The TWiV team reveals the repertoire of anti-viral antibodies in newborn humans, and a complement protein that binds the adenovirus capsid and prevents release of the viral DNA. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Maternal anti-viral antibodies in newborns (Nat Med) Complement protein blocks adenovirus uncoating (Cell Host Micr) Antibodies neutralize ...
Apr 21, 2019•1 hr 48 min•Ep. 544
The TWiV team discusses Medusavirus, isolated from a hot spring in Japan, and induction of neurodegeneration by recurrent herpes simplex virus 1 infection of mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Medusavirus (J Virol) Recurrent herpes simplex virus-1 and Alzheimer's (PLoS Path) Image credit Letters read on TWiV 543...
Apr 14, 2019•1 hr 48 min•Ep. 543
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases. Host: Vincent Racaniello Guests: Terry Bowlin, Zach Aron, Grace Lui, and Islam Hussein Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Microbiotix, Inc. MBX-400 Microbiotix pipeline Microbiotix publications Timestamp...
Apr 07, 2019•1 hr 5 min•Ep. 542
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene . Thanks! Weekly Science Picks Alan- Where and when t...
Mar 31, 2019•1 hr 29 min•Ep. 541
The TWiVstars reveal the diversity of herpes simplex virus type 2 in a neonatal population, and parallel adaptation of rabbits in three countries to myxoma virus. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Alan Dove , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Diversity of HSV2 in neonates (mSphere) Adaptation of rabbits to myxoma virus (Science) Principal component analysis (YouTube) Image credi...
Mar 24, 2019•1 hr 49 min•Ep. 540
The TWiV hosts present two potentially seminal papers, on long-distance chemoattraction of a host by a chlorovirus, and replication of a nanovirus across multiple cells in a plant. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Paul Has Measles now in German (virology blog) Chloroviruses lure hosts (J Virol) Multicellular replication in plants...
Mar 17, 2019•1 hr 42 min•Ep. 539
TWiV travels to the University of Iowa to speak with Wendy Maury and Stanley Perlman about their research on Ebolavirus entry and coronavirus pathogenesis. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Wendy Maury and Stanley Perlman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TIM-1 is receptor for Ebolaviruses (Proc Natl Acad Sci) TIM-1 is receptor for Lassa virus (J Virol) SARS coronavirus causes neuronal death...
Mar 10, 2019•1 hr 2 min•Ep. 538
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Roald Dahl endorses measles vaccine Viruses encode ribosomal proteins...
Mar 03, 2019•1 hr 44 min•Ep. 537
Vincent and Alan travel to Tufts Veterinary School where they meet up with members of the Runstadler lab to talk about their work on influenza virus circulation in water birds and seals. Hosts: Vincent Racaniello and Alan Dove Guests: Jonathan Runstadler , Nichola Hill, Wendy Puryear, and Kate Sawatzki Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Cummings School of Veterinary Medicine Influenza virus in North Atlantic grey seals (Emerg ...
Feb 24, 2019•1 hr 28 min•Ep. 536
The TWiV team discuss the use of quantum dots to study uncoating of influenza virus in real time, and induction of endothelial dysfunction by flavivirus NS1 proteins in a tissue-specific manner. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Quantum dots to visualize ...
Feb 17, 2019•1 hr 36 min•Ep. 535
The TWiV crew reveal a unique portal on the calcivirus capsid formed upon receptor engagement, and the regulation of interferon responses in virus-infected cells by methylation of mRNA. Hosts: Vincent Racaniello , Dickson Despommier , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Calicivirus portal visualized (N...
Feb 10, 2019•1 hr 35 min•Ep. 534
The TWiVosophers review the Chinese plasma virome revealed by non-invasive prenatal testing, and a new filovirus genome from bats in China. Hosts: Vincent Racaniello , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Jerard Hurwitz age 90 RIP Paul has Measles now in French (virology blog) Chi...
Feb 03, 2019•1 hr 52 min•Ep. 533
The TWiVers discuss the spread of African swine fever virus and its threat to pig farming, and the zoonotic potential of peste des petits ruminants virus. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed ASV in Poland does not let go...
Jan 27, 2019•1 hr 39 min•Ep. 532
Patrick Moore returns to TWiV to discuss the discovery from the Chang-Moore laboratory of circular RNAs in cells infected with herpesviruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Patrick Moore Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 European Congress of Virology 2019 ASM Clinical Virology Symposium Intel ISEF judges needed Cancer virolog...
Jan 20, 2019•1 hr 47 min•Ep. 531
Steve Goff returns to TWiV to discuss the work of his laboratory on how retroviral genomes are silenced in infected cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Guest: Steve Goff Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! 🎼 They'll histone you when you start to transcribe, And they'll histone you just for tryin' to get by, So be careful when you uncoat your genome, 'Cause everybody must histone. Links for this epis...
Jan 13, 2019•1 hr 43 min•Ep. 530
At the University of Wisconsin-Madison, Vincent meets up with one of his virology heroes, Roland R. Rueckert, to talk about his research and his second career as a forest manager. Host: Vincent Racaniello Guest: Roland R. Rueckert Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Video of this episode (YouTube) Roland's first paper (Anesthesiol) Purification of phiX174 (Virology) Studies on viral structure (Virology) Automated gel fractionat...
Jan 08, 2019•1 hr 16 min•Ep. 529
In the first episode for 2019, the TWiV team reviews the amazing virology stories of the past year. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research TWiV World Tour 2018 t-shirt (Amazon) Cool virology from 2018 Viruses behind AD? TWiV 505 , TWiV 519 , ...
Jan 06, 2019•2 hr 8 min•Ep. 528
The TWiV team summarizes the discovery of Sin Nombre virus, and presents evidence that neurotropic flaviviruses can cause intestinal dysmotility syndromes after systemic infection of mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Outbreak ( exh...
Dec 30, 2018•1 hr 27 min•Ep. 527
The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Please take the TWiV listener survey ASV 2019 Satellite Symposia Crowdfunding for EV-D68 research Aaron Klug , 1926-2018 (Nature) Prions in sCJD eyes (mBio) Evolutio...
Dec 23, 2018•1 hr 44 min•Ep. 526
Vaccine scientist, pediatrician, and autism dad Peter Hotez talks about his new book, Vaccines Did Not Cause Rachel's Autism . Host: Vincent Racaniello Guest: Peter Hotez Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Peter Hotez at Baylor College of Medicine Peter Hotez on Twitter Vaccines Did Not Cause Rachel's Autism (Amazon) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your virology questions and comments to ...
Dec 19, 2018•19 min
Michelle Flenniken joins TWiV to talk about honeybees and the work of her laboratory on honeybee viruses. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Michelle Flenniken Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MSU Pollinator Health Center Honeybee antiviral defenses (Sci Rep) The buzz about honeybee viruses (PLoS Path) Recently identified bee viruses (Curr Op Insect Sci) Videos on...
Dec 16, 2018•1 hr 39 min•Ep. 525
Raul Andino joins Vincent and Amy to talk about the finding that a cricket paralysis virus protein restricts RNA-based immunity in insects by regulating the activity and stability of the Argonaute protein. Hosts: Vincent Racaniello and Amy Rosenfeld Guest: Raul Andino Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode TWiV 138: RISCy business with Raul Andino TWiV 33: Live in Philly Viral protein restricts insect immunity (Cell Host Micr) Tim...
Dec 12, 2018•1 hr 16 min•Ep. 524
At the University of Zürich, Vincent speaks with virologists Cornel Fraefel, Urs Greber, and Silke Stertz about their careers and their work on AAV2, adenovirus entry, and influenza virus. Hosts: Vincent Racaniello Guests: Cornel Fraefel , Urs Greber , and Silke Stertz Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode AAV2 and HSV1 co-infections (J Virol) Movies of HeLa Fucci cells (J Virol) Cathepsin W and influenza virus entry (mBio) Plaqu...
Dec 09, 2018•1 hr 17 min•Ep. 523
The TWiVsters review isolation of a naturally occurring DNA virus from fruit flies, and the cell-type specific function of a small transmembrane protein encoded in an open reading frame upstream of the enterovirus polyprotein. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Genome-edited babies (Nature) Second CRISPR pregnancy ? (MIT Tech Rev) Naturally occur...
Dec 02, 2018•1 hr 47 min•Ep. 522
Team TWiV cover the discovery of another giant virus from 30,000 year old Siberian permafrost, and how viral aggregation accelerates the production of new infectious viruses and increases fitness, demonstrating an Allee effect. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School ...
Nov 25, 2018•1 hr 54 min•Ep. 521
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode PhD and postdoctoral programs at Dept of Microbiology, Icahn School of Medicine ...
Nov 18, 2018•1 hr 56 min•Ep. 520
The TWiVomers review a potential role for herpes simplex virus type 1 as a cause of Alzheimer's Disease, including the finding that amyloid-beta acts as an antiviral by enveloping virus particles. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Virology Comics on sale (Amazon) Clinical Trial: antiviral for AD HHV6 and HHV7 transcripts in AD brain ...
Nov 11, 2018•1 hr 36 min•Ep. 519
Vincent travels to Penn State College of Medicine in Hershey, PA to speak with Nick and Leslie about their careers and their work on human cytomegalovirus and retroviruses. Host: Vincent Racaniello Guests: Nicholas Buchkovich and Leslie Parent Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode HIV-1 gag membrane binding domain (J Virol) Nuclear experience for gag (PNAS) Gag in nucleolus (J Virol) YB-1 for retrovirus assembly (J Virol) HCMV co...
Nov 04, 2018•1 hr 26 min•Ep. 518
Brianne and Vincent tackle two studies that utilize infectious viruses to examine zoonotic potential of Bombali virus, a new ebolavirus from an insectivorous species in Sierra Leone, and a human mumps-like virus from an African flying fox in DRC. Hosts: Vincent Racaniello and Brianne Barker Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regional Meetings It's not SARS 2.0 ( ...
Oct 28, 2018•1 hr 19 min•Ep. 517
Lonya and Jeremy take the TWiV team beTWIXt primate immunodeficiency virus proteins Vpx and Vpr and how they counteract transcriptional repression of proviruses by the HUSH complex. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guests: Leonid Yorkovetskiy and Jeremy Luban Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Pan American Society for Clinical Virology San Diego and Houston Regi...
Oct 21, 2018•2 hr 1 min•Ep. 516
