#1768 Vitamin B6 Toxicity - David Gillespie - podcast episode cover

#1768 Vitamin B6 Toxicity - David Gillespie

Jan 16, 202531 minSeason 1Ep. 1768
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Episode description

Sounds like a boring and not-relevant-for-most topic but it was a surprisingly interesting and relevant-for-many conversation. Did you know that some widely-used magnesium supplements contain up to forty times (40X) the RDI (recommended daily intake) of vitamin B6? Even more ridiculous when you consider that most people don't even know these products contain any B6 because they're actually trying to supplement their magnesium! And what are the potential consequences of overdosing on B6? Oh, only muscle weakness, nerve damage, numbness, tingling, nausea, loss of balance, peripheral pain, vision damage and more. Guess who just checked and (subsequently) chucked his magnesium tabs in the bin?

See omnystudio.com/listener for privacy information.

Transcript

Speaker 1

I'll get our team. Welcome to another installment the show. It's Fatty Harps, It's a less bow. It's Tiffany and I've got a rock in my bra and I've found Navana cook. Can I cook?

Speaker 2

Get they Harps?

Speaker 1

But do you still have that rock in your undergarments?

Speaker 2

Or have you sometimes it slips out?

Speaker 1

Oh? Really?

Speaker 2

Yeah? The weekend Christmas, I went missing for a week.

Speaker 1

Are you still holding onto any semblance of the inner tranquility and nirvana that you brought back from the far away lands? Or have you just faltered to your hangry self?

Speaker 3

Well?

Speaker 4

There, I never let myself get angry because that's just dangerous, whether there's a rock in my bra or not.

Speaker 1

Yeah, right, Well, there's a simple solution to hangar in ess. It's called food.

Speaker 2

Yeah, yeah, but I'm all over that.

Speaker 3

Yeah, you're going to have to catch me up a little here, guys, Why is Tiffany wearing a rock in around it?

Speaker 2

Actually it's in my bra.

Speaker 3

That's a lot part of you.

Speaker 1

That's part of your undergarments.

Speaker 2

Even no one calls them mondays.

Speaker 1

Al Right, all right, well, both gillispo and I am not fucking twenty one years old, So give us some break. I did so, explained to Gillespo the aforementioned correlation between Nirvana and the rock and your bra.

Speaker 4

Well, Gillispo, when I came back from my trip to the Himalayas late last year, I brought half of the Himalayas with me. I flogged a piece of the Himalayas off every peak we hiked to, and there was one little piece that I like to just one day, I walked and I popped it in my bra that I just stuck my hands down.

Speaker 2

Now, I didn't mean to do that. I was in my own world then, like this is.

Speaker 4

Not video, and I forgot about it right, and I slept with it in there, and that night I had the best night sleep I've ever had recorded on my stra on my garment in my life.

Speaker 3

So so now you do it every night, I'll put.

Speaker 2

It in there sometimes.

Speaker 1

Well, but when she did come back, and I didn't know any of the rock story, but there was a I reckon there was about a week where you were really different than a week where you were kind of, you know, still in the ballpark. But I reckon, you know you've not you. I reckon, you're still about thirty percent of that. But you're definitely not exactly where you were when you got back from me.

Speaker 4

I'm not since Christmas, since after Christmas the break and yeah, I'm exhaust Perhaps it's the pause, I reckon.

Speaker 1

Yeah, well it's also because you fucked your back at the gym deadlifting that that's that's exhausting as well. So you have a deadlift glespo. I know we're not talking about deadlifting.

Speaker 3

I maybe you did it once or twice when I was young and stupid in university. But when I saw the guys, you know, strappen the belts on to stop there in its falling out when they did it, I thought, yeah, maybe that's not for me.

Speaker 1

I actually think that makes you in it's more likely to fall out because it adds abdominal pressure. Yeah there, oh yeah, yeah. I'm not a big fan of the belts. But you know, I'm just going to tell for everyone who wants to hear this, I'm going to give you a quick tip on belts. One, it's not that they're terrible, but the design of most belts is actually bad design.

Because most weight belts that you see is wide at the back, like something like one hundred mil or ten centimeters or four inches and narrow at the front quite often like thirty mel or one and a quarter or one and a half inches. An actual fact, that should be the same with about one hundred mil all the way around to actually give you that stability. Nobody needed to know that. But just for all of those who think I'm thinking of getting a weight belt, no, you know, preferably, well,

I shouldn't say don't you use one? But I haven't used one for I used one three times about forty years ago, in not one since, so that doesn't mean anything. David Gillespie, We're not talking about strength training rocks in bras or in a piece or Nirvana. We were going to talk about booze because you wrote an article about booze, but you wanted to chat and Tip has got very excited at the idea of chatting about vitamin B six. I did not read that article. I do not know anything.

So Tip might have a question. But I'm just going to open the vitamin B six door and you're going to tell us, and if I think of something brilliant or not brilliant, I'll ask it as we go.

Speaker 3

Right. Oh okay, so.

Speaker 1

No pressure, no pressure be amazing.

Speaker 3

Can't take any credit for the original story, which was an investigation done I think on the seven thirty report last week on the ABC. Not a show I can admit to watching terribly regularly, but I and to be wandering past the telly when my wife was watching it, and she was very interested in it. And I'll tell

you why in a moment. But the show was about people overdosing on vitamin B six and it was It featured a doctor, I think she's retired now, emergency medicine specialist who had been diagnosed with all sorts of consequences that are generally known to be associated with overdosing on vitamin B six, most notably the peripheral neuropathy, which is you know where you get tingling in your fingers and your toes, your extremities and so on, and sometimes associated

with diabetes and so on. But B six overdosing can be really really bad. It can be extremely toxic. And what the story was about was that a lot of Australians are unintentionally, particularly older women, menopausal women in particular, unintentionally overdosing on this not because they're racing out and golfing down tubs of B six supplements, but because they're

taking magnesium tablets. So really magnesium tablets are you know, the reason most people take them is that they help with leg cramps, so you know, they're good for muscles, they help with leg cramps. There's a lot of leg cramping going on in menopause, so a lot of women who are approaching or in menopause are often told to take magnesium tablets, which is of course why my dear wife was watching this show with great interest, because she's

taking magnesium tablets. What she hadn't realized is that those tablets often come with a very significant dose of vitamin B six. The one she was taking had fifty milligrams per tablet. Now that's meaningless to anybody who doesn't know the dosing recommendations for vitamin B but the recommended dose of vitamin B six for Australians is somewhere between one and two milligrams per day, so fifty is a lot. It's a hell of a one one and two Mili.

Speaker 1

I was just looking right now, yeah one, as you were doing that, I was looking at one point three to one point seven, So yeah, give will take one to two yep. And what did you say? Fifty million, fifty and.

Speaker 3

Not even not even highlighted. So you're taking a magnesium tablet. Yeah, and if you if you read the fine print on the back, you realize, actually, this magnesium tablet has fifty milligrams per tablet? Was vitamin B six in it? Now?

Speaker 1

Can I just read something that's interesting for this? So this is the idea, this Australian RDII is right. So nine to fifty year old people one point three, fifty one to seventy that's you, David one point seven and U Tiff.

Speaker 3

Are we going to get to your age group soon?

Speaker 1

Hey, hey, I'm making fun of you. Pregnant women one point nine breastfeeding women too, So the absolute upper limit is breastfeeding women where the RDI or recommended daily intagers two milligrams and based on that, so even at the very upper limit recommendation, that's got twenty five times the recommended amount in those magnesium cells.

Speaker 3

And they're not the worst. Like I had a quick look around the supermarket after this, and there are a few brands there with sixty milligrams in per tablet. And the first thing that might occur to you is why why is vitamin B six being added into these tablets, And the answer is because vitamin B six is thought

to help with magnesium absorption. So the people are selling magnesium perls have said, oh, well, vitamin's helps with absorption, so we'll go ahead and whack that in the in the pill without any real regard by the look of it, to the possibility that you might be seriously overdosing vitamin B six. Now, the question, by the way, is do

we need any vitamin B six. You won't find too many supplements that claim it or that you can just go on by the vitamin B six because we get that one to two milligrams easily from our food supply. So it's a water soluble vitamin. Green leafy veedged that the usual story about vitamins. Okay, it's it's the sort of thing that people don't need to supplement for deficiency.

Envitamin B six in Australia is almost non existent. So and if you were deficient vitamin B six, then you would probably be seeing a doctor who would give you an appropriate prescription for an appropriate level of B six supplementation. But the problem here is that we've got a large segment of the population unintentionally taking very serious doses of

this stuff. Now, the TGA recently reviewed the evidence on this in twenty twenty and decided, you know, whoopsie, this could be a bit of a problem and required the manufacturers to put in place warnings on anything that has more than ten milligrams per dose. So the TGA says, you know, the therapeutic goods. The regulator who regulates vitamins in Australia said, oh geez, that's a bit unfortunate. So listen. What we'll do is we'll make them put a warning

on the label. So they've got more than ten milligrams in, they've got to say that that's the case. So I went looking for the warning on the ones that my wife was taking, because fifty milligrams is definitely more than ten, and I certainly hadn't noticed a warning when buying them. But it was there. It was there. It was in very very very small print under a lot of other very very small print in black on an orange background, which is really easy to read, and it said if

you notice tingling in your fingers, stop taking these. Wow.

Speaker 1

Wow, that is can I just read? Also, something else interesting I'm doing research while you're doing that. So vitin B six toxicity also known as mega vitamin B six syndrome because when someone takes too much, as David says, so symptoms everyone numbness and tingling hands, feet, blah blah blah,

muscle weakness. Having a really scary thought as I'm saying all this, which I'll share with you, muscle weakness, weakness in the legs and glutes, or a gradual deterioration of muscle strength, painful skin lesions or bone pains, walking difficulty,

balanced difficulty, other symptoms heartburn, nausea, sensitivity, sunlight. This I'm when I get off this call, I'm going to ring my mum and see if my dad started taking a magnesium supplement in the last six months, because my like, he's getting old, but in the last six months, his all of this stuff we're talking about is increased. It seems to have ten xt like at a disproportionate rate, which may or may have been not related. But yeah,

that's really interesting. And also here's another one, just quickly, David, A twenty fifteen study conducted at London Hospital, so just with random patients who are in there for other reasons. They check their B six and thirty eight percent of them had, So that's just a random sample thirty eight percent of a general group, and ten percent of them exhibited sensory in Europe fee and that's like they weren't in there for that. That was just a group that they wow.

Speaker 3

Okay, Well, a lot of people could be seriously overdosing on B six without the slightest knowledge of it. A lot of multi vitamins included, as we said, but the big one here is magnesium. It's a seriously large dose.

By the way, you can buy magnesium tablets that have no B six in them, which is of course what I've gone and done, but you have to really be looking for it because the vast majority of them have B six in them, and they all have the compulsory warning label on them in the very very fine print way way at the back. But this is a serious, serious issue, and the story on seven thirty, which I'd

recommend anyone go take a look at. I'm sure Tiffany can put a link in the show notes, but anyone can go look at that, and I think it's worth watching it because this is a doctor that they're talking about She's an emergency medicine specialist, has been, has practiced all her life, and knew nothing about this, absolutely nothing about this. The TGA says, oh, we told all the doctors,

and she's saying, well, no one told me. And I rather suspect that many gps don't know about this, and even if they do know about B six toxicity, they're probably not asking their patients are you taking magnesium tablets? Because putting the two together is a bit of a leap.

Speaker 1

Imagine if it was I mean anything else where we said, you know, like, for example, I think the idea for sodium is something like two thousand milligrams a day or something.

Two grams is it? But imagine if imagine if so two thousand milligrams because it's salt, and we go, oh, yeah, fuck, you can't have too much sold it'll kill your blood pressure and all that, right, Imagine if there was something that had, you know, twenty five times that, so instead of two thousand, it had fifty thousand milligrams of salt, we'd all be running around with our arms in the air.

Speaker 3

But you know, well, the other thing to know about this, sorry to interrupt you, but the other thing to know about this is we get rid of I mean, we're urinate out like all water soluble vitamins. You know, we get rid of this stuff. The trouble is we're pretty good at retaining it too. So one tablet that contains fifty milligrams is thirty days worth. It will take us

thirty days to get rid of that let alone. If we're taking it every single day, which is usually the recommended dose from magnesium tablet, then you are seriously taking it because then it's a cumulative effect.

Speaker 1

That old kind of I was going to say lifestyle. It's not a lifestyle. But I actually used to train a doctor I wish I'm not going to mention in his name, and this was I've trained a bunch of doctors, but this was early day. I clearly remember him saying to me when I was talking him about vitamins. He goes, well, they don't really do much for a start, That's what he said. And he goes, but you can't overdose on any of that stuff. You'll just piss it out. Excuse

my language, but that's what he said. But I'm thinking, and for a long time I believed him that. Well, it didn't really matter, like, you know, if you took if you took too much, it didn't matter because you're just weird out when you go to the toilet.

Speaker 3

But yeah, I was definitely in that camp too for a long time. But there's starting to be some really concerning things even with water. So there's two different types of vitamins, fat soluble and water soluble. The vast majority of them, the ones we come across normally are water soluble, so vitamin C, vitamin B and so on, and yeah, will urinate those out. But even with vitamin C, the people think you you can't possibly have too much of

a good thing with that. There really are some quite concerning studies about links between high dose vitamin C and urinary issues in males, so prostate cancer and other urinary difficulties. So look, I don't want to be scaring your listeners to death on that one, but there are studies out

there that sort of ring alarm bells about that. Now they are high dose y. You know, I'm not saying popping the occasional vitamin C is going to be doing anyone any harm, But yeah, I don't think it's entirely true to say that there are no there's no chance of harm from vitamin consumption. But particularly where you're talking about something like this where the person's not intentionally taking the vitamin at all. They don't even know they're taking the vitamin.

Speaker 1

That's the important thing. Like they are literally being given a ridiculous sleep MEGAMEGAMEGA dose of something that they didn't choose, Like they're actually getting it for the magnesium.

Speaker 3

At least with vitamin C, if you're taking high dose vitamin C, you know, if you're chugging half a bottle of thousand milligram tablets vitamin C every day, you know you're doing it. It would be something to work your way through. So and you might well think to yourself, I wonder if I should do a bit of research about whether this is good for me or not. But

in this circumstance, you don't even know you're doing it. Now, with the fat soluble vitamins, you've got to be even more cautious because a lot of them are permanently part of us or don't go away quickly. So there are certainly other vitamins where you know there are maximum limits for very very good reasons.

Speaker 1

So I've just enlisted the services of my personal assistant also known as chat GPT, and he tells me because mine's a bloke, so certain vitamins can be toxic when consuming excessive amounts, which we know, particularly fat soluble vitamins. Yeah, Vitamin A, D, E, and K is on their list. Wow A symptoms headache, dissiness, nausea, liver damage, blurred vision, fucking our bone pain or fractures, and during pregnancy, excessive viamin A can cause birth defects.

Speaker 3

Wow.

Speaker 1

Vitamin D in takes above four thousand iu a day and not recommended. Nausea, vomiting, kidney damage, muscle weakness, calcification of soft tissues. Vitamin E includes risk of bleeding, impaired blood clotting blah but blood Vitamin K rare but can occur, liver damage and hemolytic anemia. Water the wages quickly, B six and B three.

Speaker 3

Yeah. The thing though, once again coming back to it, is you're not going to be act dentally taking any of those the BC except B six, except B six. Yeah.

I mean for most of those, you are going to be quite intentionally taking them, probably under the advice of a health professional, because you've been diagnosed as being deficient in some way, and there's probably a really good reason for that, but this one, you're getting huge doses, way over the recommended limits, doses that require warnings on products, and and you don't even know it.

Speaker 1

Amazing, that's amazing, and so well that, like, what what would happen from? I mean, you're a lawyer as well as a researcher and a general bloody noel, but we love you for that. What would what would have to happen for? I mean, this is maybe a bigger question than then I should ask, But what would have to happen for that? Like? What's the process? Would that years to undo that? So that they're assuming you warnings on labels and stuff? Ah?

Speaker 3

Well, I don't know. I think it would take one big lawsuit to get to get some pretty serious action there. Personally, I think the TGA should be doing more than requiring people to put virtually invisible warnings on labels when there's something like this going on, particularly when they themselves have assessed the evidence and said there is real risk of harm here, you know, I feel we should get more from our regulators when there's something like this going on.

I don't think we should be hearing about it on a news show on Telly. I think it should be our regulators jumping all over this and saying, hang on, this can't happen.

Speaker 1

Yeah, can I ask? I was going to say, can I ask a personal question and then ask a personal question? So ignore the first question. My personal question is do you take any supplements? And if so, what if you're happy to share?

Speaker 3

I have started in the last few years taking garlic pearls. That's the only supplement I take.

Speaker 1

Is that because you've got six kids and you don't want any more?

Speaker 3

There are other ways to sort that out. I'll share you some pictures later.

Speaker 1

Ple he's done.

Speaker 3

No, but garlic piells are primarily because there's been some really really interesting research. There's a particular chemical in garlic that prevents the attachment of many viruses, and so if you want a general prophylactic against being infected with a multitude of viruses, then it's not a bad habit to get into. And how that are chomping on garlic every day? Yeah?

Speaker 1

What's in garlic pills? Here we go?

Speaker 3

Oh, so does chat ebt have a name? Is it Fred or something like that?

Speaker 4

Yeah?

Speaker 3

Brian, Brian Brian.

Speaker 1

What supplements do you I should know this, but I actually don't. What supplements do you take regularly?

Speaker 4

I take creatine, fish oil, and I just had just got back into taking magnesium, which is why I fell over backwards after seeing that article.

Speaker 1

Did you go did you look at the amount of whatever I forget already? B six sorry B six in your magnesium?

Speaker 2

And I think it was from memory. I think it was like forty milligrams or something.

Speaker 1

Wow?

Speaker 2

Yeah, wow?

Speaker 1

And where are those those pills now?

Speaker 3

In the bin?

Speaker 2

It's a powder and he's going straight in the bin.

Speaker 1

Hey, Gil, I spose I've got another related but not specific to this conversation, but related question. So I recognize started reading labels, you know, on food and supplements and pills and powders and potions. And I don't know when I was as long as they've been around late thirty years. And and because I've read so many labels, and I look at them, you know, look at the whatever I'm going to buy, not just the ingredients, but then the

breakdown of what's in per hundred grams. I reckon that at least half of the things that I look at that what is in that what is in the the one hundred milligrams you know, per hundred milligrams, what you know the different vitamins, minerals, macro nutrients, fat, protein, carbs, sugar. I reckon they're inaccurate. I reckon a huge amount of them are inaccurate. Do you do you is there Do you have any insight into that, like.

Speaker 3

Any inaccurate in what sense what it was?

Speaker 1

As in, I don't like, I don't think what they're saying is in there? Is in there? Yeah?

Speaker 3

I think what's an example?

Speaker 1

Well, I mean I literally looked at something the other day and it was per hundred grams and if you added up that just the protein and the carbohydrate, it came out to one hundred and twelve grams per hundred grams.

Speaker 3

Well then that was it an American product?

Speaker 1

No, No, okay, it was Australian. But I mean literally, like when I was looking at it, and I don't want to throw anyone under the bus, but I was looking at it, I'm like, well, what this label says? And it also I was looking at something and it also said like I literally looked at this product which is a supplement, and it said that it had this huge amount of protein in it, and I looked at the ingredients and there was not only was there not

that amount of protein, there was zero protein in there. Zero.

Speaker 3

Wow, okay, like zero.

Speaker 1

There was not one ingredient in this product that contained protein.

Speaker 3

There are significant penalties for false and misleading conduct in the labeling of products, so you could report that manufacturer to the TGA or who I think they're the regulator, and they would be investigated. So by and large, I've found products are roughly right. I would say that, but I'm only looking at food products. I'm not looking at

supplements and so on. Sometimes you see one where it's clearly impossible, where either it doesn't add up to one hundred or there's just no way that product contains that much protein or fat or carbohydrate or whatever it is they're claiming, and it's clearly an error on the label. But I'd say I've encountered that maybe one in one hundred, which is probably too high. But yeah, I haven't found it's an extremely regular currents.

Speaker 1

Yeah. Wow, wow, Well that was interesting. I think we'll do the other one next time. But that was good. Have you got any questions tip? Before we say goodbye to the great man. I'm actually I'm actually keen to go and look at my magnesium and see what's in there, because it might be going. I think it's probably going to be going in the bin.

Speaker 2

I'm just yeah, replacement.

Speaker 3

I did find one, but I don't have it in front of me. Unfortunately. I got it. I think it was at the local calls. There's quite a lot of brands of magnesium, but one of them had no added anything. It was just straight up magnesium.

Speaker 1

While I've got you here and while we're still recording, I want to say two things. One is blatant plug and one is some info that I keep getting when I say keep a couple of times a week I get asked this. So the first one is, so the mayo that David recommended that it is, the mayo that I use is called good fat Mayo. It's called good fat Mao. I buy it all worse. It's about twelve bucks or something.

Speaker 3

Too much, is what it is. It's too damn much.

Speaker 2

It is it is.

Speaker 1

It's kind of I mean, you can buy the shit one for four, but fuck the shit one, shout and get the good one for twelve. But I mean, it's not unless you're spooning it on with a dessert spoon. It lasts a fair one. It's called good fat mayo. I have no affiliation with them. I'm not suggesting you buy it. But for the people who keep asking me, what was the one that he recommends and the one that I use, That is the answer to your question. Twelve bucks.

Speaker 3

Just on that one, Hang on on that one. I will send. I will send Tiffany the recipe. It is very easy to make mayo? How very easy?

Speaker 1

How long does that?

Speaker 3

It takes out takes me on a minute to make it. So you need olive oil and an egg. So it's, well, well.

Speaker 1

We're here, Just give the fucking recipe.

Speaker 2

I mean, he just did, didn't he.

Speaker 3

I'll I'll give it to you in writing, because you know there's some technique. But but yeah, it's it doesn't take long as long as you've got a blender. If you haven't got a blender, it will take you a long time.

Speaker 1

Wow, I'm pretty sure. Anyway. And the other thing I want to say, which is completely unrelated to guests by gillspo, but February three, my new mentoring program kicks off. Everybody, February three, go to my website Craig Harper dot net and have a captain cooker that mate, We appreciate you as always. That was I reckon. That was better than last week. So well done. Keep trying.

Speaker 3

I'll try try harder.

Speaker 1

Do your best. And also, how fucking good is your kid by the way, James.

Speaker 3

James, Yeah, I mean he's got a new cover.

Speaker 1

You're on the slide, he's on the rise.

Speaker 3

Tell you what he's thing on Monday. I mean I was watching the media keeping an eye off for him, and I think he ended up well over two hundred media appearances on Monday, So that's amazing.

Speaker 1

And if you don't know what you're talking about. Everybody interviewed James a week or so ago and it came out well, it had to. It was embargoed until Monday yesterday. What is today? Monday? Monday six am and our stuff goes up at midnight, so we had to put it up yesterday. But great chat with him, and yeah, no, he is apart from the fact that the work he's doing is great and great, I mean it's just a great thing that he's doing and highlighting something that needs

to be highlighted and addressing it. But also, Yeah, he's so good. Is such a natural? Yeah, so well done him?

Speaker 3

Will you?

Speaker 1

I know you probably don't say things like this because you're an old fashioned dad, but is there any pride in there? Do you go?

Speaker 3

Fuck?

Speaker 1

He's doing all right?

Speaker 3

Look I know he's got room improvement. You know what I mean?

Speaker 1

Have you been to the Ron Harper School of Platitudes?

Speaker 3

Come away with the two points? That's all the man is.

Speaker 1

That's hilarious. All right, Mike, We'll see you next week.

Speaker 3

Alright, I see you later.

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#1768 Vitamin B6 Toxicity - David Gillespie | The You Project podcast - Listen or read transcript on Metacast