Mark Martin joins TWiM to describe nano-sized parasitic bacteria that inhabit humans, and the construction of whole-cell biosensors for detecting arsenic in drinking water. Hosts: Vincent Racaniello , Elio Schaechter , and Michael Schmidt Guest: Mark O. Martin Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Become a patron of TWiM. Links for this episode Ultra-small parasitic bacteria in humans (Cell Rep) Arsenic (WHO) Arsenic and drinking water (CDC) ...
Jul 30, 2020•1 hr 19 min•Ep. 222
TWiM reveals a potential mucus-busting weapon for patients with cystic fibrosis, and bacteria in the intestinal tract that can oxidize cholesterol, leading to lower levels of the lipid in blood. Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Become a patron of TWiM. Links for this episode Biofilm eradication with nitric oxide release (ACS Inf Dis) Pseudomonas quorum sensing network (Protein) Cholesterol metabolism by gut bacteria (Cell Host Microbe) M...
Jul 16, 2020•1 hr 9 min•Ep. 221
TWiM reveals that methane-producing bacteria might survive beneath the surface of Mars, and identification of a cytopathogenic toxin in a bacterium associated with preterm birth. Hosts: Vincent Racaniello , Elio Schaechter , Michele Swanson and Michael Schmidt Become a patron of TWiM. Links for this episode: Archaea could make methane on Mars (Sci Rep) Cytopathogenic toxin in bacterium associated with preterm birth (J Bact) Music used on TWiM is composed and performed by Ronald Jenkees and used ...
Jul 03, 2020•43 min•Ep. 220
The TWiM discusses eradicating racism in academia and STEM, and a peptide from commensal bacteria that protects skin from damage caused by MRSA Become a patron of TWiM Links for this episode: Responsibility in academic research Improving equity in faculty hiring (MBoC) #ShutDownSTEM Peptide protects skin from microbial damage (AAC) Agr phase variants in S. aureus (mBio) S. aureus quorum sensing system (BMC Res Notes) COVID-19 joins pandemic legion (mBio) Music used on TWiM is composed and perfor...
Jun 19, 2020•1 hr 2 min•Ep. 219
The TWiM team explains how breathing can transmit SARS-CoV-2, and how lack of breathing leads to loss of mitochondria in a multicellular parasitic animal. Become a patron of TWiM. Links for this episode: Reducing transmission of SARS-CoV-2 (Science) Why social distancing is important (NY Times) Parasite without mitochondria (PNAS) Letters read on TWiM 218 Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and comments to twim...
Jun 06, 2020•1 hr 2 min•Ep. 218
The TWiM team explains an experimental vaccine to prevent E. coli urinary tract infections, and the remarkable three-way symbiosis of narnaviruses, bacteria, and fungi. Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Become a patron of TWiM. Links for this episode Developing a vaccine for UTI (mBio) Narnaviruses and bacteria-fungal symbioses (ISME J) 20% off The Invisible ABCs for TWiM listeners! Use promo code: ABC20 at checkout. TWiM Listener survey...
May 22, 2020•52 min•Ep. 217
The TWiM team discuses saliva as more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swab and how Mycobacterium tuberculosis sulfolipid-1 activates nociceptive neurons and induces cough. Links for this episode: Preventing the next pandemic (NY Times) COVID-19 treatment guidelines (NIH) Saliva sensitive for SARS-CoV-2 detection (medRxiv) A mycobacterial molecule provokes cough (Cell) Letters read on TWiM 216 20% off The Invisible ABCs for TWiM listeners! Use promo cod...
May 01, 2020•1 hr 4 min•Ep. 216
A ferret model for infection by SARS-CoV-2, and how Neolithization lead to emergence of a human bacterial pathogen. Hosts: Vincent Racaniello , Elio Schaechter , Michele Swanson and Michael Schmidt Links for this episode: Infection and transmission of SARS-CoV-2 in ferrets (Cell Host Micr) Neolithization led to emergence of Salmonella enterica (Nat Ecol Evol) Arnold Demain (Wikipedia) Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology ...
Apr 17, 2020•57 min•Ep. 215
Vincent, Elio and Michael reveal the ASM COVID-19 summit, and how Salmonella injects a protein into the cell to drive suppression of the immune response. ASM COVID-19 Summit Value of SARS-CoV-2 diagnostic testing (mBio) How SARS-CoV-2 is changing (nextstrain) Contribute to COVID-19 data Salmonella effector suppresses inflammation (Cell Host Micr) Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Become a patron of TWiM....
Apr 03, 2020•59 min•Ep. 214
Vincent, Elio and Michael discuss the stability of human coronaviruses on surfaces and in aerosols, and peptidoglycan production by a mosaic consisting of a bacterium within a bacterium within an insect. Links for this episode: Human coronavirus 229E infectivity on common surfaces (mBio) Aerosol and surface stability of SARS-CoV-2 (medRxiv) Peptidoglycan synthesis by a insect-bacteria mosaic (Cell) Letters read on TWiM 213 Become a patron of TWiM. Music used on TWiM is composed and performed by ...
Mar 20, 2020•1 hr 1 min•Ep. 213
The TWiM team reviews the coronavirus outbreak that began in Wuhan, China, and the finding that an IRF deficiency underlies Whipple’s disease. 2019-nCoV case tracking (JHU) Clinical features of infection with 2019-nCoV (Lancet) Early transmission dynamics of 2019-nCoV (NEJM) Isolation of 2019-nCoV (NEJM) TLR4 defect in Whipple’s disease (eLife) Become a Patron of TWiM ! Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology questions and c...
Feb 06, 2020•55 min•Ep. 212
The Fellowship of the TWiM reveal that colorectal cancer-associated microbiota are associated with higher numbers of methylated genes in colonic mucosa, and identification of metabolites needed by the fire blight disease bacterium for virulence in apples. Become a patron of TWiM. Links for this episode: Colorectal cancer and the gut microbiome (PNAS) Fire blight (YouTube) Fire blight spreads north (NY Times) E. amylovora auxotrophs (Appl Environ Micro) Music used on TWiM is composed and performe...
Jan 09, 2020•1 hr 18 min•Ep. 211
The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival. Hosts: Vincent Racaniello , Elio Schaechter , Michele Swanson and Michael Schmidt Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Become a patron of TWiM. Links for this episode P. aeruginosa PQS repels bacteria (J Bact) PQS signaling (J Bact) Letters r...
Dec 05, 2019•1 hr 16 min•Ep. 210
The TWiM team reveals how ribosome modification resuscitates bacterial persister cells, and explain how a phage tail fiber protein exploits rotation of flagella to move towards the cell membrane. Become a patron of TWiM. Links for this episode: Ribosome modification resuscitates persister cells (Environ Micro) Flagellotrophic phage targets host with tail fiber (Mol Micro) Hydrodynamics of phage migration along flagella (Phys Rev Fluids) Music used on TWiM is composed and performed by Ronald Jenk...
Nov 14, 2019•58 min•Ep. 209
Hosts: Vincent Racaniello , Michele Swanson and Michael Schmidt Guests: Deanna Beatty , Mark Hay , Gina Lewin , Frank Stewart , and Marvin Whiteley At Georgia Tech, members and trainees of the Center for Microbial Dynamics and Infection discuss the identification of pathogen essential genes during coinfections, and how coral management can improve coral defenses against pathogens. Become a patron of TWiM. Links for this episode: Center for Microbial Dynamics and Infection Pathogen essential gene...
Oct 31, 2019•1 hr 23 min•Ep. 208
From ASM Microbe 2019 in San Francisco, Vincent speaks with Victoria McGovern, Carl Nathan, and Dan Portnoy about advancing human health through innovative collaborations. Host: Vincent Racaniello Guests: Victoria McGovern , Carl Nathan , and Dan Portnoy Links for this episode: Getting grants (Virulence) N itric oxide synthase protects against tuberculosis (PNAS) Actin filaments and Listeria monocytogenes (J Cell Biol) Become a Patron of TWiM ! Music used on TWiM is composed and performed by Ron...
Oct 17, 2019•1 hr 7 min•Ep. 207
The TWiM holobionts pay tribute to Stuart Levy, and reveal the remarkably diverse array of cyclic nucleotides synthesized by bacteria that likely mediate interactions with animal and plant hosts. Become a patron of TWiM. Links for this episode: Stuart Levy, Antibiotic Resistance Researcher, Dies Resistance fighter (The Scientist) Stuart Levy on TWiM 16 Stuart Levy on Meet the Scientist episode 17 Segregation of R factors (Nature) Infectious drug resistance (Sci Am) Spread of antibiotic resistanc...
Oct 03, 2019•1 hr 5 min•Ep. 206
The tetracoccal TWiM team visits Tardigrades on the Moon, and the twelve year quest to isolate an archaeon that provides insights into the emergence of the first eukaryotic cell. Links for this episode: Tardigrades on the moon (Mashable) Meet the Tardigrade (WaPo) Archaeon at prokaryote-eukaryote interface (bioRxiv) Subscribe to TWiM (free) on iTunes , Google Podcasts , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Become a Patron o...
Sep 20, 2019•1 hr 7 min•Ep. 205
Host: Vincent Racaniello Guests: Nicholas Arpaia and Tal Danino Vincent meets up with Nick and Tal to explain how they engineered E. coli to lyse within tumors and deliver an antibody that causes tumor regression in mice. Links for this episode: Programmable bacteria induce tumor immunity (Nat Med) Synchronized cycles of bacterial lysis (Nature) TWiM Listener survey Subscribe to TWiM (free) on iTunes , Google Podcasts , Stitcher , Android , RSS , or by email. You can also listen on your mobile d...
Sep 06, 2019•1 hr 8 min•Ep. 204
The TWiM team reveals thousands of small novel genes in the human microbiome, and a mutualistic symbiosis between marine protists covered with magnetosome-containing bacteria. Hosts: Vincent Racaniello , Elio Schaechter , Michele Swanson and Michael Schmidt Links for this episode Thousands of small novel genes in human microbiome (Cell) A magnetotactic consortium under the sea (Nat Micro) Image credit Letters read on TWiM 203 Music used on TWiM is composed and performed by Ronald Jenkees and use...
Aug 22, 2019•58 min•Ep. 203
Hosts: Vincent Racaniello , Elio Schaechter , Michele Swanson and Michael Schmidt Guest: Julie Wolf Julie joins the TWiM team to reveal how microbiome and gut anatomy of a wood-feeding beetle promotes lignocellulose deconstruction, and bacteria that degrade PET plastic. How wood-feeding beetles deconstruct lignocellulose (PNAS) Meet the Microbiologist hosted by Julie Wolf Bacteria that degrade PET plastic (Micr Res Ann) Microbiology resource of the month (ASM) Morgan Vague’s TED talk Pacific gar...
Aug 08, 2019•1 hr 2 min•Ep. 202
Mark Martin joins Vincent and Michael to present compelling papers suitable for teaching microbiology to undergraduate students. Become a patron of TWiM. Links for this episode: Paradigm shifts, paradigm drifts ( pdf ) Introducing THOR (mBio) Engineering bacteriophages to treat mycobacterial infection (Nat Med) Biofilms by Colter (Int Microbiol) Life in a world without microbes (PLoS Biol) Reduction of cholera in Bangladeshi villages (PNAS) Placenta goes viral (PLoS Biol) #OMG ( jpg ) #OMG illus...
Jul 26, 2019•1 hr 24 min•Ep. 201
Vincent, Michele, and Michael travel to San Diego to reminisce with Elio about his career, his work in microbiology, and his love for microbes and mushrooms. VIDEO VERSION AVAILABLE: https://www.youtube.com/watch?v=Menlo1YvPko Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Get the entire ASM Podcast Network via our Microbeworld app . Become a patron of TWiM. Links for this episode Elio’s profile Elio’s memoirs Elio’s first paper , 1952 (J Bact) In the...
Jul 12, 2019•1 hr 1 min•Ep. 200
From ASM Microbe 2019, the Microbials meet up with Susanna L. Harris and Alex Politis to talk about mental health in graduate school and NIH peer review. Hosts: Vincent Racaniello , Michele Swanson and Michael Schmidt Guests: Susanna L. Harris and Alex Politis Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Get the entire ASM Podcast Network via our Microbeworld app . Become a patron of TWiM Links for this episode PhD Balance Susanna’s video (Vimeo) NI...
Jun 28, 2019•1 hr 15 min•Ep. 199
The TWiM team presents an extracellular bacterium associated with Paramecium, and induction of antiviral immunity by a bacteriophage that prevents bacterial clearance. Subscribe to TWiM (free) on iTunes , Google Podcasts , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app . Become a Patron of TWiM ! Bacteria on the outside of paramecia (ISME) Phage trigger antiviral immunity (Science) Image credit Letters read on TWiM 198 Music used on TW...
Jun 01, 2019•1 hr•Ep. 198
The Microbials reveal how a chemosynthetic symbiont stores energy for its marine flatworm host, and extraction of nutrients from host cells by E. coli injectisome components. Become a patron of TWiM. Links for this episode: Take the TWiM listener survey Bacteria store energy for gutless worms (PNAS) Paracatenula on TWiM #21 E. coli extracts nutrients from host cells (Cell) Image credit Music used on TWiM is composed and performed by Ronald Jenkees and used with permission. Send your microbiology...
Apr 26, 2019•1 hr 10 min•Ep. 197
The Microbials discuss how ambrosia beetles utilize ethanol to farm fungi, and how cleaved cochlin protein sequesters bacteria in the inner ear to preserve hearing function. Links for this episode: Ambrosia beetles, ethanol, and farmed fungi (PNAS) Cleaved cochlin protects the inner ear (Cell Host Microbe) Importance of flossing (ADA) Subscribe to TWiM (free) on iTunes , Google Podcasts , Stitcher , Android , RSS , or by email. You can also listen on your mobile device with the Microbeworld app ...
Mar 29, 2019•1 hr 4 min•Ep. 196
Michael and Vincent discuss the finding of immunity to Cas9 protein in humans, and a potential role for an oral bacterium in Alzheimer’s disease. Subscribe to TWiM (free) on Apple Podcasts , Google Podcasts , Android , RSS , or by email. Get the entire ASM Podcast Network via our Microbeworld app . Become a patron of TWiM. Links for this episode Immunity to Cas9 protein in humans (Nat Med) P. gingivalis and Alzheimer’s disease (Science) Clinical trial of COR388 in AD patients (clinicaltrials.gov...
Mar 04, 2019•1 hr 15 min•Ep. 195
Vincent Racaniello , Michael Schmidt , Michele Swanson and Elio Schaechter How a bacterium helps dengue virus replicate in the mosquito gut, and minicells as a damage disposal mechanism in E. coli. Become a patron of TWiM. Links: Please take the TWiM listener survey Bacteria help dengue virus in mosquito gu t (Cell Host Micr) Fungus helps dengue virus in mosquito gut ( TWiV 479 ) Minicells for disposal of damaged goods (mSphere) TWiM Listener survey Subscribe to TWiM (free) on iTunes , Google Po...
Feb 14, 2019•1 hr 5 min•Ep. 194
The TWiM team explore how Lactobacillus reuteri can rescue social deficits in three mouse models of autism spectrum disorder, and the role of Salmonella persisters in undermining host defenses during antibiotic treatment. Subscribe to TWiM (free) on iTunes , Google Podcasts , Stitcher , Android , RSS , or by email. Become a Patron of TWiM ! Please take the TWiM listener survey Bacteria alter behavior in mouse autism models (Neuron) Mice behaving badly ( TWiM 131 ) Salmonella persisters undermine...
Jan 31, 2019•1 hr 1 min•Ep. 193
