Episode 9: Hepatitis | As Easy As A, B, C, D... E...
Summary
Delve into the fascinating history of hepatitis, from ancient jaundice epidemics to the discovery of five distinct viruses (A, B, C, D, E) that all affect the liver. The episode covers pivotal research, including ethically controversial human experiments during wartime, leading to the identification of transmission methods and the development of vaccines and diagnostic tools. Learn about the unique characteristics of each virus, their transmission pathways, the risks of chronic infection, and the revolutionary direct-acting antiviral drugs that now offer a cure for Hepatitis C, highlighting its significant global impact.Episode description
Scattered throughout history are epidemics of catarrhal or campaign jaundice (the latter was experienced during military campaigns). The pivotal moment was during World War II where troops became sick with jaundice due to a contaminated Yellow Fever vaccine and sporadic jaundice outbreaks in different countries. While the symptoms appeared similar (ie jaundice), one did not confer immunity to the other and further investigation was needed.
This discovery of Hepatitis A and B lead to the discovery of Non-hepatitis A and Non-hepatitis B: other illnesses that caused jaundice and liver damage. This lead to the identification of Hepatitis C, D, and E. Although they have similar names, these are 5 separate virus and require different tests for identification.
This is the story of hepatitis.
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