TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Astrocytes close the critical period (Science) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to twin@mic...
May 02, 2022•1 hr 2 min•Ep. 29
TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: Vincent Racaniello , Timothy Cheung , and Vivianne Morrison Click arrow to play Download TWiN 028 (77 MB .mp3, 64 min) Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Glia 101 ( TWiN 19 ) Oligodendrocytes enhance axonal energy metabolism (Neuron) Timestamps by Jolene . Th...
Apr 04, 2022•1 hr 14 min•Ep. 28
TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): Apple Podcasts , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Remapping retinal projections (Nature) Sweet vs bitter taste (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees S...
Mar 03, 2022•1 hr 4 min•Ep. 27
TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a patron of TWiN! Links for this episode Memory of immunity (Cell) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to [email protected]...
Jan 31, 2022•54 min•Ep. 26
TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: Vincent Racaniello , Jason Shepherd , and Timothy Cheung Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Males and females in neuroscience studies (New Scientist) Brain rotates memories (Quanta) Odorant receptors in brain ( one , two ) Neutrophils promote neuron...
Dec 28, 2021•1 hr 3 min•Ep. 25
Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: Vincent Racaniello and Timothy Cheung Guests: Ioana Carcea and Robert Froemke Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Oxytocin neurons and social transmission of behavior (Nature) Timestamps by Jolene . Than...
Nov 24, 2021•1 hr 13 min•Ep. 24
Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that those sensory signals are sustained as they travel long distances to the brain. Hosts: Vincent Racaniello , Timothy Cheung , and Vivianne Morrison Guest: Bruce Carter Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this epi...
Oct 31, 2021•1 hr 11 min•Ep. 23
TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd, Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Lupus autoantibodies bind GluN2A-containing NMDA receptors (Nat Commun) Timestamps by Jolene . Thanks! Music is by Ronald Je...
Sep 29, 2021•1 hr 8 min•Ep. 22
TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: Vincent Racaniello , Ori Lieberman , and Timothy Cheung Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Listener poll - please take it Striatal dopamine and hallucination in mice (Science) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Se...
Aug 24, 2021•1 hr 28 min•Ep. 21
While perceptual constancy requires the brain to maintain a stable representation of sensory input, TWiN explores a study showing that odor-evoked responses in the olfactory cortex drift over periods of days to weeks. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Representational drift in olfactory cortex (Nature) ( open preprint ) Ed Yong on representati...
Jul 14, 2021•1 hr 18 min•Ep. 20
On this episode, Vivianne gives a primer on glial cells, with the goal of thinking about the central nervous system holistically and appreciating the different cell types that contribute to its function. Hosts: Vincent Racaniello , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Music is by Ronald Jenkees Send your neuroscience questions and comments to [email protected]...
Jun 21, 2021•1 hr 13 min•Ep. 19
Mauro Costa-Mattioli joins TWiN to discuss how his laboratory dissects the contribution of host genetics and the microbiome in complex neurodevelopment disorders such as autism spectrum disorders. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Mauro Costa-Mattioli Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Mauro’s work on TWiM 131 and 193 Separating genetics and microbiome in...
May 12, 2021•1 hr 11 min•Ep. 18
Michael Nitabach joins TWiN to discuss the finding that the nematode C. elegans, which do not have eyes, can discriminate between colors to guide foraging decisions and move them away from harmful bacteria that produce a blue-pigment toxin. Hosts: Vincent Racaniello , Ori Lieberman , Jason Shepherd , Timothy Cheung , and Vivianne Morrison Guest: Michael Nitabach Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode C. elegans discriminates color...
Apr 21, 2021•1 hr 22 min•Ep. 17
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice. Hosts: Ori Lieberman , Andres Bendesky , Jason Shepherd , and Vincent Racaniello Guest: Helen Vuong Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Maternal microbiome influences fetal neurodevelopment (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and comments to t...
Feb 17, 2021•50 min•Ep. 15
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation. Hosts: Ori Lieberman , Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Reducing Alzheimer-like pathology in mice (Nat Neuros...
Jan 14, 2021•1 hr 11 min•Ep. 14
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse. Hosts: Ori Lieberman , Erin Calipari, Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Transcriptional programs associated with long-term memory (Nature) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Sen...
Dec 15, 2020•1 hr 8 min•Ep. 13
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell. Hosts: Ori Lieberman , Vincent Racaniello , and Jason Shepherd Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Thalamic orphan receptor in short term memory (Cell) Anosmia in SARS-CoV-2 infected mice (Nature) Letters read on TWiN 12 Timestamps by Jolene . Thanks! ...
Nov 11, 2020•1 hr 13 min•Ep. 12
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron. Hosts: Ori Lieberman , Andres Bendesky , and Vincent Racaniello Guest: Maria Tosches Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Single-cell transcriptomics of reptile cortex (Science) Innovations in primate interneurons (Nature) Human versus mouse cortex (Nature) Letters read on TWiN 11 Time...
Oct 14, 2020•1 hr 6 min•Ep. 11
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation. Hosts: Ori Lieberman , Andres Bendesky , Erin Calipari , Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode IL-33 promotes synaptic plasticity (Cell) Timestamps by Jolene . Thanks! Music is by Ronald Jenkees Send your neuroscience questions and c...
Sep 29, 2020•1 hr 7 min•Ep. 10
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease. Hosts: Ori Lieberman , Andres Bendesky , Jason Shepherd and Vincent Racaniello Guest: Genna Waldman Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Preparing a neurology department for COVID-19 (Neurology) Managing comatose COVID-19 patients (Ann Neurol) Neuro...
Aug 11, 2020•1 hr 7 min•Ep. 9
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons. Hosts: Ori Lieberman , Erin Calipari , Jason Shepherd and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Converting glia to neurons (Cell) Reversing Parkinson's disease (Nature) Letters read on TWiN 8 Timestamps by Jolene . Thanks! Intro music is by Ronal...
Jul 07, 2020•1 hr 11 min•Ep. 8
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses. Hosts: Ori Lieberman , Jason Shepherd , Erin Calipari and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for the episode The hair cycle (J Cell Sci) Hyperactivation of sympathetic nerves drives hair greying (Nature) Brain control of humoral immune responses (Nature) Letters read on TWiN 7 Timestamps by Jolene . ...
Jun 13, 2020•1 hr 24 min•Ep. 7
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes. Hosts: Ori Lieberman , Andres Bendesky , and Jason Shepherd Guest: Nirao Shah Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Nirao Shah laboratory Neural circuit remodeling and sexual behavior (Cell) Timestamps by Jolene . Thanks! Intro music is by Ronald Jenkees . Send your neuroscience questions and c...
May 20, 2020•1 hr 4 min•Ep. 6
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19. Hosts: Ori Lieberman , Andres Bendesky , Jason Shepherd , Erin Calipari and Vincent Racaniello Guest: Bob Datta Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Expression of SARS-CoV-2 entry genes in nasal olfactory epithelium (bioRxiv) Expression of SAR...
Apr 18, 2020•59 min•Ep. 5
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons. Hosts: Andres Bendesky , Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Arc is a repurposed retrotransposon gag protein that mediates intercellular RNA transfer (Cell) Drosophila gag-like ARC1 (Cell) Letters read on TWiN #4 Timestamps by Jolene . Thanks!...
Jan 09, 2020•1 hr 8 min•Ep. 4
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction. Hosts: Ori Lieberman , Erin Calipari , Jason Shepherd , and Vincent Racaniello Click arrow to play Download TWiN 003 (52 MB .mp3, 86 min) Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Dopamine neurons encode reward probability and uncertainty (Science) L...
Dec 18, 2019•1 hr 21 min•Ep. 3
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing. Hosts: Ori Lieberman , Andres Bendesky , Jason Shepherd , and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiN! Links for this episode Bendesky lab Recycling Endosomes Supply AMPA Receptors for LTP (Science) AM...
Nov 05, 2019•1 hr 26 min•Ep. 2
The synaptics launch the first episode of TWiN by revealing their training, research interests, and goals for the podcast. Hosts: Ori Lieberman , Erin Calipari , Jason Shepherd , and Vincent Racaniello Become a patron of TWiN! Links for this episode Lieberman lab Calipari lab Shepherd lab Image credit Intro music is by Ronald Jenkees . Send your neuroscience questions and comments to [email protected]...
Oct 26, 2019•44 min•Ep. 1
