Translational Medicine

Research in Medicine needs to ultimately translate into better treatment of patients. Researchers at the Nuffield Department of Medicine, University of Oxford, collaborate to develop better care and improved preventive measures. Findings in the laboratory are translated into changes in clinical practice, from Bench to Bedside.

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Episodes

Drug Discovery

Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have allowed him to progress promising clinical candidates into Phase I, II, III studies, and to market. Drug candidates are first selected by screening compounds capable of binding to a target protein. Those...

Dec 20, 2010•5 min

Genetic Variation in Inflammation and Immunity

Dr Julian Knight explains how new insights into genetic variants which modulate gene expression allow us to better understand why people develop these diseases, and allow us to target treatments more effectively. Dr Julian Knight studies how genetic variation between individuals affect the way immune and inflammatory genes are expressed. This helps understand genetic susceptibility to common conditions such as infectious, inflammatory or autoimmune diseases. He recently published a book titled '...

Nov 29, 2010•5 min

Chromatin Remodelling

Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Dr Erika Mancini is interested in the role of chromatin in the regulation of gene transcription. All our cells contain the same set of genes, but only some of them are transcribed at any point in a particular tissue. Regulation of gene transcription is strongly linked to chromatin, physical packaging of the DNA within the nucleus. Molecula...

Nov 15, 2010•5 min

Malaria and Global Health

Dr Climent Casals-Pascual explains how the development of new tools to diagnose and manage malaria more effectively will allow us to decrease the mortality of this condition. Dr Climent Casals-Pascual is interested in severe malaria, particularly its diagnosis and clinical management. Clinical symptoms of severe malaria are similar to those of other diseases like pneumonia and meningitis. In tropical countries, poor diagnosis often results in sub-optimal treatments. Integrating proteomic, genomi...

Nov 02, 2010•8 min

Malaria Vaccines

Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Professor Hill develops vaccines against malaria based on inducing cellular immune responses (T lymphocytes) instead of the more commonly used stimulation of antibodies. Prophylactic vaccines developed in Oxford are now showing great promise in clinical trials.

Oct 18, 2010•5 min

Women's Health

Dr Krina Zondervan is interested is women's health conditions, particularly endometriosis. Dr Zondervan studies genetic, molecular and environmental factors influencing this complex disorder. Women suffering from endometriosis experience severe pelvic pain and may suffer from infertility. Endometrial-like cells develop outside the uterine cavity. These cells are influenced by hormonal changes and respond similarly as the cells lining the uterus. Causes of endometriosis remain unknown and treatme...

Sep 30, 2010•7 min

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