Episode description
Episode description
Two downsides of PFA including autonomic tone and hemolysis, a bad surrogate in AF care, and controversies in defining cardiac risk are the topics John Mandrola, MD, covers in this week's podcast.
This podcast is intended for healthcare professionals only.
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I.PFA and Its (lack of) Effect on Autonomic Tone
Pulsed Field Ablation for AF: Are US Electrophysiologists Too Easily Impressed?
- Autonomic Tone Paper https://doi.org/10.1016/j.jacep.2024.05.005
- ADVENT https://www.nejm.org/doi/full/10.1056/NEJMoa2307291
II. Second PFA Study JACC-EP—on Hemolysis
- Hemolysis study https://doi.org/10.1016/j.jacep.2024.05.001
- MANIFEST 17K https://www.nature.com/articles/s41591-024-03114-3
- Defaye Editorial https://www.jacc.org/doi/abs/10.1016/j.jacep.2024.06.007
III. A Self-serving Surrogate Marker: Diagnosis to Ablation Time.
- CAPLA Study https://jamanetwork.com/journals/jama/fullarticle/2800186
- CAPLA Substudy https://doi.org/10.1016/j.jacep.2024.05.031
- EHJ RCT Early vs Late https://doi.org/10.1093/eurheartj/ehad247
- LOOP; Diederichsen and colleagues 10.1016/j.jacc.2019.09.050
- Groningen and Maastricht Group study https://heart.bmj.com/content/109/3/186
IV. Future Cardiac Risk
- Diao and colleagues Study of AHA PREVENT Risk Equations https://jamanetwork.com/journals/jama/fullarticle/2821624
- JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821542
- Another JAMA Editorial https://jamanetwork.com/journals/jama/fullarticle/2821628
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