Ep. 54: “Innate and Mucosal Immunity” Featuring Dr. Bana Jabri

Guest:

Dr. Bana Jabri is the Sarah and Harold Lincoln Thompson Professor in the Department of Medicine and the Research Director of the Celiac Disease Center at the University of Chicago. Her research focuses on innate and mucosal immunity, particularly in celiac disease, autoimmune disorders, and inflammatory bowel disease. She talks about the mechanisms of celiac disease and new treatment options. She also discusses how the microbiome can affect immune responses in cancer.

Featured Products and Resources:

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The Immunology Science Round Up

Capsules to Study the Intestinal Environment – Scientists developed an ingestible device that collects samples from multiple regions of the human intestinal tract during digestion.

T Cell Receptor Affinity – Repetitive pathogen exposure leads to the dominant outgrowth of T cell clones with high T cell receptor affinity to the relevant pathogen-associated antigens.

Gut Bacterial Evolution Between Species – Analyses of metagenome-resolved genomes from humans and primate species reveal significant co-diversification of bacterial gut symbionts.

A Pancreatic Cancer Vaccine – Researchers synthesized mRNA neoantigen vaccines in real time from surgically resected pancreatic ductal adenocarcinoma tumors.

Image courtesy of Dr. Bana Jabri

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