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You can visit BetterHelp.com slash Unexplainable today to get 10% off your first month. That's BetterHelp, H-E-L-P dot com slash Unexplainable. Support for the show comes from Into the Mix, a Ben and Jerry's podcast about joy and justice produced with Vox creative. Along the Mississippi River, between Baton Rouge and New Orleans, there's a stretch of land nicknamed Cancer Alley, because the cancer rate is more than seven times higher than the national average.
And it's thanks to a high concentration of petrochemical plants. In the latest episode of Into the Mix, you'll hear how one community is fighting against some of the top polluters in the country in their own backyard. You can subscribe to Into the Mix, a Ben and Jerry's podcast, wherever you listen. We're getting to that part of summer where there's nothing better to do than sit by a beach or by a pool with a good book or hide inside blasting the AC also with a good book.
So we thought why not have another edition of our Unexplainable Book Club. That's where one of us picks a book. We tell you exactly why we picked it. And then we call it the author and talk to them about it. This week, senior producer, Bird Pinkerton has a book for us. The book I chose is by a science writer named Tom Ireland and has a name that sounds almost like an oxymoron. It's called the Good Virus.
Essentially, there is this amazing group of viruses that exist solely to infect and kill bacteria. So they're called phages. We call them bacteria phages. And that's just become short into phages. And phages have started to get some attention in the last few years. Yeah, so there's a lot of interest, especially right now about the use of phages as alternatives to antibiotics.
But it wasn't until I read Tom's book that I realized that phages aren't just going to help us fight pathogens in some new-fangled future. They are helping us fight pathogens right now. Because we already have a very intimate relationship with these viruses. Actually, we live with an unbelievable amount and unbelievable diversity of different pages in us and all of us all the time. We are, it turns out, basically a whole bunch of phages in a trench coat.
There's probably more phages in the human body than there are actual human cells. And yet, we know very little about these microscopic remains. Like, we only discovered one of the most abundant phages in our bodies about a decade ago. And we still have a lot of questions about what role all these phages play in keeping pathogens if they? They're a really massive component of what's going on in our lives, which is just kind of crazy not to know about.
This is unexplainable, and today, on another edition of our book club, Tom Ireland tells us what we do and don't know about the phages inside of us. And what that might mean for our health. So, let's start with the most basic of basics here. Most simply, what is a phage and how does it work? So a phage is a virus that infects bacteria. And personally, I think as viruses go, they're pretty cool and a bit more interesting than the viruses that infect humans.
Because bacteria are a lot harder to infiltrate. So these phages kind of look like mini spaceships. You know, they have these kind of angular, weird, 20-sided heads called a capsid. They also have a tail and these little crazy legs that they use to kind of land on a bacteria and puncture its surface. And then they inject their genes in. And those genes hijacked the bacteria to make it essentially a phage factory.
So instead of using all of its metabolism to grow and replicate, the bacteria is just pumping out components of more phages. And then those phages eventually burst out of the bacteria and they go on to infect other bacterial cells. Where do we find these bacteria-eating, bacteria-fighting phages? Yeah, so they are absolutely everywhere. And that's another reason I wanted to sort of try and celebrate them in this book. They're out there in the environment. They're in rivers.
They're in soil, they're in the seas. They're in some of the most inhospitable places on earth. They are just everywhere that you'll find bacteria. You'll also find viruses of bacteria. Sometimes there's more viruses than the bacteria themselves. And you could scoop up some sea water from the middle of the ocean and there would be literally millions of phages in what looks like completely pristine, clear sea water. Interesting. So they vastly outnumber the viruses that we fear and try to avoid.
How much have we studied like phages in general? Are they sort of a complete mystery? We barely scratched the surface of. Do we understand them pretty well? Like where do we stand? So what's really interesting is that phages were first discovered in the 1910s, late 1910s. And there were immediately, there was lots of controversy around this discovery. Some people just didn't believe that it was possible that there was a microbe smaller than a bacteria that could kill bacteria.
It just seemed too far-fetched. And people immediately started using them in medicine. So people were very interested in phages that could cure disease essentially. That was sometimes successful, sometimes not. It went in and out of fashion, but that was very much the focus. And so people started using phages as like a tool in genetics and in molecular biology.
And there was actually this treaty called the phage treaty where a very powerful scientist who was at the head of this kind of field of science said everyone doing this, everyone using phages as like a tool for molecular biology has to use the same half a dozen phages. So that we've all got the same kind of so that we can all compare data, right? We're all working on the same thing and we can all compare and contrast our data.
And that was amazing from molecular biology and it achieved a huge breakthroughs. But it's really like kept the number of phages that have been studied by scientists really, really narrow. And it's only recently that people have started to actually look at phages and try and categorize and classify all of them. And so they've got a lot of work to do. And what have researchers found as they've actually started to look at phages as they've kind of branched out here.
Is there a particularly interesting example? So there's a guy called forest roa who was really interested in the viruses of corals. And he would go and dive underwater and he was collecting viruses that infect the bacteria that infect corals. So one of the most obscure things you could probably do as a biologist, you're looking at the viruses that infect the bacteria that infect corals. But what he really started to notice was that corals are covered in this kind of protective mucus.
And the mucus had actually evolved to attract phages into it. Wow. So the corals were using this mucus covered in phages as a kind of protective layer. It was like an immune system because if your outer layer is covered in phages, then that's going to make it less likely that any bacteria can infect you. Because as soon as the bacteria land on you, they get attacked by phages.
So there, I just want to make sure I'm following all these different corals have this like symbiotic relationship with phages where they say we'll give you a home. You are like our little bodyguard, like our bouncers at the club or something keeping stuff out. Acting like bodyguards. It's like being covered in velcro and there's bodyguards stuck all over the velcro. Right. Really weird analogy. But they've made themselves an immune system in this way. Yeah, it works for the phages.
They have a home that they know bacteria are going to come along and stick to and they can use that to replicate in. And the coral gets to have these little viruses living on it that are going to kill the bacteria that want to harm the coral. So for us, then his colleagues started looking at other organisms that have this kind of mucus layer on them and finding phages in those mucus layers. And then they thought, hey, we've got mucus layers like in our intestines and on the surface of our lungs.
So they started looking and exactly the same thing happens in our intestines and in our lungs. Any any part of the body that's exposed to the environment is going to be full of bacteria and full of phages. It seems that our bodies have evolved a certain type of mucus with proteins in it that actually bind to the phages that are going to protect us.
So we have this kind of layer of protection of immunity sort of stuck into those important surfaces where our, the inside of our body meets the outside of our body. And again, this was only just discovered. So we're only just learning about this kind of completely new way that we protect ourselves from bacteria. So what do we discovered about these phages so far? Like what do we figured out about how they're acting in our bodies? And what do we still need to figure out? That's after the break.
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This is the unexplainable book club, and we are talking about Tom Ireland's book, The Good Virus, which explores fages, these viruses that infect bacteria. Fages are all over the planet, but also, as Tom told us, they are all over the planet. They are all over the planet. And they're helping us eliminate bacterial pathogens in ways that we don't fully understand yet. In his book, Tom talks about how these fages might keep us healthy.
One researcher referred to them as another immune system, and researchers are studying how these fages work in concert with the rest of our microbiome. People talk about the microbiome as a whole, but they don't have to be the same. They're not the same. They're not the same. They're not the same. They're not the same. They're not the same. They're not the same. They're not the same. They're not the same.
I'm talking about the microbiome as the different populations of bacteria in the body, but it's really any microbes, so we should be considering fages as part of our microbiome. I've heard it also called, the phageome, or the viarome. So yeah, its definitely part of our microbiome, but it's a massively mysterious and understudied part. What do we know about it, I guess? Like barely anything. anything. That piece of work moving from corals to human mucus layers was really the starting point
and really not many groups of researchers are working on this. People have just started to see that some pages actually make it through the barriers of the gut, through the mucus layer and a present in areas of the body that we thought were completely sterile. So the blood, the spleen, even the brain
have got phages in it. And so people are now starting to ask, have they been allowed through into these sterile areas of the body to act as kind of like antibacterial agents that circulate in our body, in our blood and in our brain, just in case bacteria manage to squeeze through into those sterile areas. They'll immediately be pounced on by these select few body guards that
have been letting through the barriers of the body. So it's completely in its infancy, this area of science, but obviously it sounds super important to the future of our health. Do these phages interact with my regular immune system? So what we do know about the way phages interact with the human immune system is that because we have co-evolved with phages all around us,
our immune system doesn't really see them as a threat. So if as human virus entered the bloodstream, the immune system would kick off and take any number of steps to try and neutralize that invader. But generally what we know is that phages tend to float around in our bodies undisturbed. And are there particular diseases that we think we might be able to treat in some way if we followed this path of research further? Yeah, so cystic fibrosis is particularly relevant
because it is a disease of the body's mucus. It's an excess of mucus in the lungs and it often causes bacteria to colonize the mucus in a way that is kind of not responsive to antibiotics. There's often different types of bacteria colonizing the lungs of cystic fibrosis patients all at once. So yeah, it's absolutely essential that we understand what phages roll is in that mucus layer and how we can sort of add to it or modulate it in a way that can help protect
patients from the bacteria trying to colonize their lungs. Why do you think recently phages have come back to the fore or people have restarted this exploration? Yeah, I guess for many many years, the focus for the neurologists, I people who study viruses, was on the viruses that are killing and maiming people like millions of people every year. And that's understandable why that would take the focus. Whereas people studying the viruses of bacteria maybe, you know, they're not going to,
they're not getting the sexy gram money, right? It's going to be seen as obscure. I think what's changing now is that as we look desperately for ways to fight bacterial infections, as I mentioned earlier, antibiotics are not as effective as they used to be. That is causing a real interest in understanding how to use phages and the reason phages haven't been effective as medicines in the past is we didn't understand enough about them. And so people are having to work backwards
to sort of fundamentally understanding what phages are and how they work. It's normally the other way around. You would understand something really well before you start using and thinking of developing medicines. It's kind of the other way around with phages. People are desperate to use them as medicines now, but actually people have to take a massive step back and go like, well, let's just start from the beginning. How did phages and bacteria evolve inside and on other life forms?
We need to understand that three way interaction. We even just need to understand how many there are. How many there are? What they're doing, if we all have the same kind of phages or if we all have different ones, we just have to go back to the beginning and really understand these relationships in like a molecular detail because it's just an unknown at the moment. It's just so many unknowns. It's called a dark matter of biology because there's just so many different
types of virus. So many of them and yet we know so little about any of them. Tom Ireland's book is called The Good Virus. And if you want to learn more about phages and about the people trying to use them as a tool to fight off bacterial infections, I really recommend it. I also recommend sticking around because next week we'll be sharing a favorite episode of ours about how Cold War politics held phage research back for decades.
This episode was produced by me, Bird Pinkerton, and edited by Meredith Hadnott with help from Jorge Just. Meredith runs the show, Noam is our host and does the music. Christian Ayala did the mixing and the sound design, Melissa Hirsch did our fact checking. Mandy Mullen is the fact that nut hatches spend so much of their time upside down and we are always, always grateful to Brian Resnick for co-founding the show. If you have questions about this episode or thoughts, please send
them to us. We are at unexplainable at vox.com. You can support the show and all of vox's journalism by joining our membership program today. That's at vox.com slash members to sign up. Or you can always support the show by leaving us a nice rating or a review. Reviews mean a lot. Unexplainable is part of the vox media podcast network and we'll be back next week.