In his weekly clinical update, Dr. Griffin discusses China's health authorities fighting surge in cases of Mpox unknown origin, analysis of seasonal variation of antibiotic prescribing for respiratory tract diagnoses in primary care practices, prevalence and associated outcomes of co-infection between SARS-CoV-2 and influenza, comparison of bivalent and monovalent mRNA vaccine boosters, optimal duration of systemic corticosteroids in COVID-19 treatment, acute blood biomarker profiles predict cog...
Sep 09, 2023•29 min•Ep. 1042
Vincent speaks with Raul and Kostya about the development of novel oral polio vaccine from the Sabin type 2 strain, its deployment in over 600 million children, and whether it can lead to eradication of poliomyelitis. Host: Vincent Racaniello Guests: Raul Andino and Kostya Chumakov Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/...
Sep 03, 2023•1 hr 29 min•Ep. 1041
In his weekly clinical update, Dr. Griffin discusses the public health significance of finding autochthonous melioidosis cases in the continental United States, human neural larva migrans caused by Ophidascaris robertsi ascarid, Project nextgen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics, excess all-cause mortality in China after ending the zero COVID policy, international pediatric COVID-19 severity over the course of the pandemic, differences in SARS-Co...
Sep 02, 2023•49 min•Ep. 1040
TWiV describes how a viral capsid protein activates a bacterial innate immune system that interferes with protein synthesis, and human-associated redondoviruses that infect the commensal protozoan Entamoeba gingivalis . Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Jolene Ramsey Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assist...
Aug 27, 2023•2 hr 1 min•Ep. 1039
In his weekly clinical update, Dr. Griffin discusses modeling poliovirus transmission and responses in New York State, FDA approves first vaccine for pregnant individuals to prevent RSV in infants, prevention and control of seasonal influenza with vaccines: recommendations of the Advisory Committee on Immunization Practices, Nirmatrelvir resistance – de novo E166V/L50V mutations in an immunocompromised patient treated with prolonged nirmatrelvir/ritonavir monotherapy leading to clinical and viro...
Aug 26, 2023•27 min•Ep. 1038
TWiV reviews evidence that symptomatic adenovirus infection leads to thrombocytopenia, thrombosis, and production of anti-platelet factor 4 antibodies similar to the rare disorder seen after immunization with adenoviral vectored COVID-19 vaccines, and a monoclonal antibody isolated from a SARS survivor, following vaccination with a SARS-CoV-2 spike mRNA vaccine, that neutralizes a broad collection of ACE2-binding sarbecoviruses. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kath...
Aug 20, 2023•1 hr 56 min•Ep. 1037
In his weekly clinical update, Dr. Griffin discusses Florida local transmission of dengue cases reported in Broward and Miami-Dade counties, infants admitted to US intensive care units for RSV infection during the 2022 seasonal peak, long-term risk of death and readmission after hospital admission with COVID-19 among older adults, safety profile and clinical and virological outcomes of Nirmatrelvir-Ritonavir treatment in patients with advanced chronic kidney disease and COVID-19, Fluvoxamine vs ...
Aug 19, 2023•40 min•Ep. 1036
TWiV dissects a study of COVID-19 vaccination which shows that the timing of initial rollout affects disease outcomes more substantially than final coverage or degree of socioeconomic disparity, and discovery of a novel cellular defense comprising a nuclease that is activated by poxvirus infection and cleaves a specific tRNA molecule to inhibit protein synthesis. Hosts: Vincent Racaniello , Rich Condit , Alan Dove , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , em...
Aug 13, 2023•2 hr 1 min•Ep. 1035
In his weekly clinical update, Dr. Griffin discusses the immunogenicity, safety, and preliminary efficacy evaluation of OVX836, a nucleoprotein-based universal influenza A vaccine candidate, association between nose picking and SARS-CoV-2 incidence, a cohort study in hospital health care workers; effect of COVID-19 vaccination and booster on maternal-fetal outcomes, dynamics of inflammatory responses after SARS-CoV-2 infection by vaccination status in the USA, does monoclonal antibody treatment ...
Aug 12, 2023•37 min•Ep. 1034
Vincent speaks with Desirée Townsend about how she felt used and indoctrinated by the anti-vaxx movement, the science surrounding her autoimmune disorder, and why she is no longer the "flu shot cheerleader," but a cheerleader for flu shots. Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode Desiree on Instagram and LinkedIn 'Flu-shot cheerleader' speaks out (NBC) 'Flu-shot cheerleader' back with a warning (NBC) Timestamps by Jolene . ...
Aug 11, 2023•45 min
TWiV notes the passing of Harald zur Hausen, dengue breaking records in the Americas, inhibition of SARS-CoV-2 infection and inflammation by modulation of type I IFN, and an armed nanobody that protects mice against influenza A and B disease. Hosts: Vincent Racaniello , Kathy Spindler , and Angela Mingarelli Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Position in Rosenfeld L...
Aug 06, 2023•1 hr 45 min•Ep. 1033
In his weekly clinical update, Dr. Griffin discusses predicting COVID-19 incidence using wastewater surveillance data, use of wastewater metrics to track COVID-19 in the US, wastewater-based epidemiology predicts COVID-19-induced weekly new hospital admissions in over 150 USA counties, association between duration of SARS-CoV-2 positivity and long COVID, rapid direct detection of SARS-CoV-2 aerosols in exhaled breath at the point of care, effectiveness of oral Nirmatrelvir/Ritonavir vs. intraven...
Aug 05, 2023•35 min•Ep. 1032
TWiV notes the passing of virologist Michael BA Oldstone, a study to assess the performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 infection, and the presence of antibodies to type I interferons in ~40% of patients with West Nile virus encephalitis. Hosts: Vincent Racaniello , Rich Condit , and Alan Dove Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Caf...
Jul 30, 2023•2 hr 4 min•Ep. 1031
In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral r...
Jul 29, 2023•33 min•Ep. 1030
David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID. Host: Vincent Racaniello Guest: David Tuller Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server David Tuller at virology blog CFS, a long tangled tale (virology blog) Request for Correction of Prevalence Rates Cited i...
Jul 27, 2023•1 hr 1 min•Ep. 1029
TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses. Hosts: Vincent Racaniello , Dickson Despommier , Alan Dove , Kathy Spindler , and Brianne Barker Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Bec...
Jul 23, 2023•1 hr 55 min•Ep. 1028
In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA i...
Jul 22, 2023•38 min•Ep. 1027
Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience. Hosts: Vincent Racaniello , Dickson Despommier , Rich Condit , Kathy Spindler , and Brianne Barker Guest: Dan Wilson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Joe Rogan's worst misinformation yet, with RFK Jr. (YouTube) Every first vaccine has been tested in placebo-controll...
Jul 16, 2023•1 hr 59 min•Ep. 1026
In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exa...
Jul 15, 2023•35 min•Ep. 1025
Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine. Host: Vincent Racaniello Guest: Kostya Chumakov Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Mikhail Chumakov (Wikipedia) MAPREC (WHO pdf ) Kostya Ch...
Jul 14, 2023•2 hr•Ep. 1024
Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft. Host: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Katherine Wu Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server All Katherine's articles at The Atl...
Jul 09, 2023•1 hr 34 min•Ep. 1023
In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic ...
Jul 08, 2023•40 min•Ep. 1022
From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron. Host: Vincent Racaniello , Kathy Spindler , and Brianne Barker Guest: Trevor Bedford Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Nextstrain Household influen...
Jul 02, 2023•1 hr•Ep. 1021
In his weekly clinical update, Dr. Griffin discusses guidance on measles during the summer travel season, the Infectious Diseases Society of America guidelines on the diagnosis of COVID-19: antigen testing, SARS-CoV-2 variants and age-dependent infection rates among household and nonhousehold contacts, effect of COVID-19 vaccination on household transmission of SARS-COV-2 in the Omicron era, incidence of myopericarditis after mRNA COVID-19 vaccination, intrinsic and effective severity of COVID-1...
Jul 01, 2023•48 min•Ep. 1020
From ASM Microbe in Houston, Texas, Vincent speaks with Eddie Holmes about the evidence that SARS-CoV-2 spilled over into humans in the Huanan Market in Wuhan, absence of evidence for other origins, and his work on the virosphere. Host: Vincent Racaniello Guest: Eddie Holmes Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Market early COVID-19 epicenter (Science) SARSr-CoV-2 in Malayan Pangol...
Jun 25, 2023•47 min•Ep. 1019
In his weekly clinical update, Dr. Griffin discusses the CDC vaccine advisory group recommending the newly approved RSV vaccines, association of culturable-virus detection and household transmission of SARS-CoV-2, prevention of COVID-19 following a single intramuscular administration of Adintrevimab, real-world effectiveness of Nirmatrelvir/Ritonavir on COVID-19, and COVID-19 convalescent plasma outpatient therapy to prevent outpatient hospitalization. Subscribe (free): Apple Podcasts , Google P...
Jun 24, 2023•39 min•Ep. 1018
Vincent travels to the University of Pennsylvania to meet up with Susan, Rick, Gigi and David to discuss the origin of SARS-CoV-2, how the FBI might have reached its conclusion on the matter, and public and political perception of scientific risk. Host: Vincent Racaniello Guests: Susan Weiss , Rick Bushman , Gigi Gronvall , and David Joanson Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server Huanan Seafood Mar...
Jun 18, 2023•1 hr 13 min•Ep. 1017
In his weekly clinical update, Dr. Griffin discusses surveillance to track progress toward poliomyelitis eradication, genetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3, evaluation of Oseltamivir used to prevent hospitalization in outpatients with Influenza, viral emissions into the air and environment after SARS-CoV-2 human challenge, has COVID-19 threatened routine childhood vaccination, successful treatment of persistent symptomatic COVID-19 infection with exte...
Jun 17, 2023•52 min•Ep. 1016
Vincent and Rich travel to Ft. Detrick to visit USAMRIID and speak with Todd, Crystal, John and Jay about their careers, their research, and the mission of the US Army Medical Institute of Infectious Diseases. Host: Vincent Racaniello and Rich Condit Guests: Todd Bell , Crystal Burke , John Dye , and Jay Hooper Opinions, interpretations, conclusions, and recommendations are those of the panelists and no official endorsement by the U.S. Army should be inferred. Subscribe (free): Apple Podcasts , ...
Jun 11, 2023•1 hr 37 min•Ep. 1015
In his weekly clinical update, Dr. Griffin discusses estimates of SARS-CoV-2 seroprevalence and incidence of primary SARS-CoV-2 infections among blood donors, by COVID-19 vaccination status, smart thermometer–based participatory surveillance to discern the role of children in household viral transmission during the COVID-19 pandemic, COVID-19 vaccine mandates, changing severity and epidemiology of adults hospitalized with COVID-19 in the United States after introduction of COVID-19 vaccines, eff...
Jun 10, 2023•40 min•Ep. 1014
