Welcome to the February 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with questions and tra...
Feb 03, 2025•4 hr 44 min•Transcript available on Metacast A typical human lifespan is approximately three billion heartbeats in duration. Lasting that long requires not only intrinsic stability, but an impressive capacity for self-repair. Nevertheless, things do occasionally break down, and cancer is one of the most dramatic examples of such breakdown. Given that the body is generally so good at protecting itself, can we harness our internal security patrol - the immune system - to fight cancer? This is the hope of Nobel Laureate James Allison, who wor...
Jan 27, 2025•1 hr 8 min•Transcript available on Metacast Randomness plays an important role in the evolution of life (as my evil twin will tell you). But random doesn't mean arbitrary. Biological organisms are physical objects, after all, and subject to the same laws of physics as non-biological matter is. Those laws place constraints on how organisms can fulfill their basic functions of metabolism, reproduction, motility, and so on. Easy to say, but how can we turn this into quantitative understanding of actual organisms? Today I talk wit...
Jan 20, 2025•2 hr 31 min•Transcript available on Metacast Big data is ruling, or at least deeply infiltrating, all of modern existence. Unprecedented capacity for collecting and analyzing large amounts of data have given us a new generation of artificial intelligence models, but also everything from medical procedures to recommendation systems that guide our purchases and romantic lives. I talk with computer scientist Tina Elassi-Rad about how we can sift through all this data, make sure it is deployed in ways that align with our values, and how to dea...
Jan 13, 2025•1 hr 9 min•Ep 301•Transcript available on Metacast A new year, and a new centennial -- 300 (regularly-numbered) episodes of Mindscape! Our tradition is to have a solo episode, and what better topic than the nature of time? Physicists and philosophers have so frequently suggested that time is some kind of illusion that it's become almost passé to believe that it might be fundamental. This is an issue where, despite the form of the question, physics has important things to say that most philosophers haven't yet caught up to. I will talk about idea...
Jan 06, 2025•2 hr 12 min•Ep 300•Transcript available on Metacast It's the end of the year, and time for our annual holiday break here at Mindscape. But as usual, we wrap up with a Holiday Message. This year, inspired by Joni Mitchell's "Hits" and "Misses" albums, I go through my scientific papers and talk about some of my favorites -- some of which were hits, in terms of making an impact on subsequent research, and some of which were misses by that standard. But I love them all! It's an excuse to talk about process -- how papers come to be, from the initial i...
Dec 23, 2024•2 hr 1 min•Transcript available on Metacast Living organisms seem exquisitely organized and complex, with features clearly adapted to serving certain functions needed to survive and procreate. Natural selection provides a compelling explanation for why that is so. But is there a bigger picture, a more general framework that explains the origin and evolution of functions and complexity in a world governed by uncaring laws of physics? I talk with planetary scientist and astrobiologist Michael Wong about how we can define what "functions" ar...
Dec 16, 2024•1 hr 13 min•Ep 299•Transcript available on Metacast The number of neurons in the human brain is comparable to the number of stars in the Milky Way galaxy. Unlike the stars, however, in the case of neurons the real action is in how they are directly connected to each other: receiving signals over synapses via their dendrites, and when appropriately triggered, sending signals down the axon to other neurons (glossing over some complications). So a major step in understanding the brain is to map its wiring diagram, or connectome : the complete ...
Dec 09, 2024•1 hr 9 min•Ep 298•Transcript available on Metacast Welcome to the December 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions and...
Dec 02, 2024•4 hr 56 min•Transcript available on Metacast Not too long ago, Brad Pitt and Eric Bana starred in a (loose) adaptation of Homer's epic poem The Iliad ; next month, Ralph Fiennes and Juliette Binoche will headline a film based on The Odyssey . Given that the originals were written (or at least written down) in the 8th century BCE, that is some impressive staying power. But they were also written in a very different time than ours, with different cultural context and narrative expectations. We talk about t...
Nov 25, 2024•1 hr 15 min•Ep 297•Transcript available on Metacast Biological evolution via natural selection is a simple idea that becomes enormously complicated in its realization. Populations of organisms are driven toward increased "fitness," a measure of how successfully we reproduce our genetic information. But fitness is a subtle concept, changing with time and environment and interactions with other organisms around us. We talk with biologist Brandon Ogbunu about the best mathematical and conceptual tools for thinking about the messy complexities of evo...
Nov 18, 2024•1 hr 16 min•Ep 296•Transcript available on Metacast Emergence is a centrally important concept in science and philosophy. Indeed, the existence of higher-level emergent properties helps render the world intelligible to us -- we can sensibly understand the macroscopic world around us without a complete microscopic picture. But there are various different ways in which emergence might happen, and a tendency for definitions of emergence to rely on vague or subjective criteria. Recently Achyuth Parola and I wrote a paper trying to clear up some...
Nov 11, 2024•2 hr 35 min•Ep 295•Transcript available on Metacast Welcome to the November 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! S upport Mindscape on Patr...
Nov 04, 2024•4 hr 50 min•Transcript available on Metacast Erwin Schrödinger said that the important characteristic of life is that it "goes on doing something... for a much longer period than we would expect an inanimate piece of matter to keep going under similar circumstances." Living organisms are in constant motion inside; so where does this stability and persistence come from? Addy Pross points to a novel kind of chemical phenomenon -- "dynamic kinetic stability" (DKS), a feature that enables a chemical "fountain" to persist in the presence of an ...
Oct 28, 2024•1 hr 12 min•Ep 294•Transcript available on Metacast A large economy is one of the best examples we have of complex dynamics. There are multiple components arranged in complicated overlapping hierarchies, out-of-equilibrium dynamics, nonlinear coupling and feedback between different levels, and ubiquitous unpredictable and chaotic behavior. Nevertheless, many economic models are based on relatively simple equilibrium principles. Doyne Farmer is among a group who think that economists need to start taking the tools of complexity theory seriously, a...
Oct 21, 2024•1 hr 11 min•Ep 293•Transcript available on Metacast It's not immoral to kick a rock; it is immoral to kick a baby. At what point do we start saying that it is wrong to cause pain to something? This question has less to do with "consciousness" and more to do with "sentience" -- the ability to perceive feelings and sensations. Philosopher Jonathan Birch has embarked on a careful study of the meaning of sentience and how it can be identified in different kinds of organisms, as he discusses in his new open-access book The Edge of Sentience . Th...
Oct 14, 2024•1 hr 11 min•Ep 292•Transcript available on Metacast Welcome to the October 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! S upport Mindscape on Patre...
Oct 07, 2024•5 hr 30 min•Transcript available on Metacast Aging and death happen to the best of us, but there are increasing efforts to do something about it. That effort requires that we have some reasonable understanding of why aging happens, and what processes are involved. You will be unsurprised to learn that it's complicated. Venki Ramakrishnan, who won the Nobel Prize for his work on the ribosome, investigates what we know about aging in his book Why We Die: The New Science of Aging and the Quest for Immortality . We talk about aging and d...
Sep 30, 2024•1 hr 21 min•Ep 291•Transcript available on Metacast It's a wonder democracy works at all -- a collection of people with potentially different interests have to agree to abide by majority vote even when it goes against their desires. But as we know, it doesn't always work, and racial and ethnic tensions are one of its biggest challenges. Hahrie Han studies the ground-up workings of democracy, how people can come together to successfully enact change. In her new book Undivided: The Quest for Racial Solidarity in an American Church , she inves...
Sep 23, 2024•1 hr 16 min•Ep 290•Transcript available on Metacast As an experimental facility, the Large Hadron Collider at CERN in Geneva has been extraordinarily successful, discovering the Higgs boson and measuring multiple features of particle-physics interactions at unprecedented energies. But to theorists, the results have been somewhat frustrating, as we were hoping to find brand-new phenomena beyond the Standard Model. There is nothing to do but to keep looking, recognizing that we have to choose our methods judiciously. I talk with theoretical physici...
Sep 16, 2024•1 hr 22 min•Ep 289•Transcript available on Metacast It wasn't that long ago, historically speaking, that you might put on your tuxedo or floor-length evening gown to go out and hear a live opera or symphony. But today's world is faster, more technologically connected, and casual. Is there still a place for classical music in the contemporary environment? Max Richter, whose new album In a Landscape releases soon, proves that there is. We talk about what goes into making modern classical music, how musical styles evolve, and why every n...
Sep 09, 2024•1 hr 6 min•Ep 288•Transcript available on Metacast Welcome to the September 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with AMA questions an...
Sep 02, 2024•4 hr 50 min•Transcript available on Metacast One common feature of complex systems is sensitive dependence on initial conditions: a small change in how systems begin evolving can lead to large differences in their later behavior. In the social sphere, this is a way of saying that history matters. But it can be hard to quantify how much certain specific historical events have affected contemporary conditions, because the number of variables is so large and their impacts are so interdependent. Political economist Jean-Paul Faguet and collabo...
Aug 26, 2024•2 hr 33 min•Ep 287•Transcript available on Metacast Understanding how life began on Earth involves questions of chemistry, geology, planetary science, physics, and more. But the question of how random processes lead to organized, self-replicating, information-bearing systems is a more general one. That question can be addressed in an idealized world of computer code, initialized with random sequences and left to run. Starting with many such random systems, and allowing them to mutate and interact, will we end up with "lifelike," self-replicating ...
Aug 19, 2024•1 hr 21 min•Ep 286•Transcript available on Metacast Being rational necessarily involves engagement with probability. Given two possible courses of action, it can be rational to prefer the one that could possibly result in a worse outcome, if there's also a substantial probability for an even better outcome. But one's attitude toward risk -- averse, tolerant, or even seeking -- also matters. Do we work to avoid the worse possible outcome, even if there is potential for enormous reward? Nate Silver has long thought about probability and prediction,...
Aug 12, 2024•1 hr 11 min•Ep 285•Transcript available on Metacast Welcome to the August 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with transcript: https:/...
Aug 05, 2024•4 hr 37 min•Transcript available on Metacast The human brain does a pretty amazing job of taking in a huge amount of data from multiple sensory modalities -- vision, hearing, smell, etc. -- and constructing a coherent picture of the world, constantly being updated in real time. (Although perhaps in discrete moments, rather than continuously, as we learn in this podcast...) We're a long way from completely understanding how that works, but amazing progress has been made in identifying specific parts of the brain with specific functions in t...
Jul 29, 2024•1 hr 3 min•Ep 284•Transcript available on Metacast Change is scary. But sometimes it can all work out for the best. There's no guarantee of that, however, even when the change in question involves the introduction of a powerful new technology. Today's guest, Daron Acemoglu, is a political economist who has long thought about the relationship between economics and political institutions. In his most recent book (with Simon Johnson), Power and Progress: Our Thousand-Year Struggle Over Technology and Prosperity , he looks at how technological...
Jul 22, 2024•1 hr 18 min•Ep 283•Transcript available on Metacast The philosophy of mathematics would be so much easier if it weren't for infinity. The concept seems natural, but taking it seriously opens the door to counterintuitive results. As mathematician and philosopher Joel David Hamkins says in this conversation, when we say that the natural numbers are "0, 1, 2, 3, and so on," that "and so on" is hopelessly vague. We talk about different ways to think about the puzzles of infinity, how they might be resolved, and implications for mathematical realism. ...
Jul 15, 2024•1 hr 18 min•Ep 282•Transcript available on Metacast Welcome to the July 2024 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the questions themselves are good -- and sometimes group them together if they are about a similar topic. Enjoy! Blog post with questions and transcr...
Jul 08, 2024•3 hr 22 min•Transcript available on Metacast 
