The triple TWiP solve the case of the Peace Corp Veteran with Eosinophilia, and discuss the genome sequence of the hyper-prevalent parasitic eukaryote Blastocystis . Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Genome diversity of Blastocystis (PLoS Biol) Photo credit Letters read on TWiP 140 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $3...
Oct 17, 2017•1 hr 35 min•Ep. 140
The TWiPwalas solve the case of the Woman with a Worm in Her Eye, and discuss the role of nitric oxide in the resistance of rats to Schistosoma japonicum. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Nitric oxide blocks schistosome development (PNAS) Photo credit: Dave the Sheep Shearer Letters read on TWiP 139 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in ...
Sep 21, 2017•1 hr 17 min•Ep. 139
The TWiPsters solve the case of the Child from DR with Poppy Seed Sized Things On His Head Hair Shafts, and reveal how the skin parasite landscape determines the infectiousness of Leishmania. Hosts: Vincent Racaniello and Daniel Griffin Become a patron of TWiP. Links for this episode: Tr (Cell Host Microbe) Letters read on TWiP 138 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’s on the menu this week and g...
Sep 06, 2017•1 hr 23 min•Ep. 138
The TWiPtoids solve the case of the Man from India with a Neck Lump, and explore the role of a transmissible dysbiotic skin microbiome in inflammation during cutaneous leishmaniasis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Transmissible dysbiotic skin microbiome in cutaneous leishmaniasis (Cell Host Microbe) Letters read on TWiP 137 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and ...
Aug 12, 2017•1 hr 35 min•Ep. 137
The TWiP Titans solve the case of the Man from Queens with a Blister Burster, and explain the role of inflammatory monocytes during Leishmania infection of the skin. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Inflammatory monocytes and skin Leishmania (PLoS Path) Dracunculiasis ( TWiP 37 ) Photo: Daniel using a LifeStraw Letters read on TWiP 136 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingre...
Jul 11, 2017•1 hr 39 min
Dickson returns to the TWiP hosts to solve the case of the Woman from Colorado With Loose Stools, and explain how single-sex infection with female Schistosoma mansoni reduces hepatic fibrosis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: ASM Grant Writing Online Course Single-sex Schistosoma infection (PLoS NTD) Asterix the Gaul Letters read on TWiP 135 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh...
Jun 21, 2017•1 hr 54 min
Daniel and Vincent solve the case of the Haitian Girl Who Failed To Thrive, and visit two studies that address the question of whether infection with Toxoplasma gondii alters human behavior. Hosts: Vincent Racaniello and Daniel Griffin Links for this episode: ASM Grant Writing Online Course Is Toxoplasma infection related to brain and behavior impairments ? (PLoS One) Toxoplasma infection and sexual attraction (Evol Psychol) TWiP 21 - The giant intestinal worm, Ascaris lumbricoides Candiru (Wiki...
May 24, 2017•1 hr 19 min
Daniel and Vincent solve the case of the Woman With Anal Area Discomfort, and discuss the multiple functions of a clathrin adapter protein in formation of rhoptry and microneme secretory organelles of Toxoplasma gondii . Hosts: Vincent Racaniello and Daniel Griffin Become a patron of TWiP. Links for this episode: Journal of Microbiology and Biology Education SciComm Issue ( link ) TWiP 19: Enterobius vermicularis, the pinworm Multiple roles of Toxoplasma gondii clathrin adaptor AP1 protein (PLoS...
May 13, 2017•1 hr 37 min
The TWiP-tastic peeps solve the case of the Thai Man Coughing Up Blood, and reveal potential therapies for trypanosomiasis that are inhibitors of protein import into glycosomes. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Become a patron of TWiP. Links for this episode: Inhibitors of protein import into trypanosome glycosomes (Science) Hookworm ( TWiP #22 ) Photo by Nita Letters read on TWiP 132 Case Study for TWiP 132 Young NYC woman with son (10), chief complaint of dis...
Apr 29, 2017•1 hr 32 min
Jonathan from the podcast Arthro-Pod joins the TWiPerati to solve the case of the Peruvian Woman With Inguinal Insect Bite, and discuss warm autoimmune hemolytic anemic that develops after babesiosis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Jonathan Larson Become a patron of TWiP. Links for this episode: Jonathan Larson ( Twitter , Google Plus ) Arthro-Pod podcast Warm hemolytic anemia after babesiosis (NEJM) Tickborne diseases of the US (CDC) Image credit Lett...
Apr 15, 2017•1 hr 39 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPniks solve the case of the Man With AIDS, and explore how secretion of extracellular vesicles influences the social motility of Trypanosoma brucei . Become a patron of TWiP. Links for this episode: T. brucei exosomes and social motility (PLoS Path) Image credit Parasites Without Borders Letters read on TWiP 130 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service...
Apr 01, 2017•1 hr 46 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP Masters solve the case of the Australian Wildlife Carer, and review evidence that nodding syndrome may be caused by an autoimmune reaction to the parasitic worm that causes river blindness. Become a patron of TWiP. Links for this episode: Nodding syndrome an autoimmune disease? (Sci Transl Med) Nodding syndrome : Preventable and treatable (Sci Transl Med) River Blindness lyrics (Google Play) Image credit Letters read on...
Mar 15, 2017•1 hr 45 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPerati solve the case of the Man Who Sat in Feces, and discuss a study on how Dickson's favorite parasite induces the formation of a collagen capsule. Become a patron of TWiP. Links for this episode: Induction of collagen synthesis by Trichinella (Vet Parasitol) Letters read on TWiP 128 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. See what’...
Mar 04, 2017•1 hr 48 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPsters solve the case of the Peace Corps Volunteer with a Liver Lesion, and discuss the dependence of Leishmania survival on the gut microbiome of the sandfly. Become a patron of TWiP. Links for this episode: Leishmania depends on sandfly gut microbiome (mBio) Kava (Wikipedia) Letters read on TWiP 127 This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the cou...
Feb 15, 2017•1 hr 20 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP Trinity solve the case of the Peace Corps volunteer with diarrhea, and reveal how immunizing against a virus ameliorates exacerbated leishmaniasis. Become a patron of TWiP. Links for this episode: Viral vaccine prevents exacerbated leishmaniasis (PLoS NTD) For whom the trich tolls ( TWiP 47 ) A virus in a parasite in a human (virology blog) Virologists in the mist ( TWiV 128 ) Letters read on TWiP 126 This episode is br...
Feb 04, 2017•1 hr 16 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPonderers solve the case of the Timber Worker with Severe Shaking Chills, and describe an experimental malaria vaccine comprising attenuated sporozoites produced by genetic engineering. Become a patron of TWiP. Links for this episode: Genetically engineered P. falciparum sporozoite vaccine (Sci Transl Med) Parasitology Superhero: Francesco Redi Image credit: Betsy Weissbrod Letters read on TWiP 125 This episode of TWiP is...
Jan 21, 2017•1 hr 35 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The prolific podcast-shedding Hosts solve the case of the Global Health Intern with a snakelike lesion on her foot, and reveal the role of a single-stranded DNA binding protein in differentiation of trypanosomes. Become a patron of TWiP. Links for this episode: RPA protein and differentiation of T. cruzi (PLoS NTD) Image credit Letters read on TWiP 124 Case Study for TWiP 124 28 yo male from referral hospital near thai-burma bor...
Jan 05, 2017•1 hr 40 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPanorama solve the case of the Dutch Woman with Wormy Objects in Her Stool, dissect a study on cytoadhesion of malaria infected red blood cells, and introduce Parasitology Superheroes. Become a patron of TWiP. Links for this episode: Myiasis (Wikipedia) Cytoadhesion of Plasmodium in severe malaria (PLoS Path) Image credit Letters read on TWiP 123 This episode is sponsored by CuriosityStream , a subscription streaming serv...
Dec 20, 2016•2 hr 2 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPniks docs solve the case of the Female from Peru with Epistaxis, and discuss the effect of community deworming on immunosuppression. Become a patron of TWiP. Links for this episode: Community deworming and immune hyporesponsiveness (PNAS) Paul C. Beaver ( one , two ) Photo by Oscar Adam Oscarson Letters read on TWiP 122 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over 1,400...
Dec 06, 2016•1 hr 53 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPanosome docs solve the case of the Mali Man with Profuse Diarrhea, and review the presence of Trypanosoma cruzi in vectors, canids, and humans along the Texas-Mexico border. Become a patron of TWiP. Links for this episode: T. cruzi in vectors, canids, humans at Mexican border (PLoS NTD) Tetracapsuloides bryosalmonae (Wikipedia) T. cruzi in US (Clin Micro Rev) Image credit Letters read on TWiP 121 This episode is sponsore...
Nov 16, 2016•1 hr 31 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP triumvirate solve the case of the Thai Woman with Facial Swelling, and explain how Th17 T cells protect against the intracellular parasite Trypanosoma cruzi . Become a patron of TWiP. Links for this episode: Th17 cells protect against Trypanosoma cruzi (PLoS Path) Plasticity of helper CD4+ cells (Science) Image credit Letters read on TWiP 120 This episode is sponsored by CuriosityStream , a subscription streaming servic...
Nov 10, 2016•1 hr 40 min
Hosts: Vincent Racaniello and Daniel Griffin Vincent and Daniel solve the case of the Family with Eosinophilia, and discuss HIV-1 infection and genome integration in the blood fluke Schistosoma mansoni . Become a patron of TWiP. Links for this episode: Family cluster of eosinophilia (Clin Inf Dis) Dientamoeba fragilis (Wikipedia) Parasites without borders HIV integrates into Schistosoma genome (PLoS Path) Image credit Letters read on TWiP 119 This episode is sponsored by CuriosityStream , a subs...
Oct 25, 2016•1 hr 28 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPinella solve the case of the Woman from Guinea, and describe the use of CRISPR/Cas9 to identify essential apicomplexan genes. Links for this episode: Malarias in Guinea (CDC) Genome-wide CRISPR screen in Toxoplasma (Cell) Plasmodium parasitemia associated with increased Ebola survival (Clin Inf Dis) Image credit Letters read on TWiP 118 This episode is sponsored by CuriosityStream , a subscription streaming service that ...
Oct 06, 2016•1 hr 35 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The parasite prophets solve the case of the Thai Man with Abdominal Distention, and discuss the finding that metastatic leishmaniasis dependent on a virus can be prevented by blocking IL-17A. Links for this episode: TWiP 27: Trematodes Leishmaniavirus and IL-17A dependent leishmaniasis (PLoS Path) Image credit Letters read on TWiP 117 This episode is sponsored by CuriosityStream , a subscription streaming service that offers ove...
Sep 26, 2016•1 hr 51 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPtoids solve the case of the Thai Fisherman with Chronic Diarrhea, and reveal a potential new drug for treatment of leishmaniasis, Chagas diseases, and sleeping sickness. Links for this episode: Capillaria philippensis (Wikipedia) Proteasome inhibitor for three parasitic diseases (Nature) Image credit Letters read on TWiP 116 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over ...
Sep 11, 2016•1 hr 46 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPlets solve the sad case of the Boy Who Went Swimming, and explain why the tomato is resistant to the plant parasite Cuscuta . Links for this episode: Detection of plant parasite by a tomato receptor (Science) Dodder (Wikipedia) Mixed messages (TWiP 77) Image credit Letters read on TWiP 115 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over 1,400 documentaries and nonfiction ...
Aug 27, 2016•1 hr 37 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP troika solve the case of the Female from the Bronx, and reveal how feeding on different plants affects mosquito capacity to transmit malaria. Links for this episode: Plant mediated effects on malaria transmission (PLoS Path) Image credit Letters read on TWiP 114 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world's bes...
Aug 12, 2016•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Jason Zucker The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella . Links for this episode: Transgenic Eimeria as a toxoplasma vaccine (Sci Rep) Image shows cysticercus of T. solium in brain (Parasitic Diseases, 5th Ed) Letters read on TWiP 113 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over 1...
Jul 23, 2016•1 hr 41 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species. Subscribe to TWiP (free) in iTunes , by the RSS feed or by email Links for this episode: Helminth infection promotes colonization resistance (Science) NOD2 (Wikipedia) Image credit Le...
Jun 25, 2016•1 hr 38 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP trio solve the case of the bug bites all in a row, and talk about a secreted Toxoplasma protein that is central to the parasite's manipulation of host cells. Subscribe to TWiP (free) in iTunes , Google Play Music , by the RSS feed or by email Links for this episode: Pigeon mites feed on humans at night (EPA) Secreted Toxoplasma protein (mBio) Image credit Letters read on TWiP 111 This episode is sponsored by CuriositySt...
Jun 03, 2016•1 hr 25 min
