Levothyroxine is first-line for hypothyroidism, but getting it right requires precision. In this episode, Dr. Busti explains the TSH–T4–T3 feedback loop, why T4 is preferred over T3 or desiccated thyroid, and how half-life and protein binding shape dosing and monitoring. We cover steady-state timing (6–8 weeks), dose step sizes, manufacturer switches, and how food and cation supplements (calcium, iron, magnesium) alter absorption. You’ll also learn how anticonvulsants, rifampin, beta-blockers, s...
Oct 06, 2025•44 min
In this personal reflection, Dr. Busti shares a formative moment of cognitive dissonance that reshaped his approach to evidence-based medicine. When a simple question exposed a knowledge gap, it sparked a lifelong commitment to understanding the “why” behind clinical decisions—and to teaching with honesty and humility. Access bonus materials and downloads at https://thisiswhy.health Disclaimer: This content is for educational purposes only and is not intended to provide medical advice, diagnosis...
Oct 06, 2025•15 min
Cognitive dissonance—the moment we realize we don’t know something we should—can either hinder or grow us. In this episode, Dr. Busti explains how understanding and managing dissonance within the Evidence-Based Medicine framework strengthens humility, reflection, and better patient care. Learn to turn uncertainty into growth and develop true cognitive resonance. Access bonus materials and downloads at https://thisiswhy.health Disclaimer: This content is for educational purposes only and is not i...
Oct 06, 2025•19 min
The final two steps of Evidence-Based Medicine— Apply and Assess —focus on turning knowledge into better patient outcomes. Dr. Busti explains how to apply evidence to real-world practice, integrate patient preferences, and assess the impact of your decisions to continually improve care. Discover how adapting your approach over time creates a more patient-centered, evidence-driven practice. Access bonus materials and downloads at https://thisiswhy.health Disclaimer: This content is for educationa...
Oct 06, 2025•16 min
Step 3 of Evidence-Based Medicine focuses on appraising the evidence. Dr. Busti explains how to systematically evaluate research using validated critical appraisal tools (CATs), detect bias, and interpret the quality of data before applying it to patient care. Learn to distinguish strong evidence from weak studies and develop a reliable, reproducible process for evidence-based decision-making. Access bonus materials and downloads at https://thisiswhy.health Disclaimer: This content is for educat...
Oct 06, 2025•21 min
Step 2 of the EBM process is all about how to acquire evidence efficiently. Dr. Busti explains how to turn your PICO question into an effective search strategy, use Boolean logic and MESH terms, and select the best databases for your clinical question. Learn to differentiate primary, secondary, and tertiary literature and find the most relevant evidence quickly without missing key studies. Access bonus materials and downloads at https://thisiswhy.health Disclaimer: This content is for educationa...
Oct 06, 2025•38 min
Evidence-Based Medicine (EBM) has been shaping clinical decision-making for more than three decades. In this episode, Dr. Busti walks through Step 1 of the 5 A’s — Ask, focusing on how to craft clear, answerable clinical questions that drive better evidence searches and stronger patient care decisions. You’ll learn the difference between background and foreground questions, explore the structure of PICO (Population, Intervention, Comparison, Outcome), and understand how extensions like PICOT and...
Oct 06, 2025•28 min
Thiazide diuretics have been essential in managing hypertension and remain one of the most widely prescribed drug classes today. But their value becomes clearer when you understand the “why.” In this episode, Dr. Busti explains the mechanism of thiazides at the distal convoluted tubule, how this drives sodium handling, and why their clinical effects differ from loop diuretics. We cover the key agents — hydrochlorothiazide, chlorthalidone, indapamide, and metolazone — and discuss their use in hyp...
Oct 06, 2025•1 hr 4 min
MRAs—spironolactone, eplerenone, and finerenone—do far more than nudge blood pressure. They improve outcomes in heart failure, offer targeted benefits in CKD with T2D, and play a unique role in cirrhosis-related ascites. In this focused review, Dr. Busti walks through the why behind the what: aldosterone receptor blockade, tissue selectivity (kidney vs heart), and how those differences drive real-world choices, dosing, and safety. We compare agents head-to-head, unpack RAAS physiology, and trans...
Oct 06, 2025•1 hr 12 min
MRAs—spironolactone, eplerenone, and finerenone—do far more than nudge blood pressure. They improve outcomes in heart failure, offer targeted benefits in CKD with T2D, and play a unique role in cirrhosis-related ascites. In this focused review, Dr. Busti walks through the why behind the what: aldosterone receptor blockade, tissue selectivity (kidney vs heart), and how those differences drive real-world choices, dosing, and safety. We compare agents head-to-head, unpack RAAS physiology, and trans...
Oct 06, 2025•1 hr 1 min
In this introductory episode of This Is Why , Dr. Busti shares the powerful story behind the creation of the podcast — and the mission driving it. With over 30 years of experience spanning nursing, pharmacy, medicine, and education, Dr. Busti offers a rare 360-degree perspective on healthcare. He discusses the common gap in medical training: being taught what to do and how to do it, but not always why . Through his own journey — from the ICU and emergency department to academic medicine and beyo...
Oct 06, 2025•5 min•Season 1Ep. 1
H₂ receptor antagonists like famotidine and cimetidine have been around for decades, but they still play an important role in managing GERD, dyspepsia, ulcers, and even acute GI bleeding. In this episode, Dr. Busti reviews the history, pharmacology, and clinical relevance of this class, including the withdrawal of ranitidine. You’ll learn how H₂ blockers fit into the larger category of antacid therapy, why they’re effective for mild cases but limited in long-term control, and how tolerance can r...
Oct 06, 2025•43 min
Evidence-Based Medicine (EBM) is a cornerstone of clinical training, but why is it so difficult to practice and teach consistently? In this deep dive, Dr. Busti unpacks the foundation of EBM, the five A’s, and why application often falls short in practice. Drawing from his training at Oxford and years of teaching across medicine, pharmacy, and nursing, he highlights misconceptions, barriers, and practical strategies to bridge the gap between evidence, education, and patient care. This episode al...
Sep 29, 2025•38 min
In this kickoff episode on Evidence-Based Medicine (EBM), Dr. Busti explains what EBM is—and what it isn’t. You’ll learn why the classic Venn diagram (evidence, expertise, and patient factors) matters, and how the "Five A’s"—Ask, Acquire, Appraise, Apply, Assess—create a practical framework for clinical decision-making. We also unpack related terms like evidence-based practice, practitioner, and expert, showing how they fit together and why balance between literature, training, and patient prefe...
Sep 29, 2025•29 min•Season 1Ep. 2
