Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Paul Calle The TWiP trio visit the Bronx Zoo where Paul solves the case of the Four Year Old with Pulmonary Edema, and talks about his career as the Chief Veterinarian and Director of the Zoological Health program for the Wildlife Conservation Society. Links for this episode: Bronx Zoo Avian malaria (Wikipedia) Letters read on TWiP 110 Video of this episode at YouTube This episode is sponsored by CuriosityStream, a subscr...
May 21, 2016•1 hr 30 min
Hosts: Vincent Racaniello and Daniel Griffin Guest: Paul Daniel and Vincent solve the case of the Truck Driver from India, discuss why parasites resistant to an antimalarial drug are not transmitted by mosquitoes, and introduce Paul who presents a new case study. Links for this episode: Atovaquone resistant parasites not transmitted by mosquitoes (Science) Image credit Letters read on TWiP 109 This episode is sponsored by CuriosityStream , a subscription streaming service that offers over 1,400 ...
May 13, 2016•1 hr 9 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The case of the Man from Assam is solved, and phagocytosis of Leishmania by B-1 cells is brought to you by the Three Twipeteers on this episode of TWiP. Subscribe to TWiP (free) in iTunes , Google Play Music , by the RSS feed or by email Links for this episode: Kalazar detect (pdf) Phagocytosis of Leishmania promastigotes by B-1 cells (Parasite Immunol) Image credit Letters read on TWiP 108 This episode is sponsored by ASM Agar ...
Apr 23, 2016•1 hr 31 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPtastic trio solves the case of the Surfer from Switzerland, and reveal how taste-chemosensory tuft cells in the gut regulate immune responses to parasites. Links for this episode: Taste-chemosensory cells and parasite gut immunity (Science) Image credit Letters read on TWiP 107 This episode is sponsored by ASM Agar Art Contest and ASM Microbe 2016 Case study for TWiP 107 Todays case is a fun case about a 45 year old gent...
Apr 11, 2016•1 hr 33 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP triumvirate solves the case of the Missionary in Kenya, and review the finding of a soldier caste in flatworms that parasitize snails. Links for this episode: Social organization in parasitic flatworms (J Parasitol) Image credit Letters read on TWiP 106 This episode is sponsored by ASM Agar Art Contest Case study for TWiP 106 This week's case comes from an ophthalmologist colleague Florian in Switzerland. Swiss female, ...
Mar 26, 2016•2 hr 1 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity. Links for this episode: Trichinella life cycle ( pdf ) When parasites are good for health (PLoS Path) The Origin of AIDS by Jacques Pepin Letters read on TWiP 105 Case study for TWiP 105 This week's case involves a 32 yo male with several concerns. Spent 6 weeks doing rel...
Mar 12, 2016•1 hr 53 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Michael Libman Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, and discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis. Links for this episode: T. brucei life cycle ( pdf ) Natural and induced antibodies in echinococcosis (Immunobiol) The collaborative cross Letters read on TWiP 104 Case study for T...
Feb 27, 2016•1 hr 42 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Guest: Michael Libman The TWiP-scholars solve the case of the Housewife from Kolkata, discuss mutations in the IL17 gene associated with cerebral malaria, and hear a case presentation from guest Michael Libman. Links for this episode: IL-17 mutations and risk of cerebral malaria (Inf and Imm) Echinococcosis (CDC) Echinococcus life cycle (pdf) Letters read on TWiP 103 Case study for TWiP 103 This week's case concerns a 42 yo male...
Feb 13, 2016•1 hr 8 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiPyzoites solve the case of the Uncommon Parasite, and discuss the role of eosinophils in promoting the growth of Trichinella in skeletal muscle. Links for this episode: Eosinophils and IL-4 support nematode growth (PLoS Path) Balantidiasis (CDC) Letters read on TWiP 102 Case study for TWiP 102 This week's case involves a 24 yo housewife, from a village outside of Calcutta. Comes into a tertiary care hosp, 6 months coughin...
Feb 06, 2016•1 hr 40 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The doctors TWiP solve the case of the Woman with White Worms, and explain the role of a secreted growth factor from a carcinogenic parasite in wound healing and angiogenesis. Links for this episode: Wound healing growth factor from carcinogenic parasite (PLoS Path) Opisthorchis (CDC) Opisthorchis life cycle (CDC) Image credit Letters read on TWiP 101 Listener Pick Ramon - Ancient Rome was infested with parasites Case study for ...
Jan 23, 2016•1 hr 51 min
Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin The TWiP trifecta solves the case of the Woman from Bolivia with Belly Pain, and discuss a method for population modification of malaria mosquitoes using a Cas9-mediated driver gene. Links for this episode: Cas9-mediated drive for population modification of malaria mosquito (PNAS) FAQ: Gene drives (pdf) Image credit Letters read on TWiP 100 Case study for TWiP 100 This week's case is a 27 yo female, native NY, referred to outpat...
Jan 09, 2016•1 hr 53 min
The TWiP trifecta solves the case of the Professor Who Went to Brazil, and discuss an amazing case of a tapeworm that turned into a tumor in an AIDS patient. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Do young doctors need more sleep? (Slate) H. nana tumor in AIDS patient (NEJM) Hymenolepiasis (CDC) H. nana lifecycle (CDC/Wikipedia) Image credit Letters read on TWiP 99 Case study for TWiP 99 This week's case is a 53 yo woman visiting family in US,...
Dec 05, 2015•1 hr 40 min
The TWiP-lets reveal Balamuthia infection in the Children from Peru, and discuss resistance to pyrethroids revealed by RNA sequencing of Anopheles mosquitoes. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Balamuthia (CDC) Pyrethroid resistance in Anopheles (Parasit Vectors) Voltage-gated sodium channels Pyrethroid (Wikipedia) Image credit Letters read on TWiP 98 Case study for TWiP 98 This week's case is a Professor clinician, teacher, researcher. In...
Oct 31, 2015•1 hr 37 min
The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium . Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Parasite Nobel Prizes 2015 Ivermectin story (Nat Rev Micro) Ivermectin target (Brain Res) Gut microbiota and Plasmodium protection (Cell) Natural antibody (virology blog) Image credit Letters read on TWiP 97 Case study for TWiP 97 Daniel has two cas...
Oct 17, 2015•1 hr 27 min
The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Sandfly exposure and risk of cutaneous leishmaniasis (J Inf Dis) TWiP 14: Leishmania Image is L. longipalpis ( credit ) Letters read on TWiP 96 Case study for TWiP 96 Daniel's patient for this week is male patient referred for cons...
Oct 03, 2015•1 hr 43 min
Vincent, Dickson, and Daniel solve the case about the 33 year old Chinese male with watery diarrhea, and discuss whether arsenic in drinking water might lead to treatment failures for Leishmania infections. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: TWiP 17: Entamoeba histolytica Arsenic exposure and Leishmania treatment outcomes (PLoS NTD) TWiP 14: Leishmania Letters read on TWiP 95 This episode is sponsored by ASMGAP . Case study for TWiP 95 Dan...
Sep 19, 2015•1 hr 45 min
Vincent, Dickson, and Daniel solve the case about the man from El Salvador, discuss the use of tyrosine kinase inhibitors to treat onchocerciasis and filariasis. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Targeting filarial tyrosine kinases (J Inf Dis) Onchocerciasis on TWiP 24 Filariasis on TWiP TWiP 25 Image shows c-abl kinase bound to imatinib (red) Image credit What good are ticks? Letters read on TWiP 94 Case study for TWiP 94 Daniel's patien...
Sep 05, 2015•1 hr 42 min
Vincent, Dickson, and Daniel solve their fishy tale, and present a new case study for your consumption. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Freezing and the quality of sushi (Clin Inf Dis) Anisakis biology (CDC) Image credit Letters read on TWiP 93 Case study for TWiP 92 April 2015 a 177 lb 5ft10in 39 yo man seen as outpatient in ID clinic, reports 2 y ago had issues with constipation on and off; throat hurts; feels closing when lies down. ...
Aug 08, 2015•1 hr 29 min
Vincent, Dickson, and Daniel discuss how fluctuation in the price of guinea pig food could help transmission of the agent of Chagas disease, and present a new case study for your consumption. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Ascaris on TWiP 21 Ascaris lumbricoides life cycle ( jpg ) Child with distended abdomen due to Ascaris ( jpg ) Bottlenecks and Chagas disease (Proc Biol Soc) Letters read on TWiP 92 Case study for TWiP 92 A 20 yo Jap...
Jul 04, 2015•1 hr 40 min
Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum , and introduce a new case study. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Malaria life cycle ( jpg ) cAMP regulates gametocyte infected erythrocyte deformability (PLoS Path) P. falciparum in bone marrow (Blood) Image credit Letters read on TWiP 91 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subsc...
Jun 20, 2015•1 hr 29 min
Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum , and introduce a new case study. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Dermatobia hominis (Wikipedia) Plasmodium falciparum erythrocyte invasion (Science) Plasmodium life cycle (TWiP #10) Letters read on TWiP 90 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to TWiP (f...
May 30, 2015•2 hr 1 min
Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Neurocysticercosis ( TWiP 6 ) Cysticercosis (CDC) Sarah Lane's neurocysticercosis Letters read on TWiP 89 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to TWiP (free) in iTunes , by the RSS feed or by email...
May 16, 2015•1 hr 35 min
Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Leishmania (TWiP #14) Transformation by a prolyl isomerase (Nature) Theileria.org Prolyl isomerase (Wikipedia) Image from Transformation & Oncogenesis Letters read on TWiP 88 Contact Send your questions and comments (email or mp3 file) to twip@twiv....
May 02, 2015•1 hr 54 min
Vincent, Dickson, and Daniel review new insight into antigenic variation in trypanosomes, reveal the difficult solution to the last case study, and present another mystery for your solving. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Pinworm (CDC) Pinworm on TWiP #19 Dynamics of antigenic variation in T. brucei (Science) Image credit Letters read on TWiP 87 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subsc...
Apr 21, 2015•1 hr 17 min
Vincent, Dickson, and Daniel discuss how filarial infection modulates the immune response to mycobacterial infection, and reveal a new case study. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Filarial infection modulate immune response (J Immunol) Memory T cells (Wikipedia) Image: Loa loa microfilaria Letters read on TWiP 86 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to TWiP (free) in iTunes , by...
Mar 29, 2015•2 hr 5 min
Vincent, Dickson, and Daniel explain how trypanolytic factor forms membrane channels to lyse trypanosomes, and present a new case study. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Human trypanolytic factor forms channels (PNAS) Human paragonimiasis (MMWR) Don't eat raw crawfish Daniel and Dickson in studio (jpg) Image credit Letters read on TWiP 85 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to ...
Mar 14, 2015•1 hr 50 min
Vincent, Dickson, and Daniel consider the delivery of anti-trypanosome nanobodies to the tsetse fly via a bacterial symbiont, and present a new case study. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Delivery of a functional nanobody to tsetse flies (Microb Cell Fact) Nanobodies (Wikipedia) V.B. Wigglesworth (Wikipedia) VB Nimble, VB Quick Knott test Mazzotti reaction Image credit Letters read on TWiP 84 Contact Send your questions and comments (em...
Feb 28, 2015•1 hr 46 min
Vincent, Dickson, and Daniel present a new case study, and discuss the effect of chronic malaria infection on wild warbler life span and telomere degradation. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Effect of chronic malaria infection on wild warblers (Science) Image credit Letters read on TWiP 83 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to TWiP (free) in iTunes , by the RSS feed or by ema...
Feb 23, 2015•1 hr 36 min
Vincent, Dickson, and Daniel solve last week's case study, present a new one, and reveal how secreted proteins from a helminth prevent diabetes in mice. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Babesiosis (CDC) Babesiosis blood smear with Maltese cross (NEJM) Helminth proteins prevent diabetes in mice (PLoS One) Letters read on TWiP 82 Contact Send your questions and comments (email or mp3 file) to [email protected] Subscribe Subscribe to TWiP (free)...
Feb 07, 2015•1 hr 35 min
Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo. Hosts: Vincent Racaniello , Dickson Despommier , and Daniel Griffin Links for this episode: Consequences of living in a wormy world (Am Nat) Opposite effects of antihelminthic treatment on microbial infection (Science) Send your case study solutions to [email protected] Daniel's cufflinks (jpg) Daniel's TB b...
Jan 24, 2015•1 hr 40 min
