Jun 27 2025 This Week in Cardiology
Jun 27, 2025•29 min
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Summary
This week's cardiology update covers the FDA's approval of a new triple-drug polypill for hypertension, alongside a shift in opinion on its practicality. The episode provides a critical deep dive into the evidence (or lack thereof) supporting invasive pulmonary embolism therapies, exploring the factors driving their popularity despite limited data. Finally, it analyzes long-term trends in heart disease mortality, noting a decline in ischemic deaths but a rise in other causes, and briefly highlights exciting progress in diabetes care.Episode description
FDA approves triple-drug polypill, a change of opinion, a deep dive into invasive pulmonary embolism therapies, heart disease trends, and diabetes care is on fire are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
I FDA News in HTN
- FDA announcement https://george-medicines.com/george-medicines-announces-fda-approval-of-widaplik-telmisartan-amlodipine-and-indapamide-a-new-single-pill-combination-treatment-for-hypertension-in-adults-including-initial-treatment/
- Lancet Study https://doi.org/10.1016/S0140-6736(24)01744-6
- JACC study vs placebo https://www.jacc.org/doi/abs/10.1016/j.jacc.2024.08.025
- JAMA Cardiology Meta-analysis https://jamanetwork.com/journals/jamacardiology/fullarticle/2804313
II Invasive PE Therapy
- EHJ-Open review: https://academic.oup.com/ehjopen/article/5/3/oeaf071/8156689
- PEITHO Trial https://www.nejm.org/doi/10.1056/NEJMoa1302097
- REAL PE Observational Study https://pmc.ncbi.nlm.nih.gov/articles/PMC11308131/
III Heart Disease Trends
IV Diabetes Coverage
- Medscape Link https://www.medscape.com/viewcollection/37830
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Questions or feedback, please contact news@medscape.net
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