Ep. 296: “Cardiovascular Development” Featuring Dr. Maneesha Inamdar

Guest:

Dr. Maneesha Inamdar is the Director of the Institute for Stem Cell Science and Regenerative Medicine and Professor at Jawaharlal Nehru Centre for Advanced Scientific Research. Her lab uses comparative models, including mice, Drosophila, stem cell lines, and gastruloids, to study developmental biology. She talks about using embryo models to investigate teratogenicity, prioritizing ethnically diverse cell lines, and representing Indian scientists in global discussions. (44:03)

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The Stem Cell Science Round Up

Vascularized Cardiac and Hepatic Organoids – An in vitro model mimics the earliest developmental stages of cardiac and hepatic organoid vascularization. (1:50)

Mouse Liver Assembloids – A multicellular organoid system recapitulates the architecture of the liver periportal region. (14:55)

Dilated Cardiomyopathy Mechanisms – Researchers investigated the effects of cardiac troponin T dysregulation on sarcomere–mitochondrial communication in dilated cardiomyopathy. (26:05)

Mitochondrial DNA Base Editors – Scientists modeled and corrected a mitochondrial disease using engineered base editors in rat zygotes. (35:00)

Image courtesy of Dr. Maneesha Inamdar

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