Ringmaster's Out, Clown's In - Amazing Spider-Man #22 (1965)

The Circus of Crime returns this issue (shudder). After their last failure, they fire The Ringmaster's ass and get the Clown to be the new leader of the group. Luckily our boy Spider-Man is on the case, not trusting the group for a second. Continue forth to hear more about the giant snake, Princess Python and Jameson's brush with death!!