Nels and Vincent continue their discussion of SARS-CoV-2 evolution, with a report that the coronavirus proofreading enzyme stimulates RNA recombination, and debunking the conclusion that a change in the viral spike glycoprotein is associated with increased human to human transmission. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO CoV proofreading enzyme stimulates recombination (bioRxiv) CoV spike mutation pipeline (bio...
May 06, 2020•1 hr 14 min•Ep. 55
Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, including function of the furin cleavage site, whether Vervet cells are an informative system, another bat isolate, and a nomenclature to assist genomic epidemiology. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO SARS-CoV-2 in Vero cells (bioRxiv) More related SARSr virus from bat (bioRxiv) Patient isolates in Vero cells (medRxiv) N...
Apr 25, 2020•1 hr 18 min•Ep. 54
Nels and Vincent continue their discussion of SARS-CoV-2 from an evolutionary viewpoint, focusing on what the genome sequences tell us about the virus. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Clement Chow with COVID-19 (Salt Lake Trib) Scientists exposed to coronavirus (Nature) CoV by Britt Glaunsinger (YouTube) Genetic epidemiology of novel coronavirus (nextstrain.org) Time stamps by Jolene . Thanks! Science Pick...
Apr 04, 2020•1 hr 32 min•Ep. 53
Nels and Vincent examine SARS-CoV-2 from an evolutionary viewpoint, examining what the spike glycoprotein sequence informs us about the origin of the virus. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Distinct CoV name needed (Lancet) Proximal origin of SARS-COV-2 (virological) CoV spillovers not rare (Goats and Soda) SARS-CoV-2 phylodynamics analysis (virological) Bat CoV surveillance in China (PLoS Path) Image credi...
Feb 26, 2020•1 hr 23 min•Ep. 52
Nels and Vincent dive deep into evolution and consider how new proteins emerged billions of years ago, when there were no other proteins to serve as starting material. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Primordial emergence of a nucleic acid binding protein (bioRxiv) Tawfik laboratory Image credit Letters read on TWiEVO 51 Time stamps by Jolene . Thanks! Science Picks Nels - Universal principled review Vincen...
Jan 22, 2020•1 hr 11 min•Ep. 51
Nels and Vincent discuss signatures of sex chromosome evolution revealed by assembly of a young vertebrate Y chromosome from 3-spined stickleback fish. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Assembly of a young vertebrate Y chromosome (bioRxiv) Image credit Letters read on TWiEVO 50 Time stamps by Jolene . Thanks! Science Picks Nels - Genome from a 5,700-Year-Old Wad of Chewed Gum Vincent - NJ Sea-Level Rise Repo...
Dec 24, 2019•1 hr 43 min•Ep. 50
Rich joins Nels and Vincent for a debriefing on the 4th Ringberg Symposium on Giant Virus Biology in Tegernsee, Germany. Hosts: Nels Elde and Vincent Racaniello Guest: Rich Condit Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Endless giant virus forms most beautiful ( TWiV 575 ) 4th Ringberg Giant Virus Meeting Program (pdf) Photographs by Matthias Fischer Time stamps by Jolene . Thanks! Science Picks Rich - Flightradar24 Nels - Deutsches Museum Munich Vincen...
Nov 29, 2019•1 hr 53 min•Ep. 49
Nels and Vincent reveal a new choanoflagellate that forms multicellular cup shaped colonies that respond to light to alternate between feeding and swimming behavior. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Microbial accomplices in multicellularity ( TWiEVO 11 ) Light regulated collective contractility (Science) Image credit Letters read on TWiEVO 48 Time stamps by Jolene . Thanks! Science Picks Nels - How to write...
Oct 31, 2019•1 hr 34 min•Ep. 48
Nels and Vincent trace the origins of Saccharomyces cerevisiae strains used to make beer, and find that ales and lagers are made with yeasts that were derived from those used to make European grape wine and Asian rice wine. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Origins of beer yeasts (PLoS Biol) Chateau Jiahu beer Time stamps by Jolene . Thanks! Science Picks Nels - Population fluctuations in 10 biggest cities V...
Sep 19, 2019•1 hr 32 min•Ep. 47
Nels and Vincent analyze the genomes of canine transmissible tumors to provide insight into the worldwide spread of the disease from its origin in a single dog 4000-8500 years ago, and its diversity, mutation, and evolution. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Evolution and mutation of canine transmissible cancer (Science) Clam cancers ( TWiEVO 17 ) Sixth modality of infectious disease (PLoS Path) Time stamps ...
Aug 31, 2019•1 hr 32 min•Ep. 46
At ASM Microbe in San Francisco, Nels and Vincent meet up with Talia Karasov who reveals that in contrast to agriculture, wild plants are colonized by multiple lineages of pathogenic bacteria. Hosts: Nels Elde and Vincent Racaniello Guest: Talia Karasov Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Talia Karasov in the Bergelson lab Arabidopsis thaliana and Pseudomonas (Cell Host Micr) Time stamps by Jolene . Thanks! Music on TWiEVO is performed by Trampled b...
Jul 29, 2019•1 hr 2 min•Ep. 45
At ASM Microbe in San Francisco, Nels and Vincent meet up with Paul Turner to talk about evolutionary considerations in using bacteriophages to treat infections with antibiotic-resistant bacteria. Hosts: Nels Elde and Vincent Racaniello Guest: Paul Taylor Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Turner Lab at Yale Phage therapy : A renewed approach (Cell Host Microbe) Phage treatment of aortic graft (Evol Med Pub Health) Time stamps by Jolene . Thanks! S...
Jun 27, 2019•1 hr 5 min•Ep. 44
Dustin Rubinstein joins Nels and Vincent to discuss coevolution of genome architecture and social behavior, and studying social transitions in sponge-dwelling snapping shrimp. Hosts: Nels Elde and Vincent Racaniello Guest: Dustin Rubinstein Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Co-evolution of genome architecture and social behavior (Trend Ecol Evol) Social transitions in snapping shrimp (Curr Op Insect Sci) Time stamps by Jolene . Thanks! Science Pic...
May 25, 2019•1 hr 21 min•Ep. 43
Nels and Vincent review the contribution of multiple Denisovan lineages to the modern Papuan genome. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Denisovan ancestries in Papuans (Cell) Prof Murray Cox Image credit Letters read on TWiEVO 42 Time stamps by Jolene . Thanks! Science Picks Nels - Sydney Brenner - What Genomes Can Tell Us About the Past Vincent - Scientific Communication in a Post-Truth Society Music on TWiE...
Apr 24, 2019•1 hr 19 min•Ep. 42
Nels and Vincent explore the evolution of new protein-coding genes de novo from nocoding DNA sequences, using the antifreeze protein of northern codfish as a model. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Evolution of antifreeze protein gene in codfish (PNAS) Codfish diversity (Cheng lab) Frankentomatoes (Huff Post) Image credit Time stamps by Jolene . Thanks! Science Picks Nels - Science at Sundance reviews Vince...
Mar 20, 2019•1 hr 24 min•Ep. 41
Nels and Vincent move back to reproductive isolation - this time, pre-zygotic, in the charismatic orchid bee where the males make chemically distinct perfumes to attract mates of the same species. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Olfactory receptor gene underlies reproductive isolation (biorXiv) Image credit Time stamps by Jolene . Thanks! Science Picks Nels - Nature Zen: Orchid Bees Are Shiny Vincent - Wha...
Feb 15, 2019•1 hr 12 min•Ep. 40
Nels and Vincent look at the intracellular bacteria Legionella from an evolutionary perspective: the role of gene acquisition and reshuffling from plants, animals, fungi, and archaea in the emergence of human pathogens. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Over 18,000 effectors in Legionella genome (PNAS) Carmen Buchrieser lab Howard Shuman Science Picks Nels - Science in Film ( twitter ) Vincent - Lunar Eclips...
Jan 26, 2019•1 hr 17 min•Ep. 39
Nels and Vincent reveal a highly conserved protein that acts as an evolvability factor, increasing mutation and the ability of bacteria to become resistant to antibiotics. Hosts: Nels Elde and Vincent Racaniello Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Inhibiting evolution of antibiotic resistance (Mol Cell) Pushing viruses over the error threshold (virology blog) Image credit Letters read on TWiEVO 38 Science Picks Nels - Science/nature illustrator/arti...
Dec 24, 2018•1 hr 21 min•Ep. 38
David Quammen joins Nels and Vincent to talk about his new book, A Tangled Tree , including evolutionary trees, Carl Woese, Lynn Margulis, horizontal gene transfer, and much more. Hosts: Nels Elde and Vincent Racaniello Guest: David Quammen Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO David's website David on TWiV 408, Boston Quammens Axel Erlandson's trees reimagined - Gilroy Gardens Music on TWiEVO is performed by Trampled by Turtles Send your evolution qu...
Nov 17, 2018•1 hr 31 min•Ep. 37
Mia joins Nels and Vincent to unravel their finding that the transposons that maintain the ends of chromosomes in Drosophila have evolved in conflict with the genome. Hosts: Nels Elde and Vincent Racaniello Guest: Mia Levine Subscribe (free): iTunes , Google Podcasts , RSS , email Become a patron of TWiEVO Levine Lab at U Penn Telomere elongation without telomerase (bioRxiv) Letters read on TWiEVO 36 Science Picks Nels - Cinema Science podcast Vincent - Mastodon bones unearthed ( Instagram , Gra...
Oct 24, 2018•1 hr 15 min•Ep. 36
Nels and Vincent reveal that female-specific DNA associated with sex in strawberries has repeatedly changed its genomic location, possibly linking new genes with sex. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Jumping sex genes in strawberries (PLoS Biol) Red Queen by Matt Ridley Image credit Letters read on TWiEVO 35 Science Picks Nels - New snailfish and Cloned crayfish Vincent - A PhD Lab Coat Ceremony Listener Picks Steve - Diversity in simple blobs Justin - On Growth ...
Sep 21, 2018•1 hr 36 min•Ep. 35
Nels and Vincent discuss how the loss of an enzyme in marine mammals millions of years ago now makes them at risk for neurotoxicity caused by human-made organophosphorous pesticides. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Ancient losses of paraoxonase I (Science) Big Yellow Taxi (YouTube) Image credit Letters read on TWiEVO 34 Hey farmer farmer put away the chlor-pyri-fus I don’t care about spots on my apples Leave me the manatee and walruses Science Picks Nels - New d...
Aug 16, 2018•1 hr 22 min•Ep. 34
Nels and Vincent are astounded by the finding of an insect-derived virus in a fungus that manipulates the behavior of flies. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Virus in fungus in fly (bioRxiv) On a leaf, no one can hear you scream ( TWiV 443 ) Nels gives Benzer Lecture (YouTube) Domestication of fungal fly pathogen (bioRxiv) Sequencing E. muscae genome (10X genomics) Eisen's twitter stream on new iflavirus (Twitter) Science Picks Nels - Mindsuckers ; getting photos...
Jul 25, 2018•1 hr 20 min•Ep. 33
Matt joins Nels and Vincent to discuss the neutral theory of evolution and its rejection in light of genome-scale data. Hosts: Nels Elde and Vincent Racaniello Guest: Matt Hahn Become a patron of TWiEVO Hahn Lab Molecular Population Genetics by Matt Hahn Neutral theory in light of natural selection (Mol Biol Evol) Neutral Sequence Fallacy (Assembly of Fragments) Splendor and misery of adaptation (BMC Biol) Image credit Letters read on TWiEVO 32 Science Picks Nels - Inaugural Transposon Day Vince...
Jun 19, 2018•1 hr 19 min•Ep. 32
Nels and Vincent present ancient hepatitis B virus genome sequences from Bronze Age to Medieval period human remains. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Ancient hepatitis B virus genomes (Nature) Even more ancient HBV genomes (bioRxiv) Image credit Letters read on TWiEVO 31 Science Picks Nels - Sampling whale breath with drones (Preprint) Vincent - Verge Science Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twievo...
May 19, 2018•1 hr 21 min•Ep. 31
Nels and Vincent reveal how a motor protein in corn causes preferential transmission of chromosomes to egg cells, leading to non-Mendelian inheritance. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Molecular Evolution and the Cell meeting Selfish corn chromosomes (Cell) Dawe Lab - neocentromeres and meiotic drive Image credit Letters read on TWiEVO 30 Science Picks Nels - Craypot stinkhorn mushroom ( Colus pusilus ) Vincent - Doubts raised over plan to release herpesvirus to ...
Apr 21, 2018•1 hr 15 min•Ep. 30
Nels and Vincent discuss the evolution of blood feeding to nonbiting in a mosquito, and evolution of bacterial virulence in the house finch caused by incomplete host immunity. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Molecular Evolution and the Cell meeting Mosquito evolution from blood feeding to nonbiting (PNAS) Mosquito blood feeding is not a free lunch (virology blog) Incomplete immunity and evolution of virulence (Science) Image credit Letters read on TWiEVO 29 Scie...
Mar 21, 2018•1 hr 42 min•Ep. 29
Sarah Tishkoff joins Nels and Vincent to explain work from her laboratory on the genetic basis of skin pigmentation in Africans. Hosts: Nels Elde and Vincent Racaniello Guest: Sarah Tishkoff Become a patron of TWiEVO Molecular Evolution and the Cell meeting Sarah AMA on Reddit Genetics of African skin pigmentation (Science) Image credit Science Picks Nels - In Defense of Plants ( Shre w Loo ) Vincent - Contribution of NIH funding to new drug approvals Music on TWiEVO is performed by Trampled by ...
Feb 28, 2018•1 hr 20 min•Ep. 28
Taking a cue from the recent frigid weather, Nels and Vincent explore how modifications of a neuronal cold-sensing channel regulate diminished cold sensitivity in hibernating mammals. Hosts: Nels Elde and Vincent Racaniello Become a patron of TWiEVO Why ground squirrels and hamsters don't mind the cold (Cell Rep) Image credit Letters read on TWiEVO 27 Science Picks Nels - Undergrad podcasters from Stonehill College Vincent - Viruses at Target Music on TWiEVO is performed by Trampled by Turtles S...
Jan 13, 2018•1 hr 18 min•Ep. 27
Vinny Lynch joins Nels and Vincent to discuss how a zombie gene in elephants protects these large, long lived animals from cancer. Hosts: Nels Elde and Vincent Racaniello Guest: Vinny Lynch Become a patron of TWiEVO Lynch Lab Elephant zombie LIF gene induces apoptosis (bioRxiv) Image credit Science Picks Nels - Animalism Vincent - Voyager I fires up thrusters after 37 years Vinny - Rollin' Wild Music on TWiEVO is performed by Trampled by Turtles Send your evolution questions and comments to twie...
Dec 07, 2017•1 hr 14 min•Ep. 26
