TWiV #106 - Making viral DNA II
Vincent, Dickson, and Rich continue Virology 101 with a second installment of their discussion of how viruses with DNA genomes replicate their genetic information.
Nov 06, 2010•1 hr 35 min
This Week in Virology
TWiV is a weekly netcast about viruses - the kind that make you sick. Brought to you by four university professors and a science writer.
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Episodes
TWiV #105 - Finches score again
Vincent, Dickson, Alan, and Rich review eradication of rinderpest, endogenous hepatitis B virus in the zebra finch genome, and identification of the cell receptor for an extinct retrovirus.
Oct 31, 2010•1 hr 32 min
TWiV #104 - The colony-collapse blues
The entire TWiV family reviews the latest ideas about colony collapse disorder of honeybees, and resurgence of monkeypox in Africa.
Oct 25, 2010•1 hr 37 min
TWiV #103 - Shots with LJ Tan
Vincent and Alan discuss influenza vaccines with LJ Tan of the American Medical Association.
Oct 17, 2010•1 hr 17 min
TWiV #102 - Catch me if you can in Munich
A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.
Oct 11, 2010•1 hr 35 min
TWiV #101 - Sizing up adenovirus
Vincent, Alan, Rich, Dickson, and Hamish review the three-dimensional structure of adenovirus, and the role of adenovirus type 36 in obesity.
Oct 03, 2010•1 hr 16 min
TWiV #100 - TWiV catches a big fish
Vincent, Alan, and Rich celebrate the 100th episode of TWiV by talking about viruses with Nobel Laureate David Baltimore.
Sep 26, 2010•1 hr 34 min
TWiV #99 - ICAAC Boston 2010
On episode #99 of the podcast This Week in Virology , Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), speaking with exhibitors and visitors, including Professors Derek Smith , Michael Schmidt , Frederick Hayden , and Myra McClure . Host links Vincent Racaniello Links for this episode: 50th ICAAC ICAAC daily press conference videos (including Prof. Myra McClure ) Antigenic cartography Antimicrobial properties of copper...
Sep 20, 2010•1 hr 2 min
TWiV #98 - Murine musings, electric shirts, and rabid pathologists
On episode #98 of the podcast This Week in Virology , Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.
Sep 13, 2010•1 hr 21 min
TWiV #97 - California virology
On episode #97 of the podcast This Week in Virology , Vincent visited Peter Sarnow and Bert Semler during a trip to California, and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.
Sep 06, 2010•1 hr 32 min
TWiV #96 - Making viral DNA
On episode #96 of the podcast This Week in Virology , Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.
Aug 22, 2010•1 hr 30 min
TWiV #95 - Does a virus shift in the woods?
On episode #95 of the podcast This Week in Virology , Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota. Host links Vincent Racaniello , Dickson Despommier , Alan Dove , and Rich Condit Links for this episode: WHO declares end of influenza H1N1 pandemic CDC's FluView WHO global monitoring of influenza Locally acquired dengue in Key West, Florida ( MMWR ) CDC page...
Aug 15, 2010•1 hr 35 min
TWiV #94 - XMRV with Dr. Ila Singh
On episode #94 of the podcast This Week in Virology , Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome. Host links Vincent Racaniello , Alan Dove , Rich Condit , and Ila Singh Links for this episode: CFIDS Association of America Discovery of XMRV ( PLoS Pathogens ) Detection of XMRV in CFS patients ( Science ) Presence of XMRV in malignant prostate ( PNAS ) Inhibi...
Aug 08, 2010•1 hr 18 min
TWiV #93 - Our infectious inbox
On episode #93 of the podcast This Week in Virology , Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan. Host links Vincent Racaniello , Alan Dove , and Rich Condit Links for this episode: Biomedical Advanced Research and Development Authority ( BARDA ) SIGA responds to BARDA request for smallpox antiviral BARDA contract for filo...
Aug 01, 2010•1 hr 45 min
TWiV #92 - Live at ASV in Bozeman
Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets. Host links Vincent Racaniello , Rich Condit , Karla Kirkegaard , and Marilyn Roosinck Links for this episode: Lifestyles of plant viruses Using pyrosequencing to understand virus ecology A virus in a fungus in a plant Trans-domin...
Jul 25, 2010•58 min
TWiV #91 - You're an ERVous wreck
On episode #91 of the podcast This Week in Virology , Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals. Host links Vincent Racaniello , Dickson Despommier , Alan Dove , Rich Condit , and Welkin Johnson Links for this episode: Welkin blogs at Small Things Considered Constructing primate phylogenies from ancient retrovirus sequences ( PNAS ) Filoviruses are ancient ...
Jul 18, 2010•1 hr 29 min
TWiV #90 - Guano happens
On episode #90 of the podcast This Week in Virology , Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh. Host links Vincent Racaniello , Alan Dove , Rich Condit , and Eric F. Donaldson Links for this episode: Vaccinia virus infection after sexual contact with vaccinee Smallpox vaccination overview Smallpox v...
Jul 11, 2010•1 hr 29 min
TWiV #89 - Where do viruses vacation?
On episode #89 of the podcast This Week in Virology , Vincent and Alan review recent findings on the association of the retrovirus XMRV with ME/CFS, reassortment of 2009 pandemic H1N1 influenza virus in swine, and where influenza viruses travel in the off-season. Host links Vincent Racaniello and Alan Dove Links for this episode: Conflicting XMRV papers on hold Leak of PNAS paper CDC study on XMRV in CFS patients ( Retrovirology ) and Science update Where influenza viruses travel in the off seas...
Jul 04, 2010•1 hr 18 min
TWiV #88 - A bug fix, an AIDS treatment, and an undead retrovirus
On episode #88 of the podcast This Week in Virology , Vincent, Alan, and Marc discuss using a virus for beetle control, RNA based gene therapy for AIDS, and reconstitution of a endogenous human retrovirus. Host links Vincent Racaniello , Alan Dove , and Marc Pelletier Links for this episode: Controlling the palm rhinoceros beetle with a virus The virologist in the Hawaiian shirt Information on Orcytes rhinocerus nudivirus ( one , two , three ) RNA based gene therapy for AIDS Reconstitution of an...
Jun 27, 2010•1 hr 31 min
TWiV #87 - A PHIREside chat with Professor Graham Hatfull
On episode #87 of the podcast This Week in Virology , Vincent, Alan, and Rich hear from Professor Graham Hatfull how students in the Phage Hunters Integrating Research and Education (PHIRE) program learn about scientific inquiry by doing research on bacteriophages. Host links Vincent Racaniello , Rich Condit , Alan Dove , and Graham Hatfull Links for this episode: Bacteriophage Research: Gateway to learning science Mycobacterium smegmatis at NCBI Prof. Steve Cresawn Scientist infected with compu...
Jun 20, 2010•1 hr 26 min
TWiV #86 - Dark matter with Dr. Eric Delwart
On episode #86 of the podcast This Week in Virology , Vincent and Rich travel to the Blood Systems Research Institute in San Francisco to speak with Eric Delwart about his work on virus discovery. Host links Vincent Racaniello , Rich Condit , and Eric Delwart Links for this episode: List of Dr. Delwart's open-access journal articles ( pdf ) - to find each one, type PMID # into PubMed CDC says don't give rotavirus vaccines to infants with SCID The Brighton Collaboration Product sheet for RotaTeq ...
Jun 13, 2010•1 hr 21 min
TWiV #85 - Hepatitis C virus with Professor Michael Gale
On episode #85 of the podcast This Week in Virology , Vincent and Michael Gale discuss the origin, pathogenesis, prevention, of hepatitis C virus, and how it evades innate immune responses. Host links Vincent Racaniello and Michael Gale Links for this episode: The Gale Laboratory at the University of Washington Incredible view from the Gale laboratory ( jpg ) Evasion and disruption of innate immune signalling by hepatitis C and West Nile viruses ( review ) New potent HCV inhibitor HCV virion and...
Jun 06, 2010•56 min
TWiV #84 - Gators go viral
On episode #84 of the podcast This Week in Virology , Vincent and Rich spoke with Dave Bloom and Grant McFadden about their work on herpesviruses and poxviruses in this episode recorded before an audience at the University of Florida, Gainesville - home of the Gators . Host links Vincent Racaniello , Rich Condit , Dave Bloom , and Grant McFadden Links for this episode: Epigenetic modulation of herpes simplex virus gene expression (thanks, Matthew!) The Red Queen and Tierra virtual environment: a...
May 31, 2010•1 hr 39 min
TWiV #83 - An hour with Dr. Kiki
On episode #83 of the podcast This Week in Virology , Vincent, Alan, Rich, and special guest Dr. Kirsten Sanford talk about her career in science media, then consider whether smallpox eradication led to the AIDS pandemic, high fidelity RNA synthesis, and a new Ebola virus vaccine. Host links Vincent Racaniello , Alan Dove , Rich Condit , and Kirsten Sanford Links for this episode: Does smallpox vaccine protect against HIV? (thanks, Srinivas; Washington Post and BMC Immunology ) Was the deltaCRR5...
May 23, 2010•1 hr 31 min
TWiV #82 - Immunology in silico
On episode #82 of the podcast This Week in Virology , Vincent and Rich talk about how thymic selection of T cells might lead to better control of HIV-1 infection, and a mouse model for severe antibody-induced dengue virus disease. Host links Vincent Racaniello and Rich Condit Links for this episode: Effect of thymic selection of T-cells on control of AIDS Mouse model of antibody-induced severe dengue virus disease Natural antibody protects against viral infection Kary Mullis idea for fighting in...
May 16, 2010•1 hr 22 min
TWiV #81 - Be a virus, see the world
On episode #81 of the podcast This Week in Virology , Vincent and Rich answer listener questions on viruses and gluten allergy, RNA silencing, influenza virus, herpes simplex virus, HIV/AIDS, chronic fatigue syndrome, manicure salons, and the koala tea of Marseilles. Host links Vincent Racaniello and Rich Condit Links for this episode: Virus infections and gluten intolerance on TWiS (thanks Jesper!) Viral small RNAs in PLoS Pathogens (thanks Jason!) Canadian Summit Awards (thanks Jim!) Experimen...
May 09, 2010•1 hr 35 min
TWiV #80 - How much X could a woodchuck chuck?
On episode #80 of the podcast This Week in Virology , Vincent, Alan, and Rich speak with Michael Bouchard about hepatitis B virus discovery, replication, and pathogenesis. Host links Vincent Racaniello , Alan Dove , Rich Condit , and Michael Bouchard Links for this episode: The enigmatic X gene of hepatitis B virus Tableau public (thanks Ricardo!) Molecular phylogeny of Archaea from soil (thanks Etienne!) Habitats of Archaea (thanks Cedric!) Timer remote controls (thanks Bill!) Letters read in e...
May 03, 2010•1 hr 20 min
TWiV #79 - Red hot chili viruses
On episode #79 of the podcast This Week in Virology , Vincent and Alan converse about making published science accessible to everyone, global eradication of poliomyelitis, and whether a plant virus can cause disease in humans. Host links Vincent Racaniello and Alan Dove Links for this episode: Making published science accessible to everyone ( Nature News ) Federal Research Public Access Act Is disease eradication a waste of money ? Do we have an ethical obligation to eradicate polio? Signs of pr...
Apr 25, 2010•1 hr 11 min
TWiV #78 - Darwin gets weird
On episode #78 of the podcast This Week in Virology , Vincent, Alan, Dickson, and Rich talk about treating arthritis with a tanapox virus protein, Darwinian evolution of prions in cell culture, and the connection between cold weather fronts and outbreaks of avian H5N1 influenza in Europe. Host links Vincent Racaniello , Alan Dove , Dickson Despommier , and Rich Condit Links for this episode: Treating arthritis with a tanapox virus protein that antagonizes TNF ( press release and research article...
Apr 18, 2010•1 hr 13 min
TWiV #77 - Non-nuclear proliferation
On episode #77 of the podcast This Week in Virology , Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, and whether seasonal influenza immunization increases the risk of infection with the 2009 H1N1 pandemic virus. Host links Vincent Racaniello , Alan Dove , and Rich Condit Links for this episode: Contamination of Rotarix vaccine with porcine circovirus 1 DNA Do you want to know what is in your vaccines...
Apr 11, 2010•1 hr 23 min
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