Jens returns to present a brief history of bioweapons, with a focus on the program in the Soviet Union, the largest ever undertaken, and his experience working in the decommissioned Soviet bioweapons laboratory known as Vector. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Guest: Jens Kuhn Become a patron of TWiV! Links for this episode Russia's Bioweapons Labs (Nature) Medical Aspects of Biological Warfare The Soviet Biological Weapons Program by Leitenberg, ...
Aug 26, 2018•2 hr 8 min•Ep. 508
The TWiV team discuss the biology of Ebola viruses, and how localization of the membrane proteins of vaccinia virus drive function: the fusion machinery sits at the tips of virions, and binding proteins are at the sides. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Outbreak at the Smithsonian Outbreak (TWiV 501) Latest Ebola virus outbrea...
Aug 19, 2018•1 hr 59 min•Ep. 507
David Tuller returns to provide an update of his investigative work to expose the methodological and ethical problems with the PACE trial for ME/CFS. Host: Vincent Racaniello Guest: David Tuller Become a patron of TWiV! Links for this episode Article by Lubet and Tuller (STAT) David's Australian trip (virology blog) Sir Simon scores own goal (virology blog) Lightning process (virology blog) Letter to Parliament (virology blog) Crowdfunding is not conflict of interest (virology blog) Open letter ...
Aug 17, 2018•1 hr 9 min
The TWiVniks explain how the three-dimensional structure of the giant Cafeteria roenbergensis virus suggests a new mode of assembly, and the apparent elimination of dengue fever in an Australian city by release of mosquitoes harboring Wolbachia . Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference New DRC Ebola strains distinct (Outbreak News) Immunizations for new DRC Ebola ...
Aug 12, 2018•1 hr 37 min•Ep. 506
The TWiV hosts review persistence of Ebola virus after the end of the Liberian outbreak, and the potential role of two herpesviruses in the pathogenesis of Alzheimer's disease. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , Kathy Spindler and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference Trump picks science advisor (Scientist) Hendra vaccine: no effect on horses racing (Aust Vet J) Persistence of Ebola vir...
Aug 05, 2018•2 hr 2 min•Ep. 505
The TWiVerinos discuss Nipah virus and the recent outbreak in India, and the first cast of polio in Papua New Guinea in 18 years. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Brianne Barker Become a patron of TWiV! Links for this episode Support Viruses & Cells Gordon Conference TWiV 501: Outbreak Nipah virus infection (JCM) Anatomy of an outbreak (The Hindu) Do we need to worry about Nipah virus? (Tufts Now) Nipah virus infection of bats (EID) Papua New Gui...
Jul 29, 2018•1 hr 51 min•Ep. 504
Vincent, Rich and Kathy travel to ASV 2018 at the University of Maryland to speak with Svetlana Folimonova and Anne Simon about their work on viruses that infect plants. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Svetlana Folimonova and Anne Simon Become a patron of TWiV! Links for this episode Simon laboratory Folimonova laboratory CTV superinfection exclusion (Virol) 3'-CITEs in viral genome (J Virol) Video of this episode (YouTube) Intro music is by Ronald Jenkees . ...
Jul 22, 2018•1 hr 2 min•Ep. 503
The TWiV team travels to Texas A&M University, home of the Center for Phage Technology, where they speak with Ry Young and Jason Gill about their work on viruses that infect bacteria. Hosts: Vincent Racaniello , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jason Gill and Ry Young Become a patron of TWiV! Links for this episode Center for Phage Technology at TAMU Personalized phage therapy (PNAS) Phage for biolipid extraction (Sci Rep) Viral protein antibiotic (Nat Micro) Acinetobacte...
Jul 13, 2018•1 hr 32 min•Ep. 502
Vincent visits the Smithsonian Institution and speaks with Sabrina Sholts, Jon Epstein, and Ed Niles about the exhibit Outbreak: Epidemics in a Connected World. Host: Vincent Racaniello Guests: Sabrina Sholts , Jon Epstein , and Ed Niles Become a patron of TWiV! Links for this episode Sabrina Sholts Jonathan Epstein EcoHealth Alliance Outbreak at the Smithsonian ASM partners with Smithsonian (bLog Phase) Vincent as museum object (AMNH) Video of this episode (YouTube) Intro music is by Ronald Jen...
Jul 08, 2018•1 hr 30 min•Ep. 501
The entire TWiV team visits The University of Texas in Austin to record episode #500 with guests Jinny Suh, Jason McClellan, and Jon Huibregtse. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guests: Jinny Suh , Jason McClellan , and Jon Huibregtse Become a patron of TWiV! Links for this episode A big list of science podcasts Immunize Texas McClellan Lab Huibregtse Lab John Ring LaMontagne Center for Infectious Disease Video of this episode (YouTube...
Jul 01, 2018•2 hr•Ep. 500
Vincent and Alan travel to the Canadian Society for Virology meeting in Halifax, Nova Scotia to speak with Nathalie and Craig about their vision for the society, and with Kate and Ryan about their careers and their research. Hosts: Vincent Racaniello and Alan Dove Guests: Nathalie Grandvaux , Craig McCormick , Kate O'Brien , and Ryan Noyce Become a patron of TWiV! Links for this episode TWiV 2018 World Tour CSV 2018 To wheeze or not to wheeze (Lancet Respir Med) Synthetic infectious horsepox (PL...
Jun 24, 2018•58 min•Ep. 499
Vincent, Kathy and Rich travel to ASM Microbe 2018 in Atlanta where they speak with Stacy Horner and Ken Stapleford about their careers and their research. Hosts: Vincent Racaniello , Rich Condit , and Kathy Spindler Guests: Stacy Horner and Ken Stapleford Become a patron of TWiV! Links for this episode TWiV 2018 World Tour RNA modifications go viral (Plos Path) N6-methyladenosine in flavivirus genomes (Cell Host Micr) Chikungunya virus evolution (Cell Host Micr) Intro music is by Ronald Jenkees...
Jun 17, 2018•1 hr 8 min•Ep. 498
At Europic 2018, a meeting on picornaviruses in the Netherlands, Vincent speaks with Sasha Gorbalenya, Jim Hogle, Ann Palmenberg and Frank van Kuppeveld about their careers and their research. Hosts: Vincent Racaniello and Rich Condit Guests: Sasha Gorbalenya , Jim Hogle , Ann Palmenberg , and Frank van Kuppeveld Become a patron of TWiV! Intro music is by Ronald Jenkees . Send your virology questions and comments to twiv@microbe.tv...
Jun 10, 2018•1 hr•Ep. 497
Vincent and Rich recorded this episode at Vaccines in the 21st Century, a meeting held at the University of California, Irvine, where they spoke with Stacy Schultz-Cherry, Douglas Diekema, and Andrew Noymer about vaccine facts and fiction. Hosts: Vincent Racaniello and Rich Condit Guests: Stacey Schultz-Cherry , Douglas Diekema , and Andrew Noymer Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Me...
Jun 03, 2018•1 hr 16 min•Ep. 496
The TWiVerati follow up on the Ebola virus outbreak, virulence of Ebola-Makona, and reveal how a parasitoid is revealed to hyperparasitoids, and binding of influenza virus to a calcium ion channel to mediate influenza virus entry. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium Tracing Ebola vir...
May 27, 2018•1 hr 51 min•Ep. 495
Vincent, Kathy, and Alan review the ongoing outbreak of Ebola virus in the Democratic Republic of the Congo, and the finding that mutations identified in the 2015 West African epidemic do not alter pathogenesis in animals. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine International dsRNA Virus Symposium New Ebola virus outbreak ...
May 20, 2018•1 hr 13 min•Ep. 494
The TWiVerati discuss the FDA Advisory Committee deliberation on the anti-poxvirus drug tecovirimat, and immune cells in gut-associated lymphoid tissue as the major target during acute murine norovirus infection. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine FDA meeting materials for tecovirima...
May 13, 2018•1 hr 40 min•Ep. 493
The Masters of the TWiXome review the development of sensitive, portable, and field-based viral diagnostics using the CRISPR-Cas system. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Norovirus outbreaks from nori (Emerging Inf Dis) SHERLOCK (Science) HUDSON (Science) DETECTR (Science) Letters r...
May 06, 2018•1 hr 49 min•Ep. 492
The TWiVome deconstructs the evolutionary history of RNA viruses, and immune promortion of murine norovirus pathogenesis by replication in intestinal tuft cells. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Evolutionary history of RNA viruses (Nature) The amphioxus song Norovirus tropism for t...
Apr 29, 2018•1 hr 37 min•Ep. 491
From the TWiV team, human cowpox infection possibly acquired from a pet cat, and a new giant mimivirus of green algae with genes encoding enzymes of fermentation. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV Job Site revamped Support Viruses & Cells Gordon Conference Faculty positions at Icahn School of Medicine Dick Courtney obit Human cowpox infection (NEJM) Mimivirus encodes fermentat...
Apr 22, 2018•1 hr 37 min•Ep. 490
Vincent visits Sandra Urdaneta-Hartmann at Drexel University College of Medicine in Philadelphia to talk about the development of the mobile video game 'CD4 Hunter'. Host: Vincent Racaniello Guest: Sandra Urdaneta-Hartmann Become a patron of TWiV! Links for this episode CD4 Hunter iOS Android Sandra on Twitter Carla Brown on Twitter Inactivation of HIV in breast milk (Retrovirology) Nipple shield to inactivate HIV (Int J Pharm) Intro music is by Ronald Jenkees . Send your virology questions and ...
Apr 15, 2018•1 hr 6 min•Ep. 489
The TWiV team reveals that recent mumps virus outbreaks in the US are due to waning vaccine efficacy, and an intranasally delivered small interfering RNA that controls West Nile infection in the brain. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode ASM Microbe 2018 ASV 2018 Microbiology Student Symposium at UC Berkeley Support Viruses & Cells Gordon Conference Waning mumps vaccine in US (Sci Trans Med) siRNA con...
Apr 08, 2018•1 hr 42 min•Ep. 488
At the Medical College of Wisconsin, Vincent talks with current and former members of the Department of Microbiology and Immunology about their work and their careers. Host: Vincent Racaniello Guests: Dominique Carter , Sid Grossberg , John Kirby , Scott Terhune , and Vera Terakanova Become a patron of TWiV! Intro music by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv...
Apr 01, 2018•1 hr 3 min•Ep. 487
Sean Whelan returns to TWiV to speak with Vincent about using haploid cell lines to identify genes encoding cell receptors for viruses, including Ebolavirus, Lassa virus, and more. Host: Vincent Racaniello Guest: Sean Whelan Become a patron of TWiV! Links for this episode Ebola virus entry requires the cholesterol transporter Niemann-Pick C1 (Nature) Lassa virus entry requires a trigger-induced receptor switch (Science) Infectious Entry Pathway Mediated by the Human ERV K Envelope Protein (J Vir...
Mar 25, 2018•1 hr 3 min•Ep. 486
The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Insulin-like peptides in Iridovirus genomes (PNAS) Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr) Carla Saleh on insect antiviral imm...
Mar 18, 2018•1 hr 26 min•Ep. 485
The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Tailed giant Tupanvirus (Nat Commun) Soda Lakes (Wikipedia) Dampened STING in bats (Cell Host Microbe) Image credit Letters read on TWiV 484 Weekly Science Picks Kathy - How to read a ...
Mar 11, 2018•1 hr 27 min•Ep. 484
Vincent and the Virals review undermining of antiviral effectiveness by genital inflammation, and heterogeneity of influenza virus infection in single cells. Hosts: Vincent Racaniello , Alan Dove , and Kathy Spindler Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Genital inflammation and antiviral effectiveness (Nat Med) Single cell infection heterogeneity (eLife) Single-cell poliovirus infection (Virology) Image credit Letters read on TWiV 483 Weekly Scienc...
Mar 04, 2018•1 hr 41 min•Ep. 483
The TWiV Masters discuss serologic evidence of Ebolavirus infection in a population with no outbreaks, and the set of endogenous viral elements in the mosquito genome. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Become a patron of TWiV! Links for this episode USA Science and Engineering Festival Ebolavirus infection without an outbreak (J Inf Dis) A. aegypti EVEome (Curr Biol) One Loop to Rule Them All (Trends Biochem Sci) Image credit Letters...
Feb 25, 2018•1 hr 38 min•Ep. 482
The TWiVodrome considers the intestinal tract as an alternative infection route for MERS coronavirus, and how reduced accumulation of defective viral RNAs might lead to severe influenza. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Become a patron of TWiV! Links for this episode HaHa influenza virus (mBio) MERS coronavirus intestinal transmission (Sci Adv) Simulated gastric and intestinal fluids Stomacher Defective genomes and severe influenza (PL...
Feb 18, 2018•1 hr 42 min•Ep. 481
Scott Hensley joins the TWiVites to review the current influenza season and presence of the virus in exhaled breath of symptomatic cases. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Kathy Spindler Guest: Scott Hensley Become a patron of TWiV! Links for this episode Weekly influenza surveillance (CDC) Influenza vaccination status (CDC) H3N2 glycosylation site and eggs (PNAS) Influenza virus in exhaled breath (PNAS) Geometric Defects and Icosahedral Viruses (Viru...
Feb 11, 2018•1 hr 54 min•Ep. 480
