Ep. 23: “Dendritic Cells and the Immune System” Featuring Dr. Caetano Reis e Sousa

Guest:

Dr. Caetano Reis e Sousa is the Assistant Research Director and Senior Group Leader at the Francis Crick Institute. His lab studies the molecular pathways that trigger dendritic cells into action. He talks about the mechanisms of dendritic cell cross-presentation, RNA interference, and dendritic cell progenitors in influenza.

Featured Products and Resources:

• Differentiate Human Monocytes into Dendritic Cells with ImmunoCult Dendritic Cell Culture Kit
• The STEMdiff Monocyte Kit generates millions of monocytes ready for downstream assays or further development into macrophages or dendritic cells.

The Immunology Science Round Up

T Cell Responses to Omicron – T cell responses in individuals with prior infection, vaccination, both prior infection and vaccination, and boosted vaccination are largely preserved to Omicron spike and non-spike proteins.

Curing Cancer with CAR T Therapy – Ten years after treatment, two leukemia patients remained in remission and had long-persisting CD4+ CAR T cells.

Vimentin Helps SARS-CoV-2 Enter Endothelial Cells – Vimentin could facilitate SARS-CoV-2 infection and contribute to vascular complications associated with COVID-19.

Probing T Cell Function with CRISPR – Researchers mapped the functional gene networks regulating interleukin-2 and interferon gamma in human T cells.

Image courtesy of Dr. Caetano Reis e Sousa

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