Evolution is a messy business, involving as it does selection pressures, mutations, genetic drift, and the effects of random external interventions. So in the end, how much of it is predictable, and how much is in the hands of chance? Today we’re thrilled to have as a guest my evil (but more respectable, by most measures) twin, the biologist Sean B. Carroll. Sean is both a leader of the modern evo-devo revolution , and a wonderful and diverse writer. We talk about the importance of randomn...
Oct 05, 2020•1 hr 21 min•Ep 117•Transcript available on Metacast How can, and should, we talk to each other, especially to people with whom we disagree? “Free speech” is rightfully entrenched as an important value in liberal democratic societies, but implementing it consistently and fairly is a tricky business. Political theorist Teresa Bejan comes to this question from a philosophical and historical perspective, managing to relate broad principles to modern hot-button issues. We talk about the importance of tolerating disreputable beliefs, the senses in whic...
Sep 28, 2020•2 hr 44 min•Ep 116•Transcript available on Metacast Stephen Hawking made a number of memorable contributions to physics, but perhaps his greatest was a puzzle : what happens to information that falls into a black hole? The question sits squarely at the overlap of quantum mechanics and gravitation, an area in which direct experimental input is hard to come by, so a great number of leading theoretical physicists have been thinking about it for decades. Now there is a possibility that physicists might have made some progress, by showing how su...
Sep 21, 2020•1 hr 27 min•Ep 115•Transcript available on Metacast Sexuality is, and always has been, a topic that is endlessly fascinating but also contentious. You might think that asexuality would be more straightforward, but you’d be wrong. Asexual people, or “aces,” haven’t been front and center in the public discussion of gender and sexuality, and as a result there is confusion about such basic issues as what “asexuality” even means. Angela Chen is a science journalist and an ace herself, and she’s written a new book about asexuality and how i...
Sep 14, 2020•1 hr 9 min•Ep 114•Transcript available on Metacast You can’t always get what you want, as a wise person once said. But we do try, even when someone else wants the same thing. Our lives as people, and the evolution of other animals over time, are shaped by competition for scarce resources of various kinds. Game theory provides a natural framework for understanding strategies and behaviors in these competitive settings, and thus provides a lens with which to analyze evolution and human behavior, up to and including why racial or gender groups are ...
Sep 07, 2020•1 hr 20 min•Ep 113•Transcript available on Metacast Not too long ago nobody carried a mobile phone; now almost everybody does. That’s the kind of rate of rapid progress we’re seeing with our ability to directly edit genomes. With the use of CRISPR-Cas9 and other techniques, gene editing is becoming commonplace. How does that work — and perhaps more importantly, how are we going to put it to use? Fyodor Urnov has worked in this area from its beginning, having coined the term “gene editing.” We talk about how this new technology can be ...
Aug 31, 2020•1 hr 20 min•Ep 112•Transcript available on Metacast Human civilization is only a few thousand years old (depending on how we count). So if civilization will ultimately last for millions of years, it could be considered surprising that we’ve found ourselves so early in history. Should we therefore predict that human civilization will probably disappear within a few thousand years? This “Doomsday Argument” shares a family resemblance to ideas used by many professional cosmologists to judge whether a model of the universe is natural or not. Philosop...
Aug 24, 2020•1 hr 21 min•Ep 111•Transcript available on Metacast Physicists have traditionally simplified systems as much as possible, in order to shed light on fundamental properties. But small, simple parts build up into large, complex wholes. Are there new rules and laws of nature that apply specifically to the realm of complexity? This has been a popular question for a few decades now, and we have some answers but not as many as we would like. Neil Johnson is an expert on complex systems generally, and information networks in particular. We discuss how se...
Aug 17, 2020•1 hr 24 min•Ep 110•Transcript available on Metacast It’s easy to foresee that technological progress will change how we live; it’s much harder to anticipate exactly how. Self-driving cars represent an enormous technological challenge, but one that is plausibly on the way to being solved. What will be the unanticipated consequences when autonomous vehicles become commonplace? Jason Torchinsky is a fan of technology, but also a fan of driving, and his recent book Robot, Take the Wheel examines how our relationship with cars is likely to...
Aug 10, 2020•1 hr 18 min•Ep 109•Transcript available on Metacast We are living, in case you haven’t noticed, in a world full of bullshit. It’s hard to say whether the amount is truly increasing, but it seems that everywhere you look someone is trying to convince you of something, regardless of whether that something is actually true. Where is this bullshit coming from, how is it disseminated, and what can we do about it? Carl Bergstrom studies information in the context of biology, which has led him to investigate the flow of information and disinformation in...
Aug 03, 2020•1 hr 24 min•Ep 108•Transcript available on Metacast Despite occasional and important disagreements, most people are in rough agreement about what it means to be moral, to do the right thing. There’s much less agreement about why we should be moral, or even what kind of answer to that question could be convincing. Philosopher Russ Shafer-Landau is one of the leading proponents of moral realism — the view that objective moral truths exist independently of human choices. That’s not my own view, but ethics and meta-ethics are ...
Jul 27, 2020•2 hr 31 min•Ep 107•Transcript available on Metacast Someday, most likely, we will encounter life that is not as we know it. We might find it elsewhere in the universe, we might find it right here on Earth, or we might make it ourselves in a lab. Will we know it when we see it? “Life” isn’t a simple unified concept, but rather a collection of a number of life-like properties. I talk with astrobiologist Stuart Bartlett, who (in collaboration with Michael Wong ) has proposed a new way of thinking about life based on four pillars: dissipation, ...
Jul 20, 2020•1 hr 26 min•Ep 106•Transcript available on Metacast We gather empirical evidence about the nature of the world through our senses, and use that evidence to construct an image of the world in our minds. But not all senses are created equal; in practice, we tend to privilege vision, with hearing perhaps a close second. Ann-Sophie Barwich wants to argue that we should take smell more seriously, and that doing so will give us new insights into how the brain works. As a working philosopher and neuroscientist, she shares a wealth of fascinating informa...
Jul 13, 2020•1 hr 18 min•Ep 105•Transcript available on Metacast Creativity is one of those things that we all admire but struggle to define or make concrete. Music provides a useful laboratory in which to examine what creativity is all about — how do people become creative, what is happening in their brains during the creative process, and what kinds of creativity does the audience actually enjoy? David Rosen and Scott Miles are both neuroscientists and musicians who have been investigating this question from the perspective of both listeners and performers....
Jul 06, 2020•1 hr 26 min•Ep 104•Transcript available on Metacast Cooking is art, but it’s also very much science — mostly chemistry, but with important contributions from physics and biology. (Almost like a well-balanced recipe…) And I can’t think of anyone better to talk to about the intersection of these fields than Kenji López-Alt: professional chef and restauranteur, MIT graduate, and author of The Food Lab . We discuss how modern scientific ideas can improve your cooking, and more importantly, how to bring a scientific approach to cooking anything ...
Jun 29, 2020•1 hr 15 min•Ep 103•Transcript available on Metacast The best chess and Go players in the world aren’t human beings any more; they’re artificially-intelligent computer programs. But the best poker players are still humans. Poker is a laboratory for understanding how rationality works in real-world situations: it features stochastic events, incomplete information, Bayesian updating, game theory, reading other people, a battle between emotions and reason, and real-world stakes. Maria Konnikova started in psychology, turned to writing, and then took ...
Jun 22, 2020•1 hr 20 min•Ep 102•Transcript available on Metacast I recently saw an estimate that if you took all the novel coronaviruses in the world (the actual viruses, not patients), you could fit them into a bucket no more than a couple of liters in volume. A huge impact has been wrought by a very small amount of stuff. The world of viruses is vast and complicated, and we’re still learning some of its basic features. Today’s guest David Baltimore won the Nobel Prize in Physiology or Medicine for the discovery that genetic information in viruses could flow...
Jun 15, 2020•1 hr 14 min•Ep 101•Transcript available on Metacast A podcast only hits the century mark once! And for Mindscape, this is it. There have been holiday messages and bonus episodes and the like. But this is the 100th officially-numbered episode. To celebrate, I decided to treat myself to a solo episode in which I reflect, somewhat non-systematically, on the age-old question of the meaning of life. I end up spending a lot (most?) of the time talking about the meaning of “life,” i.e. what it means to be a living organism in a naturalistic universe. Bu...
Jun 08, 2020•2 hr 33 min•Ep 100•Transcript available on Metacast There are some problems for which it’s very hard to find the answer, but very easy to check the answer if someone gives it to you. At least, we think there are such problems; whether or not they really exist is the famous P vs NP problem , and actually proving it will win you a million dollars . This kind of question falls under the rubric of “computational complexity theory,” which formalizes how hard it is to computationally attack a well-posed problem. Scott Aaronson is one of the...
Jun 01, 2020•2 hr 53 min•Ep 99•Transcript available on Metacast Each of us is different, in some way or another, from every other person. But some are more different than others — and the rest of the world never stops letting them know. Societies set up “norms” that define what constitute acceptable standards of behavior, appearance, and even belief. But there will always be those who find themselves, intentionally or not, in violation of those norms — people who we might label “weird.” Olga Khazan was weird in one particular way, growing up in a Russian imm...
May 25, 2020•1 hr 2 min•Ep 98•Transcript available on Metacast Humans build machines, in part, to relieve themselves from the burden of work on difficult, repetitive tasks. And yet, despite the fact that machines are everywhere, most of us are still working pretty hard. But maybe that’s about to change. Futurists like John Danaher believe that society is finally on the brink of making a transition to a world in which work would be optional, rather than mandatory — and he thinks that’s a very good thing. It will take some adjusting, personally as well as eco...
May 18, 2020•1 hr 23 min•Ep 97•Transcript available on Metacast The past few centuries of scientific progress have displaced humanity from the center of it all: the Earth is not at the middle of the Solar System, the Sun is but one star in a large galaxy, there are trillions of galaxies, and so on. Now we know that we’re not even made of the same stuff as most of the universe; for every amount of ordinary atoms and other known particles, there is five times as much dark matter, some kind of stuff we haven’t identified in laboratory experiments. But we do kno...
May 11, 2020•1 hr 22 min•Ep 96•Transcript available on Metacast Everybody talks about the truth, but nobody does anything about it. And to be honest, how we talk about truth — what it is, and how to get there — can be a little sloppy at times. Philosophy to the rescue! I had a very ambitious conversation with Liam Kofi Bright, starting with what we mean by “truth” (correspondence, coherence, pragmatist, and deflationary approaches), and then getting into the nitty-gritty of how we actually discover it. There’s a lot to think about once we take a hard look at...
May 04, 2020•2 hr 36 min•Ep 95•Transcript available on Metacast Artificial intelligence has made great strides of late, in areas as diverse as playing Go and recognizing pictures of dogs. We still seem to be a ways away from AI that is “intelligent” in the human sense, but it might not be too long before we have to start thinking seriously about the “motivations” and “purposes” of artificial agents. Stuart Russell is a longtime expert in AI, and he takes extremely seriously the worry that these motivations and purposes may be dramatically at odds with our ow...
Apr 27, 2020•1 hr 27 min•Ep 94•Transcript available on Metacast Human beings have a strange fascination with dangerous, predatory animals — bears, lions, wolves, sharks, and more. The top of the food chain is an interesting and precarious place to live; while you might be the boss of your local environment, you also depend on the functioning of an entire ecology. Rae Wynn-Grant is a carnivore ecologist who studies how large predators migrate, feed, reproduce — and especially how they interact with humans. We talk about the diverse social structures of differ...
Apr 20, 2020•1 hr 2 min•Ep 93•Transcript available on Metacast It’s hard doing science when you only have one data point, especially when that data point is subject to an enormous selection bias. That’s the situation faced by people studying the nature and prevalence of life in the universe. The only biosphere we know about is our own, and our knowing anything at all is predicated on its existence, so it’s unclear how much it can teach us about the bigger picture. That’s why it’s so important to search for life elsewhere. Today’s guest is Kevin Hand, a plan...
Apr 13, 2020•2 hr 56 min•Ep 92•Transcript available on Metacast If one of the ambitious goals of philosophy is to determine the meaning of life, one of the ambitious goals of psychology is to tell us how to achieve it. An influential work in this direction was Abraham Maslow’s hierarchy of needs — a list of human needs, often displayed suggestively in the form of a pyramid, ranging from the most basic (food and shelter) to the most refined. At the top lurks “self-actualization," the ultimate goal of achieving one’s creative capacities. Psychologi...
Apr 06, 2020•1 hr 19 min•Ep 91•Transcript available on Metacast Science costs money. And for a brief, glorious period between the start of the Manhattan Project in 1939 and the cancellation of the Superconducting Super Collider in 1993, physics was awash in it, largely sustained by the Cold War. Things are now different, as physics — and science more broadly — has entered a funding crunch. David Kaiser, who is both a working physicist and an historian of science, talks with me about the fraught relationship between scientists and their funding sources throug...
Mar 30, 2020•2 hr 35 min•Ep 90•Transcript available on Metacast What direction does time point in? None, really, although some people might subconsciously put the past on the left and the future on the right, or the past behind themselves and the future in front, or many other possible orientations. What feels natural to you depends in large degree on the native language you speak, and how it talks about time. This is a clue to a more general phenomenon, how language shapes the way we think. Lera Boroditsky is one of the world’s experts on this phenomenon. S...
Mar 23, 2020•1 hr 29 min•Ep 89•Transcript available on Metacast This is a special episode of Mindscape, thrown together quickly. Many thanks to Tara Smith for joining me on short notice. Tara is an epidemiologist, and a great person to talk to about the novel coronavirus (and its associated disease, COVID-19) pandemic currently threatening the world. We talk about what viruses are, how they spread, and a lot of the science behind virology and pandemics. We also take a practical turn, talking about what measures (washing hands, social distancing, self-isolati...
Mar 18, 2020•1 hr 21 min•Transcript available on Metacast 
