TWiM #43: Bacterial caveolae and zapping acne with phages
Vincent, Michael, Elio review formation of caveolae in a bacterium, and the limited genetic diversity and broad killing activity of P. acnes bacteriophages.
Oct 10, 2012•1 hr 20 min
This Week in Microbiology
This Week in Microbiology is a podcast about unseen life on Earth hosted by Vincent Racaniello and friends. Following in the path of his successful shows 'This Week in Virology' (TWiV) and 'This Week in Parasitism' (TWiP), Racaniello and guests produce an informal yet informative conversation about microbes which is accessible to everyone, no matter what their science background.
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Episodes
TWiM #42: Staphylococcus, a three-star pathogen
Vincent, Michael, Elio, and Joe review highlights of the 15th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI) in Lyon, France.
Sep 26, 2012•1 hr 12 min
TWiM #41: ICAAC live in San Francisco
Vincent and Michael travel to San Francisco for the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), where they meet with Bill, John, and Victor to discuss tuberculosis, monitoring infectious disease outbreaks with online data, and outside-the-box approaches to antibacterial therapy.
Sep 13, 2012•1 hr 43 min
TWiM #40: A mecca for microbiology
**MicrobeWorld app users, click the "e" symbol in the bottom right corner of this description to watch a bonus video version of this episode!** Vincent and Stanley meet with Waclaw Szybalski and John Kirby at Cold Spring Harbor Laboratory on the occasion of its designation as a Milestones in Microbiology site. They reminisce about how the well known laboratory has advanced the science and teaching of microbiology, and discuss John’s work on the soil dwelling, predatory myxobacteria. If you don't...
Aug 29, 2012•1 hr 2 min
TWiM #39: What Darwin never knew
Vincent, Michael, and Elio reviews chapters from Microbes and Evolution, a collection of short, personal essays by microbiologists.
Aug 15, 2012•1 hr 16 min
TWiM #38: The sound of whooping cough
Vincent, Jo, Michael, and Elio review an outbreak of pertussis in Washington, and how culturing can reveal rare members of the soil biosphere.
Aug 02, 2012•1 hr 11 min
TWiM #37: Microbial Jekyll and Hyde
Vincent, Jo, Michael, and Elio discuss two examples of dynamic microbial symbioses that switch between mutualistic and pathogenic states.
Jul 18, 2012•1 hr 18 min
TWiM #36: Domesticating a pathogen
Vincent, Michael, and Elio explore the origin of Mycoplasma pathogens of ruminants, and share their thoughts on the recent ASM General Meeting.
Jul 04, 2012•1 hr 20 min
TWiM #35: Ohne hauch
Vincent, Michael, and Elio review necrotizing fasciitis, and a link between surface remodeling in gram-positive and gram-negative bacteria.
Jun 21, 2012•1 hr 10 min
TWiM #34: Doing the DISCO with Emiliania
Hosts: Vincent Racaniello , Michael Schmidt , and Elio Schaechter Vincent, Michael, and Elio discuss changing populations of Emiliania huxleyi and their viruses in the North and Black Seas. Right click to download TWiM #34 (50 MB .mp3, 69 minutes). Links for this episode: The protist wonderland (Microbe) Emiliania huxleyi home page DISCO in the North Sea (FEMS Microbiol Ecol) 7000 years of Emiliania huxleyi in the Black Sea (Science) Cheshire cat escape by Emiliania huxleyi (PNAS) Letters read o...
Jun 04, 2012•1 hr 9 min
TWiM #33: Tuning the immune organ
Vincent, Michael, and Ivo review the requirement for segmented, filamentous bacteria for the induction of a specific type of helper T cell in the gut. Links for this episode: Induction of Th17 cells by segmented filamentous bacteria (Cell) Segmented filamentous bacteria take the stage (Nature) Genome of segmented filamentous bacteria reveals auxotrophy (Cell) Segmented filamentous bacteria and diabetes protection (PNAS) Send your microbiology questions and comments (email or mp3 file) to twim@tw...
May 16, 2012•1 hr 8 min
TWiM #32: Not the shadow biosphere
Rosie Redfield talks about her evidence that a bacterium cannot grow on arsenic instead of phosphorus.
May 02, 2012•1 hr 7 min
TWiM 31: Screen door on a submarine
Hosts: Vincent Racaniello , Jo Handelsman , and Michael Schmidt Vincent, Jo, and Michael discuss an archetypal protein transport system in bacterial outer membranes, and evidence that gut microbial enterotypes might not fall into defined groups. Links for this episode: Discovery of a TAM, a new bacterial protein transport system (Nat Struct Mol Biol) Commentary on TAM discovery Enterotypes of the human gut microbiome (Nature) Gut enterotypes might be less clear-cut (Ed Yong) Letters read on TWiM...
Apr 18, 2012•1 hr 15 min
TWiM #30: Unraveling melioidosis and insulin resistance
On episode #30 of the podcast, Vincent, Elio, and Michael review how a toxin from Burkholderia pseudomallei inhibits protein synthesis, and the role of the gut microbiome in modulating insulin resistance in mice lacking an innate immune sensor.
Apr 04, 2012•1 hr 10 min
TWiM #29: Death and an iron-loaded spike
On episode #29 of the podcast, Vincent and Stanley review how a phage pierces the cell membrane with an iron-loaded spike, and two programmed cell death systems in E. coli.
Mar 21, 2012•1 hr 3 min
TWiM #28: Not unorganized bags of enzymes
Vincent, Michael, and Elio review how competition within a host drives virulence of Streptococcus pneumoniae, and the expanding universe of the bacterial cytoskeleton.
Mar 07, 2012•1 hr 17 min
TWiM #27: An inflamed gut is good for Salmonella
Vincent, Elio, and Michael review how inflammation allows Salmonella to compete with fermenting gut microbes, and a riboswitch in bacterial and Archeal species that is triggered by fluoride.
Feb 22, 2012•1 hr 15 min
TWiM #26: Suum cuique
Vincent, Elio, and Michael discuss the finding of Sutterella species in the gut of autistic children, and methods for cultivating oral bacteria.
Feb 08, 2012•1 hr 15 min
TWiM #25: Magnetotactic bacteria and totally drug resistant TB
On episode #25 of the podcast, Vincent, Elio, and Michael review bacteria that use the earth’s magnetic field for navigation, and identification of totally drug resistant Mycobacterium tuberculosis.
Jan 25, 2012•1 hr 17 min
TWiM #24: This year in microbiology
Vincent, Michael, and Cliff review ten compelling microbiology stories from 2011.
Jan 11, 2012•1 hr 19 min
TWiM #23: Fighting antibiotics with toxic gas and starvation
Vincent, Jo, Elio, and Michael explain how a swarming bacterium helps disperse a non-motile fungus, and bacterial antibiotic tolerance mediated by hydrogen sulfide and starvation responses.
Dec 28, 2011•1 hr 16 min
TWiM #22: Microbiology 911
Vincent and Michael speak with Alfred Sacchetti, MD, Chief of Emergency Services at Our Lady of Lourdes Medical Center, about microbial infections encountered in the emergency room.
Dec 14, 2011•1 hr 38 min
TWiM #21: Symbiotic margheritas
Vincent and Elio discuss ancient symbiosis between Alphaproteobacteria and catenulid flatworms, and a toxin from Helicobacter pylori that engages the mitochondrial fission machinery to induce host cell death.
Nov 30, 2011•1 hr 8 min
TWiM #20: Facebook for bacteria
On episode #20 of the podcast This Week in Microbiology, Vincent, Michael, and Elio follow up on the outbreaks of E. coli in Germany and cholera in Haiti, then discuss genes that confer self-identity to Proteus mirabilis.
Nov 16, 2011•1 hr 8 min
TWiM #19: Your microbiome is what you eat
Vincent, Michael, Elio, and Jo discuss the genome sequence of Y. pestis from victims of the Black Death, and the effect of diet on gut microbial enterotypes.
Nov 02, 2011•59 min
TWiM #18: Escherichia coli K-12, an emerging pathogen?
Vincent, Michael, Elio, and Stanley explain how to make the human intestinal commensal and benign laboratory bacterium Escherichia coli K-12 into an invasive organism, and the unearthing of century-old spores in New York City.
Oct 19, 2011•1 hr 14 min
TWiM #17: Debugging endosymbiosis
Vincent, Michael, and Elio focus on endosymbiosis: the rapid spread of Ricekttsia in whitefiles, and a metabolic patchwork in nested symbionts of mealybugs.
Oct 05, 2011•1 hr 11 min
TWiM #16: ICAAC Live
On episode #16 of the podcast This Week in Microbiology, Vincent , Michael , Arturo , Stuart , and David converse about antimicrobial resistance and why most fungi do not cause disease at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)....
Sep 22, 2011•1 hr 29 min
TWiM #15: Microbial long distance relationships
On episode #15 of the podcast This Week in Microbiology, Vincent, Michael and Jo review the number of species on Earth, evidence that the 2010 Haitian cholera outbreak originated in Nepal, and how gut microbiota influence the immune response to influenza virus infection of the lung.
Sep 07, 2011•59 min
TWiM #14: Vomocytosis and microbial transistors
On episode #14 of the podcast This Week in Microbiology, Stanley, Margaret, Michael and Elio review how the fungus Cryptococcus escapes from macrophages, and electrical conductivity in nanowires formed by the bacterium Geobacter.
Aug 24, 2011•1 hr 8 min
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