184: CRISPR-Cas immune systems
Sep 07, 2018•1 hr 26 min•Ep. 184
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Episode description
Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.
Host: Vincent Racaniello
Guest: Sam Sternberg
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Links for this episode- Sternberg Laboratory at Columbia
- Mechanism of substrate selection by Cas9 (RNA)
- DNA interrogation by Cas9 (Nature)
- Conformational control of DNA target cleavage by Cas9 (Nature)
- A Crack in Creation by Doudna and Sternberg
- What if we could rewrite the human genome? (YouTube)
- Sam Sternberg
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