Vincent and Rich discuss the SARS-CoV-2 D614G amino acid change in the spike glyprotein, duration of infectious virus shedding from patients, virus transmission among hamsters infected in the laboratory, and tackle listener email. Hosts: Vincent Racaniello and Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Austin TX key indicators for staging D614 amino acid change (Scripps) Virus shedding in hospitalized patients (medRxiv) Ha...
Jun 18, 2020•1 hr 53 min•Ep. 628
Vincent visits the National Centre for Infectious Diseases and speaks with Executive Director Leo Yee-Sin and Consultant Nancy Tee about the main hub for both clinical treatment of infectious diseases and outbreak management in Singapore. Host: Vincent Racaniello Guests: Leo Yee-Sin and Nancy Tee Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode National Centre for Infectious Diseases National Public Health Laboratory Intro music is by Ronal...
Jun 17, 2020•1 hr 31 min•Ep. 627
Daniel Griffin provides a clinical update on COVID-19, then Ralph Baric joins TWiV to discuss SARS-CoV-2 transmission, vaccines, diagnostic tests, and a new animal model from his laboratory that does not use transgenic mice. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Ralph Baric Subscribe (free): iTunes , Google Podcasts , RSS , email Links for this episode Mouse-adapted SARS-CoV-2 model (bioRxiv) SARS-...
Jun 14, 2020•2 hr 43 min•Ep. 626
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field. Hosts: Vincent Racaniello and Rich Condit Guest: Frederick A. Murphy Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Link for this episode (UTMB) Intro music is by Ronald Je...
Jun 11, 2020•1 hr 40 min•Ep. 625
Daniel Griffin provides a clinical update on COVID-19, then Sabra Klein joins us to discuss the effect of sex, gender, and age on viral infectious disease, including COVID-19. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin , Chuck Knirsch, and Sabra Klein Click arrow to play Download TWiV 624 (91 MB .mp3, 152 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this epi...
Jun 07, 2020•2 hr 3 min•Ep. 624
Peter Daszak joins TWiV to explain the work of EcoHealth Alliance in surveillance of bats in China for SARS-related coronaviruses to provide the information needed to prevent future pandemics, and why NIH recently withdrew financial support for their work. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Peter Daszak Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Bats are reservoirs of SARSr-CoV (Scienc...
Jun 04, 2020•1 hr 22 min•Ep. 624
Emmie de Wit joins TWiV to explain her work on the pathogenesis of infection with SARS-CoV-2 in rhesus macaques, including studies on remdesivir and vaccine candidate. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Emmie de Wit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Respiratory disease in macaques inoculated with SARS-CoV-2 (Nature) Clinical benefit of remdesivir in SARS-CoV-2 infected macaques (bioRxiv) Remde...
Jun 02, 2020•1 hr 8 min•Ep. 622
Daniel Griffin provides a clinical update on COVID-19, then we review an Ad5 vectored SARS-CoV-2 vaccine, reports on remdesivir and hydroxychloroquine, a drug repurposing study, why some patients infect many others, reducing viral transmission, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guests: Daniel Griffin and Chuck Knirsch Subscribe (free): iTunes , Google Podcasts , RSS , email Become a...
May 31, 2020•2 hr 15 min•Ep. 621
Jon Yewdell returns to explain studies on detection of antibodies and T cell epitopes in patients who have recovered from COVID-19. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Jon Yewdell Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode T cell targets in COVID-19 patients (Cell) SARS-CoV-2 seroconversion in humans (Nat Med) Convergent antibody responses to SARS-CoV-2 infection (bioRxiv) Timestamps by Jolene . Thanks!...
May 29, 2020•1 hr 51 min•Ep. 620
Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2. Hosts: Vincent Racaniello , Rich Condit , and Brianne Barker Guest: Raul Rabadan Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Rabadan Laboratory Understanding Coronavirus (Amazon) Topological Data Analysis for Genomics and Evolution (Amazon) Recombination and mutation shaped SARS-CoV-2 (bioRxi...
May 27, 2020•1 hr 12 min•Ep. 619
From the Nipah Virus International Conference in Singapore, Vincent speaks with meeting participants about the history of the first Nipah virus outbreak, lessons learned from Hendra virus, surveillance of bats for viruses, and the development of a vaccine. Hosts: Vincent Racaniello Guests: John Mackenzie , Jon Epstein , Eun-Chung Park , and Linfa Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions ...
May 26, 2020•58 min•Ep. 618
Daniel Griffin provides a clinical update on COVID-19, then we review TETRIS by Paterson NJ, modeling the effects of intervention in the US on cases and deaths, mixing PCR and serology data, and much more, including listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Playing tennis safely (USTA) Scie...
May 24, 2020•2 hr 32 min•Ep. 617
Vincent, Kathy and Rich discuss COVID-19 research paper overload, Moderna's mRNA vaccine Phase I results, increase of ACE2 RNA by cigarette smoke, and answer listener questions. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Drowning in COVID-19 papers (Science) CORD-19 2019 NCRC AI powered literature review SciSight Graphical guide to CoV vaccines (Nature) Moderna Phase I resul...
May 21, 2020•1 hr 43 min•Ep. 616
Vincent speaks with Peter Daszak, President of EcoHealth Alliance, a global nonprofit organization dedicated to protecting wildlife and public health from the emergence of disease. Hosts: Vincent Racaniello Guests: Peter Daszak Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . 20% off The Invisible ABCs for TWiV listeners! Use promo code: ABC20 at checkout. Send your virology questions and comments to twiv@microbe.tv...
May 19, 2020•36 min•Ep. 615
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Trip...
May 17, 2020•2 hr 47 min•Ep. 614
Vincent, Kathy and Rich explain the Jenner Institute's SARS-CoV-2 vaccine, the NIH decision to stop the Remdesivir study, and answer listener questions. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 brings out dark side of science ( Mother Jones , Wired ) Jenner Institute COVID-19 vaccine (BioSpace) Recombineering (Nucleic Acids Res) Vaccines lecture (YouTube) ChAdOx1 M...
May 14, 2020•1 hr 46 min•Ep. 613
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases. Hosts: Vincent Racaniello Guests: Richard Hatchett and Linfa Wang Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
May 12, 2020•36 min•Ep. 612
Daniel Griffin provides a weekly clinical update on COVID-19, then Michael Schmidt discusses how dentistry can be safely practiced during a pandemic, followed by answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Guests: Daniel Griffin and Michael Schmidt Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode OSHA guidance for dentistry COVID0-19 challenges for dentistry (J ...
May 10, 2020•2 hr 25 min•Ep. 611
The TWiV team summarizes serology-based tests for SARS-CoV-2, lack of effect of ACE inhibitors or ARBs on COVID-19 severity, and answers listener questions. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode FDA revises statement on antibody tests (FDA) Serology-based tests for SARS-CoV-2 (Center for Health Security) ACE inhibitors, ARBs not linked to COVID-19 severi...
May 07, 2020•1 hr 39 min•Ep. 610
Susan Weiss recalls some of her 40 years of research on coronaviruses, including mouse hepatitis virus, MERS-CoV, and now SARS-CoV-2. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Susan Weiss Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Coronaviruses by Susan Weiss (YouTube) Forty years with coronaviruses (JEM) No credible evidence that SARS-CoV-2 came from a lab (Em...
May 03, 2020•1 hr 15 min•Ep. 609
Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions. Hosts: Vincent Racaniello and Rich Condit Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pulmonary embolism in COVID-19 (Emerg Inf Dis) Patch Study Remdesivir in adults with severe COVID-19 (Lancet) ACTT remdesivir trial (NIAID) Commentary on remdesivir ...
May 01, 2020•57 min•Ep. 608
Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months. Hosts: Vincent Racaniello and Rich Condit Guest: Jeff Shaman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode COVID-19 findings and simulations (Shaman Lab) Reconciling diverse esti...
Apr 29, 2020•1 hr 8 min•Ep. 607
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Kathy Spindler Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Inactivated SARS-CoV-2 vaccine prot...
Apr 26, 2020•1 hr 54 min•Ep. 606
Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus. Hosts: Vincent Racaniello, Rich Condit , and Kathy Spindler Guests: Ralph Baric , Mark Heise , and Nat Moorman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode READDI.org CEPI DNDi Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send...
Apr 23, 2020•53 min•Ep. 605
Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Nonpathogenic enteroviruses to prevent human disease ( pdf ) OPV for COVID-19 ( pdf ) Enteroviruses to prevent human infections ( pdf ) Timestamps by Jolene . Thanks! I...
Apr 21, 2020•1 hr 4 min•Ep. 604
Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode CpG frequency in SARS-CoV-2 genome (...
Apr 19, 2020•1 hr 56 min•Ep. 603
Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine. Hosts: Vincent Racaniello, Rich Condit , Kathy Spindler , and Brianne Barker Guest: Stanley Perlman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Perlman Laboratory An Iowa Caucus of Viruses ( TWiV 538 ) Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) T cell responses ...
Apr 16, 2020•1 hr 14 min•Ep. 602
Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2. Host: Vincent Racaniello Guest: Christian Drosten Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Das Coronavirus podcast Identification of SARS-CoV in Germany (NEJM) 29 nt deletion in genome of SARS-CoV (Sci Rep) 382 nt deletion in genome of SARS-CoV-2 (bioRxiv) Virological assessment of COVID-19 patients (Nature) Timestamps by Jo...
Apr 14, 2020•56 min•Ep. 601
Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email. Hosts: Vincent Racaniello, Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode 382 nt deletion in genome of SARS-CoV-2 (bi...
Apr 12, 2020•1 hr 53 min•Ep. 600
Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6. Hosts: Vincent Racaniello, Alan Dove , Rich Condit , and Brianne Barker Guest: Doris Cully Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Ivermectin inhibits SARS-CoV-2 in cel...
Apr 08, 2020•2 hr 8 min•Ep. 599
