Vector Signals - podcast cover

Vector Signals

Maddy Chang McDonough
A private, AI-curated podcast delivering 15-20 minute deep dives into the latest Nature articles on mosquito-borne viruses and AI-driven therapeutic breakthroughs. Designed for the researchers of the Saleh Lab at Institut Pasteur, each episode distills cutting-edge science into accessible insights—so you can stay current, even during your busiest bench days.
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Episodes

AI for Culex Mosquito Identification using Wing Patterns (July 2025)

Detailed Briefing Document: Application of Wing Interference Patterns (WIPs) and Deep Learning (DL) for Culex spp. Classification Application of wings interferential patterns (WIPs) and deep learning (DL) to classify some Culex. spp (Culicidae) of medical or veterinary importance Arnaud Cannet, Camille Simon Chane, Aymeric Histace, Mohammad Akhoundi, Olivier Romain, Pierre Jacob, Darian Sereno, Marc Souchaud, Philippe Bousses & Denis Sereno Scientific Reports volume 15, Article number: 21548...

Jul 01, 202516 minEp. 120

Battle of the Mosquitoes: Genetic War on Malaria (June 2025)

Detailed Briefing Document: The Battle of the Mosquitoes - A New Approach to Malaria Control Source: Adepoju, P. Battle of the mosquitoes. Nat Med 31 , 1722–1726 (2025). https://doi.org/10.1038/s41591-025-03753-0 Dates: Published - 11 June 2025 | Issue Date - June 2025 I. Executive Summary This briefing document summarizes the key themes and facts from the provided source, "Battle of the Mosquitoes," detailing the innovative approach of using genetically modified mosquitoes to combat malaria, pa...

Jun 27, 202517 minEp. 119

Greenland Mosquito Virome: Arctic Aedes Uniqueness (May 2025)

Briefing Document: Unique Virome of Arctic Mosquitoes in Greenland Source: https://doi.org/10.1038/s41598-025-01086-z : "Metagenomic analysis of mosquitoes from Kangerlussuaq, Greenland reveals a unique virome" by Schilling, Jagdev, Thomas, & Johnson (2025). Date: Received - 17 January 2025 | Accepted - 02 May 2025 | Published - 17 May 2025 Subject: Metagenomic analysis of mosquito viromes in Kangerlussuaq, Greenland and implications in the context of climate change. Summary: This study prov...

May 30, 202521 minEp. 118

Novel Quinolones Counteract Insecticide Resistance in Malaria Vectors (May 2025)

BRIEFING DOCUMENT: Novel Approach to Malaria Control Targeting Mosquito-Stage Plasmodium Parasites Date: Received - 29 March 2025 | Accepted - 17 April 2025 | Published - 21 May 2025 Source: Excerpts from "In vivo screen of Plasmodium targets for mosquito-based malaria control" by Probst et al. (Published online xx xx xxxx, Nature) https://doi.org/10.1038/s41586-025-09039-2 Subject: Development and testing of novel antiparasitic compounds for incorporation into mosquito bed nets to combat insect...

May 30, 202525 minEp. 117

Blocking Malaria Transmission with PfPIMMS43 Nanobodies (April 2025)

Briefing Document: Nanobody-Mediated Blocking of Malaria Transmission Targeting PfPIMMS43 Source: Excerpts from "s42003-025-08033-8.pdf" (A Nature Portfolio journal; https://doi.org/10.1038/s42003-025-08033-8 ) Authors: Chiamaka Valerie Ukegbu, et al. Date: Received - 04 December 2024 | Accepted - 02 April 2025 | Published - 30 April 2025 Executive Summary: This study explores a novel strategy to block malaria transmission by targeting the Plasmodium falciparum protein PfPIMMS43 using single-dom...

May 03, 202513 minEp. 116

Nanofiber Encapsulation of Pseudomonas for Sustained Mosquito Larvicide Release (April 2025)

Briefing Document: Nanofiber Encapsulation of Pseudomonas aeruginosa for Sustained Mosquito Larvicide Release Date: Received - 13 December 2024 | Accepted - 04 April 2025 | Published - 21 April 2025 Source: Excerpts from "Nanofiber encapsulation of Pseudomonas aeruginosa for the sustained release of mosquito larvicides" https://doi.org/10.1038/s41598-025-97400-w 1. Executive Summary: This study investigates a novel approach for mosquito vector control using nanofiber encapsulation of the bacteri...

Apr 21, 202514 minEp. 115

Predicting Aedes Albopictus Spread in Europe via Climate and Population (April 2025)

Population Dependent Diffusion Model for Aedes Albopictus Spread in Europe Source: Barman et al., "A climate and population dependent diffusion model forecasts the spread of Aedes Albopictus mosquitoes in Europe," Nature Portfolio journal , 2025, https://doi.org/10.1038/s43247-025-02199-z Date: Received - 25 November 2024 | Accepted - 07 March 2025 | Published - 09 April 2025 Key Themes and Important Ideas/Facts: This paper presents a novel spatio-temporal diffusion model that accurately forecas...

Apr 11, 202513 minEp. 114

Malaria Transmission: Parasite and Vector Circadian Clock Coordination (April 2025)

Parasite and Vector Circadian Clocks Mediate Efficient Malaria Transmission Source: Bento et al., "Parasite and vector circadian clocks mediate efficient malaria transmission," Nature Microbiology , Published online 31 March 2025, https://doi.org/10.1038/s41564-025-01949-1 Date: Received: 03 September 2024 | Accepted: 26 March 2025 | Published: 04 April 2025 Key Themes: This study uncovers a critical tripartite relationship between the Anopheles mosquito vector, the Plasmodium malaria parasite, ...

Apr 04, 202516 minEp. 113

Radiation Induces Alternative Splicing in Aedes aegypti (March 2025)

Briefing Document: Radiation-Induced Alternative Splicing in Aedes aegypti Mosquitoes Source: Bendzus-Mendoza, H., Rodriguez, A., Debnath, T., Bailey, C. D., Luker, H. A., & Hansen, I. A. (2025). Radiation exposure induces genome-wide alternative splicing events in Aedes aegypti mosquitoes. Scientific Reports , 15 , 5885. Date of Publication: Received - 19 June 2024 | Accepted - 14 March 2025 | Published - 24 March 2025 Key Themes and Important Ideas/Facts: This study investigates the impact...

Mar 24, 202520 minEp. 112

Mosquito Prefoldin Targeting Blocks Plasmodium Transmission (March 2025)

Briefing Document: Targeting the Mosquito Prefoldin–Chaperonin Complex to Block Plasmodium Transmission Citation: Dong, Y., Kang, S., Sandiford, S.L. et al. Targeting the mosquito prefoldin–chaperonin complex blocks Plasmodium transmission. Nat Microbiol (2025). https://doi.org/10.1038/s41564-025-01947-3 Date: Received - 22 November 2024 | Accepted - 27 January 2025 | Published - 06 March 2025 Overview: This study investigates the role of the conserved Anopheles mosquito prefoldin (PFDN)–chapero...

Mar 07, 202520 minEp. 111

Engineered Bacteria Combat Concurrent Malaria and Arbovirus Transmission (March 2025)

Briefing Document: Engineered Symbionts for Concurrent Malaria and Arbovirus Transmission Control Citation: Hu, W., Gao, H., Cui, C. et al. Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission. Nat Commun 16, 2104 (2025). https://doi.org/10.1038/s41467-025-57343-2 Dates: Received - 27 July 2024 | Accepted - 19 February 2025 | Published - 01 March 2025 Prepared for: Saleh Lab Executive Summary: This research presents a novel paratransgenesis strategy utilizing...

Mar 02, 202522 minEp. 110

Mosquito Viral Tolerance Enhanced by Prolonged Heat Exposure (February 2025)

Briefing Document: Heat Exposure and Mosquito-Virus Interaction Source: Perdomo, H. D., Khorramnejad, A., Cham, N. M., Kropf, A., Sogliani, D., & Bonizzoni, M. (2025). Prolonged exposure to heat enhances mosquito tolerance to viral infection. Communications Biology , 8 (1), 761. https://doi.org/10.1038/s42003-025-07617-8 Dates: Received - 27 September 2024 | Accepted - 28 January 2025 | Published - 04 February 2025 Prepared for: Saleh Lab Executive Summary: This study investigates the impact...

Feb 04, 202515 minEp. 109

Bunyavirus NSm: Key to Transmission Between Vertebrates and Mosquitoes (January 2025)

Briefing Document: NSm Protein's Critical Role in Bunyavirus Transmission Citation: Terhzaz, S., Kerrigan, D., Almire, F. et al. NSm is a critical determinant for bunyavirus transmission between vertebrate and mosquito hosts. Nat Commun 16 , 1214 (2025). https://doi.org/10.1038/s41467-024-54809-7 Date: Received - 03 May 2024 | Accepted - 21 November 2024 | Published - 31 January 2025 Prepared for: Saleh Lab Key Themes: NSm as a Unique Feature of Vector-Borne Bunyaviruses: The study establishes a...

Jan 31, 202519 minEp. 108

Zika Virus Alters Human Skin to Attract Mosquito Vectors (January 2025)

Detailed Briefing Document: Zika Virus Modulation of Human Fibroblasts Enhances Transmission Success Source: Mozūraitis, R., Cirksena, K., Raftari, M., et al. (2025). Zika virus modulates human fibroblasts to enhance transmission success in a controlled lab-setting. Communications Biology , 8 (1), 754. https://doi.org/10.1038/s42003-025-07543-9 Date of Briefing: Received - 02 July 2024 | Accepted - 14 January 2025 | Published - 30 January 2025 1. Executive Summary: This study investigates how Zi...

Jan 30, 202520 minEp. 107

Mosquito Hsf1-sHsp Cascade: A Pan-Antiviral Defense (January 2025)

Briefing Document: Pan-Antiviral Activity of the Hsf1-sHsp Cascade in Mosquito Cells Source: Qu, J., Schinkel, M., Chiggiato, L., Machado, S. R., Overheul, G. J., Miesen, P., & van Rij, R. P. (2025). The Hsf1-sHsp cascade has pan-antiviral activity in mosquito cells. Nature Communications Biology , 8 (1), 74. https://doi.org/10.1038/s42003-024-07435-4 Date: Received - 05 July 2023 | Accepted - 20 December 2024 | Published - 25 January 2025 1. Executive Summary: This research paper investigat...

Jan 25, 202512 minEp. 106

Toxic Seminal Proteins Reduce Female Insect Lifespan (January 2025)

Briefing Document: "Recombinant venom proteins in insect seminal fluid reduce female lifespan" Source: Article "Recombinant venom proteins in insect seminal fluid reduce female lifespan" by Samuel J. Beach & Maciej Maselko, published in Nature Communications (DOI: 10.1038/s41467-024-54863-1). Date: Current date (based on when the briefing document is created). Prepared for: [Intended Audience - e.g., Pest Management Stakeholders, Research Community, Regulatory Bodies] Executive Summary: This...

Jan 07, 202522 minEp. 105

Predicting Infectious Disease Outbreaks with AHP and Transfer Learning (December 2024)

Briefing Document: Leveraging AHP and Transfer Learning for Infectious Disease Outbreak Prediction Dates: Received - 10 August 2024 | Accepted - 26 November 2024 | Published - 31 December 2024 Citation: Abdallah, R., Abdelgaber, S. & Sayed, H.A. Leveraging AHP and transfer learning in machine learning for improved prediction of infectious disease outbreaks. Sci Rep 14, 32163 (2024). https://doi.org/10.1038/s41598-024-81367-1 Keywords: Infectious diseases, AHP, Transfer learning, Risk factors...

Dec 31, 202412 minEp. 104

Ontario West Nile Virus: Mosquitoes, Humans, and Risk Factors (Nature, December 2024)

Briefing Document: Spatial and Temporal Analysis of West Nile Virus Infection in Ontario, Canada (2003-2022) Citation: Talbot, B., Ludwig, A., O’Brien, S.F. et al. Spatial and temporal analysis of West Nile virus infection in mosquito and human populations based on arboviral detection testing data. Sci Rep 14 , 31343 (2024). https://doi.org/10.1038/s41598-024-82739-3 Dates: Received - 09 July 2024 | Accepted - 09 December 2024 | Published - 28 December 2024 Prepared for: Saleh Lab Executive Summ...

Dec 28, 202416 minEp. 103

Explainable Deep Learning for Molecular Discovery (December 2024)

Briefing Document: Explainable Deep Learning for Molecular Discovery Citation: Wong, F., Omori, S., Li, A. et al. An explainable deep learning platform for molecular discovery. Nat Protoc (2024). https://doi.org/10.1038/s41596-024-01084-x Dates: Received - 11 March 2024 | Accepted - 26 September 2024 | Published - 09 December 2024 Source: Excerpts from "An explainable deep learning protocol for de novo molecular discovery" (s41596-024-01084-x.pdf) Executive Summary This briefing document summari...

Dec 08, 202419 minEp. 102

Mosquito Salivary Protein Structure Relevant to Pathogen Transmission (February 2023)

Briefing Document: Native Structure of Mosquito Salivary Protein Uncovers Domains Relevant to Pathogen Transmission Dates: Received - 04 October 2022 | Accepted - 07 February 2023 | Published - 17 February 2023 Source: Liu, S., Xia, X., Calvo, E., & Zhou, Z. H. (2023). Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. Nature Communications , 14 (1), 1-20. https://doi.org/10.1038/s41467-023-36577-y Executive Summary: This study, published in Nat...

Feb 18, 202323 minEp. 101
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