Y Combinator Startup Podcast - podcast cover

Y Combinator Startup Podcast

Y Combinatorwww.ycombinator.com
We help founders make something people want. The Y Combinator Podcast is where builders talk about building. From the earliest days of an idea to scaling a company that changes the world, YC partners and founders share real stories, lessons, and tactics from the frontlines.
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Episodes

Why Domain Experts Are Winning In The Age Of AI

Bryant Chou co-founded Webflow, which today powers around 1% of all websites on the internet. Now he's back in the current YC batch with Ploy, an AI-powered website and marketing platform that doesn't just build your site — it connects to your analytics, CRM, and search console to optimize your marketing while you sleep. In this episode of the Lightcone he explains how he built Ploy to be “anti slop,” how building today compares to his first startup, and why founders with domain expertise are ma...

Jun 19, 202643 min

How To Pick A Startup Idea

Many founders get stuck trying to find the perfect startup idea before they commit. But the perfect idea doesn't exist in the abstract. The only way to find what works is to pick one, go deep, and get feedback from real customers. In this episode of Startup School, YC's Jon Xu breaks down how to choose what to build, "burn the other boats," and go deep enough to practically run your customer's business— and why that depth is what surfaces the better idea underneath.

Jun 17, 202612 min

"The CEO Must Be the Chief AI Officer"

Brex co-founder and CEO Pedro Franceschi believes most people still underestimate how much AI will change the way companies are built. AI isn't just another tool, it's a new foundation for building products, teams, and companies.In this episode of Lightcone, Pedro shares why he thinks we're only months into a platform shift as significant as the invention of electricity, how AI has changed the way he works, and why every founder should be "token maxing" to understand the limits of the technology...

Jun 10, 202654 min

How to Build an AI-Native Services Company

Some of the biggest companies of the next decade won't be software businesses, they'll be services companies like insurance carriers, law firms, and tax practices rebuilt from scratch with AI doing most of the work. In this episode of Startup School, YC Visiting Partner Charlie Warren walks through the playbook for building AI native services companies, covering how to pick a market with the right traits, why variance kills these businesses faster than anything else, and the P&L math that’ll...

Jun 03, 202611 min

How To Build Superintelligence Inside Your Company

This episode explores how Y Combinator is integrating AI not merely as a feature, but as the core operating system of its internal processes. Pete Koomen details the journey of building YC's agent infrastructure, from empowering the finance team with SQL-querying agents to developing self-improving skill loops. The discussion emphasizes the power of centralized data, transparent agent interactions, and a trust-default culture in fostering organizational superintelligence and a "personal AI revolution."

May 27, 202646 min

How The Best Companies Defend Against Mediocrity And Rot

In this episode of the Main Function Garry sits down with Eric Ries, author of "The Lean Startup", about his new book, "Incorruptible: Why Good Companies Go Bad And How Great Companies Stay Great". Ries breaks down why shareholder primacy often leads to company and product degradation, how founders can lose control of the companies they build, and what legal structures and governance models can protect a company's core mission from outside threats.

May 25, 202650 min

Paul Graham: Should you move to Silicon Valley?

Paul Graham is a co-founder of Y Combinator. He's funded and mentored companies like Dropbox, Airbnb, DoorDash, and thousands of others through YC, and is one of the most influential voices in the startup world. In this talk at our YC | Stockholm event last month, Paul walks through why ambitious founders should move to Silicon Valley at least briefly, what makes it uniquely valuable — from serendipitous meetings and faster investor decisions to a deeply embedded pay-it-forward culture — and why...

May 13, 202622 min

Tokenmaxxing: How Top Builders Use AI To Do The Work Of 400 Engineers

We're entering a new era of software where a single person, working with AI agents, can build products that previously required entire teams.In this episode of Lightcone, the hosts break down the rise of AI coding agents, "tokenmaxxing", and the emerging workflows behind tools like Claude Code and OpenClaw. They discuss why AI systems today feel less like productivity tools and more like collaborators, why the future of AI should be personal and user-controlled, and how founders are starting to ...

May 08, 202641 min

Beyond Bigger Models: Recursion As The Next Scaling Law In AI

A 7-million parameter model outperforming models a thousand times its size on tasks like ARC Prize. That's what recursive reasoning unlocks.In this episode of Decoded, YC's Ankit Gupta and Francois Chaubard break down two recent papers on recursive AI models, HRMs and TRMs, that are achieving state-of-the-art results with a fraction of the parameters of today's largest models.They explain why standard LLMs hit a fundamental ceiling on certain reasoning tasks, how recursion at inference time give...

May 01, 202638 min

How to Build the Future: Demis Hassabis

Demis Hassabis has had one of the most extraordinary careers in tech. He started as a chess prodigy and video game designer at 17 before getting a PhD in neuroscience and going on to found DeepMind. His lab cracked Go, solved protein structure prediction with AlphaFold, and then gave it away free to every scientist on earth. That work won him the 2024 Nobel Prize in Chemistry. Today he leads Google DeepMind, pushing toward the same goal he set as a teenager: AGI. On this special live episode of ...

Apr 29, 202641 min

The $9B Startup That Wants to Create a Billion New Developers

Replit is the leading no-code app builder for consumers and enterprise, letting anyone with an idea build real, deployed software using natural language. The company just raised a $400 million Series D at a $9 billion valuation.In this episode of Founder Firesides, co-founder and CEO Amjad Masad sat down with YC's Andrew Miklas to talk about Replit's 10-year journey from browser IDE to vibe coding platform, why the people getting the most value aren't traditional developers but founders and doma...

Apr 25, 202639 min

The Playbook For Building An AI Native Company

AI isn't just making teams more productive. It's changing how companies should be built. In this episode of Startup School, YC Partner Diana Hu explains what it means to build an AI-native company, where AI isn't just a tool but the operating system your company runs on. She breaks down how to make your company queryable so agents can improve across every function, why management hierarchies break down when an intelligence layer replaces human middleware, and why early-stage founders have a mass...

Apr 24, 202610 min

Stripe Head of Design Katie Dill Breaks Down Their New Website

Even the most successful websites eventually need a redesign. Take Stripe for example. After six years with the same homepage, they recently unveiled a brand new site that reflects how the fintech giant has evolved over the past few years. So when is the time right for a new landing page? And what should you prioritize in the redesign? In this episode of Design Review YC’s Aaron Epstein sat down Stripe’s Head of Design Katie Dill to pull the curtain back on their high profile redesign and to dis...

Apr 22, 202644 min

The GPT Moment for Robotics Is Here

Physical Intelligence is building a foundation model that can control any robot to do any task — what the team describes as the GPT-1 moment for robotics. The company's cross-embodiment approach trains across many different robot platforms, and recent results show tasks being performed zero-shot that last year required hundreds of hours of data collection. In this episode of The Lightcone, co-founder Quan Vuong sat down with Garry, Jared, Diana, and Harj to talk about why robotics is finally rea...

Apr 16, 202649 min

This Startup Wants To Catch Cancer Before It Spreads

1 in 11 babies born in America this year will be screened by a genetic test that didn't exist a decade ago.Biotech startup BillionToOne turned a simple but radical idea—detecting rare fragments of fetal DNA in a mother's blood—into one of the most widely used prenatal tests in the U.S. And they're not stopping there. The same approach could unlock something even bigger: early-stage cancer detection from a blood test, a breakthrough that could one day save millions of lives.In this episode of Har...

Apr 06, 202621 min

This Startup Secretly Detects Fraud For Fortune 500s

In this episode of Founder Firesides, YC Managing Partner Jared Friedman talks to Karine Mellata, co-founder of Variance (W23), who is coming out of stealth and announcing their $21 million Series A. Variance builds purpose-built AI agents for risk and compliance — automating fraud detection, content review, and identity verification for Fortune 500 companies and platforms like GoFundMe. They discuss why Variance built in the shadows for three years, detecting state-sponsored fraud rings, and th...

Mar 31, 202631 min

How François Chollet Is Building A New Path To AGI

François Chollet has spent years asking a different question than most of the AI world. Instead of scaling what already works, he’s trying to understand what intelligence actually is—and how to build it from first principles. In this episode of Lightcone, he traces that path from his early work on deep learning to the creation of the ARC prize, and the launch of ARC V3, a new benchmark designed to measure something deeper than performance: the ability to learn, adapt, and reason efficiently in e...

Mar 27, 202657 min

Inside The Startup Reinventing America’s Trillion Dollar Chemical Industry

Solugen is reinventing the trillion-dollar chemical manufacturing industry by combining biology and chemistry in a new way. In this episode of Hard Tech, YC's Jared Friedman visits co-founders Gaurab Chakrabarti and Sean Hunt at their Houston HQ to see how they went from a $7,000 PVC reactor to a billion-dollar company competing with industry giants. They cover the breakthrough behind their enzymatic + catalytic production, how they found their first customers, and why starting small and staying...

Mar 20, 202613 min

Building A Global AI Startup From India

In this episode of The Lightcone, we talk with Mukund and Madhav Jha, the founders of Emergent - an AI platform that lets anyone build and ship production-ready software. In just eight months, users have created more than 7 million apps on Emergent, with the number doubling in just the last 45 days. We discuss how they built one of the most powerful AI coding agents, why they focused on non-technical users and what it's like building in India for a global audience. Apply to Y Combinator: https:/...

Mar 16, 202640 min

The Future Of Brain-Computer Interfaces with Science's Max Hodak

YC alum Max Hodak is the co-founder of Neuralink and founder of Science, a company building brain-computer interfaces that can restore sight.Science has developed a tiny retinal implant that stimulates cells in the eye to help blind patients see again. More than 40 patients have already received the treatment in clinical trials, including one who recently read a full novel for the first time in over a decade.In this episode of How to Build the Future, Max joined Garry to discuss how BCIs work, w...

Mar 09, 202653 min

How To Avoid AI Design Slop

As no-code design tools become more common, so do the pitfalls. You know what they look like - the purple gradients, annoying hover effects, sections that fade as you scroll. So how do you avoid a site that feels vibe coded while still taking advantage of these new tools? In this episode of Design Review, YC’s Aaron Epstein is joined by Visiting Partner Raphael Schaad, the founder and designer of Cron (now Notion Calendar). Together they’ll review user submitted sites with an eye for how to leve...

Mar 06, 202637 min

The Fastest Path To Super Intelligence

Poetiq is a new startup founded by former DeepMind researchers that recently achieved a major jump on the ARC-AGI and Humanity's Last Exam benchmark by layering a recursive self-improvement system on top of existing models. In this episode of Lightcone, Poetiq's Founder & CEO Ian Fischer joined us to discuss how small teams can build “reasoning harnesses” that outperform base models, what that means for startups and why automating prompt engineering may be one of the most powerful levers in ...

Feb 27, 202620 min

The AI Agent Economy Is Here

With the takeoff of OpenClaw and MoltBook, a new agent-driven economy is taking shape. In this episode of the Lightcone, we took a look at the explosive growth of AI dev tools and whether the time has come for builders to make something agents want.

Feb 21, 202623 min

Inside Claude Code With Its Creator Boris Cherny

A very special guest on this episode of the Lightcone! Boris Cherny, the creator of Claude Code, sits down to share the incredible journey of developing one of the most transformative coding tools of the AI era.

Feb 17, 202650 min

The New Way To Build A Startup

In the AI era, startups aren't winning by hiring faster — they're winning by automating as many internal functions as possible. In this episode of Main Function, Garry breaks down how tiny teams are beating companies 20x their size by building automations into every workflow, from engineering to ops to customer support.

Feb 14, 20268 min

OpenClaw And The Future Of Personal AI Agents

Creator Peter Steinberger details the journey of OpenClaw, a local-first, open-source AI agent that's gone viral for its task execution capabilities and deep integration with personal devices. He explores how such agents could make many current apps obsolete, emphasizing the critical importance of individual data ownership and privacy. Steinberger also shares his unique development philosophies, including how he instilled personality into his agent and his belief in "swarm intelligence" for AI's future.

Feb 07, 202623 min

We're All Addicted To Claude Code

Wondering why your maker-turned-manager suddenly seems distracted in meetings? Maybe they're addicted to coding agents! In this episode of Lightcone, Calvin French-Owen — a co-founder of Segment and former engineer on OpenAI's Codex team — joins us to talk about why coding agents suddenly feel so powerful, the differences between Codex, Claude Code, and Cursor, and what the future of work will look like.

Feb 06, 202646 min

How To Get Your First Customers

When you're starting out, it isn’t enough to just build a minimum viable product. You also need a minimum evolvable product - one that can adapt to the needs of those critical early customers. In this episode of Main Function, YC General Partner Ankit Gupta offers an update to the classic MVP playbook. He’ll outline strategies for getting your first customers, the power of adaptability and how feedback from early users will ultimately shape the future of your product and your company. Apply to Y...

Jan 14, 20266 min

Inside The Startup Building Reusable Rockets

Stoke Space is racing to build the world's first fully reusable rockets that can launch, survive reentry, and fly again and again. In this episode of Hard Tech, YC’s Aaron Epstein sits down with Stoke Space co-founders Andy Lapsa and Tom Feldman to find out why they chose to take on one of the hardest problems in rocket science, how an obsession with efficiency gives them an edge, and what full reusability could unlock for the future of spaceflight. Apply to Y Combinator: https://www.ycombinator...

Jan 08, 202616 min

What Surprised Us Most In 2025

This episode of The Light Cone discusses key surprises in the AI landscape in 2025, highlighting the shift in preferred LLMs at YC from OpenAI to Anthropic and Gemini, driven by performance in specific tasks and user familiarity. The hosts examine the "AI bubble" and infrastructure challenges, arguing that the current "installation phase" creates immense opportunities for application-layer startups in the upcoming "deployment phase." They also touch on the rise of specialized AI models, the stabilization of the AI economy, and how human and organizational inertia are allowing society to absorb AI at a more measured pace.

Dec 22, 202530 min
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