This Week in Parasitism - podcast cover

This Week in Parasitism

Vincent Racaniellomicrobe.tv
TWiP is a monthly netcast about eukaryotic parasites. Vincent Racaniello and Dickson Despommier, science Professors from Columbia University, deconstruct parasites, how they cause illness, and how you can prevent infections.

Episodes

TWiP 50: Antagonism in the mosquito midgut

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito. Links for this episode: Malaria parasites co-opt factor H (Cell Host Microbe) Complement system (Wikipedia) Letters read on TWiP 50 Contact Send your questions and comments (email or mp3 file) to [email protected]...

Feb 16, 20131 hr 11 min

TWiP 49: Making sense of toxo and heme

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss innate immune sensing of Toxoplasma gondii in mice, and heme metabolism in protozoan parasites. Links for this episode: Sensing Toxoplasma in mice (Cell Host Microbe) Make it, take it, or leave it (PLoS Path) Heme (Wikipedia) Letters read on TWiP 49 Contact Send your questions and comments (email or mp3 file) to [email protected]...

Jan 26, 20131 hr 34 min

TWiP 48: A parasitic cloaking device

Hosts: Vincent Racaniello , Dickson Despommier , and Josef Sabo Vincent, Dickson, and Josef discuss tetraspanins on the surface of schistosomes as vaccine candidates and immune evasion proteins. Links for this episode: S. japonicum tetraspanin-2 as a vaccine target (PLoS NTP) Protection with S. mansoni tetraspanin-2 (PLoS NTP) S. mansoni tetraspanins confer protection (Nat Med) Tetraspanins Letters read on TWiP 48 Contact Send your questions and comments (email or mp3 file) to [email protected]. Subs...

Dec 18, 20121 hr 7 min

TWiP 47: For whom the trich tolls

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review evidence that a virus of the protozoan parasite Trichomonas vaginalis may exacerbate disease. Links for this episode: Endobiont viruses sensed by the human host (PLoS One) Letters read on TWiP 47 Contact Send your questions and comments (email or mp3 file) to [email protected]...

Nov 28, 20121 hr 9 min

TWiP 46: Malaria gets the (zinc) finger

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson meet with Judith Straimer and Marcus Lee to discuss their method for site-specific genome editing in Plasmodium falciparumusing zinc finger nucleases. Right-click to download TWiP #46 (46 MB .mp3, 64 minutes). Links for this episode: Judith Straimer and Marcus Lee Genome editing in P. falciparum with zinc finger nucleases (Nature Methods) Zinc finger nucleases (Sigma-Aldrich) Gene-editing nucleases (Nature Methods) Illustration...

Oct 17, 20121 hr 4 min

TWiP 45: Free range Toxoplasma with John Boothroyd

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss Toxoplasma biology with Stanford University Professor John Boothroyd . Links for this episode: T. gondii and free range animals Kiss and spit: Toxoplasma rhoptries (Nat Rev Micro) Toxoplasma cell invasion (Curr Opin Micro) Loading of IRG onto parasitophorous vacuole (Cell Micro) Toxoplasma gondii on TWiP #12 Contact Send your questions and comments (email or mp3 file) to [email protected]. Subscribe (free) Subscribe to TWiP ...

Sep 26, 20121 hr 1 min

TWiP 44: Parasites provide a cricket subsidy for trout

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson explain how a nematode manipulates cricket behavior and alters the food web of a stream. Links for this episode: Nematomorph parasites alter food web of streams (Ecol Lett) Manipulation of cockle behavior by a trematode (Parasitology) Cockles infected by one parasite are more susceptible to a second (J Parasitol) Letters read on TWiP 44 Contact Send your questions and comments (email or mp3 file) to [email protected]....

Sep 07, 20121 hr 20 min

TWiP 43: Two remarkable host-parasite conflicts

Vincent and Dickson review how sickle cell microRNAs contribute to malaria resistance, and inhibition of innate immune responses by an enzyme from trypanosomes. Links for this episode: microRNAs involved in sickle cell resistance to Plasmodium (Cell Host Microbe) Trypanosome adenylate cyclases modulate innate immune response (Science) Letters read on TWiP 43 Contact Send your questions and comments (email or mp3 file) to [email protected]....

Aug 23, 20121 hr 32 min

TWiP 42: The tick keeps on ticking

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson answer listener emails about Leishmania, dual infection of vectors, tapeworms, liver flukes, toxoplasmosis, and much more. Links for this episode: Metabolic pathways required by Leishmania (Ann Rev Micro) Tapeworms in people's brains (Carl Zimmer) Poison Ivy Bovine tuberculosis disguised by liver fluke (Nature) Giant kidney worm (YouTube) Crowd-sourced games for telepathology Ivermectin for alcohol abuse Ivermectin and alcohol ...

Aug 10, 20121 hr 15 min

TWiP 41: Flying and crawling beasts

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review medically important arthropods. Links for this episode: Thomas Eisner Incomplete metamorphosis in insects (jpg) Complete metamorphosis in an insect with aquatic immature stages (jpg) Complete metamorphosis in an insect with terrestrial immature stages (jpg) Letters read on TWiP 41 Contact Send your questions and comments (email or mp3 file) to [email protected]....

Jun 27, 20121 hr 34 min

TWiP 40: Doctor, there's a worm in my eye!

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson discuss loaiasis caused by the filarial nematode Loa loa. Right-click to download TWiP #40 (52 MB .mp3, 73 minutes). Links for this episode: Albendazole therapy for US-bound refugees (NEJM) Microfilaria of Loa loa (png) Loa loa life cycle (png) Letters read on TWiP 40 Contact Send your questions and comments (email or mp3 file) to [email protected]....

May 17, 20121 hr 13 min

TWiP 39: I encyst, said the amoeba

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson review the biology and pathogenesis of the amoebae Naegleria fowlerii and Acanthamoeba castellani. Links for this episode: N. fowlerii life cycle (CDC) N. fowlerii at Artful Amoeba Naegleria and amoebic meningoencephalitis (MDPH) First case of Naegleria PAM in Italy (Emerg Inf Dis) N. fowlerii in well water (Emerg Inf Dis) Recent N. fowlerii case in Minnesota (Clin Inf Dis) Beat the holiday bug (Sydney Morning Herald) Is your n...

Apr 26, 20121 hr 25 min

TWiP 38: How to Trichomonas

Hosts: Vincent Racaniello and Dickson Despommier Vincent and Dickson tackle the backlog of listener email, then consider the life cycle and pathogenesis of Trichomonas vaginalis, the flagellated protozoan transmitted by sexual contact. Links for this episode: T. vaginalis life cycle (jpg) T. vaginalis hydrogenosome (jpg) Letters read on TWiP 38 Contact Send your questions and comments (email or mp3 file) to [email protected]....

Apr 03, 20121 hr 14 min

TWiP 37: Dracunculiasis

Vincent and Dickson discuss the life cycle and pathogenesis of Dracunculus medinensis, the filarial nematode that causes dracunculiasis, or Guinea worm disease. Links for this episode: Dracunculus emerging from foot (jpg) Dracunculus medinensis life cycle (jpg) Guinea worm - WHO Guinea worm eradication - The Carter Center War against Guinea worm (YouTube) Caduceus vs staff of Asclepius Vincent and Dickson - the dogs (jpg) Letters read on TWiP 37...

Feb 19, 20121 hr 42 min

TWiP #33 - Hide and seek

Vincent and Dickson review an in silico pipeline for identifying molecular mimicry candidate proteins in the genomes of parasites, and catch up on listener email.

Nov 24, 20111 hr 28 min

TWiP #31 - A malaria vaccine

Vincent and Dickson discuss the promising results of a phase III trial of a malaria vaccine in African children.

Oct 21, 20111 hr 10 min

TWiP #27 - Trematodes

Vincent and Dickson continue their discussion of trematodes, or flukes, which have a snail as a reservoir host.

Jun 22, 20111 hr 17 min

TWiP #26 - The schistosomes

Vincent and Dickson take on the schistosomes, agents of a series of related diseases in humans referred to as schistosomiasis.

May 27, 20111 hr 35 min

TWiP #25 - Wuchereria bancrofti

Vincent and Dickson review Wuchereria bancrofti, the nematode that causes lymphatic filariasis, also known as elephantiasis.

Apr 28, 20111 hr 7 min

TWiP 22 - Hookworm

Vincent and Dickson discuss possibly the most socially and politically important nematode of humans, the hookworm Ancylostoma duodenale and Necator americanus .

Feb 09, 20110Ep. 22
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