TWiV reviews the FDA decision to update COVID-19 vaccine boosters in the fall, the meaning of fatigue with respect to long COVID, and a skin volatile induced by flavivirus reproduction that attracts mosquitoes to the infected host. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 vaccine booster composition (FDA) Settling in for the long haul (Cro...
Jul 17, 2022•1 hr 42 min•Ep. 919
In COVID-19 clinical update #123, Dr. Griffin discusses rapid diagnostic testing in response to the monkeypox outbreak, leading causes of death in the US during the COVID-19 pandemic, antibody evasion by subvariants, broadly-neutralizing antibodies against emerging variants, factors associated with severe outcomes among hospitalized immunocompromised adults, measurement of the burden of hospitalizations during the pandemic, parental vaccine hesitancy in diverse communities, evaluating saliva sam...
Jul 16, 2022•41 min•Ep. 918
Paul Offit returns to TWiV to discuss why, during the recent FDA advisory committee meeting, he voted against releasing revised COVID-19 vaccines containing an Omicron component, and the reasons why children must be vaccinated against the disease. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Paul Offit Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 28 June 2022 VRBPAC meeting materials (...
Jul 10, 2022•1 hr 43 min•Ep. 917
In COVID-19 clinical update #122, Dr. Griffin discusses vaccine availability and coverage among children, post-infection health impairments in children and adolescents, infection detection using salvia and nasopharyngeal samples, effectiveness of vaccines during delta dominance, durability of vaccine against severe outcomes, concern in the postvaccination era, infection rebound after Paxlovid & Molnupiravir, lack of improvement after adding ivermectin to standard care, duration of shedding o...
Jul 09, 2022•47 min•Ep. 916
TWiV discusses the recent decision by an FDA advisory committee to update COVID vaccines for the fall, the monkeypox virus outbreak, and the finding that enteric viruses infect the salivary glands and are transmitted through saliva. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Postdoctoral position in the Kielian Laboratory ( pdf ...
Jul 03, 2022•1 hr 55 min•Ep. 915
In COVID-19 clinical update #121, Dr. Griffin discusses age as a risk factor for severe disease, updated vaccine boosters for the fall, pediatric infection and antibody seroprevalence in Arkansas over the first year of the COVID-19 pandemic, all-cause maternal mortality in the United States before and during the pandemic, and the effect of 2-week interruption in methotrexate treatment and how it impacts vaccine immunity. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a p...
Jul 02, 2022•37 min•Ep. 914
TWiV explains the meaning of vaccine-derived poliovirus found in London sewage, risk of long COVID after infections with Delta or Omicron variants of SARS-CoV-2, and enhancers of innate immune signaling as broad-spectrum antivirals. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler . Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Poliovirus in UK sewage ( ProMedMail and Science ) Poliovi...
Jun 26, 2022•1 hr 57 min•Ep. 913
In COVID-19 clinical update #120, Dr. Griffin discusses outcomes of SARS-CoV-2 reinfection, CDC recommendation for vaccines in young children, neurodevelopment outcomes in infants of mothers testing positive for COVID during pregnancy, efficacy of monoclonal antibodies and antivirals in hamsters, rebound phenomenon after PAXLOVID in high-risk persons, hospitalization for infection after PAXLOVID treatment, and risk of long COVID with different variants. Subscribe (free): Apple Podcasts , Google ...
Jun 25, 2022•45 min•Ep. 912
TWiV provides an update on hepatitis of unknown etiology in children, an experimental nanoparticle vaccine for Epstein-Barr virus, and minimal impact of bamlanivimab therapy on antiviral antibodies induced by vaccination. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Hepatitis of unknown etiology (MMWR) Clinical recognition of monkeypox (CDC) Epstein-Ba...
Jun 19, 2022•1 hr 55 min•Ep. 911
In COVID-19 clinical update #119, Dr. Griffin reviews tixagevimab for infection prevention, ivermectin for outpatient infection treatment, symptom rebound after PAXLOVID treatment, bamlanivimab minimally impacting immune response to vaccination, in-hospital mortality among infection patients, residual viral antigen in patients following infection, usage of Casirvimab/Imdevimab and Remdesivir in infected patients with depleted B-cells, and rheumatic symptoms following infection. Subscribe (free):...
Jun 18, 2022•47 min•Ep. 910
From ASM Microbe 2022 in Washington DC, Vincent and Michael speak with science artists Michele Banks and Jane Hartman about their work and their inspiration. Hosts: Vincent Racaniello and Michael Schmidt Guests: Michele Banks and Jane Hartman Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Trilobite Glassworks (Jane Hartman) Artologica (Michele Banks) Science art with Michele Banks ( TWiV 352 ) Timestamps by Jolene . Thanks! Intro ...
Jun 16, 2022•47 min•Ep. 909
TWiV discusses the situation with monkeypox, risk factors for SARS-CoV-2 infections of cats and dogs, and a lineage-tracing mouse model for studying papillomavirus infections. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (CDC) SARS-CoV-2 infection of cats and dogs (Emerg Inf Dis) Mouse papillomavirus identification (Vet Patrol) Mouse model for papillom...
Jun 12, 2022•1 hr 45 min•Ep. 907
In COVID-19 clinical update #118, Dr. Griffin discusses management of hair loss after infection, FDA announcements on vaccine schedule and recommendations, Moderna announcement on bivalent booster candidate, association between vaccination and infection during pregnancy, population-level implications of Israel's booster campaign, PAXLOVID outcomes during recent infection surge, efficacy and safety of Tixagevimab-cilgavimab, diagnostic accuracy of infection by canines, efficacy of colchicine in h...
Jun 11, 2022•46 min•Ep. 908
TWiV reviews human monkeypox infections, evidence for human Mimivrus infections, and incidence of long COVID in post-vaccine SARS-CoV-2 infections. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox update (ProMedMail) Multi-country monkeypox outbreak (WHO) Monkeypox new global threat (Science) Monkeypox outbreak 9 US states (MMWR) Mimivirus in...
Jun 05, 2022•1 hr 46 min•Ep. 906
In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen tes...
Jun 04, 2022•44 min•Ep. 905
Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research. Hosts: Vincent Racaniello Guests: David Baltimore , John Coffin , and Harold Varmus Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Fifty Years of Reverse Transcriptase (Cold Spring Harbor Laboratory) 50th Anniversary ...
May 29, 2022•59 min•Ep. 904
In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and b...
May 28, 2022•48 min•Ep. 903
In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox multi-country outbreak risk assessment ( pdf , ECDC) Monkeypox update (ProMedMail) Monkeypox virus genome sequences (Nextstrain) Intro music is by Ronald Jenkees Send your questions for Dr. Griffin t...
May 26, 2022•26 min
TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Monkeypox in MA (ProMed Mail) Possible monkeypox in NYC (NY Times) Occupational monkeypox, Wisconsin (Emerg Inf...
May 22, 2022•2 hr 7 min•Ep. 902
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Limited cross-variant immunity without vaccinatio...
May 21, 2022•1 hr•Ep. 901
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Richard R. Ernst Lecture Infected macrophages drives severe COVID-19 (Nature) Timestamps by Jolene . Thanks! Weekly Picks Brianne – ...
May 15, 2022•1 hr 35 min•Ep. 900
In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Effects of ...
May 14, 2022•56 min•Ep. 899
TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Herd immunity may not apply to COVID-19 (J Inf Dis) Smallpox vaccination increases skin bacte...
May 08, 2022•1 hr 38 min•Ep. 898
In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron o...
May 07, 2022•48 min•Ep. 897
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello , Dickson Despommier , and Amy Rosenfeld Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Climate change and viral zoonosis risk (Nature) COVID-19 mRNA boost effect on memory B cells (Nature) Letters read on TWiV 89...
May 01, 2022•1 hr 42 min•Ep. 896
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Seroprevalence of Infection-Induced Antibodies (CDC) Authorization for...
Apr 30, 2022•36 min•Ep. 895
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection. Hosts: Vincent Racaniello , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Severe hepatitis in children (WHO) TMPRSS2 inhibitor (Nature) Omicron less dependent on TMPRSS2 ( TWiV 879 ) Letters read on TWiV...
Apr 28, 2022•1 hr 40 min•Ep. 894
Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate. Hosts: Vincent Racaniello , Dickson Despommier , and Brianne Barker Guests: Kartik Chandran , Denise Haslwanter , and Gorka Lasso Cabrera Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode...
Apr 24, 2022•1 hr 28 min•Ep. 893
In COVID-19 clinical update #111, Dr. Griffin discusses vaccine coverage and mortality in Hong Kong, immune response to boosters in kids, hospitalization of kids, breath based diagnostic test, viral co-infections, bivalent mRNA vaccine, intramuscular Evusheld, and global long COVID. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Vaccine coverage and mortality, Hong Kong (MMWR) Kids behind on routine vaccinations (Politico) Immune ...
Apr 23, 2022•54 min•Ep. 892
Elke, Adam, and Gabor join TWiV to discuss their work on Lloviu virus, a filovirus, including recovery of infectious virus from a DNA copy of the genome and from Schreiber's bats in Hungary. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Elke Muhlberger , Adam Hume , and Gabor Kemenesi Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Elke on TWiV 200 and Threading the NEIDL Infectious Lloviu vi...
Apr 21, 2022•1 hr 25 min•Ep. 891
