Send us a text Amol and Reena want you to understand the following: 1. When added to moderate dose statin, the IMPROVE-IT randomized trial showed that ezetimibe improved clinical outcomes in patients after acute coronary syndrome. 2. A network meta-analysis showed that no blood pressure lowering therapy improved mortality in patients with diabetes and chronic kidney disease. The combination of ACE-inhibitors and ... The post Debatable Landmarks: Ezetimibe and clinical outcomes, BP lowering in di...
Jun 12, 2015•30 min
Send us a text Amol and Nathan want you to understand the following: 1. A short duration (4 days) of antibiotics for intra-abdominal sepsis was equivalent to a longer duration (approx. 8 days) of antibiotics for intra-abdominal sepsis after an appropriate source control procedure. 2. A population-based cohort study of elderly patients showed that lipid lowering therapy for primary prevention was ... The post On Our Soapbox: Antibiotics in intraabdominal sepsis and lipid therapy in the elderly ap...
Jun 05, 2015•31 min
Send us a text Amol and Fahad want you to understand the following: 1. There are dramatic hospital-level variations in the care of extremely pre-term infants. 2. A randomized trial showed that an electronic alert to identify hospital patients with acute kidney injury was not effective in improving patient outcomes. Continuing Medical Education Internists can receive 0.5 hours of Continuing Medical ... The post Lifelong Learning: Variations in Care of Pre-term Infants and Electronic Alerts for Ac...
May 29, 2015•28 min
Send us a text Amol and Janice want you to understand the following: 1. Several RCTs and observational studies suggest that Transcatheter Aortic Valve Replacement reduces mortality and improves symptoms in frail, elderly patients. 2. A historical analysis demonstrates that the sugar industry had heavy influence in setting national dental research priorities in the 1970s, which is relevant for industry relations ... The post The Sweet Truth: Transcatheter Aortic Valve Replacements and Sugar Indus...
May 22, 2015•29 min
Send us a text Originally Aired Jan 30: Eosinophilic esophagitis, outbreaks associated with duodenoscopy, and the rise of private endoscopy clinics Samir and Amol want you to understand the following: 1. Eosinophilic esophagitis is an important and under-recognized clinical condition that causes significant symptoms and is very treatable. 2. Endoscopy, and particularly duodenoscopy, is an important potential source of infection transmission. ... The post Re-Play: Gastroenterology Edition with Dr...
May 15, 2015•38 min
Send us a text Amol and Nathan want you to understand the following: 1. A large randomized evaulation of a quality improvement intervention demonstrated a modest but significant reduction in rates of cesarean-section in Quebec. 2. A large double-blind randomized-controlled-trial of over 1100 patients showed that pentoxifylline is not beneficial in the treatment of alcoholic hepatitis and prednisolone may have mild ... The post A Hippocratic Dilemma: Reducing rates of c-sections and prednisolone ...
May 08, 2015•28 min
Send us a text This week: The MARQUIS study of interventions to reduce medication errors in hospital, super-utilizer patients, and the potential of community health workers for population health and medical education. Amol and Shail want you to understand the following: 1. Medication errors are an important problem in hospital and a multi-faceted intervention can be effective in addressing this issue. 2. ... The post What we loved at SGIM 2015: Medication Safety, Super-Utilizers, and Community H...
May 01, 2015•27 min
Send us a text Effects of participation in the National Surgical Quality Improvement Program and Prednisone in Community Acquired Pneumonia Nathan and Amol want you to understand the following: 1. Participation in the National Surgical Quality Improvement Program has not appeared to improve overall patient outcomes or cost. 2. Adjunct prednisone treatment in community acquired pneumonia reduces time to clinical ... The post Replay-The Royal We: Effects of Participation in NSQIP, Steroids for Pne...
Apr 24, 2015•30 min
Send us a text This week: Empiric antibiotic choices for community acquired pnuemonia and clindamycin versus trimethoprim-sulfamethoxazole for skin and soft tissue infections. Fahad and Amol want you to understand the following: 1. A large, high quality RCT showed that there was no significant difference between an empiric treatment strategy of beta-lactam vs beta-lactam plus macrolide vs respiratory fluoroquinolone for the ... The post The Antibiotics Jam: Community Acquired Pneumonia and Skin ...
Apr 23, 2015•36 min
Send us a text This week: A Randomized Controlled Trial of Resident Call Schedules in the ICU and The Natural History of Benign Thyroid Nodules. Nathan and Amol want you to understand the following: 1. There was no significant difference between three different call schedules in the ICU in terms of resident sleepiness or patient outcomes. 2. Benign thyroid nodules are ... The post Take me to the Bank: Resident call schedules in the ICU and Thyroid Nodules appeared first on Healthy Debate ....
Apr 17, 2015•24 min
Send us a text Originally aired September 3, 2014: Perioperative AFib and Long-Term Risk of Ischemic Stroke; Paracetamol not more effective than placebo in acute low back pain Nathan and Amol want you to: 1. Understand that perioperative atrial fibrillation is associated with increased long-term risk of ischemic stroke. 2. Recognize that a high quality Randomized Controlled Trial demonstrates that paracetamol is ... The post Replay: We’re Back (pain)! Perioperative Atrial Fibrillation, Paracetam...
Apr 03, 2015•26 min
Send us a text This week: The TITRE2 trial about hemoglobin transfusion strategies after cardiac surgery and the RETRACE study about intracranial bleeding in patients on warfarin. Nathan and Amol want you to understand the following: 1. In cardiac surgery patients, a restrictive transfusion strategy was no different than liberal transfusion in terms of combined clinical outcomes of infectious and vascular events ... The post All About Bleeding: Transfusion targets after cardiac surgery and intra...
Mar 27, 2015•32 min
Send us a text This week: New studies of PCSK9 inhibitors for lipid lowering and a randomized controlled trial of early peanut exposure to prevent allergy Fahad and Amol want you to understand the following: 1. PCSK9 inhibitors are new cholesterol-lowering monoclonal antibodies that have been shown to reduce LDL beyond standard therapy with statins and have been associated with reduced ... The post Peanut Placebo, Nocebo, PCSK9: Lipid lowering and peanut allergy appeared first on Healthy Debate ...
Mar 21, 2015•29 min
Send us a text Originally aired March 11, 2014: obesity, palliative care, hepatitis c Amol, Fahad, and Travis want you to: 1. Understand trends in obesity prevalence in adults and children. 2. Appreciate the effect of early palliative care on quality of life in patients with advanced cancer. 3. Recognize new therapeutic options in chronic Hepatitis C infection and their associated cost ... The post We turned one! “Too rich for my blood: Obesity, palliative care, hepatitis c” appeared first on He...
Mar 13, 2015•34 min
Send us a text VOICE: Tenofovir and Emtricitabine for HIV pre-exposure prophylaxis in African women and SARAH: Hand exercises in Rheumatoid Arthritis Fahad and Amol want you to understand the following: 1. Pre-exposure prophylaxis was not effective in a population of African women. Medication adherence was apparently excellent based on self-report and pill counting, however serum drug levels demonstrated that it ... The post SARAH’s VOICE: Pre-exposure prophylaxis in HIV and exercise for the rhe...
Mar 06, 2015•24 min
Send us a text The CHIPS trial of Hypertension in Pregnancy and TIPPS trial of Thrombophilia in Pregnancy Janice and Amol want you to understand the following: 1. Tight blood pressure control in pregnancy does not affect fetal outcomes in pregnancy compared with loose blood pressure control. The only difference in maternal outcomes is a reduced risk of severe hypertension ... The post Obstetrical Medicine Special: Hypertension and Thrombophilia in Pregnancy appeared first on Healthy Debate ....
Feb 27, 2015•25 min
Send us a text Effects of participation in the National Surgical Quality Improvement Program and Prednisone in Community Acquired Pneumonia Nathan and Amol want you to understand the following: 1. Participation in the National Surgical Quality Improvement Program has not appeared to improve overall patient outcomes or cost. 2. Adjunct prednisone treatment in community acquired pneumonia reduces time to clinical ... The post The Royal We: Effects of Participation in NSQIP, Steroids for Pneumonia ...
Feb 20, 2015•29 min
Send us a text Originally aired July 2, 2014: Cryptogenic Stroke and Atrial Fibrillation, Naloxegol for Opioid-Induced Constipation Fahad and Amol want you to: 1. Appreciate the importance of subclinical atrial fibrillation in cryptogenic stroke and consider longer monitoring to detect it. 2. Recognize Naloxegol as a targeted therapy for opioid-induced constipation that is more effective than placebo but its effectiveness has not been compared directly ... The post Getting “Travis-y”: Stroke and...
Feb 13, 2015•23 min
Send us a text Factor XI Antisense Oligonucleotides for Post-operative VTE and Intra-arterial Treatment for Stroke Nathan and Amol want you to understand the following: 1. Factor XI is a promising treatment target for preventing VTE, with a recent study showing that an antisense oligonucleotide was more effective in reducing VTE and had less associated bleeding than enoxaparin. 2. Intra-arterial ... The post These are not real stock tips: Post-op DVT Prophylaxis and Intra-arterial Treatment of S...
Feb 06, 2015•27 min
Send us a text Eosinophilic esophagitis Samir and Amol want you to understand the following: 1. Eosinophilic esophagitis is an important and under-recognized clinical condition that causes significant symptoms and is very treatable. 2. Endoscopy, and particularly duodenoscopy, is an important potential source of infection transmission. 3. The rise of outpatient endoscopy clinics requires the development of an appropriate remuneration, regulatory, ... The post Special Gastroenterology Edition wit...
Jan 30, 2015•38 min
Send us a text Neighbourhood Disadvantage and 30-day Rehospitalization; Teixobactin – a Novel Antibiotic Reena and Amol want you to understand the following: 1. Neighbourhood disadvantage was associated with an increased risk of readmission similar to the presence of chronic diseases like COPD. 2. Teixobactin is a new antibiotic with activity against gram positive organisms that was discovered using ... The post From SES to Soil: Neighbourhood Disadvantage and A Groundbreaking New Antibiotic app...
Jan 23, 2015•27 min
Send us a text Originally Aired October 1, 2014: Blood Transfusions in Upper GI Bleeding, Aspirin in DVT prophylaxis, Vasopression and Steroids in Cardiac Arrest, MRSA Decolonization, Fluid and Sodium Restriction in Heart Failure Fahad and Amol want you to gain familiarity with a number of major new studies in hospital medicine published in 2013. Continuing Medical Education Internists can ... The post Best of Hospital Medicine 2013 Part II appeared first on Healthy Debate ....
Jan 16, 2015•30 min
Send us a text Originally Aired September 24, 2014: Fecal Transplantation & Probiotics for C. difficile; Prone Positioning in ARDS; Steroids in COPD; Hospital Management of Diabetes. Fahad and Amol want you to gain familiarity with a number of major studies in hospital medicine published in 2013. 1. Fecal transplantation is effective for recurrent C. difficile infection. 2. Probiotics are ... The post Best of Hospital Medicine 2013 Part I appeared first on Healthy Debate ....
Jan 09, 2015•25 min
Send us a text This week, Travis and Amol want you to recognize that: 1. Recognize whole exome sequencing is an important new method of identifying genetic mutations associated with disease. 2. Understand that the 4-year follow-up of the PROTECT AF study showed that left atrial appendage closure devices may be superior to warfarin in preventing strokes in patients with atrial ... The post Value Judgments: Whole exome sequencing and left atrial appendage closure devices appeared first on Healthy ...
Dec 05, 2014•24 min
Send us a text This Week: Baseline cardiovascular risk calculators and hypertension treatment, and dual antiplatelet treatment after coronary stenting This week, Fahad and Amol want you to understand that: 1. A cardiovascular risk calculator can predict the degree of treatment benefit that patients may derive from blood pressure treatment. 2. There is limited evidence to recommend continuing dual antiplatelet therapy beyond ... The post Getting Cardiovascular: Baseline Risk and Hypertension Trea...
Nov 28, 2014•24 min
Send us a text Implementation of a Handoff Program in Pediatric Hospitals and Treating Depression in Cancer Patients Nathan and Amol want you to: 1.Recognize that a standardized handoff program reduced medical errors in academic pediatric hospitals. 2. Appreciate that a targeted program to treat depression in cancer patients was more effective than usual care. Continuing Medical Education Internists can ... The post Dubious Acronyms: Handoff Quality and Treating Depression in Cancer Patients app...
Nov 21, 2014•28 min
Send us a text Originally Aired September 10, 2014: Simvastatin in Secondary Progressive Multiple Sclerosis and Communicating With Patients About Risk Rebecca and Amol want you to: 1. Recognize that simvastatin reduces the rate of whole brain atrophy in secondary progressive MS, which may be a promising new use for statins. 2. Understand that effective strategies to communicate risk include: Using ... The post 100% Bullish: Simvastatin in MS, Communicating Risk appeared first on Healthy Debate ....
Nov 14, 2014•24 min
Send us a text This Week: Travis and Amol want you to: 1. Recognize IL-25 levels are good predictors of steroid-responsiveness in asthma. 2. Understand that the majority of patients who undergo elective percutaneous coronary intervention for stable angina are misinformed about its benefits. Continuing Medical Education Internists can receive 0.5 hours of Continuing Medical Education credit for each podcast ... The post Unintended Puns: Predicting Steroid Response in Asthma and Patient Perception...
Nov 07, 2014•22 min
