Send us a text Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of infrequent zoledronate administration on vertebral fracture prevention in early postmenopausal women, and the efficacy and safety of semaglutide in adults with type 1 diabetes and obesity. Two papers, here we go! Fracture Prevention with Infrequent Zoledronate in Women 50 to 60 Years of Age (0:00 – 10:24) Semaglut...
Aug 21, 2025•20 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a Classic Rapid Fire episode. This week, Drs. Mike and John Fralick discuss two recent papers: the effects of perioperative hypotension-avoidance versus hypertension-avoidance strategies on delirium and 1-year cognitive decline after noncardiac surgery, and the effect of as-needed albuterol–budesonide on risk of severe asthma exacerbation among patients with moderate-to-severe asthma. Two papers, here we go! Effects of a ...
Aug 14, 2025•23 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining the effect of bedtime vs morning administration of antihypertensive medications on major cardiovascular events and death. Here we go! Antihypertensive Medication Timing and Cardiovascular Events and Death: The BedMed Randomized Clinical Trial (0:00 – 5:18). The Good Stuff: Resources for trainees (5:19 - 6:20): Medicine Pods:...
Aug 07, 2025•6 min
Send us a text Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2024: Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction (FINEARTS-HF) (0:00 – 4:09) Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA) (4:10 – 9:28) Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW) (9:29 – 14:23) Tirzepatide for Metabol...
Jul 31, 2025•25 min
Send us a text Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the simultaneous initiation of SGLT2 inhibitors and finerenone (a nonsteroidal mineralocorticoid receptor antagonist) in persons with chronic kidney disease and type 2 diabetes. Here we go! Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (0:00 – 9:28). Calling keen trainees! (9:29 - 10:28) Trainees, med st...
Jul 24, 2025•10 min
Send us a text Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. Karim Ladak—rheumatologist and internist, Clinical Assistant Professor at McMaster University, and host of the Rheumatology for the Royal College podcast —to talk about leukocytoclastic vasculitis. Here we go! Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods...
Jul 17, 2025•23 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial exploring the effects of add-on sotatercept in patients with advanced pulmonary arterial hypertension and a high risk of death. Here we go! Sotatercept in Patients with Pulmonary Arterial Hypertension at High Risk for Death (0:00 – 5:38). The Good Stuff: 2025 Scripps National Spelling Bee winning word: éclaircissement (5:39 - 6:34) Qu...
Jul 10, 2025•7 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast. This week, Dr. Mike Fralick and guest host Danielle Cutler discuss the top papers from the 2025 American Diabetes Association (ADA) Scientific Session. Hot off the presses, here we go! Once-Monthly Maridebart Cafraglutide for the Treatment of Obesity — A Phase 2 Trial (0:00 - 6:05) Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes (6:06 - 13:22) Stem Cell–D...
Jul 03, 2025•22 min
Send us a text Welcome back Rounds Table Listeners! Today we have the next episode in our Clinical Practice Guidelines series. Drs. Mike and John Fralick discuss the top takeaways from the 2024 KDIGO Clinical Practice Guidelines for chronic kidney disease. Here we go! 1. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease (0:00 - 24:24) Access the KDIGO 2024 "Top 10 Takeaways" PDFs here: https://kdigo.org/guidelines/ckd-evaluation-and-management/ Th...
Jun 26, 2025•26 min
Send us a text Welcome back Rounds Table Listeners! Today we have another special episode— Trial Files turns two years old this June, and we're celebrating with an episode summarizing the Top 5 RCTs in the Trial Files catalogue to date. Dr. Mike Fralick takes us through five trials in 15 minutes. Here we go! 1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (0:00 - 3:08) 2. Restrictive or Liberal Transfusion Strategy in Myocardial Infarction and Anemia (3:09 - ...
Jun 19, 2025•14 min
Send us a text Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Trial Files series, where we provide an overview of a recent Trial Files issue. This week, Dr. Mike Fralick discusses three trials included in a recent throwback issue: opioids versus non-opioids for chronic pain; IV albumin for renal impairment and mortality; and omeprazole before endoscopy in patients with GI bleed. Three trials, 9 minutes, here we go! 1. Effect of Opioid vs Nonopi...
Jun 12, 2025•9 min
Send us a text Welcome back Rounds Table Listeners! Today we have a solo episode with Dr. Mike Fralick. This week, he discusses a recently published head-to-head trial exploring the safety and efficacy of tirzepatide compared to semaglutide for obesity management. Here we go! Tirzepatide as Compared with Semaglutide for the Treatment of Obesity (0:00 – 7:07). The Good Stuff: Trial Files , a free monthly newsletter on practice-changing trials, delivered straight to your inbox. (7:08 - 7:53) Quest...
Jun 05, 2025•8 min
Send us a text Welcome back Rounds Table Listeners! We are back this week with a special podcast episode. Dr. Mike Fralick sits down with Dr. David Juurlink, pharmacologist and internist, Professor of Medicine at the University of Toronto, and head of the Clinical Pharmacology and Toxicology division at Sunnybrook Health Sciences Centre, to chat about the top drug interactions you might be missing. Here we go! Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork ...
May 29, 2025•25 min
Send us a text Welcome back, Rounds Table Listeners! This week we have a solo episode with Dr. John Fralick, discussing a recently published trial of the GLP-1 receptor agonist semaglutide for the treatment of metabolic dysfunction–associated steatohepatitis (MASH). Here we go! Phase 3 Trial of Semaglutide in Metabolic Dysfunction–Associated Steatohepatitis (0:00 – 6:33). The Good Stuff: Go Leafs go! Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicineP...
May 22, 2025•7 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the safety and efficacy of lorundrostat (an aldosterone synthase inhibitor) in treatment of uncontrolled and treatment-resistant hypertension. Here we go! Lorundrostat Efficacy and Safety in Patients with Uncontrolled Hypertension (0:00 – 7:02). The Good Stuff: Trial Files , a free monthly newsletter on practice-changing tri...
May 15, 2025•8 min
Send us a text Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast. This week, Dr. Mike Fralick and special guest Dr. Laiya Carayannopoulos from the Intern at Work Podcast and our Medicine Pods collaboration discuss two recent papers: the use of brensocatib (a DPP-1 inhibitor) to treat bronchiectasis, and the effect of alteplase administered 4.5 to 24 hours after stroke in patients with mild posterior circulation stroke who did not receive thrombectomy. Two...
May 08, 2025•26 min
Send us a text Welcome back Rounds Table Listeners! Today we're introducing a new format—the first episode in our Clinical Practice Guidelines series. This week, Drs. Mike and John Fralick discuss the 2025 ACC/AHA Clinical Practice Guidelines for Acute Coronary Syndrome. Here we go! 2025 ACC/AHA/ACEP/NAEMSP/SCAI Guideline for the Management of Patients With Acute Coronary Syndromes (0:00 - 18:56) Mike's interview with Dr. Jeff Carson: Episode 110 - Restrictive versus Liberal Transfusion in Myoca...
May 01, 2025•21 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of tirzepatide in weight reduction and diabetes prevention in persons with obesity. Here we go! Tirzepatide for Obesity Treatment and Diabetes Prevention (0:00 – 10:24). The Good Stuff: We've launched qMonthly , a monthly blog highlighting headliners and hidden gem trials published each month. Check it out here! (10...
Apr 24, 2025•11 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick. This week, he discusses a recently published trial examining liberal fluid intake vs. fluid restriction in chronic heart failure. Here we go! Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial (0:00 – 4:20). And for the Good Stuff: starpowerdrummer on YouTube (4:21 – 5:20). Questions? Comments? Feedback? We’d love to hear from you! @rou...
Apr 17, 2025•5 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he discusses a recently published trial exploring the role of high-dose Vitamin D therapy in reducing disease activity in patients with clinically isolated syndrome (CIS) typical of multiple sclerosis (MS). Here we go! High-Dose Vitamin D in Clinically Isolated Syndrome Typical of Multiple Sclerosis: The D-Lay MS Trial (0:00 – 7:35). Announcements (7:36 – 9:15): Canadian ph...
Apr 10, 2025•9 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a special Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss top papers from the 2025 American College of Cardiology (ACC) Annual Scientific Session. Hot off the presses, here we go! Extended Reduced-Dose Apixaban for Cancer-Associated Venous Thromboembolism (0:00 - 5:55) Dapagliflozin in Patients Undergoing Transcatheter Aortic-Valve Implantation (DapaTAVI) (5:56 - 9:51) Oral Semaglutide and Cardiovascular...
Apr 03, 2025•21 min
Send us a text Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Dr. John Fralick and guest host Dr. Chunpeng Nie discuss two recent papers: resmetirom for the treatment of Nonalcoholic Steatohepatitis (NASH)—now known as Metabolic Dysfunction-Associated Steatohepatitis (MASH)—with liver fibrosis, and the effect of a Mediterranean diet on disease activity, inflammation, and the gut microbiome in patients with ulcerative colitis. Two papers, he...
Mar 27, 2025•18 min
Send us a text Welcome back Rounds Table Listeners! In this throwback episode, Drs. Mike and John Fralick chat about five important research studies published in 2023: Hydrocortisone in Severe Community-Acquired Pneumonia (0:00 – 5:39). Tirzepatide vs Insulin Lispro Added to Basal Insulin in Type 2 Diabetes (5:40 – 8:48). Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes (8:49 – 12:29). Cefepime vs Piperacillin-Tazobactam in Adults Hospitalized With Acute Infection (12:30 – 17:...
Mar 20, 2025•26 min
Send us a text Welcome back Rounds Table Listeners! We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Jeffrey Carson, Distinguished Professor of Medicine at the Rutgers Robert Wood Johnson Medical School and Provost at Rutgers University, to chat about his recent publication - Restrictive versus Liberal Transfusion in Myocardial Infarction — A Patient-Level Meta-Analysis . Here we go! Questions? Comments? Feedback? We’d love to hear from you! @roundstable ...
Mar 13, 2025•29 min
Send us a text Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss two recent papers examining the effect of glucagon-like peptide-1 receptor agonists (GLP1's) on patients living with Parkinson’s disease. Two papers, here we go! Trial of Lixisenatide in Early Parkinson's Disease (0:00 – 10:24). Exenatide once a week versus placebo as a potential disease-modifying treatment for people with Parkinson's disease (1...
Mar 06, 2025•20 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick. This week, he will discuss a paper exploring endovascular treatment (EVT) for acute ischemic stroke due to medium-vessel occlusion. Here we go! Endovascular Treatment of Stroke Due to Medium-Vessel Occlusion (0:00 – 6:02). This episode is sponsored by Northern Ontario Resident Streamlined Training and Reimbursement Program (NORSTAR). Check out details here ! Questions? Comments? Feedb...
Feb 27, 2025•6 min
Send us a text Welcome back Rounds Table Listeners! We are back today with our Classic Rapid Fire Podcast! This week, Drs. Mike and John Fralick discuss two recent papers - the role of continuous glucose monitoring for diabetes management in hospital and the benefit of tirzepatide in patients with heart failure with preserved ejection fraction and obesity. Two papers, here we go! Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity (0:00 – 11:26). DIATEC: A Randomized Contr...
Feb 20, 2025•22 min
Send us a text Welcome back Rounds Table Listeners! We are back this week with a special podcast episode! Dr. Mike Fralick sits down with Dr. Amy Yu, a Stroke Neurologist, Clinician-Scientist, and Associate Professor of Medicine at the University of Toronto and Sunnybrook Hospital, to chat about her hot-off-the press publication - Population-Level Screening for Diabetes and Dyslipidemia After Pregnancies Complicated by Hypertension or Diabetes ! Questions? Comments? Feedback? We’d love to hear f...
Feb 19, 2025•19 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. Mike Fralick! This week, he will discuss a paper exploring the role of intravenous thrombolytic therapy in patients with minor ischemic stroke and intracranial vessel occlusion. Here we go! Tenecteplase versus standard of care for minor ischaemic stroke with proven occlusion (TEMPO-2): a randomised, open-label, phase 3 superiority trial (0:00 – 6:18). And for the Good Stuff: Trial Files (6:18 – 7:5...
Feb 13, 2025•8 min
Send us a text Welcome back Rounds Table Listeners! We are back today with a solo episode with Dr. John Fralick! This week, he will discuss a paper exploring infliximab versus cyclophosphamide for the treatment of severe Behçet's Syndrome. Here we go! Infliximab versus Cyclophosphamide for Severe Behçet's Syndrome (0:00 – 5:15). And for the Good Stuff: Bob Ross and Painting (5:15 – 6:28). Questions? Comments? Feedback? We’d love to hear from you! @roundstable @InternAtWork @MedicinePods...
Feb 06, 2025•6 min
