Aug 08 2025 This Week in Cardiology
Aug 08, 2025•32 min
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Summary
Dr. John Mandrola dissects listener feedback on the SURPASS CVOT trial for diabetes drugs, underscoring the complexities of non-inferiority trials and active comparators. He then delivers a sharp critique of a major meta-analysis on AF ablation, exposing significant methodological flaws. The episode also covers an FDA alert regarding air embolism with the Watchman device, prompting a vital discussion on the inherent risks of preventive procedures. Lastly, Mandrola analyzes new data concerning switching oral anticoagulation in frail elderly patients, offering practical clinical guidance for shared decision-making.Episode description
Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
I SURPASS CVOT
- This Week in Cardiology Podcast, August 1 https://www.medscape.com/viewarticle/1002781
- Mounjaro Appears More Heart Protective Than Trulicity in Trial Of Eli Lilly Diabetes Drugs
II Catheter and Surgical AF ablation
- Catheter and Surgical Ablation for AF: Meta-Analysis https://www.acpjournals.org/doi/10.7326/ANNALS-25-00253
III Watchman Air Embolism Alerts
- Looming Pay Cut to LAAO Triggers Objection From Card Groups
IV Switching Oral Anticoagulants in Frail Older Adults Patients
- FRAIL AF Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.066485
- COMBINE AF Substudy https://doi.org/10.1016/j.jacc.2025.05.060
- The Most Important Study From ESC: FRAIL-AF https://www.medscape.com/viewarticle/996063
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net
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