Dr. Dugel discusses 1 and 2 year results of HAWK and HARRIER on Brolucizumab for neovascular AMD. Full reference: Dugel, P. U., Koh, A., Ogura, Y., Jaffe, G. J., Schmidt-Erfurth, U., Brown, D. M., . . . Investigators, H. S. (2019). HAWK and HARRIER: Phase 3, Multicenter, Randomized, Double-Masked Trials of Brolucizumab for Neovascular Age-Related Macular Degeneration. Ophthalmology . doi:10.1016/j.ophtha.2019.04.017
Sep 02, 2019•20 min
Dr. Sun discusses Protocol V results that investigated efficacy of 3 treatment approaches for DME in eyes with vision of 20/25 or better: aflibercept injections, focal laser, or observation. Reference to the publication: Baker CW, Glassman AR, Beaulieu WT, Antoszyk AN, Browning DJ, Chalam KV, Grover S, Jampol LM, Jhaveri CD8, Melia M, Stockdale CR, Martin DF, Sun JK; DRCR Retina Network. Effect of Initial Management With Aflibercept vs Laser Photocoagulation vs Observation on Vision Loss Among P...
Jul 22, 2019•24 min
Dr. Tamer Mahmoud discusses an innovative surgical method for closure of refractory macular holes using autologous retinal transplants. Full reference of the discusses article: Grewal, D. S., Charles, S., Parolini, B., Kadonosono, K., & Mahmoud, T. H. (2019). Autologous Retinal Transplant for Refractory Macular Holes: Multicenter International Collaborative Study Group. Ophthalmology . doi:10.1016/j.ophtha.2019.01.027
Jun 03, 2019•36 min
Dr. Mark Gillies from Sydney, Australia discusses 2-year results of the RIVAL Study which investigated rates of geographic atrophy and visual acuity changes in patients with wet AMD. Full reference: Gillies, M. C., Hunyor, A. P., Arnold, J. J., Guymer, R. H., Wolf, S., Ng, P., . . . McAllister, I. L. (2019). Effect of Ranibizumab and Aflibercept on Best-Corrected Visual Acuity in Treat-and-Extend for Neovascular Age-Related Macular Degeneration: A Randomized Clinical Trial. JAMA Ophthalmol . doi...
Apr 22, 2019•28 min
Dr. Richard Rosen discusses a review of perfusion density changes (measured by OCT-Angiography) as measured before and immediately after intravitreal injections. Full reference of the article: Barash, A., Chui, T. Y. P., Garcia, P., & Rosen, R. B. (2019). Acute Macular and Peripapillary Angiographic Changes with Intravitreal Injections. Retina . doi:10.1097/IAE.0000000000002433
Mar 31, 2019•30 min
Dr. Peter Kertes discusses the publication of the first year results of the CANTREAT study that investigates monthly vs treat-and-extend dosing of ranibizumab for wet AMD. Full reference: Kertes, P. J., Galic, I. J., Greve, M., Williams, R. G., Rampakakis, E., Scarino, A., & Sheidow, T. (2019). Canadian Treat and Extend Analysis Trial with Ranibizumab in Patients with Neovascular Age-related Macular Disease: 1-Year Results of the Randomized CANTREAT Study. Ophthalmology . doi:10.1016/j.ophth...
Feb 22, 2019•15 min
Dr. Schrag discusses his publication on the prevalence of cardiovascular risk factors in patients who present with Central Retinal Artery Occlusion. Discussed article: Lavin, P., Patrylo, M., Hollar, M., Espaillat, K. B., Kirshner, H., & Schrag, M. (2018). Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. Am J Ophthalmol, 196 , 96-100. doi:10.1016/j.ajo.2018.08.027
Jan 21, 2019•15 min
Dr. Jason Hsu discusses the review of patients with PDR who were lost to followup after limited anti-VEGF or PRP treatment and returned for treatment after at least 6 mo. Full reference: Obeid, A., Su, D., Patel, S. N., Uhr, J. H., Borkar, D., Gao, X., . . . Hsu, J. (2018). Outcomes of Eyes Lost to Follow-up with Proliferative Diabetic Retinopathy That Received Panretinal Photocoagulation versus Intravitreal Anti-Vascular Endothelial Growth Factor. Ophthalmology . doi:10.1016/j.ophtha.2018.07.02...
Dec 17, 2018•25 min
Drs. Muni and Hillier discuss the results of the PIVOT study that prospectively compared results of pneumatic retinopexy vs. pars plana vitrectomy for repair of rhegmatogenous retinal detachment. This podcast episode is simulcast with the online appearance of the article. Full reference: Hillier, R. J., Felfeli, T., Berger, A. R., Wong, D. T., Altomare, F., Dai, D., . . . Muni, R. H. (2018). The Pneumatic Retinopexy versus Vitrectomy for the Management of Primary Rhegmatogenous Retinal Detachmen...
Nov 26, 2018•29 min
Professor Robyn Guymer from Melbourne, Australia discusses results of the LEAD trial that investigated the use of nanopulase laser for dry AMD. Full reference of the article: Guymer, R. H., Wu, Z., Hodgson, L. A. B., Caruso, E., Brassington, K. H., Tindill, N., . . . Laser Intervention in Early Stages of Age-Related Macular Degeneration Study, G. (2018). Subthreshold Nanosecond Laser Intervention in Age-Related Macular Degeneration: The LEAD Randomized Controlled Clinical Trial. Ophthalmology . ...
Nov 12, 2018•13 min
Dr. Ozkok describes his publication on the association of Red Blood Cells Distribution Width (RDW) and vision in patients with Central or Branch Retina Vein Occlusion. Full Reference of the article: Ozkok, A., Nesmith, B. L. W., & Schaal, S. (2018). Association of Red Cell Distribution Width Values with Vision Potential in Retinal Vein Occlusion. Ophthalmology Retina, 2 (6), 582-586. doi:10.1016/j.oret.2017.09.018
Oct 16, 2018•18 min
Dr. Jennifer Sun discusses 5-year results of DRCR.net Protocol S that investigated outcomes of treatment of proliferative diabetic retinopathy using traditional PRP laser vs intravitreal ranibizumab injections. Full reference: Gross, J. G., Glassman, A. R., Liu, D., Sun, J. K., Antoszyk, A. N., Baker, C. W., . . . Diabetic Retinopathy Clinical Research, N. (2018). Five-Year Outcomes of Panretinal Photocoagulation vs Intravitreous Ranibizumab for Proliferative Diabetic Retinopathy: A Randomized C...
Sep 11, 2018•26 min
Dr. Camiel Boon from Leiden University Medical Center (LUMC) and Amsterdam University Medical Centers in Amsterdam discusses the results of his research work on the comparison of half-dose PDT vs micropulse laser to treat central serous chorioretinopathy. Full reference of the discussed article: van Dijk, E. H. C., Fauser, S., Breukink, M. B., Blanco-Garavito, R., Groenewoud, J. M. M., Keunen, J. E. E., . . . Boon, C. J. F. (2018). Half-Dose Photodynamic Therapy versus High-Density Subthreshold ...
Jul 17, 2018•26 min
Dr. Chakravarthy from Belfast, UK discusses a secondary analysis of the IVAN Trial to compare effects of intravitreal anti-VEGF therapy on serum VEGF levels with possible trends in system adverse events in the context of wet AMD. Full reference: Chris A.Rogers, Lauren J.Scott, Barnaby C.Reeves, Susan Downes, Andrew J.Lotery, Andrew D.Dick, Usha Chakravarthy for IVAN trial investigators, Serum Vascular Endothelial Growth Factor Levels in the IVAN Trial; Relationships with Drug, Dosing, and System...
Jun 11, 2018•15 min
Dr. Charles Wykoff discusses results of DRCR protocol T ancillary study on plasma free VEGF concentrations after different intravitreal anti-VEGF injections for diabetic macular edema. Full reference of the discussed article: Jampol, L. M., A. R. Glassman, D. Liu, L. P. Aiello, N. M. Bressler, E. J. Duh, S. Quaggin , et al. "Plasma Vascular Endothelial Growth Factor Concentrations after Intravitreous Anti-Vascular Endothelial Growth Factor Therapy for Diabetic Macular Edema." Ophthalmology (Mar ...
May 30, 2018•21 min
Dr. Sean Adrean discusses his retrospective analysis of patients with wet AMD who had over 50 anti-VEGF injections. Full reference of the discussed article: Adrean, S. D., S. Chaili, H. Ramkumar, A. Pirouz, and S. Grant. "Consistent Long-Term Therapy of Neovascular Age-Related Macular Degeneration Managed by 50 or More Anti-Vegf Injections Using a Treat-Extend-Stop Protocol." Ophthalmology (Feb 10 2018).
May 14, 2018•18 min
Dr. Mark Humayun discusses the results of his team's work on implantation of RPE stems cells placed on a bioengineered surface for dry AMD. Full reference of the article: Kashani, A. H., Lebkowski, J. S., Rahhal, F. M., Avery, R. L., Salehi-Had, H., Dang, W., . . . Humayun, M. S. (2018). A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Sci Transl Med, 10 (435). doi:10.1126/scitranslmed.aao4097
Apr 23, 2018•27 min
Dr. David Almeida discusses the result of his group's large retrospective analysis of management and outcomes of 40 cases of endophthalmitis from over 258,000 intravitreal anti-VEGF injections. Full reference: Xu, K., Chin, E. K., Bennett, S. R., Williams, D. F., Ryan, E. H., Dev, S., . . . Almeida, D. R. P. (2018). Endophthalmitis after Intravitreal Injection of Vascular Endothelial Growth Factor Inhibitors: Management and Visual Outcomes. Ophthalmology . doi:10.1016/j.ophtha.2018.01.022...
Apr 09, 2018•23 min
Dr. Rajeev Muni describes the results of his research on the correlation of cytokine levels (VEGF, ICAM, etc) and the anatomical response to intravitreal ranibizumab for the treatment of diabetic macular edema. Full reference of the article: Hillier, R. J., Ojaimi, E., Wong, D. T., Mak, M. Y. K., Berger, A. R., Kohly, R. P., . . . Muni, R. H. (2018). Aqueous Humor Cytokine Levels and Anatomic Response to Intravitreal Ranibizumab in Diabetic Macular Edema. JAMA Ophthalmol . doi:10.1001/jamaophtha...
Mar 28, 2018•40 min
Dr. SriniVas Sadda discusses development of macular atrophy in an analysis of HARBOR Study which investigated treatment of wet AMD using 0.5 mg and 2.0 mg of Ranibizumab dosing. Full reference of the discussed article: Sadda, S. R., Tuomi, L. L., Ding, B., Fung, A. E., & Hopkins, J. J. (2018). Macular Atrophy in the HARBOR Study for Neovascular Age-Related Macular Degeneration. Ophthalmology . doi:10.1016/j.ophtha.2017.12.026
Mar 12, 2018•15 min
Dr. David Brown discusses his recent article in Ophthalmology about the role of targeted peripheral retinal laser photocoagulation to lower the treatment burden for diabetic macular edema. Full reference of the article: Brown, D. M., Ou, W. C., Wong, T. P., Kim, R. Y., Croft, D. E., Wykoff, C. C., & Group, D. S. (2018). Targeted Retinal Photocoagulation for Diabetic Macular Edema with Peripheral Retinal Nonperfusion: Three-Year Randomized DAVE Trial. Ophthalmology . doi:10.1016/j.ophtha.2017...
Feb 26, 2018•24 min
Dr. M. Ali Khan describes his article on the long term outcomes of 27-gauge vitrectomy for 390 eyes. Full reference of the articles is: Khan, M. A., Kuley, A., Riemann, C. D., Berrocal, M. H., Lakhanpal, R. R., Hsu, J., . . . Regillo, C. D. (2017). Long-Term Visual Outcomes and Safety Profile of 27-Gauge Pars Plana Vitrectomy for Posterior Segment Disease. Ophthalmology . doi:10.1016/j.ophtha.2017.09.013 Please leave your comments on iTunes or via theretinachannel@gmail.com...
Feb 13, 2018•23 min
Dr. Chirag Shah discusses his pilot randomized clinical trial on the application of YAG Vitreolysis to reduce symptoms of floaters associated with Weiss ring. The full reference of the discussed article is: Shah, C. P., & Heier, J. S. (2017). YAG Laser Vitreolysis vs Sham YAG Vitreolysis for Symptomatic Vitreous Floaters: A Randomized Clinical Trial. JAMA Ophthalmol, 135 (9), 918-923. doi:10.1001/jamaophthalmol.2017.2388 Please leave your feedback and comments in iTunes or via theretinachann...
Jan 29, 2018•25 min
Dr. Raj Maturi from DRCR.net discusses final results of the DRCR.net protocol U, which investigated addition of Dexamethasone implant to ranibizumab for the treatment of persistent diabetic macular edema. The full reference of the article is: Maturi, R. K., Glassman, A. R., Liu, D., Beck, R. W., Bhavsar, A. R., Bressler, N. M., . . . Diabetic Retinopathy Clinical Research, N. (2017). Effect of Adding Dexamethasone to Continued Ranibizumab Treatment in Patients With Persistent Diabetic Macular Ed...
Dec 24, 2017•19 min
Dr. Charlie Wykoff describes the treat-and-extend (TREX) approach for the treatment of wet AMD. He then explains the study design and the 3-year results of the TREX-AMD trial. The full reference of the article is: Wykoff, C. C., Ou, W. C., Croft, D. E., Payne, J. F., Brown, D. M., Clark, W. L., . . . Group, T.-A. S. (2017). Neovascular age-related macular degeneration management in the third year: final results from the TREX-AMD randomised trial. Br J Ophthalmol . doi:10.1136/bjophthalmol-2017-3...
Dec 08, 2017•29 min
Dr. Robert Devenyi discusses the 5-year safety and performance results of the Argus II retinal prosthesis implant. He also share his own experience with the device including surgical steps and patient outcomes. The episode logo reflects the retinal images of the 11 devices that he has implanted so far. The full reference of the article is: da Cruz, L., et al. (2016). "Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial." Ophthalmology 123(10): 2248...
Nov 26, 2017•45 min
Dr. Brian Ballios uses his expertise to talk about the article titled "Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration" by Mandai et al. The article reports use of induced pluripotent stems to culture and transplant Retinal Pigment Epithelial Cells in a patient with advanced Age-Related Macular Degeneration. The full reference to the article: Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration, Mandai M, Watanabe A, Kurimoto Y, Hirami Y, Morina...
Nov 10, 2017•30 min
Dr. Amin Kherani discusses the Clarity study which compares use of intravitreal aflibercept injections versus PRP laser for proliferative diabetic retinopathy. We also briefly discuss DRCR.net protocol S results that compare intravitreal ranibizumab versus PRP laser for the same indication. Full reference of the Clarity article: Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at ...
Oct 23, 2017•23 min•Season 1Ep. 1
