: http://www.ingentaconnect.com/content/aalas/jaalas/2018/00000057/00000003/art00007;jsessionid=2je0i010idu59.x-ic-live-03* A method for transplantation of human HSCs into zebrafish, to replace humanised murine transplantation models :https://f1000research.com/articles/7-594/v1* Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-018-0530-7

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